检索结果-南通市图书馆

Agricultural Sciences in China 2009年第2期8卷 137-143页

作者： LI Yu-ling dong yong-bin niu Su-zhen CUI Dang-qun Agronomy College Henan Agricultural University Zhengzhou 450002 P.R.China

Normal corn germplasm can be used to improve popcorn （Zea mays L.） through 1-2 backcrosses with popcorn as recurrent parents. Popping characteristics of derived lines from popcorn × dent or flint corn crosses play a determinant role in popcorn breeding. Advanced backcross QTL methods can effectively combine QTL identification and plant breeding. 220 selected BC2F2 families developed from a cross between Dan 232, a dent corn inbred line, and N04, an elite popcorn inbred line, were evaluated for three popping characteristics, popping volume, flake size, and popping rate, under two environmental conditions. Using composite interval mapping, a total of 10 significant QTLs were detected, and of these, 2 to 4 QTLs were identified for each trait. Six QTLs had favorable alleles contributed by Dan 232. Comparison with the 15 QTLs detected in the F2：3 families showed that 3 QTLs were the same in both populations. The QTLs should be redetected in generations developed through severe selection. Improved N04 and near isogenic lines could be developed from this BC2F2 population through selfing or another 1 to 2 backcrosses with N04.

关键词： Zea mays L. popcorn BC2F2 population quantitative trait loci popping characteristics

A Fault-Tolerant Mobility-Aware Caching Method in Edge Computing

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第7期140卷 907-927页

作者： yong Ma Han Zhao Kunyin Guo Yunni Xia Xu Wang Xianhua niu dongge Zhu Yumin dong School of Computer Information Engineering Jiangxi Normal UniversityNanchang330000China School of Digital Industry Jiangxi Normal UniversityShangrao334000China The College of Computer Science Chongqing UniversityChongqing400044China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400030China School of Computer and Software Engineering Xihua UniversityChengdu610039China Electric Power Research Institute of State Grid Ningxia Electric Power Company Ltd. Yinchuan750002China College of Computer and Information Science Chongqing Normal UniversityChongqing401331China

Mobile Edge Computing(MEC)is a technology designed for the on-demand provisioning of computing and storage services,strategically positioned close to *** the MEC environment,frequently accessed content can be deployed and cached on edge servers to optimize the efficiency of content delivery,ultimately enhancing the quality of the user ***,due to the typical placement of edge devices and nodes at the network’s periphery,these components may face various potential fault tolerance challenges,including network instability,device failures,and resource *** the dynamic nature ofMEC,making high-quality content caching decisions for real-time mobile applications,especially those sensitive to latency,by effectively utilizing mobility information,continues to be a significant *** response to this challenge,this paper introduces FT-MAACC,a mobility-aware caching solution grounded in multi-agent deep reinforcement learning and equipped with fault tolerance *** approach comprehensively integrates content adaptivity algorithms to evaluate the priority of highly user-adaptive cached ***,it relies on collaborative caching strategies based onmulti-agent deep reinforcement learningmodels and establishes a fault-tolerancemodel to ensure the system’s reliability,availability,and *** results unequivocally demonstrate that FTMAACC outperforms its peer methods in cache hit rates and transmission latency.

关键词： Mobile edge networks mobility fault tolerance cooperative caching multi-agent deep reinforcement learning content prediction

Molecular mechanism for the involvement of nuclear receptor FXR in HBV-associated hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2011年第2期1卷 73-79页

作者： yong-dong niu Wen Xie Wen-xin Qin State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteShanghai Jiao Tong University School of MedicineShanghai 200032China Center for Pharmacogenetics Department of Pharmaceutical SciencesUniversity of PittsburghPittsburghPA 15261USA

Farnesoid X receptor(FXR,also termed nuclear receptor NR1H4)is critically involved in the regulation of nascent bile formation and bile acid enterohepatic *** and bile acids have been shown to play roles in liver regeneration and inflammatory *** is increasing evidence suggesting that FXR and the FXR signaling pathway are involved in the pathophysiology of a wide range of liver diseases,such as viral hepatitis,cirrhosis,and hepatocellular carcinoma(HCC).Here we discuss the latest discoveries of FXR functions with relevance to bile acid metabolism and HBVassociated *** specifically,the goal of this review is to discuss the roles of FXR and bile acids in regulating HBV replication and how disregulation of the FXR-bile acid signaling pathway is involved in HBV-associated hepatocarcinogenesis.

