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Fault diagnosis of HVAC system with imbalanced data using multi-scale convolution composite neural network

Building Simulation 2024年第3期17卷 371-386页

作者： Rouhui Wu yizhu Ren Mengying Tan Lei Nie School of Mechanical Engineering Hubei University of TechnologyWuhan430068China Industrial Research Institute of Xiangyang Hubei University of Technology Xiangyang441100China

Accurate fault diagnosis of heating,ventilation,and air conditioning(HVAC)systems is of significant importance for maintaining normal operation,reducing energy consumption,and minimizing maintenance costs.However,in practical applications,it is challenging to obtain sufficient fault data for HVAC systems,leading to imbalanced data,where the number of fault samples is much smaller than that of normal samples.Moreover,most existing HVAC system fault diagnosis methods heavily rely on balanced training sets to achieve high fault diagnosis accuracy.Therefore,to address this issue,a composite neural network fault diagnosis model is proposed,which combines SMOTETomek,multi-scale one-dimensional convolutional neural networks(M1DCNN),and support vector machine(SVM).This method first utilizes SMOTETomek to augment the minority class samples in the imbalanced dataset,achieving a balanced number of faulty and normal data.Then,it employs the M1DCNN model to extract feature information from the augmented dataset.Finally,it replaces the original Softmax classifier with an SVM classifier for classification,thus enhancing the fault diagnosis accuracy.Using the SMOTETomek-M1DCNN-SVM method,we conducted fault diagnosis validation on both the ASHRAE RP-1043 dataset and experimental dataset with an imbalance ratio of 1:10.The results demonstrate the superiority of this approach,providing a novel and promising solution for intelligent building management,with accuracy and F1 scores of 98.45%and 100%for the RP-1043 dataset and experimental dataset,respectively.

关键词： fault diagnosis chiller imbalanced data SMOTETomek multi-scale neural networks

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50-110 GHz,high isolation,and high-power linearity single-pole double-throw switch utilizing 100-nm GaN HEMT technology

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The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 38-43,71页

作者： Han Qunfei Hu Sanming Zhang Tianyu Chen Qing Shen yizhu Wang Weibo Tao Hongqi School of Information Science and Engineering Southeast UniversityNanjing 210096China Nanjing Electronic Devices Institute Nanjing 210016China State Key Laboratory of Millimeter Waves Southeast UniversityNanjing 210096China

This article presents the design and performance of a single-pole double-throw(SPDT)switch operating in 50-110 GHz.The switch is fabricated in a 100-nm GaN high-electron-mobility transistors(HEMT)technology.To realize high-power capability,the dimensions of GaN HEMTs are selected by simulation verification.To enhance the isolation,an improved structure of shunt HEMT with two ground holes is employed.To extend the operation bandwidth,the SPDT switch with multi-section resonant units is proposed and analyzed.To verify the SPDT switch design,a prototype operating in 50-110 GHz is fabricated.The measured results show that the fabricated SPDT switch monolithic microwave integrated circuit(MMIC)achieves an input 1 dB compression point(P_(1dB))of 38 dBm at 94 GHz,and isolation within the range of 33 dB to 54 dB in 50-110 GHz.The insertion loss of the switch is less than 2.1 dB,while the voltage standing wave ratios(VSWR)of the input port and output port are both less than 1.8 in the operation bandwidth.Based on the measured results,the presented SPDT switch MMIC demonstrates high power capability and high isolation compared with other reported millimeter-wave SPDT MMIC designs.

关键词： GaN high-electron-mobility transistors(HEMT) millimeter-wave single-pole double-throw(SPDT) switch

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Plasmonic polydopamine-modified TiO_(2)nanotube substrates for surface-assisted laser desorption/ionization mass spectrometry imaging

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Nano Research 2023年第2期16卷 3028-3039页

作者： Dong Chen Mingyi Du Yudi Huang yizhu xu Yingying Chen Lianlian Ma Qingrong Xie Xinhai Zhu Zilong Chen Hanhong xu Xinzhou Wu Zhibin Yin State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources and Key Laboratory of Natural Pesticide and Chemical Biology of the Ministry of Education South China Agricultural UniversityGuangzhou 510642China Agro-biological Gene Research Center Guangdong Academy of Agricultural SciencesGuangzhou 510640China Instrumental Analysis and Research Center Sun Yat-sen UniversityGuangzhou 510275China

