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Design， fabrication and characteristics of optofluidic variable aperture based on electromagnetic-driving

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Optoelectronics Letters 2024年

作者： ZHANG Anning zhao Rui WEI xian LIANG Zhongcheng HAN Zefeng Center of Optofluidic Technology， College of Optoelectronic Engineering， Nanjing University of Posts and Telecommunications

An electromagnetic-driving variable liquid aperture is designed and fabricated. It consists of a driving cavity， an optical cavity and a storage chamber， a polydimethylsiloxane（PDMS）elastic film， an annular magnet and a driving coils. The driving cavity is filled with dyeing liquid while the colorless transparent liquid fills the optical cavity and the storage chamber. When applying current， the annular magnet moves downward driven by the magnetic field leading to deformation of the PDMS film. Being squeezed by the moving magnet with the deforming film， the dyeing liquid flows from the driving cavity into the optical cavity， which contributes to the decrease of the clear aperture diameter in the optical cavity. Our proposed aperture performs continuous variable ability up to 2.775 mm in diameter of clear aperture when the current increases from 0 to 0.33A， and its relative transmittance ranges from 98.539% to 22.776% ～390 nm.

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电弧离子镀Al-Cr-O/Zr-O+NiCoCrAlSiY和Al-Cr-O+NiCoCrAlSiY涂层的抗氧化性和隔热性能

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Transactions of Nonferrous Metals Society of China 2024年第4期34卷 1237-1250页

作者：鲜丽君赵海波范洪远鲜广四川大学机械工程学院成都610065 四川大学分析测试中心成都610065

采用电弧离子镀在高温合金表面沉积Al-Cr-O/Zr-O多层涂层和Al-Cr-O单层涂层+NiCoCrAlSiY结合层,并在1000~1200℃下进行热处理。利用扫描电子显微镜和X射线衍射仪分析涂层的显微组织和物相结构。结果表明,Al-Cr-O/Zr-O多层涂层和Al-Cr-O... 详细信息

采用电弧离子镀在高温合金表面沉积Al-Cr-O/Zr-O多层涂层和Al-Cr-O单层涂层+NiCoCrAlSiY结合层,并在1000~1200℃下进行热处理。利用扫描电子显微镜和X射线衍射仪分析涂层的显微组织和物相结构。结果表明,Al-Cr-O/Zr-O多层涂层和Al-Cr-O单层涂层均呈现出致密的球形结构。热处理后,Al-Cr-O/Zr-O涂层表面出现裂纹,且裂纹随着温度的升高而增多和变粗。然而,Al-Cr-O涂层经热处理后其表面胞状结构转变为紧密连接的粒状结构,并且随着热处理温度的升高,粒状结构显著长大。由于作为氧离子导体以及t-ZrO_(2)的致密度低于α-Al_(2)O_(3),Al-Cr-O/Zr-O涂层中的t-ZrO_(2)为氧离子向涂层内扩散提供了通道,因此,Al-Cr-O单层涂层+NiCoCrAlSiY涂层体系的高温抗氧化性优于Al-Cr-O/Zr-O多层涂层+NiCoCrAlSiY涂层体系。但是,由于更大的陶瓷涂层厚度,t-ZrO_(2)相的低热导率以及层间界面的热反射作用,Al-Cr-O/Zr-O多层涂层+NiCoCrAlSiY涂层体系的隔热性能优于Al-Cr-O单层涂层+NiCoCrAlSiY涂层体系。

关键词：电弧离子镀 Al-Cr-O/Zr-O多层涂层抗氧化性隔热性能

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氢氧燃料电池电解饱和食盐水的微型实验

化学教育（中英文） 2024年第13期45卷 104-109页

作者：赵琦赵景娴杭州第九中学浙江杭州310020 杭州市春蕾中学浙江杭州310003

基于对教材中氢氧燃料电池的输出电压和电解饱和食盐水分解电压的测定,设计了使用石墨片作电极,包裹滤纸浸润硫酸钠溶液作电解质,制成串联的微型燃料电池组。并采用反复充放电的方法活化电极,增强电池容量。可以和电解饱和食盐水的液滴... 详细信息

