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A prospective study assessing the efficacy of abdominal computed tomography scan without bowel preparation in diagnosing intestinal wall and luminal lesions in patients presenting to the emergency room with abdominal complaints

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World Journal of Gastroenterology 2005年第13期11卷 1981-1986页

作者： Michal Mizrahi yoav mintz Avraham Rivkind David Kisselgoff Eugene Libson Mayer Brezis Eran Goldin Oren Shibolet Gastroenterology Unit Department of General Surgery Department of Radiology School of Public Health

AIM: To evaluate the positive predictive value of abdominal non-prepared computed tomography (CT) for diagnosing intestinal lumen or wall lesions in patients presenting to the emergency room (ER) with abdominal ***: For 1-year we prospectively evaluated all ER patients hospitalized after abdominal CT scan detected either intraluminal or intestinal wall lesions. These patients underwent colonoscopy serving as gold standard. Patients with prior abdominal pathology or CT findings of appendicitis or diverticulitis were ***: Five hundred and sixty-eight abdominopelvic CT scans were performed in the ER, 96 had positive colonic findings. Sixty-two patients were excluded, 46 because of diverticulitis or appendicitis, 16 because of prior abdominal pathology. Of the remaining 34 patients, 14 did not undergo colonoscopy during *** eligible patients were included in the study. The positive predictive value of the CT scans performed in the ER was calculated to be 45% (95% CI 25-67).CONCLUSION: CT findings correlated with colonoscopic findings only in approximately half of the cases. Relying on non-prepared CT scan findings in planning patient management and colonoscopy may lead to unnecessary diagnostic work-ups.

关键词： Abdominal computed tomography Intestinal lesions Emergency room

Evaluation of hand infections in the emergency department using point-of-care ultrasound

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World Journal of Emergency Medicine 2024年第4期15卷 283-288页

作者： David Ahmad Haidar David mintz Brandon M Wubben Omar Rizvi Srikar Adhikari Department of Emergency Medicine Michigan MedicineAnn Arbor 48109-1382USA University of Arizona College of Medicine Tucson 85724USA Department of Emergency Medicine University of IowaIowa City 52242-1009USA Department of Surgery University of Arizona College of MedicineTucson 85724USA Department of Emergency Medicine University of Arizona College of MedicineTucson 85724USA

BACKGROUND:We aimed to evaluate the utility of point-of-care ultrasound(POCUS)in the assessment of hand infections that present to the emergency department(ED)and its impact on medical decision making and patient ***:We conducted a retrospective review of patients who presented to two urban academic EDs with clinical presentations concerning for skin and soft tissue infections(SSTI)of the hand between December 2015 and December *** trained POCUS fellowship physicians reviewed an ED POCUS database for POCUS examinations of the *** then reviewed patients’electronic health records(EHR)for demographic characteristics,history,physical examination findings,ED course,additional imaging studies,consultations,impact of POCUS on patient care and final ***:We included a total of 50 cases(28 male,22 female)in the final *** most common presenting symptoms and exam findings were pain(100%),swelling(90%),and erythema(74%).The most common sonographic findings were edema(76%),soft tissue swelling(78%),and fluid surrounding the tendon(57%).POCUS was used in medical decision making 68%of the time(n=34),with the use of POCUS leading to changes in management 38%of the time(n=19).POCUS use led to early antibiotic use(11/19),early consultation(10/19),and led to the performance of a required procedure(8/19).The POCUS diagnosis was consistent with the discharge diagnosis of flexor tenosynovitis 8/12 times,abscess 12/16 times,and cellulitis 14/20 ***:POCUS is beneficial for evaluating of hand infections that present to the ED and can be used as an important part of medical decision making to expedite patient care.

