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Clinical efficacy and mechanism study of mid-frequency anti-snoring device in treating moderate obstructive sleep apnea-hypopnea syndrome

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World Journal of Clinical Cases 2024年第5期12卷 942-950页

作者： Bao Qian Zhan-Jun Chen yong-sheng wang Xiao-Yan Hu Xiao-Biao Hu yong-Hua Zheng Pulmonary Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China Radiology Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China

BACKGROUND Obstructive sleep apnea-hypopnea syndrome(OSAHS)is primarily caused by airway obstruction due to narrowing and blockage in the nasal and nasopha-ryngeal,oropharyngeal,soft palate,and tongue base *** mid-frequency anti-snoring device is a new technology based on sublingual nerve *** principle is to improve the degree of oropharyngeal airway stenosis in OSAHS patients under mid-frequency wave ***,there is a lack of clinical application and imaging *** We selected 50 patients diagnosed with moderate OSAHS in our hospital between July 2022 and August *** underwent a 4-wk treatment regimen involving the mid-frequency anti-snoring device during nighttime *** the treatment,we monitored and assessed the sleep apnea quality of life index and Epworth Sleepiness Scale ***,we performed computed tomo-graphy scans of the oropharynx in the awake state,during snoring,and while using the mid-frequency anti-snoring ***-sectional area measurements in different states were taken at the narrowest airway point in the soft palate posterior and retrolingual *** Compared to pretreatment measurements,patients exhibited a significant reduction in the apnea-hypopnea index,the percentage of time with oxygen saturation below 90%,snoring frequency,and the duration of the most prolonged apnea *** lowest oxygen saturation showed a notable increase,and both sleep apnea quality of life index and Epworth Sleepiness Scale scores *** computed tomography scans revealed that in OSAHS patients cross-sectional areas of the oropharyngeal airway in the soft palate posterior area and retrolingual area decreased during snoring compared to the awake ***,during mid-frequency anti-snoring device treatment,these areas increased compared to *** The mid-frequency anti-snoring device demonstrates the potential to enhance various sleep parameters in pat

关键词： Mid-frequency anti-snoring device Obstructive sleep apnea-hypopnea syndrome Sleep monitoring Oropharyngeal computed tomography Curative effect

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Value of negative pressure sealing drainage on wound healing of Gustilo IIIB and IIIC open fractures

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World Journal of Clinical Cases 2024年第20期12卷 4199-4205页

作者： Bo Fang yong-sheng wang Wei Li Kai Ying Gang Zong Department of Trauma Surgery The Second People’s Hospital of DalianDalian 116019Liaoning ProvinceChina

BACKGROUND Gustilo III fractures have a high incidence and are difficult to *** often experience difficulty in wound *** pressure drainage technology can help shorten wound healing time and has positive value in improving patient *** To explore the clinical value of the negative pressure sealing drainage technique in wound healing of Gustilo IIIB and IIIC open *** Eighty patients with Gustilo IIIB and IIIC open fractures with skin and soft tissue injuries who were treated in the Second People’s Hospital of Dalian from March 2019 to December 2021 were selected as the research *** were divided into a study group(n=40,healed with negative pressure closed drainage)and a control group(n=40,healed with conventional dressing changes)according to the variation in the healing they *** efficacy of the clinical interventions,the variations in the regression indicators(time to wound healing,time to fracture healing,time to hospitalization),and the conversion and healing of bacterial wounds were compared 1-3 mo after the *** The total effective rate of patients among the study group was 95.00%(38/40),which was notably higher than 75.00%(30/40)among the control group(P<0.05).The wound healing time,fracture healing time,and hospital stay of the patients in the study group was shorter than the control group(P<0.05).After the intervention,the negative bacterial culture at the wound site rate and wound healing rate of the patients among the study group increased compared to the control group(P<0.05).CONCLUSION Negative pressure sealing and drainage technology has a good therapeutic effect on patients with Gustilo IIIB and IIIC open fracture wounds with skin and soft tissue *** can notably enhance the wound healing rate and the negative rate of bacteria on the wound surface and help to speed up the recovery process of patients.