Mass spectrometry imaging(MSI)has made the spatio-chemical characterization of a broad range of small-molecule metabolites within biological tissues possible.However,available matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)suffers from severe background interferences in low-mass ranges and inhomogeneous matrix deposition.Thus,surface-assisted LDI-MS(SALDI-MS)has been an attractive alternative for high-sensitivity detection and imaging of small biomolecules.In this study,we construct a new composite substrate,hydrophobic polydopamine(hPDA)-modified TiO_(2)nanotube(TDNT)coated with plasmonic gold nanoparticle(AuNP-hPDA-TDNT),as a dual-polarity SALDI substrate using an easy and cost-effective fabrication approach.Benefitting from the synergistic effects of TDNT semiconductor and plasmonic PDA modification,this SALDI substrate exhibits superior performance for dual-polarity detection of a vast diversity of small molecules.Highly reduced background interferences,lower detection limits,and spot-to-spot repeatability can be achieved using AuNP-hPDA-TDNT substrates.Due to its unique imprinting performance,various metabolites and lipids can be visualized within jatropha integerrima petals,ginkgo leaves,strawberry fruits,and latent fingerprints.More valuably,the universality of this matrix-free substrate is demonstrated for mapping spatial distribution of lipids within mouse brain tissue sections.Considered together,this AuNP-hPDA-TDNT material is expected to be a promising SALDI substrate in various fields,especially in nanomaterial development and life sciences.

关键词： TiO_(2)nanotube surface-assisted laser desorption/ionization(SALDI) mass spectrometry imaging latent fingerprint tissue imaging

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Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia

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Frontiers of Medicine 2024年第2期18卷 327-343页

作者： Niu Qiao yizhu Lyu Feng Liu Yuliang Zhang Xiaolin Ma Xiaojing Lin Junyu Wang Yinyin Xie Ruihong Zhang Jing Qiao Hongming Zhu Li Chen Hai Fang Tong Yin Zhu Chen Qiang Tian Saijuan Chen Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Hematology Second Hospital of Dalian Medical UniversityDalian116021China

The treatment of PML/RARA+acute promyelocytic leukemia(APL)with all-trans-retinoic acid and arsenic trioxide(ATRA/ATO)has been recognized as a model for translational medicine research.Though an altered microenvironment is a general cancer hallmark,how APL blasts shape their plasma composition is poorly understood.Here,we reported a cross-sectional correlation network to interpret multilayered datasets on clinical parameters,proteomes,and metabolomes of paired plasma samples from patients with APL before or after ATRA/ATO induction therapy.Our study revealed the two prominent features of the APL plasma,suggesting a possible involvement of APL blasts in modulating plasma composition.One was characterized by altered secretory protein and metabolite profiles correlating with heightened proliferation and energy consumption in APL blasts,and the other featured APL plasma-enriched proteins or enzymes catalyzing plasma-altered metabolites that were potential trans-regulatory targets of PML/RARA.Furthermore,results indicated heightened interferon-gamma signaling characterizing a tumor-suppressing function of the immune system at the first hematological complete remission stage,which likely resulted from therapy-induced cell death or senescence and ensuing supraphysiological levels of intracellular proteins.Overall,our work sheds new light on the pathophysiology and treatment of APL and provides an information-rich reference data cohort for the exploratory and translational study of leukemia microenvironment.

