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“Transient”or“Persistent”Coding for Working Memory

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Neuroscience Bulletin 2020年第10期36卷 1233-1235页

作者： yixuan ku Ti-Fei Yuan Guangdong Provincial Key Laboratory of Social Cognitive Neuroscience and Mental Health Department of PsychologySun Yat-sen UniversityGuangzhou 510006China Peng Cheng Laboratory Shenzhen 518040China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China

Working memory(WM)maintains information temporarily for subsequent goal-directed behaviors,such as remembering a telephone number to *** serves as a supporting mental workspace for many cognitive functions such as mental calculation,reading,and learning new *** critical role of persistent activity in the prefrontal cortex in WM,originally proposed to bridge sensory information and motor responses[1],has been severely debated recently[2,3].

关键词： telephone such tempo

Prefrontal cortex and sensory cortices during working memory: quantity and quality

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Neuroscience Bulletin 2015年第2期31卷 175-182页

作者： yixuan ku Mark Bodner Yong-Di Zhou Key Laboratory of Brain Functional Genomics Ministry of Education Shanghai Key Laboratory of Brain Functional Genomics Institute of Cognitive Neuroscience School of Psychology and Cognitive Science East China Normal University MIND Research Institute Department of Neurosurgery Johns Hopkins University NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai

The activity in sensory cortices and the prefrontal cortex （PFC） throughout the delay interval of working memory （WM） tasks reflect two aspects of WM-quality and quantity, respectively. The delay activity in sensory cortices is fine-tuned to sensory information and forms the neural basis of the precision of WM storage, while the delay activity in the PFC appears to represent behavioral goals and filters out irrelevant distractions, forming the neural basis of the quantity of task-relevant information in WM. The PFC and sensory cortices interact through different frequency bands of neuronal oscillation （theta, alpha, and gamma） to fulfill goal-directed behaviors.

关键词： working memory prefrontal cortex capacity limit memory precision neuronal oscillations

Cognitive and Neural Modulation of Working Memory

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Cognitive and Neural Modulation of Working Memory

Analysis of influencing factors of visual working memory in young adult patients with schizophrenia

第二十二届全国心理学学术会议

作者： yixuan ku East China Normal University

Working memory(WM) is the ability to maintain and manipulate input information shortly to fulfill goal-directed behavior. WM is the global workspace for various cognitive functions but has very limited capacity and restricted precision. The capacity is related to general intelligence and other cognitive functions, and is difficult to change. There are severe debates about the training effect of working memory. Whether the change in working memory capacity exists is still unclear. We proposed a working memory quantity-quality(QQ) model in which the neural mechanisms of quantity(capacity) and quality(precision) correspond to the frontoparietal network and the sensory cortices, respectively. Our recent series of studies further supports the role of sensory cortex in representing precision and the role of the frontoparietal cortices in representing capacity. We further apply our basic research in working memory to schizophrenia and Alzheimer’s disease, to deeply understand the reasons for their decline in working memory ability. Our studies using tools of cognitive and neural modulation may provide a basis for future training and enhancement application.

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General Psychiatry 2018年第6期31卷 122-127页

作者： Li Zhang Xuemei Ran Ting Li yixuan ku Li Liu Tingming Huang Wenjia Yan Outpatient Shanghai Changning District Mental Health Center Institute of Cognitive Neuroscience East China Normal University

Background Patients with schizophrenia have general cognitive impairments, and the impairment of working memory is considered to be the basis of cognitive impairments. The research on visual working memory, one of the subcomponents, is getting more and more ***, the influencing factors which cause the deficits of visual working memory in patients with schizophrenia have not been clearly explained. To provide evidence for cognitive impairment interventions, the present study explored the factors influencing the deficits of patients' visual working *** The present study discussed the relevant factors influencing the visual working memory of patients with schizophrenia by measuring the accuracy of the visual working memory of patients with schizophrenia and healthy *** Colour-recall paradigm was employed to measure the accuracy of the visual working memory of 61 healthy controls and 61 patients who met the International Classification of Diseases, Tenth Revision diagnostic criteria for schizophrenia. The age range of subjects was18-50. Scale for the Assessment of Positive Symptoms(SAPS) and Scale for the Assessment of Negative Symptoms(SANS) were used to evaluate the patients' clinical *** Compared with the healthy control group, the accuracy of visual working memory of patients with schizophrenia was significantly impaired(t=3.062,p=0.003). The accuracy of visual working memory of patients with schizophrenia was not related to age(r=0.023,p=0.860),the age of onset(r=-0.003,p=0.979),the duration of illness(r=-0.038, p=0.769),education level(r=-0.181, p=0.162),continuous working time before illness(r =-0.107, p=0.413) or the daily dose of antipsychotic drugs(r =0.062, p=0.635); however, it was positively related to the number of hospitalisations(r =0.471,p<0.001). The total score of Scale for the Assessment of Positive Symptoms(SAPS) was negatively related to the accuracy of visual working memory(r=-0.388, p=0.005), while t