关键词： Negative pressure closed drainage Gustilo type III open fracture Wound healing Clinical outcome Research value

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Tensile and compressive behavior of Ti-based bulk metallic glass composites

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International Journal of Minerals,Metallurgy and Materials 2013年第6期20卷 582-588页

作者： yong-sheng wang Guo-jian Hao Jun-pin Lin State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing

This article focuses on the tensile and compressive characteristics of a Ti-based bulk metallic glass composite （BMGC）. It is found that the yield stress, maximum strength, and fracture strain are 1380 MPa, 1516 MPa, and 4.3% for uniaxial tension, but 1580 MPa, 4010 MPa, and 29% for uniaxial compression, respectively. The composite displays a linear ＂work hardening＂ capacity under compression; however, the ＂work softening＂ behavior is observed in the true engineering stress-strain curve upon tensile loading. The fracture surfaces of specimens also exhibit dissimilar properties under the different loadings.

关键词： metallic glass composite materials tensile testing compression testing fracture

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Anti-oxidation characteristics of Cr-coating on surface of Ti-45Al-8.5Nb alloy by plasma surface metallurgy technique

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Chinese Physics B 2020年第12期29卷 386-395页

作者： Bing Zhou Ya-Rong wang Ke Zheng yong Ma yong-sheng wang sheng-wang Yu Yu-Cheng Wu Institute of New Carbon Materials Taiyuan University of TechnologyTaiyuan 030024China

TiAl-based alloys have received extensive attention recently due to their excellent properties. However, the weak oxidation resistance at temperatures higher than 800℃ can limit their further high-temperature structural *** improve the oxidation resistance of a high-Nb-content γ-TiAl alloy(Ti-45 Al-8.5 Nb, in units of at.%), a chromium(Cr)coating is prepared by using the plasma surface alloying technique, separately, at 800℃ and 1000℃. The x-ray diffraction(XRD) patterns reveal that an oxide surface layer consisting of Cr2O3, Al2O3, and TiO2 is produced on the Cr-coated Nb containing γ-TiAl substrates during the initial oxidation. However, the Cr2O3 is dominated in the oxide surface layer after being isothermally oxidized for 300 h. The oxidation kinetic curves are composed of a parabolic law stage(≤ 90 h) and a biquadratic law stage(≥ 90 h), fit by weight–gain curves. Due to diffusion in the fabrication process and oxidation process,the Cr-coated specimens have an adhesion force after being isothermally oxidized, specifically 69 N for a specimen after oxidation for 300 h. These results demonstrate that the Cr coating enhances the oxidation resistance and adhesion of a Ti-45 Al-8.5 Nb alloy, which may provide a new feasible scheme for designing oxidation protection layers.

关键词： titanium aluminum alloy coating isothermal oxidation plasma surface alloying technique

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Tribological Properties of a Dendrite-reinforced Ti-based Metallic Glass Matrix Composite under Different Conditions

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Journal of Iron and Steel Research International 2016年第1期23卷 57-63页

作者： Teng ZHANG Xiao-min LIN Hui-jun YANG yong LIU yong-sheng wang Jun-wei QIAO Research Institute of Surface Engineering Taiyuan University of Technology

The tribological properties of the in-situ dendrite-reinforced metallic glass matrix composite（Ti42Zr22V14-Cu5Be17）prepared by copper mould casting were analyzed at different normal loads under the dry condition and *** results showed that the average value of the frictional coefficients and micro-hardness ascended with increasing the normal load,while the wear rate showed a trend of decline under the dry *** electrochemical test results showed that the surface of samples was pitting corroded in the *** matrices were corroded *** the dendrites were exposed,leading to the damage of the *** the frictional coefficients and wear rate of the composite in the rainwater were larger than those under the dry condition,primarily owing to the corrosion of chloride ions on the worn *** wear mechanisms of composites were mainly adhesive wear,accompanied by the abrasive wear under the dry condition and corrosive wear in the *** composites have higher wear resistance both under the dry condition and rainwater due to the lower wear rate.

关键词： sliding wear surface topography electrochemical test pitting corrosion

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In situ growth of different numbers of gold nanoparticles on MoS_2 with enhanced electrocatalytic activity for hydrogen evolution reaction

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Chinese Physics B 2018年第6期27卷 473-478页

作者： Xuan Zhao Da-Wei He yong-sheng wang Chen Fu Key Laboratory of Luminescence and Optical Information Beijing Jiaotong University Beijing 100044 China

Producing hydrogen through a hydrogen evolution reaction（HER） by splitting water at the suitable overpotential is a great alternative to solving the problems of environmental pollution and the energy crisis. Molybdenum sulfide（MoS2）has attracted extensive attention as one of the most promising catalytic materials for HER. In this work, we design a facile method to in situ grow gold nanoparticles（Au NPs） on MoS2. Different numbers of Au NPs with MoS2 are used to find the best catalytic activity. Due to the larger active surface area and higher conductivity of the Au–MoS2 composites, all the Au–MoS2 composites exhibit more enhanced HER electroactivity than pure MoS2. In brief, the new material architecture exhibits optimized HER activity with a low onset overpotential of 0.12 V, low Tafel slope of 0.163 V·dec^（-1）, and an excellent stability in acidic solution.

关键词： MoS2 AuNPs hydrogen evolution reaction electrocatalysts

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Energy modeling and optimization of building condenser water systems with all-variable speed pumps and tower fans:A case study

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Building Simulation 2024年第7期17卷 1085-1111页

作者： yong Cao Chuang wang sheng wang Xiao Fu Xinguo Ming School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Air-Conditioning Equipment and System Energy Conservation Zhuhai 519070China GREE Electric Appliances Inc.of ZhuhaiZhuhai 519070China School of Environment and Energy Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China Beijing Advanced Innovation Centerfor Future Urban Design Beijing University of Civil Engineering and ArchitectureBeijing 100044China

The emergence of building condenser water systems with all-variable speed pumps and tower fans allows for increased efficiency and flexibility of chiller plants in partial load operation but also increases the control complexity of condenser water *** study aims to develop an integrated modeling technique for evaluating and optimizing the energy performance of such a condenser water *** proposed system model is based on the semi-physical semi-empirical chiller,pump,and cooling tower models,with capabilities of fully considering the hydraulic and thermal interactions in the condenser water loop,being solved analytically and much faster than iterative solvers and supporting the explicit optimization of the pump and tower fan frequency.A mathematical approach,based on the system model and constrained optimization technique,is subsequently established to evaluate the energy performance of a typical dual setpoint-based variable speed strategy and find its energy-saving potential and most efficient operation by jointly optimizing pumps and tower *** all-variable speed chiller plant from Wuhan,China,is used for a case study to validate the system model’s accuracy and explore its *** results showed that the system model can accurately simulate the condenser water system’s performance under various operating *** optimizing the frequencies of pumps and tower fans,the total system energy consumption can be reduced by 12%–13%compared to the fixed dual setpoint-based strategy with range and approach setpoints of 4℃and 2℃.In contrast,the energy-saving potential of optimizing the cooling tower sequencing is insignificant.A simple joint speed control method for optimizing the pumps and tower fans emerged,i.e.,the optimal pump and fan frequency are linearly correlated(if both are non-extremes)and depend on the chiller part load ratio only,irrespective of the ambient wet-bulb temperature and chilled water supply *** was also foun

关键词： all-variable speed chiller plant model-based optimization hydraulic and thermal coupling analytical solution dual setpoint-based variable speed control optimal joint speed control

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Establishing guidelines for CAR-T cells： challenges and considerations

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Science China(Life Sciences) 2016年第4期59卷 333-339页

作者： Wei wang Di-Yuan Qin Bing-Lan Zhang Wei Wei yong-sheng wang Yu-Quan Wei State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China Hospital Sichuan University Chengdu 610041 China Department of Emergency West China Hospital Sichuan University Chengdu 610041 China

T cells, genetically modified by chimeric antigen receptors(CAR-T), are endowed with specificity to a desired antigen and are cytotoxic to cells expressing the targeted antigen. CAR-T-based cancer immunotherapy is a promising therapy for curing hematological malignancy, such as acute lymphoid leukemia, and is promising for extending their efficacy to defeat solid tumors. To date, dozens of different CAR-T cells have been evaluated in clinical trials to treat tumors; this necessitates the establishment of guidelines for the production and application of CAR-T cells. However, it is challenging to standardize CAR-T cancer therapy because it involves a combination of gene therapy and cell therapy. In this review, we compare the existing guidelines for CAR-T cells and discuss the challenges and considerations for establishing guidance for CAR-T-based cancer immunotherapy.

