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Chinese Journal of Natural Medicines 2016年第9期14卷 671-676页

作者： HAN Yunk-Yung SONG Mi-Young hwang Min-Sub hwang Ji-Hye PARK yong-Ki JUNG Hyo-Won 无 Korean Medicine R&D Center College of Korean MedicineDongguk UniversityGyeongju 38066Republic of Korea department of rehabilitation medicine of korean medicine college of korean medicinedongguk universityGyeongju 38066Republic of Korea Department of Acupuncture&Moxibustion College of Korean MedicineDongguk UniversityGyeongju 38066Republic of Korea Department of Herbology College of Korean MedicineDongguk UniversityGyeongju 38066Republic of Korea

Obesity is associated with a number of metabolic abnormalities such as type 2 diabetes and has become a major health problem worldwide. In the present study, we investigated the effects of Epimedium koreanum Nakai(Herba Epimedii, HE) and its main constituent icariin on the adipocyte differentiation in 3T3-L1 preadipocytes. HE extract and icariin significantly reduced lipid accumulation and suppressed the expressions of PPARγ, C/EBPα, and SREBP-1c in 3T3-L1 adipocytes. They also inhibited fatty acid synthase(FAS), acyl-Co A synthase(ACS1), and perilipin. Moreover, HE extract and icariin markedly increased the phosphorylation of AMPK. These results indicated that HE extract and icariin can inhibit the adipocyte differentiation through downregulation of the adipogenic transcription factors, suggesting that HE containing icariin may be used as a potential therapeutic agent in the treatment and prevention of obesity.

关键词： Epimedium koreanum Nakai Herba Epimedii Icariin 3T3-L1 cells Obesity

Some Limit Theorems on the Increments of l^p-valued Multi-Parameter Gaussian Processes

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Acta Mathematica Sinica,English Series 2004年第6期20卷 1019-1028页

作者： Zheng Yan LIN Seaung Hyune LEE Kyo Shin hwang yong Kab CHOI Department of Mathematics Zhejiang University Department of Mathematics Gyeongsang National University

In this paper,we establish some limit theorems on the increments of an l^p-valued multi- parameter Gaussian process under weaker conditions than those of Cs(?)rg(?)-Shao theorems published in ***.(1993).

关键词： l^P-valued multi-parameter Gaussian process Large increment

Effects of Mg Enhancement and Heat Treatment on Microstructures and Tensile Properties of Al2Ca-Added ADC12 Die Casting Alloys

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Journal of Materials Science & Technology 2016年第10期32卷 1043-1048页

作者： gil-yong Yeom Hyun Kyu Lim Shae K.Kim Soong-Keun Hyun Young-Ok Yoon Korea Institute of Industrial Technology lncheon 406-840 South Korea Department of Materials Science and Engineering Inha University lncheon 402-751 South Korea

The effects of Mg enhancement and heat treatment on the microstructures and tensile properties of Al_2Ca-added ADC12 die casting alloys were investigated. 0.3% and 0.5% Mg in the form of a master alloy including a trace amount of Al_2Ca were added to conventional ADC12（383 and AlSi10Cu2Fe） alloy with an initial Mg-content of 0.3% to increase the Mg content to 0.6% and 0.8%, respectively. To avoid heat treatmentinduced surface blisters, shortened solution treatment for 15 min at 490 ℃ and artificial aging for 6 h at 150 ℃ was undertaken. The results show that a 10% improvement in the shape factor of eutectic Si particles was achieved for Al_2Ca-added ADC12 with 0.8% Mg compared to the conventional ADC12 in the as-aged condition. Al_2Ca-added ADC12 with 0.8% Mg exhibited a yield strength of 289 MPa, a tensile strength of 407 MPa, and an elongation of 4.22%.