基于对教材中氢氧燃料电池的输出电压和电解饱和食盐水分解电压的测定,设计了使用石墨片作电极,包裹滤纸浸润硫酸钠溶液作电解质,制成串联的微型燃料电池组。并采用反复充放电的方法活化电极,增强电池容量。可以和电解饱和食盐水的液滴电解池联用,构成一体化微型实验。

关键词：滤纸燃料电池电解食盐水一体化微型实验

Design and prototyping of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility

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Nuclear Science and Techniques 2024年第4期35卷 189-199页

作者： Jie-Yu Zhu Yang-Zhou Su Hai-Bo Yang Fen-Hua Lu Yan Yang Xi-Wen Liu Ping Wei Shu-Cai Wan Hao-Qing Xie xian-Qin Li Cong Dai Hui-Jun Hu Hong-Bang Liu Shu-Wen Tang Cheng-Xin zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2027 and scheduled to be installed on the China Space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the SAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMS noise level not exceeding 0.15 fC,and the integral nonlinearity was<0.2%.To further verify the readout electronic performance,a joint test with the detector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics SAMPA Data acquisition Performance test

Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model

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World Journal of Gastroenterology 2024年第5期30卷 471-484页

作者： Hui Hua Qian-Qian zhao Miriam Nkesichi Kalagbor Guo-Zhi Yu Man Liu Zheng-Rui Bian Bei-Bei Zhang Qian Yu Yin-Hai Xu Ren-xian Tang Kui-Yang Zheng Chao Yan Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Demonstration Center for Experimental Basic Medical Science EducationLaboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Laboratory Medicine The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Primary sclerosing cholangitis(PSC)is characterized by chronic inflammation and it predisposes to cholangiocarcinoma due to lack of effective treatment *** adeno-associated virus(rAAV)provides a promising platform for gene therapy on such kinds of diseases.A microRNA(miRNA)let-7a has been reported to be associated with the progress of PSC but the potential therapeutic implication of inhibition of let-7a on PSC has not been *** To investigate the therapeutic effects of inhibition of a miRNA let-7a transferred by recombinant adeno-associated virus 8(rAAV8)on a xenobiotic-induced mouse model of sclerosing *** A xenobiotic-induced mouse model of sclerosing cholangitis was induced by 0.1% 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine(DDC)feeding for 2 wk or 6 wk.A single dose of rAAV8-mediated anti-let-7a-5p sponges or scramble control was injected in vivo into mice onset of DDC *** sacrifice,the liver and the serum were collected from each *** hepatobiliary injuries,hepatic inflammation and fibrosis were *** targets of let-7a-5p and downstream molecule NF-κB were detected using Western *** rAAV8-mediated anti-let-7a-5p sponges can depress the expression of let-7a-5p in mice after DDC feeding for 2 wk or 6 *** reduced expression of let-7a-5p can alleviate hepato-biliary injuries indicated by serum markers,and prevent the proliferation of cholangiocytes and biliary ***,inhibition of let-7a mediated by rAAV8 can increase the expression of potential target molecules such as suppressor of cytokine signaling 1 and Dectin1,which consequently inhibit of NF-κB-mediated hepatic *** Our study demonstrates that a rAAV8 vector designed for liver-specific inhibition of let-7a-5p can potently ameliorate symptoms in a xenobiotic-induced mouse model of sclerosing cholangitis,which provides a possible clinical translation of PSC of human.

