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Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function

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International Journal of Oral Science 2023年第4期15卷 664-675页

作者： Xiaoyan Li yiyang jiang Xu Liu Jingfei Fu Juan Du Zhenhua Luo Junji Xu Ujjal Kumar Bhawal Yi Liu Lijia Guo Laboratory of Tissue Regeneration and Immunology and Department of Periodontics Beijing Key Laboratory of Tooth Regeneration and Function ReconstructionSchool of StomatologyCapital Medical UniversityBeijingChina Research Institute of Oral Science Nihon University School of Dentistry at MatsudoChibaJapan Center for Global Health Research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiTamil NaduIndia Department of Orthodontics School of Stomatology Capital Medical UniversityBeijingChina

Periodontitis is caused by overactive osteoclast activity that results in the loss of periodontal supporting tissue and mesenchymal stem cells(MSCs)are essential for periodontal ***,the hypoxic periodontal microenvironment during periodontitis induces the apoptosis of *** bodies(ABs)are the major product of apoptotic cells and have been attracting increased attention as potential mediators for periodontitis treatment,thus we investigated the effects of ABs derived from MSCs on *** were derived from bone marrows of mice and were cultured under hypoxic conditions for 72 h,after which ABs were isolated from the culture supernatant using a multi-filtration *** results demonstrate that ABs derived from MSCs inhibited osteoclast differentiation and alveolar bone *** array analysis showed that miR-223-3p is highly enriched in those ABs and is critical for their therapeutic *** and luciferase activity results confirmed that Itgb1 is targeted by miR-223-3p,which interferes with the function of ***,DC-STAMP is a key regulator that mediates membrane *** and pre-osteoclasts expressed high levels of DC-STAMP on their membranes,which mediates the engulfment of ABs by *** with knock-down of DC-STAMP failed to be engulfed by ***,MSC-derived ABs are targeted to be engulfed by pre-osteoclasts via DC-STAMP,which rescued alveolar bone loss by transferring miR-223-3p to osteoclasts,which in turn led to the attenuation of their differentiation and bone *** results suggest that MSC-derived ABs are promising therapeutic agents for the treatment of periodontitis.

关键词： function attracting treatment

Solar flare forecasting based on a Fusion Model

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Earth and Planetary Physics 2025年第1期9卷 171-181页

作者： yiyang Li ShiYong Huang SiBo Xu ZhiGang Yuan Kui jiang QiYang Xiong RenTong Lin School of Earth and Space Science Technology Hubei Luojia LaboratoryWuhan UniversityWuhan 430072China

Solar flare prediction is an important subject in the field of space *** learning technology has greatly promoted the development of this *** this study,we propose a novel solar flare forecasting model integrating Deep Residual Network(ResNet)and Support Vector Machine(SVM)for both≥C-class(C,M,and X classes)and≥M-class(M and X classes)*** collected samples of magnetograms from May 1,2010 to September 13,2018 from Space-weather Helioseismic and Magnetic Imager(HMI)Active Region Patches and then used a cross-validation method to obtain seven independent data *** then utilized five metrics to evaluate our fusion model,based on intermediate-output extracted by ResNet and SVM using the Gaussian kernel *** results show that the primary metric true skill statistics(TSS)achieves a value of 0.708±0.027 for≥C-class prediction,and of 0.758±0.042 for≥M-class prediction;these values indicate that our approach performs significantly better than those of previous *** metrics of our fusion model’s performance on the seven datasets indicate that the model is quite stable and robust,suggesting that fusion models that integrate an excellent baseline network with SVM can achieve improved performance in solar flare ***,we also discuss the performance impact of architectural innovation in our fusion model.

关键词： solar flare pace weather deep learning Fusion Model

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激光近炸复合引信探测舰船目标的建模与仿真

红外与激光工程 2016年第10期45卷 45-50页

作者：姜易阳倪邦福钱红庆北京机电工程研究所北京100074

针对采用激光近炸引信与触发引信体制的飞行器,研究了探测海面舰船雷达目标的建模分析方法,并进行了引战配合仿真及优化研究。通过建立激光近炸探测装置与目标间的空间交汇运动模型,可在激光近炸引信探测光束与飞行器空间运动强耦合,且... 详细信息

针对采用激光近炸引信与触发引信体制的飞行器,研究了探测海面舰船雷达目标的建模分析方法,并进行了引战配合仿真及优化研究。通过建立激光近炸探测装置与目标间的空间交汇运动模型,可在激光近炸引信探测光束与飞行器空间运动强耦合,且舰船外型面复杂多样的情况下进行毁伤效率分析。采用同制导精度计算一致的误差干扰模型及蒙特卡罗打靶方法,统计了复合引信体制下不同引战配合方式对舰船雷达毁伤概率的影响,为优化引战配合效率、增大毁伤概率提供可靠依据。该方法可对任意支路激光近炸引信探测任何复杂舰船型面进行建模分析及毁伤概率计算,也可适用于针对其他类型目标的分析计算,具有良好的通用性和扩展性。

关键词：激光近炸引信建模与仿真蒙特卡罗打靶引战配合

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1

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A novel RNA-binding mode of the YTH domain reveals the mecha...