关键词： Al2Ca ADC12 alloy Heat treatment Die casting Inclusion

Effect of nanoclay on properties of porous PVdF membranes

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 141-147页

作者： Hae-Young hwang Deuk-Ju KIM Hyung-Jun KIM Young-Taik HONG Sang-yong NAM School of Materials Science and Engineering Engineering Research Institute i-Cube Center Gyeongsang National University Fuel Cell Research Center Korea Institute of Science and Technology Seoul 136-791 Korea Energy Material Research Center Korea Research Institute of Chemical Technology Daejeon 305-600 Korea

The main requirements for battery separators are high porosity which can serve pathways of lithium ion and space for gel electrolytes to impregnate in a membrane and mechanical strength to allow easy handling for battery assembly. Generally, it appears the trade-off relationship between the porosity and mechanical strength of the membrane. PVdF composite membranes containing nano-size clays were used to improve the mechanical strength of the membrane without affecting the membrane porosity. The composite membranes were prepared by phase inversion method controlling the membrane preparation conditions such as retention time. The resultant membranes show increased mechanical properties with similar membrane porosity around 80 % compared to the pristine PVdF membrane. Incorporation of nonoclay can be considered as an effective method to improve the mechanical strength in porous membrane supports, especially in a separator.

关键词：聚偏氟乙烯膜机械性能多孔膜纳米粘土机械强度高孔隙率电池隔膜制备条件

Mononuclear cells from the cord blood and granulocytecolony stimulating factor-mobilized peripheral blood:is there a potential for treatment of cerebral palsy?

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Neural Regeneration Research 2015年第12期10卷 2018-2024页

作者： Hani Koh Kyoujung hwang Hae-Young Lim yong-Joo Kim Young-Ho Lee Department of Translational Medicine Graduate School of Biomedical Science & EngineeringHanyang University Greencrosscell Corp Analytical Instrumentation Center Medical Branch Hanyang University Department of Pediatrics Hanyang University College of Medicine Cell Therapy Center Hanyang University Medical Center

To investigate a possible therapeutic mechanism of cell therapy in the field of cerebral palsy using granulocyte-colony stimulating factor（G-CSF）-mobilized peripheral blood mononuclear cells（m PBMCs）,we compared the expression of inflammatory cytokines and neurotrophic factors in PBMCs and m PBMCs from children with cerebral palsy to those from healthy adult donors and to cord blood mononuclear cells donated from healthy *** significant differences in expression of neurotrophic factors were found between PBMCs and m ***,in cerebral palsy children,the expression of interleukin-6 was significantly increased in m PBMCs as compared to PBMCs,and the expression of interleukin-3 was significantly decreased in m PBMCs as compared to *** healthy adults,the expression levels of both interleukin-1βand interleukin-6 were significantly increased in m PBMCs as compared to *** expression of brain-derived neurotrophic factors in m PBMC from cerebral palsy children was significantly higher than that in the cord blood or m PBMCs from healthy *** expression of G-CSF in m PBMCs from cerebral palsy children was comparable to that in the cord blood but significantly higher than that in m PBMCs from healthy *** expression of pro-inflammatory cytokines（interleukin-1β,interleukin-3,and-6）and higher expression of anti-inflammatory cytokines（interleukin-8 and interleukin-9）were observed from the cord blood and m PBMCs from cerebral palsy children rather than from healthy *** findings indicate that m PBMCs from cerebral palsy and cord blood mononuclear cells from healthy newborns have the potential to become seed cells for treatment of cerebral palsy.

关键词： neurotrophic factors inflammatory cytokines cord blood G-CSF mobilized peripheralblood mononuclear cell cerebral palsy children neural regeneration

Study of cerium-promoted rhodium alumina catalyst as a steam reforming catalyst for treatment of spent solvents

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Journal of Rare Earths 2014年第9期32卷 831-836页

作者： Hee-Chul Yang Min-Woo Lee Ho-Sang hwang Jei-Kwon Moon Dong-yong Chung Korea Atomic Energy Research Institute