关键词： Primary sclerosing cholangitis Recombinant adeno-associated virus 8 Let-7a-5p Therapeutic effects Inflammation

PIF4 interacts with ABI4 to serve as a transcriptional activator complex to promote seed dormancy by enhancing ABA biosynthesis and signaling

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Journal of Integrative Plant Biology 2024年第5期66卷 909-927页

作者： Xiaofeng Luo Yujia Dai Baoshan xian Jiahui Xu Ranran Zhang Muhammad Saad Rehmani Chuan Zheng Xiaoting zhao Kaitao Mao Xiaotong Ren Shaowei Wei Lei Wang Juan He Weiming Tan Junbo Du Weiguo Liu Shu Yuan Kai Shu Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection School of Ecology and EnvironmentNorthwestern Polytechnical UniversityXi'an 710129China Research&Development Institute of Northwestern Polytechnical University in ShenzhenShenzhen 518057China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China Institute of Ecological Agriculture Sichuan Agricultural UniversityChengdu 611130China College of Resources Sichuan Agricultural UniversityChengdu 611130China

Transcriptional regulation plays a key role in the control of seed dormancy,and many transcription factors(TFs)have been ***,the mechanisms underlying the interactions between different TFs within a transcriptional complex regulating seed dormancy remain largely ***,we showed that TF PHYTOCHROME-INTERACTING FACTOR4(PIF4)physically interacted with the abscisic acid(ABA)signaling responsive TF ABSCISIC ACID INSENSITIVE4(ABI4)to act as a transcriptional complex to promote ABA biosynthesis and signaling,finally deepening primary seed *** pif4 and abi4 single mutants exhibited a decreased primary seed dormancy phenotype,with a synergistic effect in the pif4/abi4 double ***4 binds to ABI4 to form a heterodimer,and ABI4 stabilizes PIF4 at the protein level,whereas PIF4 does not affect the protein stabilization of ***,both TFs independently and synergistically promoted the expression of ABI4 and NCED6,a key gene for ABA *** genetic evidence is also consistent with the phenotypic,physiological and biochemical analysis ***,this study revealed a transcriptional regulatory cascade in which the PIF4–ABI4 transcriptional activator complex synergistically enhanced seed dormancy by facilitating ABA biosynthesis and signaling.

关键词： ABA ABI4 PIF4 seed dormancy and germination transcriptional complex

C57BL/6J小鼠背景的CD19嵌合抗原受体T细胞的制备及优化

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中国实验血液学杂志 2024年第2期32卷 595-602页

作者：任春晓赵莉陈娴娴田宇赵恺徐州医科大学血液病研究所江苏省骨髓干细胞重点实验室徐州医科大学附属医院血液科江苏徐州221000

目的:探索C57BL/6J小鼠CD3^(+)T细胞体外刺激条件、最佳培养和感染时间,以期提高CD19嵌合抗原受体T细胞(m CD19 CAR-T)的感染效率。方法:将纯化的C57BL/6J小鼠CD3^(+)T细胞在包被CD3/CD28抗体(anti-CD3/CD28 coated)、包被CD3抗体+可溶... 详细信息

目的:探索C57BL/6J小鼠CD3^(+)T细胞体外刺激条件、最佳培养和感染时间,以期提高CD19嵌合抗原受体T细胞(m CD19 CAR-T)的感染效率。方法:将纯化的C57BL/6J小鼠CD3^(+)T细胞在包被CD3/CD28抗体(anti-CD3/CD28 coated)、包被CD3抗体+可溶性CD28抗体(anti-CD3 coated+soluble anti-CD28)和包被CD3抗体(anti-CD3 coated)3种不同条件下分别刺激12 h和24 h,后续培养24 h、48 h和72 h并记录细胞克隆数。在上述3种条件下分别刺激C57BL/6J小鼠CD3^(+)T细胞12、24和36 h,然后加入白介素(IL)-2(100 U/ml),镜下记录培养24 h、48 h和72 h的细胞克隆数;此条件下取刺激24 h的CD3^(+)T细胞,感染m CD19 CAR-T逆转录病毒,制备m CD19 CAR-T细胞,流式检测48 h时3组中GFP+CAR-T细胞的百分率。结果:利用获得BALB/c小鼠m CD19 CAR-T细胞的最优化条件,制备C57BL/6J小鼠的m CD19 CAR-T细胞感染效率仅5.23%;anti-CD3^(+)soluble anti-CD28 coated刺激C57BL/6J小鼠CD3^(+)T细胞24 h,终止刺激继续培养至48 h时细胞克隆数最高;在上述条件刺激24 h后加入IL-2培养48 h,anti-CD3^(+)soluble anti-CD28 coated组T细胞增殖克隆数量显著增加,且CAR-T细胞感染效率为17.63%±4.17%。结论:C57BL/6J小鼠来源T细胞制备CAR-T细胞的最佳条件与BABL/c小鼠不同;anti-CD3^(+)soluble anti-CD28 coated+IL-2刺激条件下诱导的T细胞感染逆转录病毒后可获得最高效率的m CD19 CAR-T细胞。