关键词： Ultrasound Point-of-care ultrasound Cellulitis Abscess Flexor tenosynovitis

Free-standing microscale photonic lantern spatial mode(De-)multiplexer fabricated using 3D nanoprinting

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Light(Science & Applications) 2024年第6期13卷 1170-1185页

作者： yoav Dana Yehudit Garcia Aleksei Kukin Lauren Dallachiesa Sterenn Guerrier Nicolas K.Fontaine Dan M.Marom Institute of Applied Physics Hebrew University of JerusalemJerusalemIsrael Nokia Bell Labs 600 Mountain AveNew ProvidenceNJ07974USA

Photonic lantern(PL)spatial multiplexers show great promise for a range of applications,such as future high-capacity mode division multiplexing(MDM)optical communication networks and free-space optical *** enable efficient conversion between multiple single-mode(SM)sources and a multimode(MM)waveguide of the same *** multiplexers operate by facilitating adiabatic transitions between the SM arrayed space and the single MM ***,current fabrication methods are forcing the size of these devices to multi-millimeters,making integration with micro-scale photonic systems quite *** advent of 3D micro and nano printing techniques enables the fabrication of freestanding photonic structures with a high refractive index contrast(photopolymer-air).In this work we present the design,fabrication,and characterization of a 6-mode mixing,375µm long PL that enables the conversion between six single-mode inputs and a single six-mode *** PL was designed using a genetic algorithm based inverse design approach and fabricated directly on a 7-core fiber using a commercial two-photon polymerization-based 3D printer and a *** the waveguides exhibit high index contrast,low insertion loss(−2.6 dB),polarization dependent(−0.2 dB)and mode dependent loss(−4.4 dB)were measured.

关键词： mode enable printing

The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction

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Molecular Plant 2024年第7期17卷 1129-1150页

作者： Paula Berman Luis Alejandro de Haro Ana-Rita Cavaco Sayantan Panda Younghui Dong Nikolay Kuzmich Gabriel Lichtenstein yoav Peleg Hila Harat Adam Jozwiaki Jianghua Cai Uwe Heinig Sagit Meir Ilana Rogachev Asaph Aharoni Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovot 7610001Israel Life Sciences Core Facilities Weizmann Institute of ScienceRehovot 7610001Israel The Maurice and Vivienne Wohl Institute for Drug Discovery Weizmann Institute of ScienceRehovot 7610001Israel Present address:Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Department of Molecular&Cellular Pharmacology University of Miami Miler School of MedicineMiamiFL 33136USA Department of Botany and Plant Sciences University of California RiversideRiversideCA 92521USA Laboratory of Plant Hormones and Development Regulation of Chongqing School of Life SciencesChongqing UniversityChongqing 401331China

Mescaline,among the earliest identified natural hallucinogens,holds great potential in psychotherapy ***,despite the existence of a postulated biosynthetic pathway for more than half a century,the specific enzymes involved in this process are yet to be *** this study,we investigated the cactus Lophophora williamsii(Peyote),the largest known natural producer of the phenethylamine *** employed a multi-faceted approach,combining de novo whole-genome and transcriptome sequencing with comprehensive chemical profiling,enzymatic assays,molecular modeling,and pathway engineering for pathway *** identified four groups of enzymes responsible for the six catalytic steps in the mescaline biosynthetic pathway,and an N-methyltransferase enzyme that N-methylates all phenethylamine intermediates,likely modulating mescaline levels in ***,we reconstructed the mescaline biosynthetic pathway in both Nicotiana benthamiana plants and yeast cells,providing novel insights into several challenges hindering complete heterologous mescaline *** together,our study opens up avenues for exploration of sustainable production approaches and responsible utilization of mescaline,safeguarding this valuable natural resource for future generations.

关键词： mescaline Lophophora williamsi Peyote biosynthetic pathway de novo genome sequencing mo-lecular modeling

A parent-centered approach to autism diagnosis in early childhood

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World Journal of Pediatrics 2018年第3期14卷 212-214页

作者： Michael E.mintz Child Development Program Children's National Health System111 Michigan Ave.NW Suite 3800WashingtonD.C.20010USA Department of Psychiatry and Behavioral Sciences George Washington University School of Medicine and Health SciencesWashingtonD.C.USA

The prevalence of autism spectrum disorders in the United States is estimated to be approximately 1 in 68 children (though the World Health Organization estimates a global prevalence of just 1 in 160 children) (1 , 2)The average age of the initial diagnosis is estimated to be 4 years of age [ 3 ], though research has shown that signs of autism can be observed by the fi rst birthday, and possibly before (4 , 5)Early identifi cation of autism is vital to prognosis, as studies have consistently shown that children who receive treatment at a younger age have better outcomes (6)Even with the right treatment, however, the degree to which caregivers are invested in the therapeutic process serves as a mediating fac-tor (7)For this reason, an autism-specifi c evaluation should aim not just to provide a diagnosis, as appropriate, but also to allow caregivers to participate in the diagnostic process in a manner that educates and empowers them.

