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Proton pump inhibitors as a risk factor for recurrence of Clostridium-difficile-associated diarrhea

World Journal of Gastroenterology 2010年第28期16卷 3573-3577页

作者： Ji Won Kim Kook Lae Lee Ji Bong Jeong Byeong Gwan Kim Sue Shin Joo Sung Kim Hyun chae jung In Sung Song Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Boramae Hospital Seoul National University College of Medicine Seoul 156-707South Korea Department of Laboratory Medicine Seoul National University Boramae Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Hospital Seoul National University College of Medicine Seoul 110-744South Korea

AIM:To investigate the risk factors for Clostridiumdifficile-associated diarrhea(CDAD)recurrence,and its relationship with proton pump inhibitors(PPIs). METHODS:Retrospective data of 125 consecutive hospitalized patients diagnosed with CDAD between January 2006 and December 2007 were collected by medical chart *** data included patient characteristics at baseline,underlying medical disease, antibiotic history before receiving a diagnosis of CDAD, duration of hospital stay,severity of CDAD,concurrenttreatment with PPIs,laboratory parameters,response to CDAD therapy,and recurrence of disease within 90 d of successful *** clinical and laboratory parameters were compared in patients in whom CDAD did or did not recur. RESULTS:Of the 125 patients(mean age,67.6± 13.9 years)that developed CDAD,98(78.4%)did not experience recurrence(non-recurrent group)and 27 (21.6%)experienced one or more recurrences(recurrent group).Prior to the development of CDAD,96% of the 125 patients were prescribed antibiotics,and 56(44.8%)of the patients received *** older than 65 years(P=0.021),feeding via nasogastric tube(NGT)(P=0.045),low serum albumin level(P =0.025),and concurrent use of PPIs(P=0.014) were found to be risk factors for CDAD recurrence by univariate ***,sex,length of hospital stay,duration and type of antibiotics used,severity of disease,leukocyte count and C-reactive protein(CRP) were not associated with risk of CDAD *** multivariate analysis,the important risk factors were advanced age(>65 years,adjusted OR:1.32,95% CI:1.12-3.87,P=0.031),low serum albumin level(< 2.5 g/dL,adjusted OR:1.85,95%CI:1.35-4.91,P= 0.028),and concurrent use of PPIs(adjusted OR:3.48, 95%CI:1.64-7.69,P=0.016). CONCLUSION:Advanced age,serum albumin level< 2.5 g/dL,and concomitant use of PPIs were found to be significant risk factors for CDAD recurrence.

关键词： Clostridium difficile Diarrhea Recurrence Risk factors Proton pump inhibitors

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Is percutaneous endoscopic gastrostomy tube placement safe in patients with ventriculoperitoneal shunts?

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World Journal of Gastroenterology 2009年第25期15卷 3148-3152页

作者： Jin-Soo Kim yong-Wan Park Hyung-Keun Kim Young-Seok Cho Sung-Soo Kim Na-Ri Youn Hiun-Suk chae Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaUijeongbu St. Mary's Hospital

AIM:To investigate whether percutaneous endoscopic gastrostomy (PEG) tube placement is safe in patients with ventriculoperitoneal (VP) ***: This was a retrospective study of all patients undergoing PEG insertion at our institution between June 1999 and June 2006. Post-PEG complications were compared between two groups according to the presence or absence of VP shunts. VP shunt infection rates, the interval between PEG placement and VP shunt catheter insertion, and long-term follow-up were also ***: Fifty-five patients qualified for the study. Seven patients (12.7%) had pre-existing VP shunts. All patients received prophylactic antibiotics. The complication rate did not differ between VP shunt patients undergoing PEG (PEG/VP group) and non-VP shunt patients undergoing PEG (control group) [1 (14.3%) vs 6 (12.5%), P=1.000]. All patients in the PEG/VP group had undergone VP shunt insertion prior to PEG placement. The mean interval between VP shunt insertion and PEG placement was 308.7 d (range, 65-831 d). The mean follow-up duration in the PEG/VP group was 6.4 mo (range, 1-15 mo). There were no VP shunt infections, although one patient in the PEG/VP group developed a minor peristomal infection during ***: Complications following PEG placement in patients with VP shunts were infrequent in this study.

