检索结果-南通市图书馆

mETTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BmSCs

引用

International Journal of oral Science 2024年第3期16卷 528-538页

作者： yizhou Jin Xiao Han Yuejun Wang Zhipeng Fan Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina Beijing Laboratory of oral Health Capital Medical UniversityBeijingChina Research Unit of Tooth Development and Regeneration Chinese Academy of Medical SciencesBeijingChina

Bisphosphonate-related osteonecrosis of jaw(BRoNJ)is characterized by impaired osteogenic differentiation of orofacial bone marrow stromal cells(BmSCs).Corin has recently been demonstrated to act as a key regulator in bone development and orthopedic ***,the role of corin in BRoNJ-related BmSCs dysfunction remains unclarified.A m6A epitranscriptomic microarray study from.our group shows that the CoRIN gene is significantly upregulated and m6A hypermethylated during orofacial BmSCs osteogenic *** knockdown inhibits BmSCs osteogenic differentiation,whereas corin overexpression or soluble corin(sCorin)exerts a promotion ***,corin expression is negatively regulated by bisphosphonates(BPs).Corin overexpression or sCorin reverses BPs-impaired BmSCs differentiation ***,we find altered expression of phos-ERK in corin knockdown/overexpression BmSCs and BmSCs under sCorin ***98059(a selective ERK inhibitor)blocks the corin-mediated promotion *** regard to the high methylation level of corin during osteogenic differentiation,we apply a non-selective m6A methylase inhibitor,Cycloleucine,which also blocks the corin-mediated promotion ***,we demonstrate that mETTL7A modulates corin m6A modification and reverses BPs-impaired BmSCs function,indicating that mETTL7A regulates corin expression and thus contributes to orofacial BmSCs differentiation *** conclude,our study reveals that corin reverses BPs-induced BmSCs dysfunction,and mETTL7A-mediated corin m6A modification underlies corin promotion of osteogenic differentiation via the ERK *** hope this brings new insights into future clinical treatments for BRoNJ.

关键词： impaired cor mediated

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent developments in three-dimensional Zn metal anodes for battery applications

引用

Infomat 2024年第1期6卷 1-30页

作者： Jianyu Chen yizhou Wang Zhengnan Tian Jin Zhao Yanwen ma Husam N.Alshareef State Key Laboratory of organic Electronics and Information Displays(KLoEID)and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts&Telecommunications(NUPT)Nanjingthe People's Republic of China materials Science and Engineering King Abdullah University of Science and Technology(KAUST)ThuwalSaudi Arabia Suzhou Vocational Institute of Industrial Technology Suzhouthe People's Republic of China

Aqueous zinc(Zn)ion batteries(AZIBs)are regarded as one of the promising candidates for next-generation electrochemical energy storage systems due to their low cost,high safety,and environmental ***,the commercialization of AZIBs has been severely restricted by the growth of dendrite at the Zn metal *** the planar-structured Zn anodes into threedimensional(3D)structures has proven to be an effective way to modulate the plating/stripping behavior of Zn anodes,resulting in the suppression of dendrite *** review provides an up-to-date review of 3D structured Zn metal anodes,including working principles,design,current status,and future *** aim to give the readers a comprehensive understanding of 3D-structured Zn anodes and their effective usage to enhance AZIB performance.

关键词： 3D metal anodes aqueous Zn ion batteries dendrite suppression Zn dendrite Zn metal anodes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Flat Zn deposition at battery anode via an ultrathin robust interlayer

引用

Nano Research 2024年第9期17卷 8104-8111页

作者： yizhou Wang Jianyu Chen Zibo Chen Qian He Zhengnan Tian Jin Zhao Yanwen ma Husam N.Alshareef materials Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia State Key Laboratory of organic Electronics and Information Displays(KLoEID)and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Suzhou Vocational Institute of Industrial Technology Suzhou 215104China

Rechargeable aqueous zinc(Zn)ion batteries(AZIBs)using low-cost and safe Zn metal anodes are considered promising candidates for future grid-scale energy storage systems,but the Zn dendrite problem severely hinders the further prospects of *** Zn depositing behaviors toward horizontal alignment is highly effective and thus has received huge ***,such a strategy is usually based on previous substrate engineering,which requires complex preparation or expensive ***,it is essential to develop a novel solution that can realize horizontally aligned Zn flake deposition via easy operation and low ***,we report an ultrathin and robust Kevlar membrane as the interlayer to mechanically suppress Zn dendrite *** to the randomly distributed flaky dendrites in the control group,the deposited Zn sheets would grow into parallel alignment with the existence of such *** the dendrites are effectively suppressed,Zn||Cu asymmetric,Zn||Zn symmetric,and Zn||m.o_(2)full batteries using Kevlar interlayer deliver significantly improved cycling ***,the Zn||m.o_(2)pouch cell using a Kevlar interlayer delivers stable cycling performance and shows stable operation during multi-angle *** believe this work provides a new possibility for regulating Zn deposition from a crystallographic perspective.

