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A novel alternative for pyrogen detection based on a transgenic cell line

Signal Transduction and Targeted Therapy 2024年第3期9卷 1221-1229页

作者： Qing He Chuan-Fei Yu Gang Wu Kai-Qin Wang yong-Bo ni Xiao Guo Zhi-Hao Fu Lan Wang De-Jiang Tan Hua Gao Can Wang Gang Chen Xu-Hong Chen Bo Chen Jun-Zhi Wang National Institutes for Food and Drug Control BeijingChina School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyangChina Shanghai Institute for Food and Drug Control ShanghaiChina KeyMed Biosciences Inc. ChengduChina

Pyrogen,often as a contaminant,is a key indicator affecting the safety of almost all parenteral drugs(including biologicals,chemicals,traditional Chinese medicines and medical devices).It has become a goal to completely replace the in vivo rabbit pyrogen test by using the in vitro pyrogen test based on the promoted‘reduction,replacement and refinement’principle,which has been highly considered by regulatory agencies from different *** used NF-κB,a central signalling molecule mediating inflammatory responses,as a pyrogenic marker and the monocyte line THP-1 transfected with a luciferase reporter gene regulated by NF-κB as an in vitro model to detect pyrogens by measuring the intensity of a fluorescence ***,we show that this test can quantitatively and sensitively detect endotoxin(lipopolysaccharide from different strains)and nonendotoxin(lipoteichoic acid,zymosan,peptidoglycan,lectin and glucan),has good stability in terms of NF-κB activity and cell phenotypes at 39 cell passages and can be applied to detect pyrogens in biologicals(group A&C meningococcal polysaccharide vaccine;basiliximab;rabies vaccine(Vero cells)for human use,freeze-dried;Japanese encephalitis vaccine(Vero cells),inactivated;insulin aspart injection;human albumin;recombinant human erythropoietin injection(CHO Cell)).The within-laboratory reproducibility of the test in three independent laboratories was 85%,80%and 80%and the interlaboratory reproducibility among laboratories was 83.3%,95.6%and 86.7%.The sensitivity(true positive rate)and specificity(true negative rate)of the test were 89.9%and 90.9%,*** summary,the test provides a novel alternative for pyrogen detection.

关键词： pyrogen rabbit replace

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多维视角下市域社会治理现代化的推进路径——以安徽省F市为例

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西华大学学报（哲学社会科学版） 2024年第4期43卷 13-23页

作者：伲永贵阜阳师范大学法学院安徽阜阳236037

推进市域社会治理现代化,是实现国家治理现代化的重要环节。文章基于理念、空间、主体、机制、制度、能力、方式等要素构建多维分析框架,以安徽省F市为例,采取问卷调查等方法深入研究了市域社会治理现代化问题。研究发现,当前推进市域... 详细信息

推进市域社会治理现代化,是实现国家治理现代化的重要环节。文章基于理念、空间、主体、机制、制度、能力、方式等要素构建多维分析框架,以安徽省F市为例,采取问卷调查等方法深入研究了市域社会治理现代化问题。研究发现,当前推进市域社会治理现代化还存在理念认识不够、市域空间布局不协调、治理主体单一、机制尚未完善、制度仍需健全、治理能力不足和方式有待改进等问题。新时代有效推进市域社会治理现代化,需要强化现代化治理理念、加强市域空间科学规划、完善多元协同机制、健全法规制度、强化教育培训以提升治理主体的治理能力、优化社会治理方式。

关键词：市域社会治理社会治理现代化城乡协调发展共建共治共享 “五治”融合

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大云山汉王陵四铢半两铸地考析

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江苏地方志 2024年第1期 36-39页

作者：倪泳现代快报社江苏南京210005

2023年1月12日,盱眙大云山汉王陵博物馆正式开馆,馆中琳琅满目的珍贵文物吸引了众多参观者。在大云山汉王陵发掘过程中,陵墓主人是谁一直充满悬念,也引起众多媒体的关注。

关键词：四铢大云山汉王珍贵文物博物馆发掘参观者

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Elastic interaction between inclusions and tunable periodicity of superlattice structure in nanowires