关键词： working memory visual The

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工作记忆的认知神经机制

生理学报 2019年第1期71卷 173-185页

作者：库逸轩华东师范大学心理与认知科学学院上海200062

工作记忆是短时间维持和控制输入信息的能力,与各种认知功能密切相关。与长时记忆相比,工作记忆的容量和精度都极为有限。以往的研究对容量和精度的认知与计算模型等方面已经有较多的讨论,但关于哪种模型对行为的拟合效果最好、是否存... 详细信息

工作记忆是短时间维持和控制输入信息的能力,与各种认知功能密切相关。与长时记忆相比,工作记忆的容量和精度都极为有限。以往的研究对容量和精度的认知与计算模型等方面已经有较多的讨论,但关于哪种模型对行为的拟合效果最好、是否存在记忆物数量的上限等问题仍存在不同的观点。近年来,与工作记忆相关的脑区和神经机制研究取得了很多进展,但是在参与工作记忆的脑区、神经振荡和分子机制等多个方面,仍然存在激烈的争论。本文对上述的研究进展做了较全面的综述,尤其针对工作记忆的脑区机制提供了我们自己研究积累的证据。进一步阐明反映前馈信息的γ振荡和反馈信息的α/β振荡与感觉皮层和额顶网络信息传递过程的关系,可能对于揭示工作记忆的神经机制起到关键作用。今后深入研究工作记忆相关的分子机制,如多巴胺和血清素等神经递质系统在工作记忆中的作用,可能会推进我们对工作记忆认知神经机制的理解;加强工作记忆在精神分裂症、阿尔茨海默病等疾病诊断中的量化指标,为工作记忆的训练和增强提供潜在的应用价值。

关键词：工作记忆额顶网络感觉参与假说多巴胺经颅磁刺激神经振荡

Neural mechanisms of tactile-visual cross-modal working memory:A single-pulse transcranial magnetic stimulation study

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右侧背外侧前额叶在视觉工作记忆中的因果性作用

中国神经科学学会第十届全国学术会议

作者： Di ZHAO yixuan ku Yong-Di ZHOU Institute of Cognitive Neuroscience School of Psychology and Cognitive ScienceEast China Normal University

Our previous monkey neurophysiological studies and human EEG studies have shown that association cortices,as well as primary sensory cortical areas,play an essential role in sequential neural processes underlying tactile-visual cross-modal working *** the present study,to further examine the neural mechanisms of tactile-visual cross-modal working memory,we applied individual MRI-based single-pulse transcranial magnetic stimulation（TMS） to bilateral primary somatosensory cortices（SI）（left SI,ipsilateral to tactile stimulation;right SI,contralateral） and the right（contralateral to tactile stimulation） posterior parietal cortex（PPC）,while subjects were performing both tactile-tactile uni-modal delayed matching-to-sample and tactile-visual cross-modal delayed matching-to-sample *** points of TMS were 100 ms,200 ms,300 ms,600 ms,900 ms after the onset of the tactile sample stimulus in the ***’ performance was significantly impaired in both the uni-modal and cross-modal tasks when TMS was applied to the contralateral SI at all of these points but *** an effect was not observed when the other two cortical areas were stimulated at the same time points,except stimulation of the right PPC at *** results indicate that SI and PPC play different roles in neural processes of cross-modal information transfer.

关键词： cross-modal TMS primary somatosensory cortex working memory

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心理学报 2018年第7期50卷 727-738页

作者：王思思库逸轩华东师范大学心理与认知科学学院上海200062

以往的影像学研究表明右侧背外侧前额叶皮层(DLPFC)在视觉工作记忆中发挥重要作用,然而缺乏因果性的证据。本研究旨在考察右侧DLPFC的激活与视觉工作记忆容量的因果关系,并探讨这一关系受到记忆负荷的调节及其神经机制。被试接受经颅直... 详细信息