关键词： parent-centered childhood early

Post-burn breast reconstruction using an artificial dermis—a long-term follow-up

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Burns & Trauma 2016年第3期4卷 254-257页

作者： yoav Gronovich Adi Maisel Lotan Meir Retchkiman Department of Plastic and Reconstructive Surgery Shaare-Zedek Medical Center12 Beith StreetJerusalemIsrael

Background:Full thickness burns of the chest in childhood are a devastating problem that requires challenging reconstructive *** is a bilaminate artificial dermis composed of shark chondroitin 6-sulfate and bovine *** dermal matrix serves as a scaffold for fibroblasts and endothelial *** of the matrix begins after 2-3 weeks,and eventually,the matrix incorporates with the tissue to create a new *** main advantage of the Integra is that the neodermis is of the same quality as a native *** presentation:In this case report,we present post-burn breast reconstruction of a 12-year-old girl using Integra,with a long follow-up of 7 *** the best of our knowledge,there is no published follow-up of breast development after reconstruction with Integra from its beginning point at the age of puberty until after the growing process has ***:Integra is a reliable reconstructive tool for burned *** done before puberty,it can help in getting normal developing tissue with satisfying esthetic results of size,shape and symmetry.

关键词： Burned breast Integra Artificial skin Burn reconstruction

Effect of Radio-Frequency and Low-Frequency Bias Voltage on the Formation of Amorphous Carbon Films Deposited by Plasma Enhanced Chemical Vapor Deposition

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Plasma Science and Technology 2014年第10期16卷 954-959页

作者： Hadar MANIS-LEVY Tsachi LIVNEH Ido ZUKERMAN Moshe H.mintz Avi RAVEH Department of Nuclear Engineering Ben-Gurion University of the NegevBeer-Sheva 84105Israel NRC-Negev Beer-Sheva 84190Israel Advanced Coatings Center Rotem Industries Ltd.Mishor YaminD.N. Arava 86800Israel

The effect of radio-frequency （RF） or low-frequency （LF） bias voltage on the for- mation of amorphous hydrogenated carbon （a-C：H） films was studied on silicon substrates with a low methane （CH4） concentration （2-10 vol.%） in CH4＋Ar mixtures. The bias substrate was applied either by RF （13.56 MHz） or by LF （150 kHz） power supply. The highest hardness values （~18-22 GPa） with lower hydrogen content in the fihns （~20 at.%） deposited at 10 vol.% CH4, was achieved by using the RF bias, However, the films deposited using the LF bias, under similar RF plasma generation power and CH4 concentration （50 W and 10 vol.%, respectively）, displayed lower hardness （~6-12 GPa） with high hydrogen content （~40 at.%）. The structures analyzed by Fourier Transform Infrared （FTIR） and Raman scattering measurements provide an indication of trans-polyacetylene structure formation. However, its excessive formation in the films deposited by the LF bias method is consistent with its higher bonded hydrogen concentration and low level of hardness, as compared to the film prepared by the RF bias method. It was found that the effect of RF bias on the film structure and properties is stronger than the effect of the low-frequency （LF） bias under identical radio-frequency （RF） powered electrode and identical PECVD （plasma enhanced chemical vapor deposition） system configuration.

关键词： amorphous carbon PECVD film deposition FTIR Raman

Descemet stripping automated endothelial keratoplasty in phakic eyes:incision modification reducing cataract formation

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 53-57页

作者： Jacqueline Beltz Silvana Madi yoav Nahum Paolo Santorum Massimo Busin Department of Ophthalmology Villa Igea Private HospitalForli 47122Italy Istituto Internazionale per la Ricerca e Formazione in Of talmologia(IRFO) Forli 47122Italy Department of Morphology Surgery and ExperimentalSurgeryUniversity of FerraraFerrara 44100Italy Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalMelbourne 3002Australia Department of Ophthalmology Alexandria University HospitalAlexandria 21527Egypt Department of Ophthalmology Rabin Medical CenterPetahTikva 49100Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 69978Israel Department of Ophthalmology San Maurizio Regional HospitalBolzano 39100Italy