关键词： Zn metal anodes Zn dendrites aqueous Zn ion batteries dendrite suppression (002)crystal plane

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A complete reference genome for the soybean ***

引用

Plant Communications 2024年第2期5卷 19-22页

作者： Yicheng Huang Dal-Hoe Koo yizhou m.o Eliot m.Herman Jianwei Zhang monica A.Schmidt National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Wheat Genetics Resource Center Department of Plant PathologyKansas State UniversityManhattanKS 66506USA BIo5 Institute School of Plant SciencesUniversity of ArizonaTucsonAZ 85721USA

Dear Editors,Soybeans are a global com.odity for their edible protein and vegetable *** global population is predicted to be 9.7 billion by 2050(UN,2022),with a concomitant drastic increase in protein *** already 2.4 billion people suffering from food insecurity(FAo et al.,2023),there is an urgent need to meet future production demands for plant-based proteins.

关键词： com.odity soybean urgent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liquid metal compartmented by polyphenol-mediated nanointerfaces enables high-performance thermal management on electronic devices

引用

Infomat 2024年第1期6卷 83-95页

作者： Chaojun Zhang Yang Tang Tianyu Guo yizhou Sang Ding Li Xiaoling Wang orlando J.Rojas Junling Guo BmI Center for Biomass materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengduSichuanthe People's Republic of China Bioproducts Institute Departments of Chemical and Biological EngineeringThe University of British ColumbiaVancouverBritish ColumbiaCanada Institute of Development Studies Southwestern University of Finance and EconomicsChengduSichuanthe People's Republic of China National Engineering Laboratory for Clean Technology of Leather manufacture Sichuan UniversityChengduSichuanthe People's Republic of China State Key Laboratory of Polymer materials Engineering Sichuan UniversityChengduSichuanthe People's Republic of China

The exponentially increasing heat generation in electronic devices,induced by high power density and miniaturization,has become a dominant issue that affects carbon footprint,cost,performance,reliability,and *** metals(Lms)with high thermal conductivity are promising candidates for effective thermal management yet are facing pump-out and surface-spreading *** in the form.of metallic particles can address these problems,but apparent alloying processes elevate the Lm melting point,leading to severely deteriorated ***,we propose a facile and sustainable approach to address these challenges by using a biogenic supramolecular network as an effective diffusion barrier at copper particle-Lm(EGaIn/Cu@TA)interfaces to achieve superior thermal *** supramolecular network promotes Lm stability by reducing unfavorable alloying and fluidity *** EGaIn/Cu@TA exhibits a record-high metallic-mediated thermal conductivity(66.1 W m^(-1) K^(-1))and fluidic ***,mechanistic studies suggest the enhanced heat flow path after the incorporation of copper particles,generating heat dissipation suitable for computer central processing units,exceeding that of commercial *** results highlight the prospects of renewable macromolecules isolated from biomass for the rational design of nanointerfaces based on metallic particles and Lm,paving a new and sustainable avenue for high-performance thermal management.

关键词： Electronic devices High thermal conductivity Liquid metals Natural polyphenols Thermal management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stability and variability of molecular subtypes: comparative analysis of primary and metastatic triple-negative breast cancer

引用

Cancer Biology & medicine 2024年第9期21卷 784-798页

作者： Xiuzhi Zhu Xiaohan Ying Yin Liu Yunyi Wang Li Chen Zhiming Shao Xi Jin yizhou Jiang Zhonghua Wang Key Laboratory of Breast Cancer in Shanghai Shanghai Institute of Infectious Disease and Biosecurity Department of Oncology Shanghai Medical College Fudan University Department of Breast Surgery Fudan University Shanghai Cancer Center