关键词： acute promyelocytic leukemia plasma proteomics plasma metabolomics cross-sectional correlation network pathogenesis treatment

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新型公共文化空间赋能乡村振兴:理论机制、制约条件与实施策略

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图书馆 2024年第5期 8-13,20页

作者：何义珠丽水学院图书与信息服务中心浙江丽水323000

文章阐述新型公共文化空间的人文性、开放性、融合性、社交性和创新性特征,从经济动力、文化资源和治理价值三重维度阐述新型公共文化空间赋能乡村振兴的理论机制,并就乡村公共文化空间普遍存在的功能弱化、主体性弱化、建设的形式化格... 详细信息

文章阐述新型公共文化空间的人文性、开放性、融合性、社交性和创新性特征,从经济动力、文化资源和治理价值三重维度阐述新型公共文化空间赋能乡村振兴的理论机制,并就乡村公共文化空间普遍存在的功能弱化、主体性弱化、建设的形式化格式化、数字贫困等制约条件进行深入分析,提出空间整合、功能整合和合作治理等新型公共文化空间赋能乡村振兴的实施策略。

关键词：新型公共文化空间乡村振兴经济动力文化资源治理价值

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Nanoparticle-immersed paper imprinting mass spectrometry imaging reveals uptake and translocation mechanism of pesticides in plants

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Nano Research 2020年第3期13卷 611-620页

作者： Xinzhou Wu Run Qin Hanxiang Wu Guangkai Yao Yue Zhang Ping Li yizhu xu Zhixiang Zhang Zhibin Yin Hanhong xu State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources South China Agricultural UniversityGuangzhou510642China Key Laboratory of Natural Pesticide and Chemical Biology of the Ministry of Education South China Agricultural UniversityGuangzhou510642China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou510006China

Design and discovery of carrier-mediated modified pesticides are vital for reducing pesticide dosage and increasing utilization,yet it remains a great challenge due to limited insights into plant translocation mechanisms.Nanostructure/nanoparticle assisted laser desorption/ionization strategy has established itself as a preferential analytical tool for biological tissue analysis,whereas potential applications in plant sciences are hindered with regard to the inability to slice plant leaves and petals.Herein,we report gold nanoparticle(AuNP)-immersed paper imprinting mass spectrometry imaging(MSI)for the spatiotemporal visualization of pesticide translocation in plant leaves.This approach plays a dual role in preserving spatial information and improving ionization efficiency for pesticides regardless of imaging artifacts due to homogenous AuNP deposition.Using this MSI platform,we proposed the elaborate plant translocation mechanism of agrochemicals for the first time,which is currently poorly understood.The dynamic processes of carrier-mediated pesticides can be clearly visualized,including crossing of plasma membranes by transporters,translocation downward in stems through the phloem,diffusion to the xylem and,conversely,accumulation at margins of the treated leaves.Moreover,this AuNP-assisted paper imprinting method could be highly compatible with laser-based MSI instruments,expediting researches across a broad range of fields,especially in nanomaterial development and life sciences.

关键词： gold nanoparticles nanoparticle-immersed paper imprinting mass spectrometry imaging plant translocation mechanism carrier-mediated pesticides

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用户体验视角下的智慧书房测评研究

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图书馆论坛 2024年第1期44卷 36-43页

作者：何逸竹茆意宏南京农业大学信息管理学院

构建智慧书房用户体验评价指标体系并对智慧书房进行测评,可助力智慧书房建设和服务开展。文章通过文献调研、网络调研等方式初步拟定智慧书房用户体验评价指标体系;运用专家咨询法确定评价体系,对智慧书房用户进行抽样调查分析;构建由... 详细信息

构建智慧书房用户体验评价指标体系并对智慧书房进行测评,可助力智慧书房建设和服务开展。文章通过文献调研、网络调研等方式初步拟定智慧书房用户体验评价指标体系;运用专家咨询法确定评价体系,对智慧书房用户进行抽样调查分析;构建由4个一级指标和20个二级指标构成的智慧书房用户体验评价指标体系,根据测评结果对智慧书房发展提出建议。

关键词：智慧书房用户体验智慧阅读空间新型公共阅读空间智慧图书馆

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1例尿黑酸尿症双膝关节置换术后患者并发急性心肌梗死的护理

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中华护理杂志 2024年第9期59卷 1118-1121页

作者：贾晓静陈一竹许志英和霞耿超天津医科大学总医院心血管内科监护室天津市300041

总结1例尿黑酸尿症双膝关节置换术后患者并发急性心肌梗死的护理。护理要点如下:严密监测病情,警惕急性心肌梗死并发症的发生;加强血栓和出血管理;早期渐进性康复锻炼,促进患肢功能康复;实施镇痛管理,改善疼痛症状;开展营养评估,给予个... 详细信息

总结1例尿黑酸尿症双膝关节置换术后患者并发急性心肌梗死的护理。护理要点如下:严密监测病情,警惕急性心肌梗死并发症的发生;加强血栓和出血管理;早期渐进性康复锻炼,促进患肢功能康复;实施镇痛管理,改善疼痛症状;开展营养评估,给予个性化营养支持;注重人文关怀,实施针对性心理护理。经过精心的治疗及护理,患者好转出院。电话随访3个月,患者恢复良好。

关键词：尿黑酸尿症关节成形术置换膝急性心肌梗死护理

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地方应用型本科院校自然地理学课程改革与实践

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科教导刊 2024年第18期 129-131页

作者：陈奕竹桂林旅游学院广西桂林541000

应用型本科院校是新时代人才培养的重要载体,自然地理学作为人文地理与城乡规划专业的基础课程,是重要的知识基础和实践基础,但目前该课程在课程内容、实践环节、课程评价等方面面临一些挑战。文章基于OBE理念,从课程目标、课程设计、... 详细信息

应用型本科院校是新时代人才培养的重要载体,自然地理学作为人文地理与城乡规划专业的基础课程,是重要的知识基础和实践基础,但目前该课程在课程内容、实践环节、课程评价等方面面临一些挑战。文章基于OBE理念,从课程目标、课程设计、教学模式、教学评价体系等四个方面探讨了自然地理学课程在应用型本科院校的改革路径,以期提高教学效果,培养学生综合能力。

关键词：自然地理学课程 OBE理念教学改革

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Simultaneous and Spatial Quantification of Telomerase Activity and DNA Methylation in Living Cells by a Deformable Satellite Nanocapsule

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CCS Chemistry 2021年第4期3卷 1231-1244页

作者： Shan Huang Cheng Ma Jiahao Lin Wenjing Wang yizhu xu Xingxin Wu Jian-Rong Zhang Jun-Jie Zhu School of Chemistry and Chemical Engineering State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjingJiangsu 210023 College of Science State Key Laboratory of Agricultural MicrobiologyHuazhong Agricultural UniversityWuhanHubei 430070 School of Life Sciences State Key Laboratory of Pharmaceutical BiotechnologyNanjing UniversityNanjingJiangsu 210023 School of Chemistry and Life Science Jinling CollegeNanjing UniversityNanjingJiangsu 210089

Telomerase plays an essential role in many biological processes.DNA methylation regulates the expression of many genes,including telomerase.Here,we propose a deformable satellite nanocapsule fluorescein isothiocyanate(FITC)-hollowbowl mesoporous organicsilica@gold nanoparticles-methyl-CpG-binding protein 2(MECP 2)-silver nanoclusters(FHBMO@AMA),for simultaneous quantitative detection of both cytoplasmic telomerase activity and the degree of DNA methylation.This strategy enabled spatial-based detection in cells.The total cytoplasmic telomerase activity was detected by fluorescence energy resonance transfer(FRET)between FHBMO and gold nanoparticles(Au NPs),while the DNA methylation in the nucleus was detected by enhanced fluorescence of silver nanoclusters(Ag NCs).Furthermore,FHBMO@AMA could intuitively distinguish between the differences in telomerase expression in cells during the DNA synthesis period at the mitotic phase(S/M)of the cell cycle.Interestingly,the ratio of the two detections(telomerase activity/DNA methylation)significantly correlated with the efficacy of anticancer drugs.At the same time,there was no apparent linear relationship between any single detection target and the efficacy of the anticancer drugs.Therefore,based on the relationship between telomerase activity and DNA methylation,our newly developed approach serves as new and feasible method for evaluating the efficacy of anticancer drugs,thereby,extending the technology toolbox for precision in medical and pharmaceutical analysis of drug potency.

关键词： telomerase DNA methylation simultaneous detection single-cell level the efficacy of anticancer drugs

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