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Chinese Chemical Letters 2024年第5期35卷 447-452页

作者： Ting Hu Yuxuan Guo yixuan Meng Ze Zhang ji Yu jianxin Cai Zhenyu Yang Key Laboratory of jiangxi Province for Environment and Energy Catalysis School of Chemistry and Chemical EngineeringNanchang UniversityNanchang 330031China

Copper phthalocyanine(CuPc)is adopted as an electrolyte additive to stabilize lithium anode for lithiumsulfur(Li-S)*** with a planar molecular structure and lithiophilic N-containing group,is likely to be adsorbed on the surface of Li anode to form a coating layer,which can restrict the direct contact between Li anode and solvents,and guide the uniform deposition of Li^(+)*** Li||Li symmetric cells demonstrate a stable cycle performance,and Li||Cu cells show high Coulombic *** Li-S batteries,the formed stable solid-electrolyte interface(SEI)film containing copper sulfides can protect Li anode from the polysulfide corrosion and side reactions with the electrolyte,leading to the compact and smooth surface morphology of Li ***,the Li-S batteries with CuPc additive deliver much higher capacity,better cycle performance and rate capability as compared to the one without CuPc additive.

关键词： Copper phthalocyanine Electrolyte additive Stable SEI film Stabilized Li anode Lithium-sulfur batteries

Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics

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Food Science and Human Wellness 2024年第4期13卷 2116-2131页

作者： Yu Peng Xiaoao Xiao Tingting ji Xinyuan Wang yixuan Xu jianbo Xiao Hui Cao Zhiyong Chen Huifan Liu Yuanqing Gao Hongxun Tao Key Laboratory of Cardiovascular and Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China Department of Analytical Chemistry and Food Science Faculty of ScienceUniversity of VigoVigo 36310Spain CISPAC Fontan BuildingCity of CultureSantiago de Compostela 15707Spain Shaanxi Academy of Traditional Chinese Medicine Xi'an 710003China Guangdong Key Laboratory of Science and Technology of Lingnan Specialty Food Zhongkai University of Agriculture and EngineeringGuangzhou 510550China State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu 610075China

Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in ***,our previous work has found that *** extract(RCE)could significantly improve the pathology associated with dextran sulfate sodium-induced ***,the current research aims to reveal the pharmacodynamic material basis of RCE,as well as its mechanism against *** chemical characterization of RCE was performed by UHPLC-HR-MS,through which a total of 88 constituents were ***,our results also found 29 constituents absorbed into blood and 8 metabolized absorbable *** decreased flavonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of *** metabolomics study revealed that colitis caused the alternation of fatty acid metabolism,steroid hormone biosynthesis and bile acid ***,RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism.

关键词： Rhodiola crenulate Colitis Chemical characterization Plasma pharmacochemistry Metabolomics

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日内交易量预测的局部波动模型及其实证研究

中国科学：数学 2021年第11期51卷 1743-1768页

作者：季怡轩徐紫怡程雪北京大学数学科学学院北京100871

本文在辨析3种典型日内交易量预测模型—加和模型、乘积模型和分解优化模型—的理论差异并使用中国市场数据实证检验的基础上,提出一种新的日内交易量预测模型:局部波动模型.在交易量预测和成交量加权平均价(volume weighted average pr... 详细信息

本文在辨析3种典型日内交易量预测模型—加和模型、乘积模型和分解优化模型—的理论差异并使用中国市场数据实证检验的基础上,提出一种新的日内交易量预测模型:局部波动模型.在交易量预测和成交量加权平均价(volume weighted average price,VWAP)策略层面,局部波动模型的稳定性均优于经典的基准方法—历史滚动均值.该模型运算速度快且可实现动态预测,预测精度方面表现良好,仅不及精度最高但速度最慢的乘积模型,且其稳健性优于乘积模型,介于乘积模型和分解优化模型之间.该模型在大盘风格数据上表现较好,且在处理频率较高的数据以及交易量波动较低的数据上具有优势.

关键词：日内交易量预测 VWAP策略分解组合方法局部波动

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Long noncoding RNA H19 inhibits the growth and invasion of trophoblasts by inactivating Wnt/β-catenin signaling via downregulation of DDX3X

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Long noncoding RNA H19 inhibits the growth and invasion of t...

