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中国有色金属学会会刊：英文版 2009年第B9期19卷 301-306页

作者： Tae-Soo KWAK yong-Chul LEE gyung-Nyun KIM Dae-Bong choi Mikio YAMANOI Hitoshi OHMORI Department of Mechanical Engineering Jinju National University

This study is focused on the application of an effective fabrication method combining electrolytic in-process dressing(ELID) grinding and magnetic assisted polishing(MAP) to nano-precision mirror surface grinding on the optics glass-ceramic named Zerodure that is commonly used in precision optics components. The results show the variation of surface roughness after MAP processes utilizing Fe+CeO2, Fe+CeO2+diamond paste and Fe+diamond paste are applied to ELID ground surfaces. The MAP surface roughnesses for ELID ground surface roughnesses(Ra) of 52.1, 39.8 and 51.1 nm using #1200 grinding wheel are improved to 6.1, 4.6 and 1.9 nm, respectively. The surface roughness of MAP process using Fe+CeO2+diamond paste is superior to that using other processes. Moreover, it takes less than 10 min to conduct the MAP processes. The combined method suggested effectively reduces the working time to get the required surface qualities.

关键词：在线电解修整光学玻璃纳米相抛光材料电解过程表面粗糙度地面粗糙度磨削

3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration

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Bioactive Materials 2023年第1期19卷 611-625页

作者： Suhun Chae Uijung yong Wonbin Park Yoo-mi choi In-Ho Jeon Homan Kang Jinah Jang Hak Soo choi Dong-Woo Cho Department of Mechanical Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea EDmicBio Inc. 111 Hoegi-roDongdaemun-guSeoul 02445South Korea Institute for Convergence Research and Education in Advanced Technology Yonsei University50 Yonsei-roSeodaemun-guSeoul03722South Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital&Harvard Medical School14913th StreetBostonMA02114USA Department of Convergence IT Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea Department of Orthopaedic Surgery Asan Medical CenterCollege of MedicineUniversity of Ulsan86 Asanbyeongwon-gilSongpa-guSeoul05505South Korea

Owing to the prevalence of rotator cuff(RC)injuries and suboptimal healing outcome,rapid and functional regeneration of the tendon-bone interface(TBI)after RC repair continues to be a major clinical *** the essential role of the RC in shoulder movement,the engineering of biomimetic multi-tissue constructs presents an opportunity for complex TBI reconstruction after RC ***,we propose a gradient cell-laden multi-tissue construct combined with compositional gradient TBI-specific bioinks via 3D cell-printing *** vitro studies demonstrated the capability of a gradient scaffold system in zone-specific inducibility and multi-tissue formation mimicking *** regenerative performance of the gradient scaffold on RC regeneration was determined using a rat RC repair *** particular,we adopted nondestructive,consecutive,and tissue-targeted near-infrared fluorescence imaging to visualize the direct anatomical change and the intricate RC regeneration progression in real time in ***,the 3D cell-printed implant promotes effective restoration of shoulder locomotion function and accelerates TBI healing in *** summary,this study identifies the therapeutic contribution of cell-printed constructs towards functional RC regeneration,demonstrating the translational potential of biomimetic gradient constructs for the clinical repair of multi-tissue interfaces.

关键词： 3D cell-printing Tissue-specific bioink Gradient tissue scaffolds Near-infrared fluorophores Rotator cuff repair

Diverse Functions of VDUP1 in Cell Proliferation,Differentiation,and Diseases

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Cellular & Molecular Immunology 2007年第5期4卷 345-351页

作者： Sang yong Kim Hyun-Woo Suh Jin Woong Chung Suk-Ran Yoon Inpyo choi Stem Cell Research Center Korea Research Institute of Bioscience and BiotechnologyYusongTaejon 305-333Republic of Korea

Vitamin D3 up-regulated protein 1 （VDUP1） is a multifunctional protein involved in maintaining cellular homeostasis. VDUP1 is induced by a variety of stresses. Inversely, VDUP1 is often reduced in various tumor tissues and cell lines. Over-expression of VDUP1 inhibits cell proliferation through cell cycle arrest. VDUP1 interacts with thioredoxin （Trx） and negatively regulates the expression and antioxidant function of Trx which is involved in redox regulation. VDUP1/ mice are more susceptible to carcinogenesis than wild-type mice and are defective in establishing immune system induding the development and function of natural killer cells. Furthermore, VDUP1^-/- mice show impaired Kreb cycle-mediated fatty acid utilization. In this review, we have discussed the multifunctional roles of VDUP1 in diverse cellular responses, in particular its relation to proliferation, apoptosis, differentiation, and diseases such as cancer and stress-related diseases.