以往的影像学研究表明右侧背外侧前额叶皮层(DLPFC)在视觉工作记忆中发挥重要作用,然而缺乏因果性的证据。本研究旨在考察右侧DLPFC的激活与视觉工作记忆容量的因果关系,并探讨这一关系受到记忆负荷的调节及其神经机制。被试接受经颅直流电刺激之后完成视觉工作记忆变化检测任务,根据被试在虚假刺激情况下从负荷4到负荷6任务记忆容量的增量将被试分为低记忆增长潜力组(简称低潜力组)和高记忆增长潜力组(简称高潜力组),结果发现正性电刺激右侧DLPFC相对于虚假电刺激显著提升了高潜力组被试在低记忆负荷(负荷4)下的记忆容量及其对应的提取阶段的脑电指标SPCN成分。表明右侧DLPFC在视觉工作记忆的提取阶段发挥重要的因果性作用;正性经颅直流电刺激右侧DLPFC可使工作记忆容量高潜力被试获得更多的脑活动增益,并导致更好的行为提升效果。

关键词：视觉工作记忆经颅直流电刺激右侧背外侧前额叶皮层 SPCN 记忆潜力

Neural correlates of visuo-tactile crossmodal paired association learning and memory in humans

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知觉表征精度对工作记忆中抑制干扰能力的影响

中国神经科学学会第十届全国学术会议

作者： Peng GUI yixuan ku Lei LI Xiaojin LI Mark BODNER Yong-Di ZHOU Liping WANG Key laboratory of Brain Functional Genomics MOE & STCSMInstitute of Cognitive NeuroscienceEast China Normal University Department of Electronic Engineering East China Normal University Krieger Mind/Brain Institute Johns Hopkins University

Studies have indicated that distinct cortical sensory systems are able to process information from different sensory ***,it still remains largely unknown when and how these cortical systems integrate and retain information across sensory modalities during *** the present study,we investigated the neural mechanisms underlying visuo-tactile crossmodal associations and memory by using a delayed paired association（PA） learning paradigm and electroencephalographic（EEG） *** the PA task,subjects were required to identify predefined visuo-tactile（crossmodal） or visuo-visual（unimodal） pairs through a process of trial and *** was provided during learning phases,but not during learned *** of different event-related potentials（ERPs） were compared between the learning and learned phases（referred to as learning effects） and between the crossmodal and unimodal tasks（referred to as modal effects）.The N400 ERP component obtained from frontal recording sites between 300-600 ms after the onset of the first stimulus showed learning（but not modal） effects,suggesting the activation of networks that represent the initial stimulus *** contrast,the P400 component in central sites showed both learning and modal effects,indicating that P400 is related to the process of association ***,a late posterior negative slow wave（LPN） was observed from 500-700 ms in posterior sites,which showed learning effects only in the crossmodal *** component may reflect the neural process of the crossmodal association ***,the crossmodal association held in the working memory was represented by alpha-band responses（8-12 Hz） in both the frontal and posterior sites from 800-1500 ms during the late delay *** together,these results provide insights into the temporal dynamics of neural networks that mediate crossmodal association and memory formation.

关键词： cross-modal paired-association learning visuo-tactile LPN working memory

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心理学报 2017年第10期49卷 1247-1255页

作者：刘志英库逸轩华东师范大学心理与认知科学学院上海200062

工作记忆的容量十分有限,需要选择性地抑制与目标无关信息的干扰,工作记忆容量高的个体,其抑制干扰的能力也更强。本研究采用带有不同形状干扰刺激的色块颜色回忆任务考察干扰对工作记忆容量和表征精度的影响,结果发现,当负荷超出工作... 详细信息

工作记忆的容量十分有限,需要选择性地抑制与目标无关信息的干扰,工作记忆容量高的个体,其抑制干扰的能力也更强。本研究采用带有不同形状干扰刺激的色块颜色回忆任务考察干扰对工作记忆容量和表征精度的影响,结果发现,当负荷超出工作记忆容量范围时,干扰减少了记忆所能表征客体的个数;当负荷在工作记忆容量范围内时,干扰降低了记忆中表征客体的精度。更进一步,研究采用独立的知觉任务来测量知觉表征的精度,并探讨作为信息加工的初始阶段的知觉表征如何影响工作记忆加工过程中抑制干扰的能力。将实验中收集的48名有效被试按照知觉表征精度的高低平均分为两组,结果发现上述干扰效应主要表现在知觉表征精度较低的组中,并且该组中知觉表征精度越高的个体,其工作记忆抑制干扰的能力也越强。本研究为实践中通过知觉训练来提升工作记忆的抑制干扰能力提供了理论指导。

关键词：视知觉工作记忆表征精度选择性注意