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p38-MAPK and CDK5,signaling pathways in neuroinflammation:a potential therapeutic intervention in Alzheimer's disease?

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Neural Regeneration Research 2024年第8期19卷 1649-1650页

作者： Vlad Ionut Viorel ylenia Pastorello Nosherwan Bajwa Mark Slevin George Emil Palade University of Medicine PharmacyScience and TechnologyTârgu MuresRomania Department of Anatomy and Embryology George Emil Palade University of MedicinePharmacyScience and TechnologyTargu MuresRomania DIAKO Hospital FlensburgGermany Center for Advanced Medical and Pharmaceutical Research(CCAMF) George Emil Palade University of MedicinePharmacyScience and TechnologyTârgu MuresRomania Manchester Metropolitan University ManchesterUK

Alzheimer’s disease(AD),the most common type of dementia,affects millions of people worldwide,putting a significant strain on healthcare infrastructure and societal *** is characte rized by the build-up of amyloid-be... 详细信息

关键词： Alzheimer Aβ tau

Can semi-quantitative evaluation of uncertain (type II) time-intensity curves improve diagnosis in breast DCE-MRI?

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Journal of Biomedical Science and Engineering 2013年第3期6卷 418-425页

作者： Roberta Fusco Salvatore Filice Vincenza Granata ylenia mandato Annamaria Porto Massimiliano D’Aiuto Massimo Rinaldo Maurizio Di Bonito Mario Sansone Carlo Sansone Antonio Rotondo Antonella Petrillo Petrillo Department of Breast Surgery and Oncology National Cancer Institute of Naples “Pascale Foundation” Naples Italy Department of Diagnostic and Laboratory Pathology National Cancer Institute of Naples “Pascale Foundation” Naples Italy Department of Diagnostic Imaging National Cancer Institute of Naples “Pascale Foundation” Naples Italy Department of Diagnostic Imaging Second University of Naples (SUN) Naples Italy Department of Electrical Engineering and Information Technology University “Federico II” of Naples Naples Italy

Objective/Background: Qualitative assessment of uncertain (type II) time-intensity curves (TICs) in breast DCE-MRI is problematic and operator dependent. The aim of this work is to evaluate if a semi-quantitative assessment of uncertain TICs could improve overall diagnostic performance. Methods: In this study 49 lesions from 44 patients were retrospectively analysed. Per each lesion one region-of-interest (ROI)- averaged TIC was qualitatively evaluated by two radiologists in consensus: all the ROIs resulted in type II (uncertain) TIC. The same TICs were semi-quantitatively re-classified on the basis of the difference between the signal intensities of the last-time-point and of the peak: this difference was classified according to two different cut-off ranges (±5% and ±3%). All patients were cytological or histological biopsy proven. Fisher test and McNemar test were performed to evaluate if results were statistically significant (p < 0.05). Results: Using ±5% cut-off 16 TICs were reclassified as type III and 12 as type I while 21 were reclassified again as type II. Using ±3% 22 TICs were reclassified as type III and 16 as type I while 11 were reclassified again as type II. The semi-quantitative classification was compared to the histological-cytological results: the sensitivity, specificity, positive and negative predictive values obtained with ±3% were 77%, 91%, 91% and 78% respectively while using ±5% were 58%, 96%, 94% and 68% respectively. Using the ±5% cut-off 26/28 (93%) TICs were correctly reclassified while using the ±3% cut-off 34/38 (90%) TICs were correctly reclassified (p < 0.05). Conclusions: Semi-quantitative methods in kinetic curve assessment on DCE-MRI could improve classification of qualitatively uncertain TICs, leading to a more accurate classification of suspicious breast lesions.

关键词： Breast Cancer Dynamic Contrast Enhanced-MRI Time Intensity Curve Tracer Kinetics Semi-Quantitative Analysis

A small,polyphyletic group of Firmicutes synthesizes trimethylamine from L-carnitine

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mLife 2023年第3期2卷 267-271页

作者： Marius Vital ylenia Heinrich-Sanchez Hannover Medical School Institute for Medical Microbiology and Hospital EpidemiologyHannoverGermany

Impact statement Gut microbiota-derived trimethylamine(TMA)is associated with cardiometabolic disorders and exemplifies a microbial involvement in the etiology of emerging,noncommunicable diseases,the leading causes of death *** bio-chemical pathways taking dietary compounds as intake have been described with distinct taxa involved that are all present at low relative abundances.A recently discovered pathway is now considered to be the main route for TMA synthesis from L-carnitine involvingγ-butyrobetaine as an intermediate *** comprehensive(meta)genomic screening of publicly available data,namely,genomes of the UHGG catalog(n>200,000)and 10 metagenomic(transcriptomic)data sets,we revealed bacteria synthesizing TMA via this pathway and specified their *** will contribute to stratification of individuals based on their gut microbiota's potential to synthesize TMA and might aid in the development of strategies restricting TMA formation.