关键词：分流安全内镜聚乙二醇脑时间平均胃并发症

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Characterization of hidden rules linking symptoms and selection of acupoint using an artificial neural network model

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Frontiers of Medicine 2019年第1期13卷 112-120页

作者： Won-Mo jung In-Soo Park Ye-Seul Lee Chang-Eop Kim Hyangsook Lee Dae-Hyun Hahm Hi-Joon Park Bo-Hyoung Jang Younbyoung chae Department of Science in Korean Medicine Graduate SchoolKyung Hee UniversitySeoul 130-701Republic of Korea Acupuncture & Meridian Science Research Center College of Korean MedicineKyung Hee UniversitySeoul 130-701Republic of Korea Department of Physiology College of Korean MedicineGachon UniversitySeoul 131-120Republic of Korea Department of Physiology School of MedicineKyung Hee UniversitySeoul 130-701Republic of Korea Department of Preventive Medicine College of Korean MedicineKyung Hee UniversitySeoul 130-701Republic of Korea

Comprehension of the medical diagnoses of doctors and treatment of diseases is important to understand the underlying principle in selecting appropriate *** pattern recognition process that pertains to symptoms and diseases and informs acupuncture treatment in a clinical setting was explored. A total of 232 clinical records were collected using a Charting Language program. The relationship between symptom information and selected acupoints was trained using an artificial neural network (ANN). A total of 11 hidden nodes with the highest average precision score were selected through a tenfold cross-validation. Our ANN model could predict the selected acupoints based on symptom and disease information with an average precision score of 0.865 (precision, 0.911;recall, 0.811). This model is a useful tool for diagnostic classification or pattern recognition and for the prediction and modeling of acupuncture treatment based on clinical data obtained in a real-world setting. The relationship between symptoms and selected acupoints could be systematically characterized through knowledge discovery processes, such as pattern identification.

关键词： acupuncture indication neural network pattern identification prediction

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Association between follistatin-related protein 1 and the functional status of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

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Chinese Medical Journal 2021年第10期134卷 1168-1174页

作者： Taejun Yoon Sung Soo Ahn jung Yoon Pyo Jason jungsik Song yong-Beom Park Sang-Won Lee Department of Medical Science BK21 Plus ProjectYonsei UniversityCollege of MedicineSeoulRepublic of Korea Division of Rheumatology Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea Institute for Immunology and Immunological Diseases Yonsei University College of MedicineSeoulRepublic of Korea

Background:Follistatin-like 1(FSTL1)plays both pro-inflammatory and anti-inflammatory roles in the inflammatory *** investigated whether serum FSTL1 could predict the current anti-neutrophil cytoplasmic antibody-associated vasculitis(AAV)-specific ***:We randomly selected 74 patients with AAV from a prospective and observational cohort of Korean patients with *** and laboratory data and AAV-specific indices were ***1 concentration was determined using the stored *** lowest tertile of the short-form 36-item health survey(SF-36)was defined as the current low *** cutoffs of serum FSTL1 for the current low SF-36 physical component summary(PCS)and SF-36 mental component summary(MCS)were extrapolated by the receiver operator characteristic ***:The median age was 62.5 years(55.4%were women).Serum FSTL1 was significantly correlated with SF-36 PCS(r=-0.374),SF-36 MCS(r=-0.377),and C-reactive protein(CRP)(r=0.307),but not with Birmingham vasculitis activity score(BVAS).In the multivariable linear regression analyses,BVAS,CRP,and serum FSTL1 were independently associated with the current SF-36 PCS(β=-0.255,β=-0.430,andβ=-0.266,respectively)and the current SF-36 MCS(β=-0.234,β=-0.229,andβ=-0.296,respectively).Patients with serum FSTL1≥779.8 pg/mL and those with serum FSTL1≥841.6 pg/mL exhibited a significantly higher risk of having the current low SF-36 PCS and SF-36 MCS than those without(relative risk 7.583 and 6.200,respectively).Conclusion:Serum FSTL1 could predict the current functional status in AAV patients.

关键词： Anti-neutrophil cytoplasmic antibody Follistatin-like 1 Functional status Vasculitis

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Voxel-based statistical analysis of regional cerebral glucose metabolism in children with attention-deficit hyperactivity disorder

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Neural Regeneration Research 2011年第36期6卷 2850-2855页

作者： Ji-Hoon Kim Young-In Chung jung Sub Lee In-Joo Kim yong-Ki Kim Seong-Jang Kim Division of Child-Adolescent Psychiatry Department of Psychiatry Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Medical Research Institute Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Psychiatry Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Orthopedic Surgery Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Nuclear Medicine Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea

The technique of region of interest-based positron emission tomography is limited by its poor reli-ability and relatively few examined brain regions. In the present study, we compared brain metabo-lism assessed using fluorine-18-fluorodeoxyglucose positron emission tomography between 14 at-tention-deficit hyperactivity disorder （ADHD） patients and 15 normal controls with scoliosis at resting state by statistical parametric mapping. Glucose metabolism was decreased in the left parahippo-campal gyrus, left hippocampus, left anterior cingulate gyrus, right anterior and posterior lobes of the cerebellum, left superior temporal gyrus, left insula, left medial and middle frontal gyri, right medial frontal gyrus, and left basal ganglia （putamen, amygdala, and caudate nucleus） in children with ADHD. These data suggest that children with ADHD exhibit hypometabolism in various brain regions compared to controls, indicating that ADHD symptoms are unlikely the result of abnormalities in specific areas.

