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Review of sub-synchronous interaction in wind integrated power systems: classification, challenges, and mitigation techniques

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Protection and Control of Modern Power Systems 2023年第2期8卷 13-38页

作者： Neevatika Verma Narendra kumar Saket gupta Hasmat Malik Fausto Pedro García Márquez Department of Electrical Engineering Delhi Technological UniversityDelhi 110042India Department of Electrical Power Engineering Faculty of Electrical EngineeringUniversiti Teknologi Malaysia(UTM)81310 JohorMalaysia Ingenium Research Group DepartmentUniversidad Castilla-La Mancha13071 Ciudad RealSpain Department of Electrical Engineering Graphic Era Deemed to be UniversityDehradun 248002India Instrumentation and Control Engineering Department Bharati Vidyapeeth’s College of EngineeringNew Delhi 110056India

Emerging sub-synchronous interactions(SSI)in wind-integrated power systems have added intense attention after numerous incidents in the US and China due to the involvement of series compensated transmission lines and power electronics *** phenomenon occurs when two power system elements exchange energy below the synchro-nous *** phenomenon related to wind power plants is one of the most significant challenges to main-taining stability,while SSI phenomenon in practical wind farms,which has been observed recently,has not yet been described on the source of conventional SSI *** paper first explains the traditional development of SSI and its classification as given by the IEEE,and then it proposes a classification of SSI according to the current research status,reviews several mitigation techniques and challenges,and discusses analysis techniques for *** paper also describes the effect of the active damping controllers,control scheme parameters,degree of series compensation,and various techniques used in wind power plants(WPPs).In particular,a supplementary damping controller with converter controllers in Doubly Fed Induction Generator based WPPs is briefly *** paper provides a real-istic viewpoint and a potential outlook for the readers to properly deal with SSI and its mitigation techniques,which can help power engineers for the planning,economical operation,and future expansion of sustainable development.

关键词： Damping controller Doubly fed induction generator(DFIG) Series compensations Sub-synchronous interactions(SSI) Sub-synchronous resonance(SSR)

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Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

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World Journal of Gastroenterology 2017年第22期23卷 3978-3998页

作者： Aarti Sharma Kiran Lata Sharma Annapurna gupta Alka Yadav Ashok kumar Department of Surgical Gastroenterology Sanjay Gandhi Post Graduate Institute of Medical Sciences Department of Biochemistry and Medical Genetics John Buhler Research Centre University of Manitoba

Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developing countries. Late diagnosis and deprived prognosis are major problems for treatment of gallbladder carcinoma. The dramatic associations of this orphan cancer with various genetic and environmental factors are responsible for its poorly defined pathogenesis. An understanding to the relationship between epidemiology, molecular genetics and pathogenesis of gallbladder cancer can add new insights to its undetermined pathophysiology. Present review article provides a recent update regarding epidemiology, pathogenesis, and molecular genetics of gallbladder cancer. We systematically reviewed published literature on gallbladder cancer from online search engine Pub Med(http://***/pubmed). Various keywords used for retrieval of articles were Gallbladder, cancer Epidemiology, molecular genetics and bullion operators like AND, OR, NOT. Cross references were manually searched from various online search engines(http://***/pubmed,https://***/, http://***/***). Most of the articles published from 1982 to 2015 in peer reviewed journals have been included in this review.

关键词： Gallbladder cancer Epidemiology Molecular genetics Pathogenesis

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Emerging targets in cancer drug resistance

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Cancer Drug Resistance 2019年第2期2卷 161-177页

作者： Shashank kumar Prem Prakash Kushwaha Sanjay gupta School of Basic and Applied Sciences Department of Biochemistry and Microbial SciencesCentral University of PunjabBathinda 151001India Department of Urology Case Western Reserve UniversityClevelandOhio 44106USA The Urology Institute University Hospitals Cleveland Medical CenterClevelandOhio 44106USA Department of Nutrition Case Western Reserve UniversityClevelandOhio 44106USA Divison of General Medical Sciences Case Comprehensive Cancer CenterClevelandOhio 44106USA Department of Urology Louis Stokes Cleveland Veterans Affairs Medical CenterClevelandOhio 44106USA.

Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer *** cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and *** the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic *** review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance.