AIM： To evaluate the efficacy of a technical modification to reduce the incidence of traumatic cataract induced by Descemet stripping automated endothelial keratoplasty（DSAEK） performed in phakic eyes. METHODS： A retrospective cohort study. The records of all patients with a clear crystalline lens and endothelial failure that underwent modified DSAEK at our insitution were reviewed. In this modification, in order to avoid inadvertent touch of the insertion forceps against the exposed crystalline lens while passing across the anterior chamber, the incision sites were shifted from the standard 9 and 3 o＇clock positions, superiorly to the 10 and 2 o＇clock position respectively. Formation of typically traumatic, anterior subcapsular cataract in these patients was compared to that observed in a cohort including all the patients with a clear crystalline lens and endothelial failure that underwent conventional DSAEK at our ***： The study group included 49 eyes following modified DSAEK and the control group included 35 eyes following DSAEK with conventional incision sites. Anterior subcapsular cataract occurring 4 mo or less postoperatively was identified in 2 of 49（4%） eyes in the study group and 7 of 35（20%） eyes in the control group. The rates of traumatic cataract were significantly higher in the control group in comparison to the study group（P=0.03, RR=4.9, 95%CI 1.08-22.1）.CONCLUSION： Traumatic cataract formation following phakic DSAEK may be avoided with a simple modification to the position of the incision sites.

关键词： cornea Descemet stripping automated endothelial keratoplasty cataract lamellar keratoplasty

Comparison of anti-vascular endothelial growth factors, laser treatments and a combination of the both for treatment of central retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 431-433页

作者： yoav Y.Pikkel Adi Sharabi-Nov Itzchak Beiran Joseph Pikkel Tzameret Medical Track Hebrew University Jerusalem 91120 Israel Research Wing Ziv Medical Center Safed Israel and Tel-Hal Academic College Kiryat Shmona 12208 Israel Department of Ophthalmology Rambam Medical Center Haifa 3525408 Israel The B. Rappaport Faculty of Medicine Israel Institute of Technology Haifa 3525427 Israel Departrnent of Ophthalmology Ziv Medical Center Safed 13100 Israel Bar Ilan University Faculty of Medicine Safed 13101 Israel

AIM：To compare changes in visual acuity and macular edema in patients with central retinal vein occlusion（CRVO）treated with intravitreal injections of bevacizumab,macular grid photocoagulation combined with pan retinal photocoagulation（PRP）,or both（bevacizumab＋grid＋PRP）.· METHODS：Our study is a retrospective cohort clinical study that examined patients that suffered from ischemic CRVO with macular *** inclusion criteria were ischemic CRVO with macula edema and the availability of complete medical records for at least 12 mo after *** were patients with diabetes or any other retinal *** reviewed the medical records of patients treated in one ophthalmology departmentcomparing changes in visual acuity and macular edema in patients treated with intravitreal injections of bevacizumab vs those that were treated with macular grid photocoagulation and PRP or *** main outcome measures were the differences in best corrected visual acuity（BCVA） and in macular thickness,as assessed by optical coherence tomography,between the enrollment and the final follow up visits.· RESULTS：Sixty-five patients met inclusion *** were no statistically significant differences among the three groups in the mean changes in macular thickness as measured by ocular coherence tomography（131.5±41.2,108.6±29.2,and 121.1±121.1,P=0.110）,or in visual acuity（0.128±0.077,0.088±0.057,and 0.095±0.065）,for intravitreal injections,macular grid photocoagulation＋PRP and a combination of the treatments,respectively,P =*** proportions of patients with macular edema after treatment were：26.1%,28.6%,and 14.3%,respectively,P=0.499.· CONCLUSION：Similar benefit was observed for intravitreal injections,laser photocoagulation,or a combined regimen in the treatment of CRVO.A nonstatistically significant trend for reduction in macular edema was observed following combined treatment.

关键词： bevacizumab grid laser photocoagulation macular edema optical coherence tomography retinal veinocclusion