关键词： attention-deficit hyperactivity disorder positron emission tomography statistical parametric mapping

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Co-administration of ursodeoxycholic acid with rosuvastatin/ezetimibe in a non-alcoholic fatty liver disease model

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Gastroenterology Report 2022年第1期10卷 440-450页

作者： Sang Hyun Seo Da Hyun Lee Yu Seol Lee Kyung Joo Cho Hye jung Park Hye Won Lee Beom Kyung Kim Jun yong Park Do Young Kim Sang Hoon Ahn Soo Han Bae Seung Up Kim Department of Internal Medicine Graduate School of Medicine ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalSeoulRepublic of Korea Severance Biomedical Science Institute Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoulRepublic of Korea

Background Ursodeoxycholic acid(UDCA),statins,and ezetimibe(EZE)have demonstrated beneficial effects against nonalcoholic fatty liver disease(NAFLD).We investigated the efficacy of the combination of UDCA and the mix of rosuvastatin(RSV)/EZE in the treatment of *** NAFLD mouse models were developed by injecting thioacetamide,fasting,and high-carbohydrate refeeding,highfat diet,and choline-deficient L-amino acid-defined high-fat diet(CDAHFD).Low-dose UDCA(L-UDCA;15 mg/kg)or highdose UDCA(H-UDCA;30 mg/kg)was administered with RSV/*** also employed an in vitro model of NAFLD developed using palmitic acid-treated Hepa1c1c7 *** Co-administration of RSV/EZE with UDCA significantly decreased the collagen accumulation,serum alanine aminotransferase(ALT)levels,and mRNA levels of fibrosis-related markers than those observed in the vehicle group in thioacetamide-treated mice(all P<0.01).In addition,in the group fasted and refed with a high-carbohydrate diet,UDCA/RSV/EZE treatment decreased the number of apoptotic cells and serum ALT levels compared with those observed in the vehicle group(all P<0.05).Subsequently,H-UDCA/RSV/EZE treatment decreased the number of ballooned hepatocytes and stearoyl-CoA desaturase 1(SCD-1)mRNA levels(P=0.027)in the liver of high-fat diet-fed mice compared with those observed in the vehicle *** the CDAHFD-fed mouse model,UDCA/RSV/EZE significantly attenuated collagen accumulation and fibrosis-related markers compared to those observed in the vehicle group(all P<0.05).In addition,UDCA/RSV/EZE treatment significantly restored cell survival and decreased the protein levels of apoptosis-related markers compared to RSV/EZE treatment in palmitic acid-treated Hepa1c1c7 cells(all P<0.05).Conclusion Combination therapy involving UDCA and RSV/EZE may be a novel strategy for potent inhibition of NAFLD progression.

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis ursodeoxycholic acid rosuvastatin ezetimibe

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A framework of hybrid authentication for link access under MIH environments

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Journal of Measurement Science and Instrumentation 2012年第4期3卷 362-369页

作者： Kangsuk chae Jiman Mun Souhwan jung School of Electronic Engineering Soongsil University

A unified hybrid authentication framework was proposed to provide proactive authentication and re-authentication for media independent handover(MIH)-based multi-wireless *** addition,a specific protocol distributing a hierarchical key after the proactive authentication from key holder to base station has been *** proposed hybrid authentication framework not only performs proactive authentication with credentials based on Chameleon hashing,which removes the authentication procedures that exchanges messages with a authentication server,but also performs re-authentication with EAP re-authentication protocol(ERP)that distributes the hierarchical key on the basis of the root key generated by the proactive authentication.

