Structural Basis for the Specific Recognition of Rho A by the Dual GTPase-activating Protein ARAP3
作者单位：Hefei National Laboratory for Physical Science at Microscale Collaborative Innovation Center of Chemistry for Life Sciences and School of Life Sciences University of Science and Technology of China
会议名称：《中国生物化学与分子生物学会2016年全国学术会议》
会议日期：2016年
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术]
摘 要：ARAP3(Arf-GAP with Rho-GAP domain,ANK repeat and PH domain-containing protein 3)is unique for its dual specificity GAPs(GTPase activating protein)activity for Arf6(ADP-ribosylation factor 6)and RhoA(Ras homolog gene family member A)regulated by Ptd Ins(3,4,5)P3(phosphatidylinositol(3,4,5)-trisphosphate)and a small GTPase Rap1-GTP and is involved