关键词： Drug resistance transforming growth factor-β Keap1-Nrf2 PI3K-Akt FOXO transcription factors focal adhesion kinases annexins MIEN1 gene splicing sphingolipids microRNA

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To explore patients’ perceptions about motivators and barriers of adherence to highly active antiretroviral therapy among people living with HIV: A qualitative study

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Journal of Integrative Nursing 2023年第4期5卷 256-265页

作者： Sonia GULATI Hariprasath PANDURANGAN Pulin kumar gupta Department of Health and Allied Sciences Amity College of NursingAmity UniversityGurugramHaryanaIndia Department of Medicine Atal Bihari Vajpayee Institute of Medical Sciences and Dr.Ram Manohar Lohia HospitalNew DelhiIndia

Objective:For people living with HIV(PLHIV),strict adherence to highly active antiretroviral therapy(HAART)is the key to effective treatment and retention in human immunodeficiency virus(HIV)*** are many factors which promote or halt the antiretroviral therapy(ART)adherence ***,the present study aimed to examine the HAART adherence levels and to explore patients’views about barriers and facilitators to HIV treatment ***:Semi-structured interviews were conducted among 15 PLHIV at the ART clinic of *** Manohar Lohia Hospital,New *** were audio-recorded in the local Hindi language,and bilingual experts(English and Hindi)transcribed *** data were coded for themes and subthemes and analyzed using a phenomenological approach as per thematic content ***:Feeling of hopelessness,delayed ART initiation,difficult initial phase of ART,forget to take ART on time,fear of disclosure of HIV diagnosis,lack of privacy and negative social support,and impact of lockdown due to COVID-19 were revealed as significant barriers to ART *** the same time,commitment to raise and educate children,ART to increase life span,maintain oneself to be physically fit and healthy,only a single pill per day,very supportive counselors and health-care professionals,and hope to give birth to a healthy child were identified as facilitators of HIV ***:Understanding patient’s perception about ART adherence,its motivational and barrier factors which are directly affecting ART adherence and retention of PLHIV in HIV treatment and follow-ups are of utmost importance to improve ART adherence during HIV patient care services.

关键词： Adherence barriers highly active antiretroviral therapy human immunodeficiency virus motivators perceptions

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Predictors of Mortality at 28-days in Infection associated Acute Kidney Injury in Cirrhosis

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World Journal of Hepatology 2022年第3期14卷 592-601页

作者： Tarana gupta Naveen Ranga Sandeep kumar Goyal Department of Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Independent Researcher Kangra 176056Himachal PradeshIndia

BACKGROUND Acute kidney injury(AKI)in cirrhosis is important complication with poor *** infections are common cause for acute *** in cirrhosis lead to acute deterioration of hemodynamics leading to precipitation of *** To study predictors of mortality in patients with infection-associated AKI in *** This was a prospective,observational study conducted at Tertiary care centre from January 2018 till April *** 119 participants with cirrhosis of liver presenting with AKI were included into the *** was defined as per international club of Ascites-AKI criteria *** were grouped into infection AKI and non-infection ***-infection AKI included patients with diuretic induced AKI and pre-renal *** regression analysis was used to determine predictors of mortality at *** Out of 119 patients,alcohol(n=104)was most common etiology of *** infection AKI included 67(56%)patients and non-infection AKI(n=52)included pre-renal AKI in 36(30%)and diuretic-induced AKI in 16(14%)*** AKI had significantly higher bilirubin,higher international normalized ratio(INR),low serum sodium,higher total leukocyte count(TLC)and higher prevalence of hepatic encephalopathy(HE)as compared to non-infection *** AKI had higher progression of AKI(19/67 vs 2/52;P=0.01)and 28-d mortality(38/67 vs 4/5;P≤0.01)as compared to non-infection *** 28-d,non-survivors(n=42)had significantly higher bilirubin,higher INR,low serum sodium,higher TLC and higher prevalence of HE as compared to survivors(n=77).On subgroup analysis of Infection AKI group,on multivariate analysis,serum bilirubin as well as presence of HE were independent predictors of 28-d *** was no significant difference of mortality at 90-d between two *** Infection AKI in cirrhosis has a dismal prognosis with higher 28-d mortality as compared to noninfection *** bilirubin and presence of HE predict

关键词： Infection Acute kidney injury Mortality Cirrhosis Bilirubin Hepatic encephalopathy

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Immunogenicity and reactogenicity of a recombinant hepatitis B vaccine in subjects over age of forty years and response of a booster dose among nonresponders

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World Journal of Gastroenterology 2003年第5期9卷 1132-1134页

作者： Kunal Das R.K.gupta V.kumar P.Kar Department of Medicine Maulana Azad Medical College & L.N.HospitalNew Delhi.Medical AdvisorPanacea Biotec Co.New Delhi

