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From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio María del carmen Durand-Vásquez Luciana del Pilar Rafael-Robles Jhean Gabriel Gonzáles-Yovera María Alejandra Quispe-Flores luis Alberto concepción-Urteaga Alejandro Román-González José Paz-Ibarra Marcio José concepción-Zavaleta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru Department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru Department of Endocrinology Clínica Javier PradoLima 15046Peru Department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru Department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru Department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru Department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis

characteristics and in-hospital mortality of elderly patients with heart failure in Spanish hospitals

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Journal of Geriatric cardiology 2023年第4期20卷 247-255页

作者： Alberto Esteban-Fernández Manuel Anguita-Sánchez Juan luis Bonilla-Palomas María Anguita-Gámez María García Joséluis Bernal Náyade del prado cristina Fernández-Pérez Julián Pérez-Villacastin Juan JoséGómez-Doblas Francisco Javier Elola cardiology Department Hospital Universitario Severo OchoaMadridSpain cardiology Department Hospital Universitario Reina SofíaCórdobaSpain cardiology Department Hospital San Juan de la CruzÚbedaSpain cardiology Department Hospital Clínico San CarlosMadridSpain Fundación Instituto para la Mejora de la Asistencia Sanitaria MadridSpain Management control Department Hospital Universitario 12 de OctubreMadridSpain Department of Preventive Medicine Área Sanitaria de Santiago de Compostela y BarbanzaInstituto de Investigación de SantiagoSantiago de CompostelaSpain cardiology Department Hospital Universitario Virgen de la VictoriaMálagaSpain

BAcKGROUND The prevalence of heart failure(HF)increases with age,and it is one of the leading causes of hospitalization and death in older ***,there are little data on in-hospital mortality in patients with HF≥75 years in *** A retrospective analysis of the Spanish Minimum Basic Data Set was performed,including all HF episodes discharged from public hospitals in Spain between 2016 and *** was performed using the International classification of Diseases,10th ***≥75 years with HF as the principal diagnosis were *** calculated:(1)the crude in-hospital mortality rate and its distribution according to age and sex;(2)the risk-standardized in-hospital mortality ratio;and(3)the association between in-hospital mortality and the availability of an intensive cardiac care unit(IccU)in the *** We included 354,792 HF episodes of patients over 75 *** mean age was 85.2±5.5 years,and 59.2%of patients were *** most frequent comorbidities were renal failure(46.1%),diabetes mellitus(35.5%),valvular disease(33.9%),cardiorespiratory failure(29.8%),and hypertension(26.9%).In-hospital mortality was 12.7%,and increased with age[odds ratio(OR)=1.07,95%cI:1.07–1.07,PcI:0.92–0.97,Pctors of mortality were the presence of cardiogenic shock(OR=19.5,95%cI:16.8–22.7,PcI:3.0–4.0,Pced cancer(OR=2.6,95%cI:2.5–2.8,PccU,the in-hospital risk-adjusted mortality tended to be lower(OR=0.85,95%cI:0.72–1.00,P=0.053).cONcLUSIONS In-hospital mortality in patients with HF≥75 years between 2016 and 2019 was 12.7%,higher in males and elderly *** main predictors of mortality were cardiogenic shock,stroke,and advanced *** was a trend toward lower mortality in centers with an IccU.

关键词： patients mortality diagnosis

Geochemical study of submicron particulate matter(PM1)in a metropolitan area

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Geoscience Frontiers 2022年第1期13卷 417-429页

作者： Ismael L.Schneider Elba c.Teixeira Guilherme L.Dotto Diana Pinto cheng-Xue Yang luis F.O.Silva Postgraduate Program in Remote Sensing and Meteorology Universidade Federal do Rio Grande do SulAv.Bento Gonçalves9500 Porto AlegreRSBrazil Department of civil and Environmental Universidad de la CostaCUCCalle 58#55-66BarranquillaAtlanticoColombia Research Department Fundação Estadual de Proteção Ambiental Henrique Luís RoesslerAv.Borges de Medeiros261Porto AlegreRSBrazil chemical Engineering Department Federal University of Santa Maria97105-900 Santa MariaBrazil School of Earth Sciences and Resources China University of Geosciences BeijingBeijing 100083PR China Departamento de Ingeniería civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600–Santiago de Surco 1503Perú