关键词： Farnesoid X receptor Hepatitis B virus Bile acids Inflammation Hepatocellular carcinoma

Machine learning-based predictions of current and future susceptibility to retrogressive thaw slumps across the Northern Hemisphere

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2024年第2期15卷 253-264页

作者： Jing LUO Guo-An YIN Fu-Jun niu Tian-Chun dong Ze-yong GAO Ming-Hao LIU Fan YU State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China China Railway Qinghai-Tibet Group Co. LtdXining 810000China University of Chinese Academy of Sciences Beijing 100049China

Retrogressive thaw slumps(RTSs)caused by the thawing of ground ice on permafrost slopes have dramatically increased and become a common permafrost hazard across the Northern Hemisphere during previous ***,a gap remains in our comprehensive understanding of the spatial controlling factors,including the climate and terrain,that are conducive to these RTSs at a global *** machine learning methodologies,we mapped the current and future RTSs susceptibility distributions by incorporating a range of environmental factors and RTSs *** identified freezing-degree days and maximum summer rainfall as the primary environmental factors affecting RTSs *** final ensemble susceptibility map suggests that regions with high to very high susceptibility could constitute(11.6±0.78)%of the Northern Hemisphere's permafrost *** juxtaposed with the current(2000-2020)RTSs susceptibility map,the total area with high to very high susceptibility could witness an increase ranging from(31.7±0.65)%(SSP585)to(51.9±0.73)%(SSP126)by the *** insights gleaned from this study not only offer valuable implications for engineering applications across the Northern Hemisphere,but also provide a long-term insight into the potential change of RTSs in permafrost regions in response to climate change.

关键词： Retrogressive thaw slump Machine learning Susceptibility map Permafrost Northern Hemisphere

Environmental factors controlling soil warming and wetting during 2000-2020 in permafrost and non-permafrost regions across the Qinghai-Tibet Plateau

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2024年第2期15卷 285-296页

作者： Guo-An YIN Jing LUO Fu-Jun niu Ming-Hao LIU Ze-yong GAO Tian-Chun dong Wei-Heng NI State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China China Railway Qinghai-Tibet Group Co. Ltd.Xining 810000China University of Chinese Academy of Sciences Beijing 100049China

The Qinghai-Tibet Plateau(QTP)has experienced rapid environmental changes,including climate warming and wetting,since the *** environmental changes significantly impact the shallow soil hydrothermal conditions,which have key roles in land-atmosphere feedback and ecosystem ***,the spatial variations and responses of soil hydrothermal conditions to environmental changes over the QTP with permafrost(PF)and seasonal frost(SF)remain *** this study,we investigated the spatial variations in soil temperature(ST)and soil moisture(SM)changes over the QTP from 2000 to 2020 using 99 in-situ sites with observations at 4 depths(i.e.10,40,100 and 200 cm).The main environmental controlling factors were further identified using a calibrated statistical *** showed that significant(p<0.05)soil warming occurred at multiple soil layers during 2000-2020 with a wide variation(i.e.0.033-0.039℃ per year on average),whereas the warming rates at PF sites were two times greater than those at SF *** addition,the soil wetting rate was high over the SF region,whereas the soil wetting rate was low over the PF *** from air temperature,changes in thawing degree days and solar radiation(Srad)contributed most to soil warming in the PF region,whereas changes in rainfall,Srad and evaporation(EVA)have been identified as the key factors in the SF *** for soil wetting,changes in snowfall,freezing degree days and vegetation have noticeable nonlinear effects over the PF region,whereas changes in EVA,Srad and rainfall highlighted distinct linear and nonlinear effects in the SF *** findings enhance our understanding of the hydrothermal impacts of future environmental changes over the QTP.