This study attempted to develop an appropriate catalyst used for the steam reforming of gasified spent solvents. Rh2O3/ CeOE-Al2O3 catalysts with various CeO2 loadings were prepared and heated at different temperatures of 500 and 800 ℃, and their surface properties were studied using X-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS）, transmission electron microscopy （TEM）, temperature programmed reduction （TPR） and Bmmauer-Emmett-Teller （BET） analyses. Rhodium existed in the form of Rh2O3, regardless of the sample composition as well as the heating temperature. In the tested range of cerium addition （up to 12 times the rhodium mass）, no significant changes in BET surface areas and binding energy corresponding to Rh 3d5/2 were observed. Instead, the addition of cerium led to a greatly enhanced dispersion of rhodium nanoparticles, and no agglomeration of rhodium was observed for samples heated even at 800 ℃. Honeycomb monolith rhodium catalysts promoted with cerium were fabricated and tested for the steam reforming of a gasified spent solvent, mainly consisting of butylene （C4H8）. The test results suggested that a cerium-promoted rhodium catalyst could be used as an appropriate reforming catalyst for treating low-quality non-methane hydrocarbons without the formation of coke at high temperatures of up to 900 ℃.

关键词： cerium rhodium catalyst steam reforming spent resin rare earths

GIGANTEA and EARLY FLOWERING 4 in Arabidopsis Exhibit Differential Phase-Specific Genetic Influences over a Diurnal Cycle

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Molecular Plant 2012年第3期5卷 678-687页

作者： Yumi Kim Miji Yeom Hyunmin Kim Junhyun Lim Hee Jung Koo Daehee hwang David Somers Hong gil Nam Division of Molecular and Life Sciences POSTECH Hyojadong Pohang Kyungbuk 790-784 Republic of Korea School of Interdisciplinary Bioscience and Bioengineering POSTECH Hyojadong Pohang Kyungbuk 790-784 Republic of Korea Department of Chemical Engineering POSTECH Hyojadong Pohang Kyungbuk 790-784 Republic of Korea Integrative Biosciences and Biotechnology POSTECH Hyojadong Pohang Kyungbuk 790-784 Republic of Korea Department of Molecular Genetics The Ohio State University 244B Rightmire Hall 1060 Carmack Road Columbus OH 43210 USA National Core Research Center for Systems Bio-Dynamics POSTECH Hyojadong Pohang Kyungbuk 790-784 Republic of Korea

The endogenous circadian clock regulates many physiological processes related to plant survival and adapt- ability. GIGANTEA （GI）, a clock-associated protein, contributes to the maintenance of circadian period length and ampli- tude, and also regulates flowering time and hypocotyl growth in response to day length. Similarly, EARLY FLOWERING 4 （ELF4）, another clock regulator, also contributes to these processes. However, little is known about either the genetic or molecular interactions between GI and ELF4 in Arabidopsis. In this study, we investigated the genetic interactions between GI and ELF4 in the regulation of circadian clock-controlled outputs. Our mutant analysis shows that GI is epistatic to ELF4 in flowering time determination, while ELF4 is epistatic to GI in hypocotyl growth regulation. Moreover, GI and ELF4 have a synergistic or additive effect on endogenous clock regulation. Gene expression profiling of gi, elf4, and gi elf4 mutants further established that GI and ELF4 have differentially dominant influences on circadian physiological outputs at dusk and dawn, respectively. This phasing of GI and ELF4 influences provides a potential means to achieve diversity in the regulation of circadian physiological outputs, including flowering time and hypocotyl growth.

关键词： microarray LHY endogenous clock GI ELF4

Design and roles of RGO-wrapping in charge transfer and surface passivation in photoelectrochemical enhancement of cascade-band photoanode

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Nano Research 2017年第7期10卷 2415-2430页

作者： Zhuo Zhang Mingi Choi Minki Baek Insung hwang Changshin Cho Zexiang Deng Jinwoo Lee Kijung yong Surface Chemistry Laboratory of Electronic Materials Department of Chemical Engineering POSTECH Pohang 790-784 Republic of Korea Advanced Functional Nanomaterial Laboratory Department of Chemical Engineering POSTECH Pohang 790-784 Repubfic of Korea State Key Laboratory of Optoelectronic Materials and Technologies School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China