Air pollution has become a major problem in urban areas due to increasing industrialization and *** this study ambient concentrations of PM1 and metal concentrations as well as source contributions were identified and quantified by using Positive Matrix Factorization(PMF)in receptor modeling in the Metropolitan Area of Porto Alegre,*** PM1 samples were collected on PTFE filters from December 2012 to December 2014 in two sampling *** ion and trace element concentrations were *** average concentrations were 12.8 and 15.2μg/m^(3) for canoas and Sapucaia do Sul sites,*** ion contributions of PM1 were secondary pollutants such as sulfate and *** elements,especially cu,Pb,Zn,cd,and Ni also made important contributions which are directly associated with anthropogenic *** results show significantly higher levels in winter than in *** of the PM1 and the analyzed PM species and elements originated from anthropogenic sources,especially road traffic,combustion processes and industrial activities,which are grouped in 7 major contributing sources.A back-trajectory analysis showed that the long-range transport of pollutants was not relevant in relation to the contribution to PM1 and metal *** work highlights the importance of urban planning to reduce human health exposure to traffic and industrial emissions,combined with awareness-raising actions for citizens concerning the impact of indoor sources.

关键词： PM1 Trace elements Source apportionment PMF Back trajectory

Metal-enriched nanoparticles and black carbon:A perspective from the Brazil railway system air pollution

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Geoscience Frontiers 2021年第3期12卷 624-635页

作者： Bianca D.Lima Elba c.Teixeira James c.Hower Matheus S.civeira Omar Ramírez cheng-Xue Yang Marcos L.S.Oliveira luis F.O.Silva Postgraduate Program in Remote Sensing and Meteorology Geosciences InstituteUniversidade Federal do Rio Grande do SulAv.Bento Gonçalves9500Porto AlegreRS 91501–970Brazil Research Department Fundação Estadual de Proteção Ambiental Henrique Luís RoesslerAv.Borges de Medeiros261Porto AlegreRS 90020–021Brazil center for Applied Energy Research University of Kentucky2540 Research Park DriveLexingtonKY 40511USA Postgraduate Program in Mines Metallurgy and MaterialsUniversidade Federal do Rio Grande do SulAv.Bento Gonçalves9500Porto AlegreRS 91501–970Brazil Faculty of Engineering Environmental EngineeringUniversidad Militar Nueva GranadaKm 2 CajicáZipaquiráColombia Institute of Earth Science China University of Geosciences(Beijing)29 Xueyuan RdHaidian DistrictChina Department of civil and Environmental Universidad de la CostaCUCCalle 58#55-66BarranquillaAtlanticoColombia Universidad de Lima Departamento de Ingeniería civil y Arquitectura.Avenida Javier Prado Este 4600–Santiago de Surco 1503Peru

Having a better understanding of air pollutants in railway systems is crucial to ensure a clean public *** study measured,for the first time in Brazil,nanoparticles(NPs)and black carbon(Bc)on two groundlevel platforms and inside trains of the Metropolitan Area of Porto Alegre(MAPA).An intense sampling campaign during thirteen consecutive months was carried out and the chemical composition of NPs was examined by advanced microscopy *** results showed that highest concentrations of the pollutants occur in colder seasons and influenced by variables such as frequency of the trains and passenger ***,internal and external sources of pollution at the stations were *** predominance of NPs enriched with metals that increase oxidative stress like cd,Fe,Pb,cr,Zn,Ni,V,Hg,Sn,and Ba both on the platforms and inside trains,including Fe-minerals as hematite and magnetite,represents a critical risk to the health of passengers and employees of the *** interdisciplinary and multi-analytical study aims to provide an improved understanding of reported adverse health effects induced by railway system aerosols.