关键词： Warming amd wetting Soil hydrothermal change Factor Permafrost Seasonal frost

Fundamentals of the Warburg Effect in Cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Nutritional Oncology 2019年第3期4卷 108-114页

作者： Pi Xian Zhang Ya Qi Xing yong dong niu Department of Biochemistry and Molecular Biology Shantou University Medical CollegeShantouGuangdong 515041China Department of Pharmacology Shantou University Medical CollegeShantouGuangdong 515041China

As the fundamental energy unit of most cells,the ATP generated from glucose is vital to maintain biological processes such as the synthesis of proteins and nucleic ***,a common feature of cancer cells is an altered metabolism with increased glucose uptake and the fermentation of glucose to lactate even in the presence of normal *** phenomenon is known as the‘Warburg effect’(now termed aerobic glycolysis).One simple explanation for this effect is that it permits cells to more easily produce energy to support rapid *** can also help to meet the biosynthetic requirements for pyruvate as a major building *** a well-known metabolic hallmark of cancer cells,the role of the Warburg effect in oncology is a newly-emerging area of growing *** this perspective,we provide some new understanding of these mechanisms based on recent progress in research on cancer *** better understanding of these mechanisms will support the development of new therapeutic strategies that take into account tumor nutrition and energy metabolism.

关键词： Warburg effect Cancer Glycolysis ATP Lactate

A New Method for Solving Nonlinear Partial Differential Equations Based on Liquid Time-Constant Networks

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2024年第2期37卷 480-493页

作者： SUN Jiuyun dong Huanhe FANG yong College of Mathematics and Systems Science Shandong University of Science and TechnologyQingdao 266590China

In this paper,physics-informed liquid networks(PILNs)are proposed based on liquid time-constant networks(LTC)for solving nonlinear partial differential equations(PDEs).In this approach,the network state is controlled via ordinary differential equations(ODEs).The significant advantage is that neurons controlled by ODEs are more expressive compared to simple activation *** addition,the PILNs use difference schemes instead of automatic differentiation to construct the residuals of PDEs,which avoid information loss in the neighborhood of sampling *** this method draws on both the traveling wave method and physics-informed neural networks(PINNs),it has a better physical ***,the KdV equation and the nonlinear Schr¨odinger equation are solved to test the generalization ability of the *** the best of the authors’knowledge,this is the first deep learning method that uses ODEs to simulate the numerical solutions of PDEs.

关键词： Nonlinear partial differential equations numerical solutions physics-informed liquid networks physics-informed neural networks

Building a More Sustainable Chinese Loess Plateau

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2024年第1期35卷 283-287页

作者： Peiyue Li Xiaomei Kou yong Wang Le niu School of Water and Environment Chang'an UniversityXi'an 710054China Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region of the Ministry of Education Chang'an UniversityXi'an 710054China Key Laboratory of Eco-Hydrology and Water Security in Arid and Semi-Arid Regions of the Ministry of Water Resources Chang'an UniversityXi'an 710054China PowerChina Northwest Engineering Corporation Limited Xi'an 710065China PowerChina Sinohydro Bureau 3 Co. LTD.Xi'an 710024China

The Chinese Loess Plateau,a region of remarkable ecological and economic value,grapples with significant water management challenges due to its distinctive geology and *** perspective offers a short review of the eco-environmental protection measures undertaken in the Loess Plateau,underscoring the transformative impacts of initiatives such as the“Grain for Green”***,it also highlights the enduring challenges,including land degradation,water resources issues,socio-economic inequities,and the implications of climate ***,water management emerges as a pivotal issue with far-reaching repercussions for soil conservation,biodiversity,and human *** paper concludes by proposing future actions,emphasizing the necessity for policy modifications,novel initiatives,and research to tackle these challenges and foster sustainable development in the Loess *** insights gained from this region could offer invaluable lessons for other regions confronted with similar challenges,thereby contributing to global efforts to mitigate desertification and champion sustainable development.