关键词：自动化系统数据处理数据收集自动分类

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Hepatocellular carcinoma in Budd-Chiari syndrome:A single center experience with long-term follow-up in South Korea

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World Journal of Gastroenterology 2012年第16期18卷 1946-1952页

作者： Hana Park Jin Young Yoon Kyeong Hye Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han chae Yoon Chon Jun yong Park Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Institute of Gastroenterology Yonsei University College of MedicineSeoul 120-752South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752South Korea Brain South Korea 21 Project for Medical Science Seoul 120-752South Korea

AIM:To evaluate long-term clinical course of BuddChiari syndrome(BCS) and predictive factors associated with the development of hepatocellular carcinoma(HCC) and ***:We analyzed 67 patients with BCS between June 1988 and May *** diagnosis of BCS was confirmed by hepatic venous outflow obstruction shown on abdominal ultrasound sonography,computed tomography,magnetic resonance imaging,or *** median follow-up period was 103 ± 156 [interquartile range(IQR)] ***:The median age of the patients was 47 ± 16(IQR) *** diagnosis,54 patients had cirrhosis,25(37.3%) Child-Pugh class A,23(34.3%) Child-Pugh class B,and six(9.0%) patients Child-Pugh class *** the follow-up period,HCC was developed in 17 patients,and the annual incidence of HCC in patients with BCS was 2.8%.Patients in HCC group(n = 17) had higher hepatic venous pressure gradient(HVPG) than those in non-HCC group(n = 50)(21 ± 12 mmHg vs 14 ± 7 mmHg,P = 0.019).The survival rate of BCS patients was 86.2% for 5 years,73.8% for 10 years,and 61.2% for 15 *** patients with BCS and HCC,survival was 79% for 5 years,43.1% for 10 years,and 21.5% for 15 ***:The incidence of HCC in patients with BCS was similar to that in patients with other etiologic cirrhosis in South *** HVPG is expected to provide additional information for predicting HCC development in BCS patients.

关键词：综合征肝癌随访韩国 BCS 毫米汞柱磁共振成像肝细胞癌

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Je-Chun-Jun induced apoptosis of human cervical carcinoma HeLa cells

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Acta Pharmacologica Sinica 2004年第10期 132-139页

作者： Han-jung chae,Kyung-mi PARK,Geun-youn LEE,Gi-seup JEONG,Hyung-rae PARK,Hyung-min KIM,Soo-wan chae,Shim-keun YOO,Hyung-ryong KIM Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Pharmacology College of Oriental Medicine Kyung Hee University Seoul South Korea Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea

AIM: To study the mechanism of Je-Chun-Jun (JCJ)-inducing the apoptosis of the human cervical carcinoma, HeLa cells. METHODS: The cell viability was assessed using MTT assay. The optical density was measured at 570 nm. The caspase activity was measured using 50 mmol/L of fluorogenic substrate, AC-DEVD-AMC (caspase-3), AC-VEID-AMC (caspase-8) or AC-LEHD-AFC (caspase-9). To confirm the expression of proteins, Western blotting was performed. To detect the characteristic of apoptosis chromatin condensation, HeLa cells were stained with Hoechst 33258 in the presence of JCJ. For the cell cycle analysis, HeLa cells were incubated with Propidium iodide (PI) solution. Fluorescence intensity of cell cycle was measured using flow cytometry system. RESULTS: The loss of viability occurred following the exposure of 10 g/L JCJ. Cells treated with 10 g/L JCJ for 3 d exhibited the apoptotic morphology (brightly blue-fluorescent condensed nuclei by Hoechst 33258-staining) and the reduction of cell volume. Cells incubated

关键词： herbal medicine apoptosis p38 MAPK HeLa cells

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Impacts of chicken manure and peat-derived biochars and inorganic P alone or in combination on phosphorus fractionation and maize growth in an acidic ultisol

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Biochar 2019年第3期1卷 283-291页

作者： Muhammad Aqeel Kamran Ren-Kou Xu Jiu-yu Li jung Jiang Ren-yong Shi State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesP.O.Box 821NanjingChina University of Chinese Academy of Sciences Beijing 100049China

The forms of phosphorus(P)in animal manure and peat are different from synthetic P fertilizers and will affect soil P fractions when they are used as P *** of chicken manure(CMB)and peat(PB)derived biochars(CMB and PB)alone or in combination with P fertilizer(KH_(2)PO_(4))and rock phosphate(RP)on plant/soil health and soil P fractions in an acidic ultisol were examined with greenhouse pot *** total P rate was constant at 120 mg kg^(−1) in all *** P fractions,P uptake,and maize growth were determined after 56 *** of CMB combined with P fertilizer or alone significantly increased soil pH,water extractable and relatively labile P,dry matter yield of maize,chlorophyll contents in maize leaves,while decreasing the Fe and Al binding ***,sole application of CMB and PB showed greater effects than application of P fertilizer alone regarding plant growth and P *** of syn-thetic inorganic P sources with CMB or sole application of CMB is more beneficial than application of inorganic P sources to improve plant growth and P availability.

关键词： Acidic soil Manure-derived biochar Peat-derived biochar Inorganic P fertilizer P fractions Plant P uptake

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