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Glucagon-like peptide 1 receptor activation:anti-inflammatory effects in the brain

Neural Regeneration Research 2024年第8期19卷 1671-1677页

作者： yolanda diz-chaves Zainab Maastor Carlos Spuch José Antonio Lamas Lucas C.González-Matías Federico Mallo Biomedical Research Centre(CINBIO) Laboratory of EndocrinologyUniversity of VigoGalicia Sur Health Research InstituteVigoSpain Translational Neuroscience Research Group Galicia Sur Health Research InstituteCIBERSAMHospitalÁlvaro CunqueiroSala InvestigaciónEstrada Clara CampoamorVigoSpain Biomedical Research Centre(CINBIO) Laboratory of NeuroscienceUniversity of VigoGalicia Sur Health Research InstituteVigoSpain

The glucagon-like peptide 1 is a pleiotropic hormone that has potent insulinotropic effects and is key in treating metabolic diseases such as diabetes and ***-like peptide 1 exerts its effects by activating a membrane receptor identified in many tissues,including diffe rent brain ***-like peptide 1 activates several signaling pathways related to neuroprotection,like the support of cell growth/survival,enhancement promotion of synapse formation,autophagy,and inhibition of the secretion of proinflammatory cytokines,microglial activation,and apoptosis during neural *** glial cells,including astrocytes and microglia,maintain metabolic homeostasis and defe nse against pathogens in the central nervous *** brain insult,microglia are the first cells to respond,followed by reactive *** activated cells produce proinflammato ry mediators like cytokines or chemokines to react to the ***,under these circumstances,mic roglia can become chro nically inflammatory by losing their homeostatic molecular signature and,consequently,their functions during many *** processes promote the development of neurological disorders and influence their pathological evolution:like the formation of protein aggregates,the accumulation of abnormally modified cellular constituents,the formation and release by injured neurons or synapses of molecules that can dampen neural function,and,of critical impo rtance,the dysregulation of inflammato ry control *** glucagonlike peptide 1 receptor agonist emerges as a critical tool in treating brain-related inflammatory pathologies,restoring brain cell homeostasis under inflammatory conditions,modulating mic roglia activity,and decreasing the inflammato ry *** review summarizes recent advances linked to the anti-inflammato ry prope rties of glucagon-like peptide 1 receptor activation in the brain related to multiple sclerosis,Alzheimer’s disease,Parkins

关键词： astrocytes brain glucagon-like peptide 1 receptor inflammation microglia

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A review of landscape ecology experiments to understand ecological processes

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Ecological Processes 2022年第1期11卷 802-811页

作者： yolanda F.Wiersma Department of Biology Memorial UniversitySt.John’sNL A1C 5S7Canada

Background:One way in which we make inferences about ecological processes is via *** ecological processes happen at landscape extents and it is at this extent that experimentation is more *** review explores the intersection between experimentation,ecological processes and landscape ***,this review seeks to discover how scientists design experiments to understand ecological processes at landscape ***:I found 87 papers where these three concepts intersected,and reviewed them in more depth to assess characteristics of scale(treatment and study area extent),replication,research question and experiment ***:The findings suggest that experimental approaches for understanding ecological processes are well established,and beginning to more readily accommodate spatial ***,there is room to integrate more spatially explicit,landscape-scale experiments into studies of ecological processes.

关键词： Inference Landscape ecology Manipulative experiment Observational experiment Scale

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Population structure and reproductive biology of the mysid Nanomysis siamensis(Crustacea:Mysida)in Songkhla Lagoon system,southern Thailand

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Journal of Oceanology and Limnology 2021年第3期39卷 997-1009页

作者： Rofiza yolanda Vachira LHEKNIM Division of Biological Science Faculty of SciencePrince of Songkla UniversitySongkhla 90112Thailand