关键词： C57BL/6J小鼠 CD19 嵌合抗原受体T细胞

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中小学课程思政一体化:内涵、困境与出路

教育理论与实践 2024年第14期44卷 28-32页

作者：赵先魁辽宁师范大学教育学部辽宁大连116029

中小学课程思政一体化基于对课程思政发展历程的回顾与分析,强调学科课程知识本身的客观独立性和超越性,区别于日常生活的思想政治教育活动。当前中小学课程思政一体化面临学段课程目标的衔接性不强、学科课程内容的嵌入性式微、学科教... 详细信息

中小学课程思政一体化基于对课程思政发展历程的回顾与分析,强调学科课程知识本身的客观独立性和超越性,区别于日常生活的思想政治教育活动。当前中小学课程思政一体化面临学段课程目标的衔接性不强、学科课程内容的嵌入性式微、学科教学方式的情境性消弭、学科评价导向的融合性疏离的困境。走出困境需要以“核心素养”为纽带,统整学段课程育人目标;以“五育融合”为依托,贯穿学科课程育人内容;以“跨学科教学”为路径,勾连学科课程育人过程;以“知行合一”为育人导向,完善学科课程评价体系。

关键词：中小学课程思政一体化课程目标课程内容教学方式评价导向

Electronic Correlation and Pseudogap-Like Behavior of High-Temperature Superconductor La_(3)Ni_(2)O_(7)

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Chinese Physics Letters 2024年第8期41卷 82-93页

作者： Yidian Li xian Du Yantao Cao Cuiying Pei Mingxin Zhang Wenxuan zhao Kaiyi Zhai Runzhe Xu Zhongkai Liu Zhiwei Li Jinkui zhao Gang Li Yanpeng Qi Hanjie Guo Yulin Chen Lexian Yang State Key Laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Key Lab for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou UniversityLanzhou 730000China Songshan Lake Materials Laboratory Dongguan 523808China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China ShanghaiTech Laboratory for Topological Physics Shanghai 200031China Shanghai Key Laboratory of High-Resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210China Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUK Frontier Science Center for Quantum Information Beijing 100084China

High-temperature superconductivity(HTSC)remains one of the most challenging and fascinating mysteries in condensed matter ***,superconductivity with transition temperature exceeding liquid-nitrogen temperature is discovered in La_(3)Ni_(2)O_(7) at high pressure,which provides a new platform to explore the unconventional *** this work,using high-resolution angle-resolved photoemission spectroscopy and ab initio calculation,we systematically investigate the electronic structures of La_(3)Ni_(2)O_(7) at ambient *** experiments are in nice agreement with ab initio calculations after considering an orbital-dependent band renormalization *** strong electron correlation effect pushes a flat band of d_(z^(2))𝑧2 orbital component below the Fermi level(E_(F)),which is predicted to locate right at E_(F) under high ***,the d_(x^(2)−y^(2)) band shows pseudogap-like behavior with suppressed spectral weight and diminished quasiparticle peak near E_(F).Our findings provide important insights into the electronic structure of La_(3)Ni_(2)O_(7),which will shed light on understanding of the unconventional superconductivity in nickelates.

关键词： effect superconductivity orbital