AIM:The study was initiated to evaluate the reactogenicity and immunogenicity of a recombinant hepatitis B vaccine in age group >40 years and to study the response of a single booster dose in primary non-responders to the hepatitis B vaccination. METHODS:A total of 102 volunteers without markers of hepatitis B infection (negative for HBsAg,anti-HBc antibody, HBeAg and anti-HBs antibody) received 20μg of recombinant HB vaccine intramuscularly at 0,1,and 6 *** HBs titers were evaluated by a quantitative Elisa kit at 90 and 210 days.A booster dose of 20μg HB vaccine was given after 6 months of the 3^(rd) vaccine dose to the 15 non- responders and anti-HBs titers were measured after i month. RESULTS:Seroprotection (anti-HBs GMT^3 10 IU/L) was achieved in 85.3 % (87/102) *** mean GMT titers of the vaccine responders was 136.1 IU/*** the seroprotected individuals,there were 32.4% (33/102) hyporesponders (anti- HBs titers 100 IU/L).All the non-responders (15/15) responded to a single dose of the booster dose of recombinant HB vaccine and their mean anti-HBs antibody titers were more than 100.5 mIU/ml after the booster dose. CONCLUSION:Recombinant hepatitis B vaccine offers good seroprotection in the age group >40 years and has a good safety profile.A single booster dose after 6 months in primary non-responders leads to good seroprotective anti-HBs antibody ***,larger population based studies are needed to evaluate the role of a booster dose in selected group of non-responders and whether such an approach will be cost effective.

关键词： Adult Age Factors Aged Female Hepatitis B Antibodies Hepatitis B Vaccines dosage Humans Immunization, Secondary Male Middle Aged Safety Vaccines, Synthetic

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Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn,root on reproductive system of female Wistar rats

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Asian Pacific Journal of Tropical Medicine 2011年第12期4卷 978-984页

作者： gupta Sandeep Ahirwar Dheeraj Sharma Neeraj kumar Jhade Deenanath Ahirwar Bharti School of Pharmacy Chouksey Engineering CollegeBilaspur(C.G.)India 495001 SLT Institute of Pharmaceutical Sciences Guru Ghasidas University.Bilaspur(C.G.)India 495001

Objective:To assess the effect of plumbagin-free alcohol extract（PFAE） of Plumbago zeylanica Linn.（Plumbaginaceae）（***） root,on female reproductive system and ferlility of adult Female wislar ***:After the oral acute toxicity study,the PFAE was administered at two dose levels to perform the estrous cycle study,anti-implantation and ahortifacient activity and hormonal ***,the estrogenic/antiestrogenic activity was evaluated at only one most effective ***:LD50 cut-off was 5 000 mg/kg body *** extract exhibited significant anti-implantation and ahortifacient activity at the tested dose levels（300 and 500 mg/ kg.p.o.）（P<0.01）.The extract dose-dependency decreased the levels of serum progesterone, follicle stimulating hormone and luteinizing hormone,while a dose-dependent increase was observed in the concentration of serum *** extract did not show any significant changes in structure and function of Uterus when given alone,hut when given along with ethinyl estradiol,it exhibited significant antiestrogenic activity in immature overieclonzed female rats（P<0.001） Biochemical parameters in the serun/blood and haematological parameters did not show appreciable changes throughout and after the course of ***,all the altered parameters returned to normalcy within 30 days following withdrawal of treatment. Conclusions:All findings suggest that the anlifcrtility activity of extract could possibly he through the changes in the implantation site,altered hormonal levels,prolonged estrous cycle and anti-estrogenic ***,the extract possesses reversible antifcrtility activity without adverse toxicity in female rats.

关键词： Anti-implantation Abortilacient Estrogenic/antiestrogenic activity Progesterone Follicle stimulating hormone Luteinizing hormone Prolactin Ethinyl estradiol Overiectomized Haematological

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Aerobic bacterial flora of the normal conjunctiva at high altitude area of Shimla Hills in India:a hospital based study

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 723-726页

作者： Sharma Parmeshri Dass Sharma Neelam gupta Ravinder kumar Singh Parul Department of Ophthalmology VCSGG Medical Sciences and Research Institute

AIM:To study the normal aerobic conjunctival flora in lower to mid Himalayan region of Shimla ***:Samples from normal conjunctiva of 200 individuals above the age of 13 years who visited Indira Gandhi Medical College Hospital Shimla for refraction or cataract surgery were taken by anaesthetising the conjunctival sac with sterile 4% Xylocaine *** were obtained by gently rubbing lower fornix with a sterile cotton wool swab moistened with normal saline and keeping the eye lids wide apart to avoid contamination from lid *** was immediately inoculated in Brain Heart infusion and subjected to standard aerobic culture and identification ***:Totally,72 eyes(36%) conjunctival sacs were *** aerobes isolated were Staphylococcus *** 120(60%) followed by Haemophilus in 16(8%),diphtheroids in 10(5%),and Escherichia coli(***) in 4(2%).A single aerobe was isolated from 98 eyes(49%) while 30 eyes(15%) yielded more than 1 *** epidermidis(***) was the most common bacterium,found alone in 58 eyes(29%) and in combination with another aerobe in 30 eyes(15%),followed by Staphylococcus aureus(***) in 18(9%) and 10 eyes(5%) ***:*** is the most common commensal organism followed by Haemophilus *** occupied the third position which otherwise are found more abundantly in *** like ***,Staphylococcus citreus and *** were also ***,preoperative administration of topical broad spectrum antibiotics is extremely important in prophylaxis against ocular *** variation in microflora of normal conjunctiva in this part of world can be attributed to geographical,climatic and ethnic characteristics of the population under study.