Songkhla Lagoon in southern Thailand is a large lagoon with brackish water where the mysid Nanomysis siamensis *** has long been the dominant mysid species in this ***,nothing is known about the biology and ecology of *** for the first time,we provide information about its demographic structure and reproductive biology in the Songkhla Lagoon *** conducted monthly sampling from June 2017 to June 2018 at five stations in Thale Sap and seven stations in Thale Sap *** were classified into six *** monthly mean density ranged 8.44-807.33 inds./100 m^(2) in Thale Sap and 8.81-434.44 inds./100 m^(2) in Thale Sap *** peak occurrence of this species was in May 2018 in Thale *** population composition was as follows:juvenile 10.13%,immature males 13.45%,immature females 10.54%,mature males 26.19%,mature females 21.63%and ovigerous females 18.05%.The proportion of ovigerous females was statistically significant and brooding females in the nauplioid stage were more dominant than embryonic phase and post-nauplioid *** size varied from 1 to 17,the embryo diameter ranging from 0.2 to 0.4 mm and the lengths of the larvae ranged from 0.5 to 1.0 *** was a positive correlation between brood size and brood length with ovigerous female body ***,mature males were predominant over the five population composition types,and reproduction in *** was observed every month.

关键词： brackish water reproductive trait Thale Sap Thale Sap Songkhla

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A generalization of the half-normal distribution

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Applied Mathematics(A Journal of Chinese Universities) 2016年第4期31卷 409-424页

作者： yolanda M. Gomez Ignacio Vidal departamento de matemáticas facultad de ciencias universidad de católica del norte Antofagasta Chile instituto de matemática y física universidad de talca Chile

In this paper we introduce an extension of the half-normal distribution in order to model a great variety of non-negative data. Its hazard rate function can be decreasing or increasing, depending on its parameters. Some properties of this new distribution are presented. For example, we give a general expression for the moments and a stochastic representation. Also, the cumulative distribution function, the hazard rate function, the survival function and the quantile function can be easily evaluated. Maximum likelihood estimators can be computed by using numerical procedures. Finally, a real-life dataset has been presented to illustrate its applicability.

关键词： half-normal distribution generalized half-normal distribution maximum likelihood estimate

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Sm-Nd systematics of metaultramafic-mafic rocks from the Arroio Grande Ophiolite(Brazil): Insights on the evolution of the South Adamastor paleo-ocean

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Geoscience Frontiers 2020年第6期11卷 2287-2296页

作者： Rodrigo chaves Ramos Edinei Koester Daniel Triboli Vieira Programa de Pòs-Graduação Em Geociências Instituto de GeociênciasUniversidade Federal Do Rio Grande Do Sul.PO Box 1500191501-970Porto AlegreRSBrazil Departamento de Geologia Universidade Federal Do Rio Grande Do Sul.Bento Gonçalves Avenue950091540-000Porto AlegreRSBrazil

In this contribution we present new insights on the evolution of the Dom Feliciano Belt,southernmost Mantiqueira Province,integrating new whole-rock Sm-Nd isotopic data for the Arroio Grande Ophiolite(Punta del Este Terrane,Brazil/Uruguay border)with previously published bulk-rock and isotope geochemistry of the South Adamastor paleo-ocean metamafic rocks located in Uruguay(Paso del Dragon Complex,Punta del Este Terrane)and Namibia(Chameis Subterrane,Marmora Terrane,Gariep Belt).For the regional geology,the new data corroborate previous hypothesis and demonstrate the depleted mantle features of the amphibolites and metagabbros of the studied *** Arroio Grande Ophiolite rocks are compared with its Uruguayan and Namibian counterparts,demonstrating their isotopic and geochemical similarities and differences,and the backarc affinity of the South Adamastor *** MORB-affinity amphibolites from the Arroio Grande Ophiolite-Paso del Dragon Complex are,so far,the most juvenile rocks in the eastern sector of the Dom Feliciano Belt,yielding εNd(640)Ma)between+7.3 and+9,and high 147Sm/144Nd(>0.169)and 143Nd/144Nd(640 Ma)ratios(0.51219-0.51229).The South Adamastor is interpreted in this paper as an internal back-arc ocean,with limited lateral extension,opened at around 750-650 Ma as the result of the closure of the older Charrua-Goianide paleoocean during the Brasiliano/Pan-African orogenic cycle and final configuration of the West Gondwana paleocontinent.

关键词： West Gondwana Brasiliano orogenic cycle Adamastor ocean

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Ocular findings in Zucker Diabetic Fatty rats emphasize the key role of neuroglia degeneration in diabetic retinopathy pathophysiology

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Neural Regeneration Research 2018年第2期13卷 239-240页

作者： ivan fernandez-bueno yolanda diebold instituto universitario de oftalmobiología aplicada university of valladolidValladolidSpain red temática de investigación cooperativa en salud(retics) oftaredinstituto de salud carlos IIIMadridSpain biomedical research networking center on bioengineering biomaterials and nanomedicineciber-bbnValladolidSpain

Diabetes mellitus is a leading cause of acquired vision loss and one of the world＇s fastest growing chronic diseases. Diabetic retinopathy （DR）, a specific complication of chronic hyperglycemia, is the leading cause of acquired vision loss worldwide in middle-aged and there- fore economically active people that also increases the medical and economic burden on the society （Klein, 2007）.

关键词： Ocular findings in Zucker Diabetic Fatty rats emphasize the key role of neuroglia degeneration in diabetic retinopathy pathophysiology

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Chromium and leather:a review on the chemistry of relevance for allergic contact dermatitis to chromium

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Journal of Leather Science and Engineering 2020年第1期2卷 234-248页

作者： yolanda S.Hedberg Division of Surface and Corrosion Science Department of ChemistrySchool of Engineering Sciences in ChemistryBiotechnologyand HealthKTH Royal Institute of TechnologyDrottning Kristinas väg 51SE-10044 StockholmSweden

As other causes decline in importance,chromium-tanned leather has become a more important source for chromium allergy,which affects around 1%of the general *** aim of this review is to give suggestions on how to minimize the risk of leather-related allergic contact dermatitis,which can be elicited in chromiumallergic persons by hexavalent and trivalent chromium released from *** chromium is the more potent chromium form and requires a lower skin dose to elicit allergic *** is formed on the surface of some,antioxidant-free,leathers at dry conditions(<35% relative humidity)and is influenced by the tanning process and other conditions,such as UV irradiation,contact with alkaline solutions,and leather *** chromium is the dominant form released from chromium-tanned leather and its released amount is sufficient to elicit allergic reactions in some chromium-allergic individuals when they are exposed repetitively and over longer time(days-months).A low initial test result(<3 mg/kg)for hexavalent chromium with the current standard test(ISO 17075)does not guarantee a low release of chromium from the leather or a low release of hexavalent chromium under typical exposure conditions during the service life of the ***,labels,and certificates regarding leather products are often insufficient to protect chromium-allergic *** labelling and information on the possible content of different allergens,as well as different tanning alternatives for certain leather products,are crucial.

关键词： Hexavalent chromium Chromium Contact dermatitis Allergy Eczema Relative humidity Antioxidants Exposure Speciation ISO 17075

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Performance of aerogel as a thermal insulation material towards a sustainable design of residential buildings for tropical climates in Nigeria

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Energy and Built Environment 2022年第3期3卷 291-315页

作者： Aminu Wali Bashir Brenda chaves Coelho Leite Departamento de Engenharia de Construção Civil Escola Politécnica da Universidade de São PauloSão Paulo 05508-010Brasil

The building sector accounts for nearly 40%of global energy *** Nigeria,more than two-thirds of the consumption comes from residential *** efficiency measures through the adoption of insulation materials are tools that could crash the peak demand of energy in buildings while improving its thermal comfort and aerogel is considered as the most effective material for insulation,owing to its unique thermal *** this paper,we present the performance of aerogel as a thermal insulation material towards a sustainable design of residential buildings for tropical climates in ***,a typical residential building in the tropical region was modeled with conventional materials utilized in the region and was later modified through the application of aerogel material on various surfaces of the model.A whole building energy simulation was then carried out in each variation and the outcome was compared to effectively conclude on the significance of aerogel in terms of thermal comfort improvement and energy consumption *** show that aerogel had the highest influence when inserted in the attic and floor slabs of the designed model.A reduction of more than 6%was attained in the recorded indoor mean air and operative temperatures while still maintaining an acceptable humidity *** energy consumption,a reduction of more than 15%was ***,the high price of aerogel may hinder its application on the studied building but could be a good investment where climate change and sustainability are of high importance and less concern is given to *** demonstrated significant potential with respect to both thermal comfort improvement and energy consumption reduction on the designed *** outcome of the study is hoped to serve as a base reference for the insulation of residential buildings with similar climate and characteristics to the adopted case building.

关键词： Aerogels Building energy consumption Energy efficiency Thermal insulation materials Thermal comfort Building energy simulation

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Limited proteomic response in the marine snail Melarhaphe neritoides after long-term emersion

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Current Zoology 2017年第5期63卷 487-493页

作者： Angel R diz Margarita ALVAREZ-RODRiGUEZ Monica R. ROMERO Emilio FOLAN-ALVAREZ Juan GALINDO Department of Biochemistry Genetics and Immunology Faculty of Biology University of Vigo Vigo 36310 Spain Toralla Marine Science Station (ECIMAT) Universidad de Vigo Vigo 36331 Spain Institute of Marine Research (IIM) CSIC Vigo 36208 Spain

Rocky intertidal organisms are commonly exposed to environmental gradients, promoting adapta-tions to these conditions. Emersion time varies along the intertidal range and in the supralittoralzone is frequently larger than a single tidal cycle, even lasting for weeks. The planktonic-dispersinggastropod Melarhaphe neritoides is a common species of the high shore, adapted to reduce waterloss in order to survive during long-term emersion. In this study, we investigated the molecular re-sponse, at the proteome level, of M. neritoides collected in high-shore tide pools to a series ofemersion periods, from 8 to 24 days, in laboratory conditions. We compared this response to indi-viduals maintained submerged during this period, because this was their original habitat. We alsoincluded a reversion treatment in the study, in which emersed individuals were returned to the sub-merged conditions. Although we detected an increase in overall protein concentration with longeremersion periods, contrary to general expectation, the two dimensional electrophoresis （2DE）-based proteomic analysis did not show significant differences between the treatments at the levelof individual protein spots, even after an emersion period of 24 days. Our results suggest that themetabolism remains unaltered independent of the treatment carried out or the changes are verysubtle and therefore difficult to detect with our experimental design. We conclude that M. neri-toides could be equally adapted to emersion and submersion without drastic physiologicalchanges.

关键词： daptation, 2DE proteomics, environmental gradient, intertidal zone, metabolic rate depression.

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Influence of gut microbiota on neuropsychiatric disorders

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World Journal of Gastroenterology 2017年第30期23卷 5486-5498页

作者： María Carmen Cenit yolanda Sanz Pilar Codoner-Franch Nutrition and Health Research Group Institute of Agrochemistry and Food Technology National Research Council (IATA-CSIC) Department of Pediatrics Obstetrics and Gynecology University of Valencia Department of Pediatrics Dr. Peset University Hospital

The last decade has witnessed a growing appreciation of the fundamental role played by an early assembly of a diverse and balanced gut microbiota and its subsequent maintenance for future health of the host. Gut microbiota is currently viewed as a key regulator of a fluent bidirectional dialogue between the gut and the brain(gut-brain axis). A number of preclinical studies have suggested that the microbiota and its genome(microbiome) may play a key role in neurodevelopmental and neurodegenerative disorders. Furthermore, alterations in the gut microbiota composition in humans have also been linked to a variety of neuropsychiatric conditions, including depression, autism and Parkinson's disease. However, it is not yet clear whether these changes in the microbiome are causally related to such diseases or are secondary effects thereof. In this respect, recent studies in animals have indicated that gut microbiota transplantation can transfer a behavioral phenotype, suggesting that the gut microbiota may be a modifiable factor modulating the development or pathogenesis of neuropsychiatric conditions. Further studies are warranted to establish whether or not the findings of preclinical animal experiments can be generalized to humans. Moreover, although different communication routes between the microbiota and brain have been identified, further studies must elucidate all the underlying mechanisms involved. Such research is expected to contribute to the design of strategies to modulate the gut microbiota and its functions with a view to improving mental health, and thus provide opportunities to improve the management of psychiatric diseases. Here, we review the evidence supporting a role of the gut microbiota in neuropsychiatric disorders and the state of the art regarding the mechanisms underlying its contribution to mental illness and health. We also consider the stages of life where the gut microbiota is more susceptible to the effects of environmental stressors, and the

关键词： Microbiota Microbiome Dysbiosis Brain-gut axis Mental health Psychiatric conditions

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