关键词： Nanoparticles Potential hazardous elements Environmental chemistry Human health Railway environment Indoor air quality

Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIc05-Sierra75 study

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Journal of Geriatric cardiology 2022年第5期19卷 354-366页

作者： Jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen cid luis Fernandez Tamara Garcia camarero cristóbal Urbano-carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández Juan Gcórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés Martínez cáceres Jose A Linares Vicente Georgina Fuertes Ferre Xavier carrillo Juan cRama Merchán catia costa Juan Sanchis Renato Fernandes Alberto Rodrigues Jose M Vegas Valle Hélder Pereira Armando Perez de prado cardiology Department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain cardiology Department Hospital Universitario San JuanAlicanteSpain cardiology Department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain cardiology Department Hospital Universitario Puerta del MarCadizSpain cardiology Department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain cardiology Department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain cardiology Department Hospital Universitario de CrucesBilbaoSpain cardiology Department Hospital Regional Universitario de MálagaMalagaSpain cardiology Department Hospital Universitario Puerta de HierroMadridSpain cardiology Department Hospital Alvaro CunqueiroVigoSpain cardiology Department Hospital Juan Ramon JimenezHuelvaSpain cardiology Department Hospital Universitario de BadajozBadajozSpain cardiology Department Hospital Universitario Lucus AugustiLugoSpain cardiology Department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain cardiology Department Hospital Santa CruzLisboaPortugal cardiology Department Hospital Clínico Universitario Lozano BlesaZaragozaSpain cardiology Department Hospital Universitario Miguel ServetZaragozaSpain cardiology Department Hospital Germans Trias i PujolBadalonaSpain cardiology Department Hospital de MeridaMeridaSpain cardiology Department Hospital São BernardoSetúbalPortugal cardiology Department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain cardiology Department Hospital do Espirito SantoEvoraPortugal cardiology Department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal cardiology Department Hospital de CabueñesGijonSpain cardiology Department Hospital Garcia de OrtaAlmadaPortugal cardiology Department Complejo Asistencial Universitario de LeónLeonSpain

OBJEcTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PcI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PcI complexity and PREcISE DAPT ***-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARc 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as *** Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(AcS)and 53.6%complex ***-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored *** stent thrombosis reported in the subgroup with 1-3 months DAPT *** compared to control group,bleeding BARc 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).cONcLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic

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波托西:城市遗产的特征

世界建筑 2019年第11期 66-69,138页

作者：路易斯·劳尔·c·普拉多·里欧斯路璐(译) 圣安德烈斯大学纯真建筑工作室

西班牙人对于波托西里科山的发现,使建立16-18世纪世界上最大的白银工业生产体系成为可能;同时,维持这一生产体系的劳动人口也在此地落户,于是必要的聚居社区也发展起来,而移民过来的西班牙人则实际上盘踞着城区的中心区域。在波托西发... 详细信息

西班牙人对于波托西里科山的发现,使建立16-18世纪世界上最大的白银工业生产体系成为可能;同时,维持这一生产体系的劳动人口也在此地落户,于是必要的聚居社区也发展起来,而移民过来的西班牙人则实际上盘踞着城区的中心区域。在波托西发展起来的这一体系,代表着美洲大陆的工业革命原型,同时催生了其本身作为现代第一座工业城市的发展。波托西的城市空间分为两个部分,中心区域的棋盘网格状空间由西班牙人占据,而其周边区域则形成一个环形带,居住着赚取薪金的土著工人,其城市空间和建筑样式都是来自前殖民地时期的土著传统。波托西曾出产著名的银币,自16世纪以来,这些银币巨大的数量和名望使其成为世界金融资本全球化初期的通行货币。

关键词：里科山工业生产体系工业城市棋盘状城市街区土著工人社区

Decline in subarachnoid haemorrhage volumes associated with the first wave of the cOVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo c Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi chandril chugh charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro Sc Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A cora Rotem Sivan-Hoffmann Roberto crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez luisa Fonseca M luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the cOVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and cOVID-19 were identified by prospective aneurysm databases or by International classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%cI−24.3%to−20.7%,pclined with 1170-1035 procedures,respectively,representing an 11.5%(95%cI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%cI−28.0%to−22.1%,pcrease in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%cI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the cOVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid