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High-density lipoprotein mimetic nanotherapeutics for cardiovascular and neurodegenerative diseases

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Nano Research 2018年第10期11卷 5130-5143页

作者： Song Ih Ahn Hyun-Ji Park diwon yom Taeyoung Kim YongTae Kim George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology Atlanta GA 30332 USA Parker H. Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Atlanta GA 30332 USA Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology Atlanta GA 30332 USA Institute for Electronics and Nanotechnology Georgia Institute of Technology Atlanta GA 30332 USA

High-density lipoprotein （HDl） serves as a natural nanoparticle with compositional and functional heterogeneity and contributes to the maintenance of lipid metabolism and various biological functions. HDl also transports endogenous microRNAs, vitamins, hormones, and proteins through blood and interstitial fluids to various organs. These unique and diverse features of HDl have encouraged its applications for the transport of therapeutics and diagnostic reagents in the last decade. In this review, we describe the heterogeneous characteristics and biological functions of HDl and highlight HDl mimetic approaches, including apolipoprotein mimetic peptides and reconstituted HDl nanoparticles. Given the potential of HDl as a nanocarrier delivering various therapeutic agents, we discuss the current representative studies of HDl mimetic nanotherapeutics for cardiovascular and neurodegenerative diseases and analyze the current challenges and future perspective.

关键词： high-density lipoprotein nanotherapeutic cardiovascular disease neurodegenerative disease

Modern Public Perception of Volunteerism in China

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Modern Public Perception of Volunteerism in China

作者： Daniel yom Tov 上海交通大学

学位级别：硕士

This research will deal with the term of modern volunteerism and how it takes effect in *** is important to notify that volunteerism wears different shapes in different *** the history,western world has deeply researched the topic of volunteerism,its meanings and how it comes into ***,this topic was irrelevant in China until just recent years,because of the nature of the socialist state and the reliability of the government on itself *** the last ten years,events like the 2008 Sichuan mega-earthquake,the 2008 Olympic Games in Beijing and 2010 Shanghai World Expo influenced the rapid growth of the widespread volunteering phenomenon all over the modern Chinese *** events led the government into understanding that in some cases the help of the citizens is much *** research will seek to understand the modern public perception of volunteerism in the context of China,and to answer the question of how does Chinese culture affects the understanding of modern *** research question was examined through Hofstede model of national culture and Meijs theory regarding modern public perception of volunteerism,which both are world leading researchers in the ***,this research used a mix-methods approach of quantitative and qualitative sections in order to deepen the depth of the *** study will focus on the city of Shanghai and will try to examine diversified Chinese society as *** to the findings,firstly it can be argued that modern Chinese society as a whole are much more obligated to their counterparts in society,and to the ideals of ***,modern public perception of volunteerism in China is becoming similar to western societies studied by Meijs,and being perceived in terms of cost and benefit of each volunteering ***,the Chinese society perceives the benefits of volunteering in a different way than in western societies,and things that will be regarded

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Modeling Municipal Solid Waste Management in Africa: Case Study of Matadi, the Democratic Republic of Congo

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Journal of Environmental Protection 2013年第5期4卷 435-445页

作者： Gregory yom Din Emil Cohen Independent Expert for Waste to Energy Projects Moshav Aniam Israel The Open University of Israel Raanana Israel Tel-Aviv University Tel-Aviv Israel

The purpose of this article is to present the key elements for best performance and profitability of Municipal Solid Waste (MSW) management in a low-income city. The research provides an overview of methods and models for integrated planning of a two-phase program: MSW collection and transportation, and MSW treatment. We present the case study of Matadi (the Democratic Republic of Congo) that has a low level of the MSW management compared to other African cities. We develop a spreadsheet model for collection and transportation of MSW which is relevant for low-income cities and enables determining the waste collection fee. A CDM decay model is used to predict the GHG emissions in disposal site. The MSW treatment plant in case of Matadi is evaluated. For the anaerobic digestion technology selected as appropriate for this plant, the key factors that ensure profitability of the plant are as follows: tipping fee from the municipality (19% of total revenue), amount of carbon credits which can sum up to 16% of the total revenue, expansion of waste collection range from 25 to 50 km. The methods of this study can be used for solving waste problem in other low-income cities where the budget for municipal services is scanty, particularly when starting from a very low level of MSW management.