Fast charge transfer and anti-photocorrosion are two crucial factors for developing efficient, durable photoanodes for photoelectrochemical （PEC） cells. Reduced graphene oxide （RGO） is a promising photoanode element that can provide both of these. In this study, we elucidated the roles of RGO in the charge transfer and surface passivation of photoanodes by the precise design of a RGO-wrapped photoanode and examination of its PEC properties. Arrays of hetero-nanorods （HNRs） with three different designs were fabricated as photoanodes using RGO, CdSe nanoparticles （NPs）, and ZnO nanorods （NRs） as building blocks. CdSe@ZnO HNRs were prepared by decorating ZnO NRs with CdSe NPs. Finite-element analysis and experimental studies demonstrated that in the CdSe@ZnO HNRs, if only the ZnO NRs were wrapped by RGO, the conductivity between CdSe and ZnO was enhanced by RGO to shuttle charges. If RGO only surrounded the outside of the CdSe@ZnO HNRs, the corrosion was slowed owing to the passivation effect of RGO, which increased the electron lifetime of the photoanode. If both CdSe and ZnO were fully wrapped by RGO, the advantages of the two aforementioned cases were both obtained. RGO-wrapped CdSe@ZnO HNRs with position-controlled designs are promising photoanode materials with a high PEC efficiency, and the developed synthesis process can be applied to explore the design and fabrication of next-generation photoanodes using RGO as a buildin~ block.

关键词： photoelectrochemical reduced graphene oxide(RGO) charge transfer surface passivation CdSe ZnO

Derivation of Regression Coefficients for Sea Surface Temperature Retrieval over East Asia

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Advances in Atmospheric Sciences 2006年第3期23卷 474-486页

作者： Myoung-Hwan AHN Eun-Ha SOHN Byong-Jun hwang Chu-yong CHUNG Xiangqian WU Remote Sensing Research Laboratory/Meteorological Research Institute Seoul Korea Office of Research and Applications National Environmental Satellite Data and Information Service National Oceanic and Atmospheric Administration

Among the regression-based algorithms for deriving SST from satellite measurements, regionally optimized algorithms normally perform better than the corresponding global algorithm. In this paper, three algorithms are considered for SST retrieval over the East Asia region （15°-55°N, 105°-170°E）, including the multi-channel algorithm （MCSST）, the quadratic algorithm （QSST）, and the Pathfinder algorithm （PFSST）. All algorithms are derived and validated using collocated buoy and Geostationary Meteorological Satellite （GMS-5） observations from 1997 to 2001. An important part of the derivation and validation of the algorithms is the quality control procedure for the buoy SST data and an improved cloud screening method for the satellite brightness temperature measurements. The regionally optimized MCSST algorithm shows an overall improvement over the global algorithm, removing the bias of about -0.13℃ and reducing the root-mean-square difference （rmsd） from 1.36℃ to 1.26℃. The QSST is only slightly better than the MCSST. For both algorithms, a seasonal dependence of the remaining error statistics is still evident. The Pathfinder approach for deriving a season-specific set of coefficients, one for August to October and one for the rest of the year, provides the smallest rmsd overall that is also stable over time.

关键词： Regional SST algorithm GMS-5 Data quality control cloud detection

冷加工过程中Zr-1Nb板材组织演化研究(英文)

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稀有金属材料与工程 2013年第4期42卷 667-672页

作者：刘彦章 Hyun-gil Kim Jeong-yong Park yong-Hwan Jeong 深圳中广核工程设计有限公司广东深圳518057 Korea Atomic Energy Research Institute Daejeon 305-353Republic of Korea

对热轧的Zr-1Nb板材进行了不同变形量的冷加工,利用背散射电子衍射(EBSD)以及透射电子显微镜(TEM)研究了冷加工及热处理对其组织的影响。结果表明,随着冷加工变形量从30%增加到70%,晶粒尺寸逐渐从双态分布变为均匀分布。各种变形下的织... 详细信息

对热轧的Zr-1Nb板材进行了不同变形量的冷加工,利用背散射电子衍射(EBSD)以及透射电子显微镜(TEM)研究了冷加工及热处理对其组织的影响。结果表明,随着冷加工变形量从30%增加到70%,晶粒尺寸逐渐从双态分布变为均匀分布。各种变形下的织构主要为(0001),且随着变形道次的增加强度逐渐增大。

关键词： Zr-1Nb 冷轧和退火组织演化背散射电子衍射