关键词： product. synthesize statement

Endoscopic fluorescent lymphography for gastric cancer

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World Journal of Gastrointestinal Endoscopy 2023年第2期15卷 32-43页

作者： Calcedonio Calcara Sila Cocciolillo ylenia Marten Canavesio Vincenzo Adamo Silvia Carenzi Daria Ilenia Lucci Alberto Premoli Digestive Endoscopy Unit S.Andrea HospitalVercelli 13100Italy Digestive Endoscopy Unit Padre Pio HospitalVasto 66054Italy Postgraduate School of Gastroenterology Genova UniversityGenova 16132Italy General Surgery Unit S.Andrea HospitalVercelli 13100Italy

Lymphography by radioisotope or dye is a well-known technique for visualizing the lymphatic drainage pattern in a neoplastic lesion and it is in use in gastric *** green(ICG)more recently has been validated in fluorescent lymphography studies and is under evaluation as a novel tracer agent in gastric *** amount and dilution of ICG injected as well as the site and the time of the injection are not *** our unit,endoscopic submucosal injections of ICG are made as 0.5 mg in 0.5 mL at four peritumoral sites the day before surgery(for a total of 2.0 mg in 2.0 mL).Detection instruments for ICG fluorescence are ***-infrared systems integrated into laparoscopic or robotic instruments(near-infrared fluorescence imaging)have shown the most promising *** fluorescence recognizes the node that receives lymphatic flow directly from a primary *** is defined as the sentinel lymph node,and it has a high predictive negative value at the cT1 stage,able to reduce the extent of gastrectomy and lymph node *** also enhances the number of lymph nodes detected during extended lymphadenectomy for advanced gastric ***,the practical effects of ICG use in a single patient are not yet *** of the technique and further studies are needed before fluorescent lymphography can be used extensively *** then,current guidelines recommend an extensive lymphadenectomy as the standard approach for gastric cancer with suspected metastasis.

关键词： Indocyanine green Fluorescence Lymphography Sentinel lymph node Gastric cancer Lymphadenectomy

Design and Evaluation of SIMpliLife, an NFC Platform to Ease Day-to-Day Actions of People＇s Life

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Computer Technology and Application 2011年第6期2卷 424-431页

作者： Carlo Maria Medaglia Alice Moroni Serena Sposato Ugo Biader Ceipidor ylenia De Rosa CATTID Sapienza University of Rome Rome 00185 ltaly

In this paper the authors describe the design, prototyping and evaluation of SIMpliLife, a framework for mobile phones with the aim of making people’s life easier, providing day-to-day services such as payment, ticketing and information retrieval by means of NFC (Near Field Communication) technology. It was developed via the collaboration between two research labs of Sapienza University of Rome: the RFID (Radio Frequency Identification) Lab and the Usability and Accessibility Lab (LUA), both belonging to CATTID (Centre for Applications of Teleservices and of Technologies for Innovation in Digital world) research centre. Technically, SIMpliLife is a SIM-based platform for NFC mobile phones that interfaces several applications able to manage the abovementioned services. The high-level User Interface has been developed by means of Smart Card Web Server (SCWS) technology, thus providing enhanced user experience if compared to traditional SIM-based implementations based on SIM Toolkit.