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Applied Mathematics and Mechanics(English Edition) 2020年第10期41卷 1461-1478页

作者： Yang YANG yong ni CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230026China

The elastic stress distribution and the variation of the elastic energy with spacing between two inclusions of arbitrary sizes in an infinite isotropic cylindrical rod are obtained by an analytical approach and the phase field microelasticity(PFM)*** results show a near-attraction and far-repulsion elastic interaction between two inclusions with hydrostatic *** critical spacing,at which the interaction changes from attraction to repulsion,is on the order of the radius of the rod,dependent on the length and Poisson’s ratio of ***,the elastic energy calculations and PFM simulation results indicate that applying the local radial stress on the rod surface can modulate the elastic interaction between inclusions and adjust the periodicity of the superlattice nanowire *** can provide some guidelines for the tunable construction of superlattice nanowire structures.

关键词： elastic interaction inclusion critical spacing superlattice structure

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Stress-mediated lithiation in nanoscale phase transformation electrodes

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Acta Mechanica Solida Sinica 2017年第3期30卷 248-253页

作者： Yuyang Lu yong ni CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics University of Science and Technology of China Hefei Anhui 230026 PR China

Development of high-performance phase transformation electrodes in lithium ion batteries requires comprehensive studies on stress-mediated lithiation involving migration of the phase interface. It brings out many counter-intuitive phenomena, especially in nanoscale electrodes, such as the slowing down migration of phase interface, the vanishing of miscibility gap under high charge rate, and the formation of surface crack during lithiation. However, it is still a challenge to simulate the evolution of stress in arbitrarily-shaped nanoscale electrodes, accompanied with phase transformation and concurrent plastic deformation. This article gives a brief review of our efforts devoted to address these issues by developing phase field model and simulation. We demonstrate that the miscibility gap of two-phase state is affected not only by stress but also by surface reaction rate and particle size. In addition, the migration of phase interface slows down due to stress. It reveals that the plastic deformation generates large radial expansion, which is responsible for the transition from surface hoop compression to surface hoop tension that may induce surface crack during lithiation. We hope our effort can make a contribution to the understanding of stress-coupled kinetics in phase transformation electrodes.

关键词： Lithium ion battery Phase transformation Miscibility gap Size effect Plasticity

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仿生异质结构的非线性力学与优化设计

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中国科学：物理学、力学、天文学 2024年第5期54卷 43-73页

作者：王泽文吴开金解丽丽何陵辉倪勇中国科学技术大学工程科学学院近代力学系中国科学院材料力学行为与设计重点实验室合肥230026 中国科学院力学研究所非线性力学国家重点实验室北京100190

轻质高强韧结构设计一直是力学和材料等学科交叉的前沿问题,也是工程应用的不懈追求.生物材料经历数百万年进化,兼具轻质、高强度和高韧性力学性能,成为高性能工程材料设计的模板.然而,生物材料往往具有跨尺度、多层级的复相结构和界面... 详细信息

轻质高强韧结构设计一直是力学和材料等学科交叉的前沿问题,也是工程应用的不懈追求.生物材料经历数百万年进化,兼具轻质、高强度和高韧性力学性能,成为高性能工程材料设计的模板.然而,生物材料往往具有跨尺度、多层级的复相结构和界面特征,会产生非线性、多过程的变形和断裂行为,进而决定强度和韧性等力学性能.如何发展定量的力学模型、阐明生物材料的结构-界面-强韧力学性能间的关系,并为高性能仿生材料制备提供优化设计方案成了近期的研究前沿.本文以极具代表性的生物“砖泥交错结构”和“扭转纤维结构”为例,从力学模型和力学机制方面,首先梳理仿生异质结构代表性单元体(RVE)的非线性力学响应与其结构间的关联;然后讨论含主裂纹仿生异质结构的断裂行为及其与RVE结构间的关联;进一步,基于力学模型和机制,给出优化强度、韧性、抗冲击性和断裂韧性等性能的力学设计方案;最后,提出仿生异质结构非线性力学与优化设计中存在的挑战和未来的发展方向.

关键词：仿生异质结构非线性力学代表性单元体断裂力学优化设计

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Phase-field simulation of the coupled evolutions of grain and twin boundaries in nanotwinned polycrystals

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Applied Mathematics and Mechanics(English Edition) 2018年第12期39卷 1789-1804页

作者： Yuanyuan DA Yuyang LU yong ni CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics University of Science and Technology of China

Nanotwinned polycrystals exhibit an excellent strength-ductility combination due to nanoscale twins and grains. However, nanotwin-assisted grain coarsening under mechanical loading reported in recent experiments may result in strength drop based on the Hall-Petch law. In this paper, a phase-field model is developed to investigate the effect of coupled evolutions of twin and grain boundaries on nanotwin-assisted grain growth. The simulation result demonstrates that there are three pathways for coupled motions of twin and grain boundaries in a bicrystal under the applied loading, dependent on the amplitude of applied loading and misorientation of the bicrystal. It reveals that a large misorientation angle and a large applied stress promote the twinning-driven grain boundary migration. The resultant twin-assisted grain coarsening is confirmed in the simulations for the microstructural evolutions in twinned and un-twinned polycrystals under a high applied stress.

关键词： nanotwin grain growth stress effect phase-field simulation

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GIANT ANHYSTERETIC RESPONSE OF FERROELECTRIC SOLID SOLUTIONS WITH MORPHOTROPIC BOUNDARIES: THE ROLE OF POLAR AniSOTROPY

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Acta Mechanica Solida Sinica 2012年第4期25卷 429-440页

作者： yong ni Armen G. Khachaturyan CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics University of Science and Technology of China Hefei 230026 China Department of Materials Science&Engineering Rutgers University 607 Taylor Road Piscataway NJ 08854 USA

Computer modeling and simulation for the Pb（Zr1-x Tix ）O3 （PZT） system reveal the role of polar anisotropy on the giant anhysteretic response and structural properties of morphotropic phase boundary （MPB） ferroelectrics. It is shown that a drastic reduction of the compositiondependent polar anisotropy near the MPB flattens energy surfaces and thus facilitates reversible polarization rotation. It is further shown that the polar anisotropy favors formation of polar domains, promotes phase decomposition and results in a two-phase multidomain state, which response to applied electric field is anhysteretic when the polar domain reorientation is only caused by polarization rotation other than polar domain wall movement. This is the case for the decomposing ferroelectrics under a poling electric field with the formation of a two-phase multidomain microstructure, wherein most domain walls are pinned at the two-phase boundaries. Indication of the microstructure dependence of the anhysteretic strain response opens new avenues to improve the piezoelectric properties of these materials through the microstructure engineering.

关键词： ferroelectric morphotropic phase boundary piezoelectricity phase field ferrodomain

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Determination of ziram in vegetable samples by square wave voltammetry

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Chinese Chemical Letters 2008年第11期19卷 1337-1340页

作者： Ping Qiu yong nian ni State Key Laboratory of Food Science and Technology Nanchang University Nanchang 330047 China Department of Chemistry Nanchang University Nanchang 330031 China

The electrochemical behaviour and electrode reaction mechanism of ziram （zinc-dimethyl dithiocarbamate） on a hanging mercury drop electrode were investigated in Britton-Robinson （B-R） buffer by using cyclic and square wave voltammetry （SWV）. Based on these studies a voltammetric method for determination of ziram wasdeveloped and applied to determine the ziram in synthetic and spiked vegetable samples, satisfactory results were obtained in both cases.

关键词： Ziram Square wave voltammetry Pesticide

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Behavior and Quantification Studies of Phoxim Pesticide Using Cyclic and Linear Sweep Stripping Voltammetry at a Mercury Electrode

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Chinese Chemical Letters 2006年第2期17卷 225-227页

作者： Ping QIU yong nian ni Department of Chemistry Nanchang University Nanchang 330047 The Key Laboratory of Food Science of MOE Nanchang University Nanchang 330047

The adsorptive and electrochemical behaviour of phoxim on a hanging mercury drop electrode were explored in NH3·H2O-NH4Cl buffer by using cyclic and linear sweep voltmmetry. The procedure was successfully applied for... 详细信息

关键词： Phoxim linear sweep stripping voltammetry pesticide.

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