objective: Triple-negative breast cancer(TNBC) is a heterogeneous and aggressive cancer. Although our previous study classified primary TNBC into four subtypes, comprehensive longitudinal investigations are ***: We assembled a large-scale, real-world cohort comprised of 880 TNBC patients [465 early-stage TNBC(e TNBC) and 415 metastatic TNBC(m TNBC) patients] who were treated at Fudan University Shanghai Cancer Center. The longitudinal dynamics of TNBC subtypes during disease progression were elucidated in this patient cohort. Comprehensive analysis was performed to compare primary and metastatic lesions within specific TNBC ***: The recurrence and metastasis rates within 3 years after initial diagnosis in the e TNBC cohort were 10.1%(47/465). The median overall survival(oS) in the m TNBC cohort was 27.2 months [95% confidence interval(CI), 24.4±30.2 months], which indicated a poor prognosis. The prognostic significance of the original molecular subtypes in both e TNBC and m TNBC patients was confirmed. Consistent molecular subtypes were maintained in 77.5% of the patients throughout disease progression with the mesenchymal-like(mES) subtype demonstrating a tendency for subtype transition and brain metastasis. Additionally, a precision treatment strategy based on the metastatic mES subtype of target lesions resulted in improved progression-free survival in the FUTURE ***: our longitudinal study comprehensively revealed the clinical characteristics and survival of patients with the original TNBC subtypes and validated the consistency of most molecular subtypes throughout disease progression. However, we emphasize the major im.ortance of repeat pathologic confirmation of the mES subtype.

关键词： Triple-negative breast cancer metastasis molecular subtype overall survival primary tumor

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

overexpression of tonoplast Ca^(2+)-ATPase in guard cells synergistically enhances stomatal opening and drought tolerance

引用

Journal of Integrative Plant Biology 2024年第8期66卷 1587-1602页

作者： Jinghan Su Bingqing He Peiyuan Li Baiyang Yu Qiwen Cen Lingfeng Xia Yi Jing Feibo Wu Rucha Karnik Dawei Xue michael R.Blatt yizhou Wang Institute of Crop Science Zhejiang UniversityHangzhou 310058China Laboratory of Plant Physiology and Biophysics University of GlasgowGlasgow G128QQUK BGI Research Sanya 572025China College of Life and Environmental Sciences Hangzhou Normal UniversityHangzhou 311121China Zhejiang Provincial Key Laboratory of Crop Germplasm Zhejiang UniversityHangzhou 310058China

Stomata play a crucial role in plants by controlling water status and responding to drought ***,simultaneously improving stomatal opening and drought tolerance has proven to be a significant *** address this issue,we employed the onGuard quantitative model,which accurately represents the mechanics and coordination of ion transporters in guard *** the guidance of onGuard,we successfully engineered plants that overexpressed the main tonoplast Ca^(2+)-ATPase gene,ACA11,which promotes stomatal opening and enhances plant ***,these transgenic plants also exhibited improved drought tolerance due to reduced water loss through their ***,onGuard assisted us in understanding the mechanism behind the unexpected stomatal behaviors observed in the ACA11 overexpressing *** study revealed that the overexpression of ACA11 facilitated the accumulation of Ca^(2+)in the vacuole,thereby influencing Ca^(2+)storage and leading to an enhanced Ca^(2+)elevation in response to abscisic *** regulatory cascade finely tunes stomatal responses,ultimately leading to enhanced drought *** findings underscore the im.ortance of tonoplast Ca^(2+)-ATPase in manipulating stomatal behavior and improving drought ***,these results highlight the diverse functions of tonoplast-localized ACA11 in response to different conditions,emphasizing its potential for future applications in plant enhancement.

关键词： ACA11 drought guard cells modeling stomata

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insights into Triclosan-Induced Endocrine Disruption:Evidence from the National Health and Nutrition Examination Survey and Zebrafish models

引用

Environment & Health 2024年第7期2卷 424-440页

作者： Zhiming Li Hongyi Xian Xiaohu Ren Rongyi Ye yizhou Zhong Yuji Huang Boxuan Liang Yanhong Deng mingzhu Dai Jie Guo Shuqin Tang Jialiang Pan Yu Feng Ruobing Bai Xueping Chen Sahoko Ichihara Gaku Ichihara Da Chen Xingfen Yang Zhenlie Huang NmPA Key Laboratory for Safety Evaluation of Cosmetics Guangdong Provincial Key Laboratory of Tropical Disease ResearchDepartment of ToxicologySchool of Public HealthSouthern Medical UniversityGuangzhou 510515China Shenzhen Key Laboratory of modern Toxicology Shenzhen Medical Key Discipline of Health ToxicologyShenzhen Center for Disease Control and PreventionShenzhen 518055China Hunter Biotechnology Inc.Hangzhou 310051China College of Environment and Climate Guangdong Provincial Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China Vitargent(International)Biotechnology Limited Shatin 999077Hong Kong SARChina Department of Environmental and Preventive medicine School of MedicineJichi Medical UniversityTochigi 329-0498Japan Department of occupational and Environmental Health Faculty of Pharmaceutical SciencesTokyo University of ScienceNoda 278-8510Japan

Triclosan(TCS)has garnered significant attention due to its widespread use and associated endocrine-disrupting ***,its impact on the neuroendocrine system and underlying mechanisms remain poorly ***,we established correlations between TCS exposure and serum sex hormone levels in participants of the National Health and Nutrition Examination Survey(NHANES).Additionally,we investigated TCS’s influence on the neuroendocrine system using adult zebrafish exposed to environmentally relevant concentrations of TCS(0.361–48.2μg/L)for 21 *** of reproductive and neurotoxicity included histopathological examination and behavioral ***,proteomics analyses,and biochemical detection were employed to elucidate mechanisms underlying TCS-induced neuroendocrine *** correlations were found between TCS exposure and estradiol,testosterone,and sex hormone-binding globulin levels in NHANES *** addition,TCS exposure inhibited ovary development and spermatogenesis in *** and proteomics analysis revealed gender-specific key signaling and metabolism-related pathways implicated in TCS-induced reproductive ***,TCS exposure induced nervous system impairment,as evidenced by histological changes and altered motor behavior,possibly associated with oxidative *** analysis further highlighted the potential connection between endocrine system disruption and nervous system impairment following TCS ***,this study provided evidence supporting TCS-induced endocrine disruption and offered insights into its underlying mechanisms.

关键词： Emerging Contaminants Ecotoxicity Public Health Endocrine-Disrupting Chemicals Endocrine-Disrupting Effects

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中药质量标志物(Q-marker)的科学计量分析

引用

中草药 2024年第4期55卷 1297-1308页

作者：徐园园王明慧魏永利李峰辛义周山东中医药大学药学院山东济南250355 聊城市人民医院药学部山东聊城252000 山东中医药大学附属医院国家中医药管理局中药制剂三级实验室山东济南250011 山东中医药大学附属医院中药饮片分子鉴定与生物评价实验室山东济南250011

目的中药质量标志物(quality marker,Q-marker)的确定是完善《中国药典》、促进中医药产业健康发展的关键内容,是中医药走向国际化和现代化需要迈出的重要一步,对Q-marker的研究现状进行充分认识很有必要。方法采用科学计量分析方法,通... 详细信息

目的中药质量标志物(quality marker,Q-marker)的确定是完善《中国药典》、促进中医药产业健康发展的关键内容,是中医药走向国际化和现代化需要迈出的重要一步,对Q-marker的研究现状进行充分认识很有必要。方法采用科学计量分析方法,通过CNKI和Web of Science数据库检索中药Q-marker相关文献,从论文的整体产出概况、研究国家和机构、研究热点及研究趋势等方面,借助VoSviewer、CiteSpace软件绘制可视化知识图谱。结果共纳入1030篇中、英文文献,分析可知中药Q-marker研究正处于快速发展阶段,概念提出人刘昌孝院士的发文量最多,该研究领域在中药质量控制、药效物质基础、炮制机制研究、中药药理与安全性评价、中药资源种植等方向已取得大量研究成果。结论中药Q-marker正处于研究的上升阶段,研究领域内各机构和团队之间的交流合作有待加强。通过全面、科学地总结中药Q-marker研究领域的发展进程、研究近况,并探讨其研究热点趋势,可为中药Q-marker的深入研究提供参考依据。

关键词：质量标志物中药科学计量分析 VoSviewer CiteSpace

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于参数解耦的变分贝叶斯自适应卡尔曼滤波

引用

雷达科学与技术 2024年第3期22卷 291-299页

作者：许红刘欣蕊邢逸舟全英汇西安电子科技大学杭州研究院浙江杭州311231 西安电子科技大学电子工程学院陕西西安710071

针对噪声协方差矩阵失配情况下的状态估计问题,本文基于变分贝叶斯框架,提出了一种适用于过程噪声协方差矩阵和测量噪声协方差矩阵均未知条件下的参数解耦的变分贝叶斯自适应卡尔曼滤波算法。所提算法选取预测误差协方差矩阵作为变分优... 详细信息

针对噪声协方差矩阵失配情况下的状态估计问题,本文基于变分贝叶斯框架,提出了一种适用于过程噪声协方差矩阵和测量噪声协方差矩阵均未知条件下的参数解耦的变分贝叶斯自适应卡尔曼滤波算法。所提算法选取预测误差协方差矩阵作为变分优化变量,并引入了其马尔可夫演化模型,构造了参数解耦的变分推断模型。同时,采用固定点迭代优化实现状态、预测误差协方差矩阵和测量噪声协方差矩阵的联合后验概率分布求解,并设计了算法的收敛性判断准则。仿真结果验证了算法的有效性。

关键词：自适应状态估计卡尔曼滤波变分贝叶斯噪声协方差矩阵参数解耦

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：