关键词：人民生活 NFC 平台评估设计网络服务器 SIM卡应用程序

High fecal calprotectin levels are associated with SARS-CoV-2 intestinal shedding in COVID-19 patients:A proof-of-concept study

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World Journal of Gastroenterology 2021年第22期27卷 3130-3137页

作者： Verena Zerbato Stefano Di Bella Mauro Giuffrè Anna Wladyslawa Jaracz ylenia Gobbo Diego Luppino Paolo Macor Ludovica Segat Raffaella Koncan Pierlanfranco D'Agaro Michael Valentini Lory Saveria Crocé Maurizio Ruscio Roberto Luzzati Infectious Diseases Unit Trieste University Hospital(ASUGI)Trieste 34125Italy Infectious Diseases Unit Clinical Department of MedicalSurgical and Health SciencesTrieste UniversityTrieste 34123Italy Liver Unit Clinical Department of MedicalSurgical and Health SciencesTrieste UniversityTrieste 34127Italy Department of Life Sciences Trieste UniversityTrieste 34127Italy Department of Hygiene and Public Health Unit Trieste University Hospital(ASUGI)Trieste 34125Italy Division of Laboratory Medicine Trieste University Hospital(ASUGI)Trieste 34125Italy

BACKGROUND One third of coronavirus disease 2019(COVID-19)patients have gastrointestinal *** acute respiratory syndrome coronavirus 2(SARS-CoV-2)RNA has been detected in stool samples of approximately 50%of COVID-19 *** calprotectin is a marker of gastrointestinal inflammation in the general *** To investigate if fecal calprotectin correlates with SARS-CoV-2 intestinal shedding in COVID-19 patients with *** Patients with SARS-CoV-2 pneumonia admitted to the Infectious Disease Unit(University Hospital of Trieste,Italy)from September to November 2020 were consecutively enrolled in the *** samples were collected and analyzed for quantification of fecal calprotectin(normal value<50 mg/kg)and SARS-CoV-2 RNA presence by polymerase chain reaction(PCR).Inter-group differences were determined between patients with and without diarrhea and patients with and without detection of fecal *** We enrolled 51 adults(40 males)with SARS-CoV-2 *** patients(20%)presented with ***-time-PCR of SARS-CoV-2 in stools was positive in 39 patients(76%),in all patients with diarrhea(100%)and in more than two thirds(29/41,71%)of patients without *** was one of the most common comorbidities(13 patients,25%);all obese patients(100%)(P=0.021)tested positive for fecal *** fecal calprotectin levels were 60 mg/kg[interquartile range(IQR)21;108];higher fecal calprotectin levels were found in the group with SARS-CoV-2 in stools(74 mg/kg,IQR 29;132.5)compared to the group without SARS-CoV-2(39 mg/kg,IQR 14;71)(P<0.001).CONCLUSION High fecal calprotectin levels among COVID-19 patients correlate with SARSCoV-2 detection in stools supporting the hypothesis that this virus can lead to bowel inflammation and potentially to the‘leaky gut’syndrome.

关键词： COVID-19 SARS-CoV-2 Obesity Fecal calprotectin Gut Viral shedding

Radiological diagnosis of hepatocellular carcinoma in non-cirrhotic patients

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Hepatoma Research 2017年第1期3卷 1-17页

作者： Alba Castán ylenia Navarro Luis Sarría Raquel Larrosa Mario Serradilla Alejandro Serrablo Department of Radiology Miguel Servet University Hospital50009 ZaragozaSpain Division of Hepato-Pancreato-Biliary Department of SurgeryMiguel Server University Hospital50009 ZaragozaSpain

Hepatocellular carcinoma (HCC) arising in non-cirrhotic livers is relatively *** with HCC arising in cirrhotic livers they have some *** in healthy livers are large tumors at diagnosis,and are detected due to the onset of abdominal symptoms,outside of any scheduled monitoring *** non-cirrhotic patients,HCC has the same appearance as the classic image of cirrhotic HCC *** presence of capsule,extensive intratumoral necrosis and typical behavior in the dynamic study after administration of intravenous contrast are present in most of the non-cirrhotic *** the presence of a suspicious lesion of HCC,we must assess the existence of underlying chronic liver ***,computed tomography,and conventional magnetic resonance are imaging techniques that have a high specificity for the diagnosis of cirrhosis,but exhibit low sensitivity for diagnosis in the early stages of the *** recent years,new imaging methods are being developed to assess emerging liver *** particular,in patients without chronic liver disease it is imperative to consider the differential diagnosis with other tumors that may settle in healthy livers with similar radiological characteristics as ***,in the presence of a lesion with pathognomonic radiological characteristics of HCC in the absence of cirrhosis,biopsy is required.

关键词： Hepatocellular carcinoma non-cirrhotic liver ultrasound elastography computed tomography magnetic resonance