A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1

第九届全国核糖核酸学术讨论会

作者：王崇元 Yuwei Zhu Hongyu Bao yiyang jiang Chao Xu Jihui Wu Yunyu Shi 中国科学技术大学

＜正＞The YTH domain-containing protein Mmi1,together with other factors,constitutes the machinery used to selectively remove meiosis-specific m RNA during the vegetative growth of fission ***1 directs meiotic m RNAs to the nuclear exosome for degradation by recognizing their DSR（determinant of selective removal）***,

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来源： cnki会议评论

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A novel RNA-binding mode of the YTH domain reveals the mecha...

第五届中国结构生物学学术讨论会

作者： Chongyuan Wang Yuwei Zhu Hongyu Bao yiyang jiang Chao Xu Jihui Wu Yunyu Shi Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences University of Science and Technology of China

The YTH domain-containing protein Mmi1, together with other factors, constitutes the machinery used to selectively remove meiosis-specific m RNA during the vegetative growth of fission yeast. Mmi1 directs meiotic m RNAs to the nuclear exosome for degradation by recognizing their DSR（determinant of selective removal） motif. Here, we present the crystal structure of the Mmi1 YTH domain in the apo state and in complex with a DSR motif, demonstrating that the Mmi1 YTH domain selectively recognizes the DSR motif. Intriguingly, Mmi1 also contains a potential m6A（N6-methyladenine）-binding pocket, but its binding of the DSR motif is dependent on a long groove opposite the m6A pocket. The DSR-binding mode is distinct from the m6A RNA-binding mode utilized by other YTH domains. Furthermore, the m6A pocket cannot bind m6A RNA. Our structural and biochemical experiments uncover the mechanism of the YTH domain in binding the DSR motif and help to elucidate the function of Mmi1.

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来源： cnki会议评论

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甲基化对牙周炎发生与发展的影响及临床应用

国际口腔医学杂志 2019年第5期46卷 593-603页

作者：姜亦洋刘怡首都医科大学附属北京口腔医院牙周科全牙再生与口腔组织功能重建北京市重点实验室组织再生免疫学实验室

牙周炎主要是由局部因素引起的牙周支持组织的慢性炎症,细菌感染与宿主免疫反应之间的抗衡影响着疾病的发生、发展。甲基化作为表观遗传修饰的一种,在这其中起到了举足轻重的作用,也成为近年来的热点,它可通过改变染色质的结构选择性地... 详细信息

牙周炎主要是由局部因素引起的牙周支持组织的慢性炎症,细菌感染与宿主免疫反应之间的抗衡影响着疾病的发生、发展。甲基化作为表观遗传修饰的一种,在这其中起到了举足轻重的作用,也成为近年来的热点,它可通过改变染色质的结构选择性地激活或抑制某些基因,影响炎症过程中炎性因子、信号分子、细胞外基质分子的表达,进而调控宿主的免疫水平。对甲基化模式的研究不仅可以增加人们对牙周炎的认识,也对临床有着深远的意义,有助于人们探索治疗牙周炎的新途径,改善牙周炎的预后和转归,是未来重要的研究内容。本文从甲基化修饰的角度对牙周炎相关的研究进展作一综述。

关键词：甲基化牙周炎细胞因子

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基于个性化时空聚类的差分隐私轨迹保护模型

信息网络安全 2024年第1期 80-92页

作者：尹春勇蒋奕阳南京信息工程大学计算机学院南京210044 南京信息工程大学软件学院南京210044

随着位置感知设备的普及,轨迹数据已广泛应用于现实生活。然而,轨迹数据通常与敏感标签相关联,不当地分享或发布这些数据可能会泄露用户的隐私,且不同数据的敏感程度互异。针对上述问题,文章提出了基于个性化时空聚类的差分隐私轨迹保... 详细信息

随着位置感知设备的普及,轨迹数据已广泛应用于现实生活。然而,轨迹数据通常与敏感标签相关联,不当地分享或发布这些数据可能会泄露用户的隐私,且不同数据的敏感程度互异。针对上述问题,文章提出了基于个性化时空聚类的差分隐私轨迹保护模型。首先,针对轨迹中海量时间数据与隐私保护的需要,文章提出模糊均值聚类算法(FCM算法);其次,在空间分割的过程中,通过密度进行聚类,并实现个性化调整隐私预算分配的目的,从而提高数据效用;再次,在轨迹合成阶段,对比真实轨迹数据,选择更具代表性的轨迹;最后,在发布阶段,引入Laplace机制对轨迹数目进行隐私保护。为了验证文章所提出的模型在轨迹效用与隐私保护上的成果,将该模型与另外两种模型在4个阶段上进行了比较。实验结果表明,文章所提出的模型在数据效用方面提升15.45%,在相同隐私预算下,隐私保护强度提升至少35.62%。

关键词：个性化预算分配差分隐私时空聚类轨迹隐私轨迹发布

Structural Basis for the Specific Recognition of Rho A by the Dual GTPase-activating Protein ARAP3

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Structural Basis for the Specific Recognition of Rho A by th...