关键词： normal conjunctival flora high altitude geographic and climatic conditions

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Co-inoculation of indigenous Pseudomonas oryzihabitans and Bradyrhizobium *** the growth,symbiotic efficacy,nutrient acquisition,and grain yield of soybean

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Pedosphere 2022年第3期32卷 438-451页

作者： Kailash Chand KUMAWAT Inderjeet SINGH Sharon NAGPAL Poonam SHARMA Rajeev kumar gupta Asmita SIRARI Department of Microbiology Punjab Agricultural UniversityLudhiana 141004(India) Department of Plant Breeding and Genetics Punjab Agricultural UniversityLudhiana 141004(India) Department of Soil Science Punjab Agricultural UniversityLudhiana 141004(India)

Soil microbes play a vital role in improving plant growth,crop productivity,and soil health through solubilization of essential *** investigation was conducted to access the efficacy of Bradyrhizobium ***-3 and the indigenous phosphate-solubilizing Pseudomonas oryzihabitans LSE-3 in improving the symbiosis,nutrient accumulation,and yield of *** isolate LSE-3,selected on the basis of phosphate solubilization,was screened for beneficial traits,antagonistic activities,and *** levels of indole acetic acid production(50.34±2.35μg mL^(-1)),phosphate solubilization(184.4±7.4 mg L^(-1)),biofilm formation(optical density at 560 mm,1.3896±0.04),siderophore production(121.46±1.61μg mL^(-1)),and 1-aminocyclopropane-1-carboxylate deaminase activity(0.51±0.07 mmolα-ketobutyrateμg^(-1) protein h^(-1))were significantly higher with the dual inoculants(LSBR-3 and LSE-3)than with the single inoculant *** plant growth-promoting traits of single and dual inoculants were evaluated for the synergistic effects on soybean under field *** plots treated with LSBR-3+LSE-3 exhibited improvement in seed germination,plant height,plant biomass,and chlorophyll content compared with the uninoculated *** inoculant treatments resulted in significantly higher symbiotic efficacy evidenced by increased nodulation(40.0±0.75 plant^(-1)),nodule biomass(188.52±6.29 mg plant^(-1)),and leghemoglobin content(11.02±0.83 mg g^(-1) fresh nodule),and significantly increased activities of phosphatase(75.16±3.17 and 58.77±6.08μg p-nitrophenol g^(-1) h^(-1) for alkaline and acid phosphatase,respectively)and dehydrogenase(32.66±1.92μg triphenylformazan g^(-1) h^(-1))compared with the *** inoculation with LSBR-3 and LSE-3 enhanced the uptake of macro-and micronutrients,reduced Na content in shoots,and resulted in 10.85%higher grain yield and ***$96.80 ha^(-1) higher profit compared with the *** is the first report on the effectiv

关键词： bacteria biofilm formation phosphate solubilization plant growth-promoting trait sustainable agriculture zinc solubilization

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Expression analysis of reactive oxygen species detoxifying enzyme genes in Anopheles stephensi during Plasmodium berghei midgut invasion

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Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 680-684页

作者： RK Chaitanya P Sridevi K Surendra kumar Babu S Mastan K Arun kumar A Dutta-gupta School of Life Sciences University of Hyderabad

Objective:To investigate the involvement of reactive oxygen species detoxification system in Anopheles stephensi during Plasmodium berghei midgut ***:Eight key reactive oxygen species metabolizing enzymes were cloned and characterized,and their expression was monitored in parasite-infected ***:Superoxide anion detoxifying superoxide dismutases(Fe/Mn SOD,Cu/Zn SOD 2,Cu/Zn SOD 3A,and Cu/Zn SOD 3B)depicted varied expression ***/Mn SOD expression declined,whereas Cu/Zn SOD expression was elevated in the infected ***,catalase and glutathione peroxidase showed lack of induction in expression during the Plasmodium berghei ***,expression of thioredoxin reductase increased in the infected mosquitoes,whereas gluthathione S-transferase levels decreased ***:Detoxification enzymes may play a role in modulating host immunity and parasite transmission.

关键词： Anophelesstephensi Detoxificationenzymes Geneexpression Malaria Oxidativestress Plasmodiumberghei Reactiveoxygenspecies

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