关键词： chimeric antigen receptor CAR-T cells guideline cancer immunotherapy

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Recent Advances in Carbon-Based Adsorbents for Adsorptive Separation of Light Hydrocarbons

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Research 2022年第4期2022卷 261-281页

作者： yong-sheng wang Xue-Jie Zhang Ya-Qi Ba Tian-Yi Li Guang-Ping Hao An-Hui Lu State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Catalytic Conversion of Carbon ResourcesSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China

Light hydrocarbons(LHs)separation is an important process in petrochemical *** current separation technology predominantly relies on cryogenic distillation,which results in considerable energy *** separation using porous solids has received widespread attention due to its lower energy footprint and higher ***,tremendous efforts have been devoted to the design and synthesis of high-performance porous *** them,porous carbons display exceptional stability,tunable pore structure,and surface chemistry and thus represent a class of novel adsorbents upon achieving the matched pore structures for LHs *** this review,the modulation strategies toward advanced carbonbased adsorbents for LHs separation are firstly ***,the relationships between separation performances and key structural parameters of carbon adsorbents are discussed by exemplifying specific separation *** research findings on the control of the pore structures as well as the quantification of the adsorption sites are ***,the challenges of carbonaceous adsorbents facing for LHs separation are given,which would motivate us to rationally design more efficient absorbents and separation processes in future.

关键词： separation adsorbent porous

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Significant benefits of osimertinib in treating acquired resistance to first-generation EGFR-TKIs in lung squamous cell cancer: A case report

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World Journal of Clinical Cases 2019年第10期7卷 1221-1229页

作者： Yan Zhang Hui-Min Chen yong-Mei Liu Feng Peng Min Yu Wei-Ya wang Heng Xu yong-sheng wang You Lu Department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pathology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Precision Medicine Center State Key Laboratory of BiotherapyPrecision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Lung squamous cell cancer(LSCC)rarely harbors epidermal growth factor receptor(EGFR)mutations,even much rarer for acquired T790M *** clinical trials of AURA series illustrated that non-small cell lung cancer(NSCLC)with EGFR T790M mutation can benefit from osimertinib,only five LSCC patients were enrolled in total;moreover,the efficacy for LSCC was not shown in the ***,the response of LSCC to osimertinib is still unclear to *** SUMMARY We report an LSCC case with T790M-related acquired resistance after treatments with first-generation EGFR-tyrosine kinase inhibitors(EGFR-TKIs)and benefited from osimertinib significantly.A 63-year-old Chinese man was diagnosed with stage IV(cT2N2M1b)LSCC harboring an EGFR exon 19-deletion *** disease progression after gefitinib and multi-line chemotherapy,rebiopsy was *** testing of EGFR by amplification refractory mutation system-polymerase chain reaction detected the exon 19-deletion without T790M ***,the patient was given erlotinib,but progression developed only 3 mo *** the frozen re-biopsy tissue was tested by next-generation sequencing(NGS),which detected an EGFR T790M ***,he was very weak with symptoms of dysphagia and ***,osimertinib was started,leading to alleviation from the *** months later,normal deglutition was restored and partial response was ***,the patient achieved an overall survival time period of 29 *** Our findings highlight that EGFR T790M mutation may also be an important acquired drug resistance mechanism for LSCC and offer direct evidence of the efficacy of osimertinib in LSCC with T790M *** and better preservation conditions may contribute to higher sensitivity of EGFR T790M detection.

关键词： Lung squamous cell cancer Lung cancer Epidermal growth factor receptor mutation T790M Osimertinib Tyrosine kinase inhibitor Targeted therapy Case report

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