关键词： Municipal Solid Waste Waste Treatment Emissions Trading Planning Economic Evaluation

Radiation exposure and reduction in the operating room: Perspectives and future directions in spine surgery

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World Journal of Orthopedics 2017年第7期8卷 524-530页

作者： Ankur S Narain Fady Y Hijji Kelly H yom Krishna T Kudaravalli Brittany E Haws Kern Singh Department of Orthopaedic Surgery Rush University Medical Center

Intraoperative imaging is vital for accurate placement of instrumentation in spine surgery. However, the use of biplanar fluoroscopy and other intraoperative imaging modalities is associated with the risk of significant radiation exposure in the patient, surgeon, and surgical staff. Radiation exposure in the form of ionizing radiation can lead to cellular damage via the induction of DNA lesions and the production of reactive oxygen species. These effects often result in cell death or genomic instability, leading to various radiation-associated pathologies including an increased risk of malignancy. In attempts to reduce radiation-associated health risks, radiation safety has become an important topic in the medical field. All practitioners, regardless of practice setting, can practice radiation safety techniques including shielding and distance to reduce radiation exposure. Additionally, optimization of fluoroscopic settings and techniques can be used as an effective method of radiation dose reduction. New imaging modalities and spinal navigation systems have also been developed in an effort to replace conventional fluoroscopy and reduce radiation doses. These modalities include Isocentric Three-Dimensional C-Arms, O-Arms, and intraoperative magnetic resonance imaging. While this influx of new technology has advanced radiation safety within the field of spine surgery, more work is still required to overcome specific limitations involving increased costs and inadequate training.

关键词： Intraoperative imaging Ionizing radiation DNA damage Genomic instability Shielding Distance Dose reduction Spinal navigation

赫坎按蚊种群近缘种核糖体基因内转录第二间隔区序列分析

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中国寄生虫学与寄生虫病杂志 2004年第5期22卷 277-279页

作者：高琪周华云李菊林李凤华 Choe Tong Gyu yom Sung Chan 朱国鼎曹俊江苏省寄生虫病防治研究所无锡214064 辽宁省疾病预防控制中心沈阳110005 朝鲜民主主义共和国国家流行病和公共卫生研究所

目的　分析赫坎按蚊种群内 4个近缘种核糖体基因内转录第二间隔区 (rDNAITS2 )特征。　方法　采用特异性ITS2 引物对中华按蚊和嗜人按蚊江苏实验株、辽宁省沈阳市和朝鲜开城现场捕获的嗜人按蚊、八代按蚊和雷氏按蚊rDNAITS2 进行PCR扩... 详细信息

目的　分析赫坎按蚊种群内 4个近缘种核糖体基因内转录第二间隔区 (rDNAITS2 )特征。　方法　采用特异性ITS2 引物对中华按蚊和嗜人按蚊江苏实验株、辽宁省沈阳市和朝鲜开城现场捕获的嗜人按蚊、八代按蚊和雷氏按蚊rDNAITS2 进行PCR扩增、基因测序和限制性内切酶酶切位点图谱分析。　结果与结论　赫坎按蚊种群近缘种中华按蚊、嗜人按蚊、八代按蚊和雷氏按蚊rDNAITS2 分别为 472、45 2、45 6和 45 6bp 。

关键词：嗜人按蚊蚊种隔区核糖体基因中华按蚊 DNA 限制性内切酶酶切位点近缘种转录

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亚洲在引领全球的创意电子商务发展

现代广告 2019年第20期 14-14页

作者： Bill yom 杰尔全球

2019 Spikes Asia创意节的一大亮点就是新增了"创意电子商务"类,旨在表彰具有创造性和革新的电子商务和支付解决方案,作品需要展现创新和优化是如何促进消费者的互动参与以及帮助企业取得商业成功的。这是一个新的奖项类别,所以对其的... 详细信息

2019 Spikes Asia创意节的一大亮点就是新增了"创意电子商务"类,旨在表彰具有创造性和革新的电子商务和支付解决方案,作品需要展现创新和优化是如何促进消费者的互动参与以及帮助企业取得商业成功的。这是一个新的奖项类别,所以对其的定义和认识也在不断的发展中。

关键词：电子商务发展创新和优化互动参与创意消费者

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高强钢热轧卷板边部翘皮的原因分析及控制

冶金信息导刊 2019年第6期56卷 15-18,51页

作者：郭银涛赵铁成余作朋李会亚温巨文尹宽李阳唐山不锈钢有限责任公司唐山063000

为提高企业竞争力,唐钢不锈钢公司不断向高端汽车用钢领域市场进军。为满足高端产品的要求,对热轧板卷表面质量提出了更高的质量要求。卷板边部翘皮缺陷一直是困扰着高强钢表面质量提升的主要障碍。通过金相和电镜分析方法确定了铸坯角... 详细信息

为提高企业竞争力,唐钢不锈钢公司不断向高端汽车用钢领域市场进军。为满足高端产品的要求,对热轧板卷表面质量提出了更高的质量要求。卷板边部翘皮缺陷一直是困扰着高强钢表面质量提升的主要障碍。通过金相和电镜分析方法确定了铸坯角部裂纹是导致边部翘皮的主要原因。为解决铸坯角部缺陷,采取了相应的优化措施,最终,高强钢热轧卷板的边部翘皮缺陷得到了有效控制。目前已形成向吉利、上汽、菲亚特、福特、宝马等知名汽车主机厂批量供货的能力。

关键词：高强钢翘皮角裂