关键词： VDUP1 thioredoxin proliferation immune cell

Understanding the physical metallurgy of the CoCrFeMnNi high-entropy alloy:an atomistic simulation study

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npj Computational Materials 2018年第1期4卷 662-670页

作者： Won-Mi choi yong Hee Jo Seok Su Sohn Sunghak Lee Byeong-Joo Lee Department of Material Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Although high-entropy alloys(HEAs)are attracting interest,the physical metallurgical mechanisms related to their properties have mostly not been clarified,and this limits wider industrial applications,in addition to the high alloy *** clarify the physical metallurgical reasons for the materials phenomena(sluggish diffusion and micro-twining at cryogenic temperatures)and investigate the effect of individual elements on solid solution hardening for the equiatomic CoCrFeMnNi HEA based on atomistic simulations(Monte Carlo,molecular dynamics and molecular statics).A significant number of stable vacant lattice sites with high migration energy barriers exists and is thought to cause the sluggish *** predict that the hexagonal close-packed(hcp)structure is more stable than the face-centered cubic(fcc)structure at 0 K,which we propose as the fundamental reason for the micro-twinning at cryogenic *** alloying effect on the critical resolved shear stress(CRSS)is well predicted by the atomistic simulation,used for a design of non-equiatomic fcc HEAs with improved strength,and is experimentally *** study demonstrates the applicability of the proposed atomistic approach combined with a thermodynamic calculation technique to a computational design of advanced HEAs.

关键词： alloy alloying entropy

Triolein emulsion infusion into the hepatic artery increases vascular permeability to doxorubicin in rabbit liver

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World Journal of Gastroenterology 2021年第2期27卷 152-161页

作者： yong-Woo Kim Hak Jin Kim Byung Mann Cho Seon Hee choi Department of Radiology Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalPusan National University College of MedicineYangsan 50612South Korea Department of Radiology Biomedical Research InstitutePusan National University HospitalPusan National University College of MedicineBusan 49241South Korea Preventive Medicine and Occupational Medicine Pusan National University School of MedicineYangsan 50612South Korea Department of Radiology Pusan National UniversityBusan 49241South Korea

BACKGROUND The infusion of triolein emulsion(TE)induced increased vascular permeability and a negligible and temporary decrease in liver function without specific histopathological *** To assess changes in doxorubicin concentration according to the percentage of TE infused via a hepatic artery to study the vascular permeability in the rabbit *** Thirty-nine healthy rabbits were divided into five groups according to the concentration of emulsified triolein infused into the hepatic arteries:Group 0,saline infusion(control group,n=5);group 1,0.3%TE(n=13);group 2,0.6%TE(n=6);group 3,0.9%TE(n=8);and group 4,1.5%TE(n=6).Doxorubicin(2.4 mg/kg)was infused immediately after TE injection via the hepatic *** 2 h,the livers were harvested,and doxorubicin concentrations were calculated *** doxorubicin concentrations were compared between TE groups and the control group,and the optimal concentrations within the TE groups were *** analysis was performed using the nonparametric Mann-Whitney U test and Kruskal-Wallis test.P0.05).CONCLUSION TE infusion into the hepatic arteries significantly increased the doxorubicin concentration approximately twofold but was not different between the TE *** findings suggest that TE infusion might be a useful adjuvant treatment of liver cancers.

关键词： Triolein emulsion Liver tumor Chemotherapy Drug delivery Vascular permeability Dexorubicin

Comprehensive evaluation of marine waste heat recovery technologies based on Hierarchy-Grey correlation analysis

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Journal of Ocean Engineering and Science 2019年第4期4卷 308-316页

作者： Jong Ju-yong Rim Chang-Hyon choi Myong-Sin Om Hyon-Chol Department of Energy Science Kim Il Sung UniversityPyongyangDemocratic People’s Republic of Korea College of Mechanical Science and Technical KimCheak University of TechnologyPyongyangDemocratic People’s Republic of Korea

In this study,comprehensive evaluation of the technologies on waste heat recovery technologies for maritime applications has been carried *** have focused our research on exhaust gas turbine system(EGT),thermodynamic organic rankine cycle(RC),Kalina cycle(KC)and thermoelectric generators(TG),which are the most appropriate and most up-to-date techniques for recovering power from marine *** technology has its own advantages and disadvantages,so the comprehensive evaluation of these technologies is essential to accurately determine which technology will be applied to which *** belongs to the multi-criteria decision(MCDM)*** combined assessment methodology,consisting of gray correlation and analysis hierarchy processes,has been applied to evaluate four waste heat recovery techniques in terms of technical,economic,social and environmental *** to the comparison results,the exhaust gas turbine system has been evaluated as the most promising technology among the various WHR technologies that can be applied to marine *** analysis suggests that if investment cost of TG falls to about the same level as the one of EGT,TG could be the best method among these *** of investment cost of TG technology could be realized by development of low cost thermoelectric *** have analyzed the correlation between each cost through DOE analysis and investigate the effect of individual costs on the total *** work helps in identifying the most suitable heat recovery technologies for marine engine.