关键词： Loess Plateau eco-environmental protection water management sustainable development climate change

UAV-assisted cooperative offloading energy efficiency system for mobile edge computing

在线全文

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第1期10卷 16-24页

作者： Xue-yong Yu Wen-Jin niu Ye Zhu Hong-Bo Zhu Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and Telecommunications Nanjing210003China Engineering Research Centerof Health Service System Based on Ubiquitous Wireless Networks Ministry of EducationNanjng Universityof Posts and Telecommunications Nanjing210003China

Reliable communication and intensive computing power cannot be provided effectively by temporary hot spots in disaster areas and complex terrain ground *** this has greatly developed the application and integration of UAV and Mobile Edge Computing(MEC)to the Internet of Things(loT).However,problems such as multi-user and huge data flow in large areas,which contradict the reality that a single UAV is constrained by limited computing power,still *** to allowing UAV collaboration to accomplish complex tasks,cooperative task offloading between multiple UAVs must meet the interdependence of tasks and realize parallel processing,which reduces the computing power consumption and endurance pressure of *** the computing requirements of the user terminal,delay constraint of a computing task,energy constraint,and safe distance of UAV,we constructed a UAV-Assisted cooperative offloading energy efficiency system for mobile edge computing to minimize user terminal energy ***,the resulting optimization problem is originally nonconvex and thus,difficult to solve *** tackle this problem,we developed an energy efficiency optimization algorithm using Block Coordinate Descent(BCD)that decomposes the problem into three convex ***,we jointly optimized the number of local computing tasks,number of computing offloaded tasks,trajectories of UAV,and offloading matching relationship between multi-UAVs and multiuser *** results show that the proposed approach is suitable for different channel conditions and significantly saves the user terminal energy consumption compared with other benchmark schemes.

关键词： Computation offloading Internet of things(IoT) Mobile edge computing(MEC) Block coordinate descent(BCD)

Acceptor-engineering tailored type-Ⅰ photosensitizer with aggregation-induced NIR-II emission for cancer multimodal phototheranostics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第8期67卷 2647-2660页

作者： Jiangao Li niu niu Deliang Wang Xue Liu Yi Qin Lei Wang Ben Zhong Tang dong Wang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target Clinical Pharmacologythe State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Exploration of single molecular species synchronously featured by long excitation/emission wavelength, accurate diagnosis, and effective therapy, remains supremely appealing to implement high-performance cancer phototheranostics. However, those previously established phototheranostic agents are undiversified and stereotyped in terms of structural skeleton, and generally exhibit insufficient phototheranostic outcomes. Herein, we innovatively utilized indanone-condensed thiadiazolo[3,4-g]quinoxaline(ITQ) as electron acceptor to construct novel photosensitizer with second near-infrared(NIR-II) emission. Experimental study and theoretical calculation demonstrated that comparing with the counterparts constituting by widely employed NIR-II building block benzobisthiadiazole(BBTD) and 6,7-diphenylthiadiazoloquinoxaline(DPTQ), ITQ-based photosensitizer(TITQ) showed superior aggregation-induced emission(AIE) characteristics, much stronger type-I reactive oxygen species(ROS) production, and prominent photothermal conversion capacity. Furthermore, TITQ nanoparticles with excellent biocompatibility were capable of effectively accumulating in the tumor site and visualizing tumor through fluorescence-photoacoustic-photothermal trimodal imaging with highly spatiotemporal resolution, and completely eliminating tumor by type-I photodynamic-photothermal therapy.

关键词： phototheranostics aggregation-induced emission NIR-Ⅱfluorescence acceptor engineering photodynamic-photothermal therapy