关键词： Waste heat recovery Marine engine Grey relational analysis Analytic hierarchy process Comprehensive evaluation

Sweet food improves chronic stress-induced irritable bowel syndrome-like symptoms in rats

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World Journal of Gastroenterology 2014年第9期20卷 2365-2373页

作者： Sang-gyun Rho yong Sung Kim Suck Chei choi Moon Young Lee Department of Emergency Medical Services Sunmoon University Chungnam Asan 336-708 South Korea Department of Gastroenterology and Wonkwang Digestive Disease Research Institute Wonkwang University Sanbon Hospital Gyeonggi Gunpo 435-040 South Korea Department of Gastroenterology and Wonkwang Digestive Disease Research Institute School of MedicineWonkwang University Jeonbuk Iksan 570-974 South Korea Department of Physiology and Institute of Wonkwang Medical Science and Wonkwang Digestive Disease Research Institute School of Medicine Wonkwang UniversityJeonbuk Iksan 570-749 South Korea

AIM: To investigate whether palatable sweet foods have a beneficial effect on chronic stress-induced colonic motility and inflammatory cytokines.

关键词： Irritable bowel syndrome Colon Stress Adrenal hormones Cytokines Rat

Recurrent intramuscular lipoma at extensor pollicis brevis:A case report

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World Journal of Clinical Cases 2023年第3期11卷 684-691页

作者： Je Yeon Byeon yong Seon Hwang Ji Hye Lee Hwan Jun choi Plastic and Reconstructive Surgery Soonchunhyang University HospitalCheonan-si 31151South Korea Department of Pathology Soonchunhyang University HospitalCheonan-si 31151South Korea

BACKGROUND This report describes and discusses recurrent intramuscular lipoma(IML)of the extensor pollicis brevis(EPB).An IML usually occurs in a large muscle of the limb or *** of IML is *** IMLs,especially those with unclear boundaries,necessitate complete *** cases of IML in the hand have been ***,recurrent IML appearing along the muscle and tendon of EPB on wrist and forearm has not been reported *** SUMMARY In this report,the authors describe clinical and histopathological features of recurrent IML at EPB.A 42-year-old Asian woman presented with a slowgrowing lump in her right forearm and wrist area six months *** patient had a history of surgery for a lipoma of the right forearm one year ago with a scar of 6cm on the right *** resonance imaging confirmed that the lipomatous mass,which had attenuation similar to subcutaneous fat,had invaded the muscle layer of *** and biopsy were performed under general *** histological examination,it was identified as an IML showing mature adipocytes and skeletal muscle ***,surgery was terminated without further *** recurrence occurred during a follow-up of five years after *** Recurrent IML in the wrist must be examined to differentiate it from *** to surrounding tissues should be minimized during excision.

关键词： Intramuscular Lipoma Recurrence Wrist Case report

Relative skeletal muscle mass and non-alcoholic fatty liver disease: from association to causation

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 509-511页

作者： Hee Yeon Kim Jong Young choi yong-Moon Park Division of Hepatology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoulKorea Epidemiology Branch National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle ParkNCUSA

The prevalence of nonalcoholic fatty liver disease(NAFLD)and its associated metabolic risk factors,including obesityand metabolic syndrome,have increased over the lastdecade in both developed and developing countries(1).NAFLD is considered to be the hepatic manifestation ofmetabolic syndrome and insulin resistance which is oneof multiple hits leading to NAFLD(2).

关键词： NAFLD liver hepatic

Differential transcriptional regulation of the NANOG gene in chicken primordial germ cells and embryonic stem cells

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Journal of Animal Science and Biotechnology 2021年第3期12卷 877-890页

作者： Hee Jung choi So Dam Jin Deivendran Rengaraj Jin Hwa Kim Bertrand Pain Jae yong Han Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences Seoul National UniversitySeoul 08826South Korea Univ Lyon UniversitéLyon 1INSERMINRAEStem Cell and Brain Research InstituteU1208USC136169500 BronFrance Institute for Biomedical Sciences Shinshu UniversityMinamiminowaNagano 399-4598Japan

Background:NANOG is a core transcription factor(TF)in embryonic stem cells(ESCs)and primordial germ cells(PGCs).Regulation of the NANOG gene by TFs,epigenetic factors,and autoregulatory factors is well characterized in ESCs,and transcriptional regulation of NANOG is well established in these *** NANOG plays a key role in germ cells,the molecular mechanism underlying its transcriptional regulation in PGCs has not been ***,we investigated the mechanism that regulates transcription of the chicken NANOG(cNANOG)gene in PGCs and ***:We first identified the transcription start site of cNANOG by 5′-rapid amplification of cDNA ends PCR ***,we measured the promoter activity of various 5′flanking regions of cNANOG in chicken PGCs and ESCs using the luciferase reporter *** expression required transcriptional regulatory elements,which were positively regulated by POU5F3(OCT4)and SOX2 and negatively regulated by TP53 in *** proximal region of the cNANOG promoter contains a positive transcriptional regulatory element(CCAAT/enhancer-binding protein(CEBP)-binding site)in ***,small interfering RNA-mediated knockdown demonstrated that POU5F3,SOX2,and CEBP played a role in cell type-specific transcription of ***:We show for the first time that different trans-regulatory elements control transcription of cNANOG in a cell type-specific *** finding might help to elucidate the mechanism that regulates cNANOG expression in PGCs and ESCs.

关键词： Chicken Embryonic stem cells NANOG gene Primordial germ cells Regulatory elements