The RING zinc finger protein LbRZF1 promotes salt gland development and salt tolerance in Limonium bicolor

第9届中国中西医结合学会妇产科专业委员会第二次学术会议

作者： Yan Ma Ningxia Sun Fei Sheng yixuan ji Haixia Ding Qing Zhang Shuhan Sun Wen Li

In our study, we highlights the importance of lnc RNA-H19 in the restriction of early placenta overgrowth and the transfer of genetic and epigenetic information from the entire genome. We examined the effects of H19 on the proliferation and invasion of human trophoblasts. To further explore the mechanism, RNA pulldown and mass spectrometry were used to identify lnc RNA-H19-binding proteins in human trophoblasts. In addition, changes in methylation of the H19 promoter region were determined using pyrophosphate sequencing *** results indicate that lnc RNA-H19 was upregulated in the spontaneous abortion samples, consistent with the hypomethylation of the differential methylation region(DMR) of lnc RNA-H19. Overexpression of lnc RNA-H19 inhibited trophoblast growth and invasion. Furthermore, our studies demonstrated that H19 inhibited Wnt-β-catenin pathway activation in trophoblasts by affecting DDX3 X function, thus clarifying the mechanism of action of H19.

关键词： Long noncoding RNA H19 early unexplained miscarriage trophoblast DDX3X Wnt-β-catenin signalling

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Journal of Integrative Plant Biology 2024年第4期66卷 787-809页

作者： Zongran Yang Ziwei Zhang Ziqi Qiao Xueying Guo yixuan Wen Yingxue Zhou Chunliang Yao Hai Fan Baoshan Wang Guoliang Han Shandong Provincial Key Laboratory of Plant Stress College of Life SciencesShandong Normal UniversityJi'nan 250014China National Center of Technology Innovation for Comprehensive Utilization of Saline-Alkali Land Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta of Shandong ProvinceDongying 257000China Dongying Institute Shandong Normal UniversityDongying 257000China

The recretohalophyte Limonium bicolor thrives in high-salinity environments because salt glands on the above-ground parts of the plant help to expel excess ***,we characterize a nucleus-localized C3HC4(RING-HC)-type zinc finger protein of *** named RING ZINC FINGER PROTEIN 1(LbRZF1).LbRZF1 was expressed in salt glands and in response to NaCl ***1 showed no E3 ubiquitin ligase *** phenotypes of overexpression and knockout lines for LbRZF1 indicated that LbRZF1 positively regulated salt gland development and salt tolerance in ***1 mutants had fewer salt glands and secreted less salt than did the wild-type,whereas LbRZF1-overexpressing lines had opposite phenotypes,in keeping with the overall salt tolerance of these plants.A yeast two-hybrid screen revealed that LbRZF1 interacted with LbCATALASE2(LbCAT2)and the transcription factor LbMYB113,leading to their *** of LbCAT2 or LbMYB113 decreased salt gland density and salt *** heterologous expression of LbRZF1 in Arabidopsis thaliana conferred salt tolerance to this *** also identified the transcription factor LbMYB48 as an upstream regulator of LbRZF1 *** study of LbRZF1 in the regulation network of salt gland development also provides a good foundation for transforming crops and improving their salt resistance.

关键词： LbRZF1 Limonium bicolor molecular mechanism salt gland development salt tolerance

An organometallic salt as the electrolyte additive to regulate lithium polysulfide redox and stabilize lithium anodes for robust lithium-sulfur batteries

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Science China Materials 2024年第9期67卷 2880-2888页

作者： yixuan Meng Meifang Zhang Youliang Wang Chen Liu Ze Zhang ji Yu jianxin Cai Zhenyu Yang Key Laboratory of jiangxi Province for Environment and Energy Catalysis School of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031China Institute of Carbon Neutral New Energy Research Yuzhang Normal UniversityNanchang330031China School of Biological and Chemical Engineering Zhejiang University of Science and TechnologyHangzhou310023China

Lithium-sulfur(Li-S)batteries with high theoretical specific energy are considered to be one of the highly promising next-generation energy storage ***,the shuttle effect of lithium polysulfides(LiPSs)and the interfacial instability of Li anodes have seriously hindered the practical application of Li-S *** the electrolyte composition with additives can significantly improve the battery performance and has attracted great ***,we propose an organometallic salt,i.e.,nickel bromide dimethoxyethane(NiBr_(2)DME),as an electrolyte additive,which serves as the dual function of regulating LiPSs redox and synchronously stabilizing Li *** reveal that NiBr_(2)DME can interact with LiPSs via Ni-S and Li-Br bonds,and accelerate the mutual transformation of LiPSs,thus reducing the accumulation of LiPSs in the *** addition,NiBr_(2)DME can form a stable LiBr-containing interfacial layer on the Li metal surface,and promote the uniform electrodeposition of Li^(+)ions,and inhibit the formation of Li ***,Li-S batteries with a concentration of 0.5 mmol L^(-1)NiBr_(2)DME show an initial capacity of 919.8 mAh g^(-1)at 0.2 C,and a high capacity retention of 89.3%after 100 *** at the 4 C rate,a high discharge capacity of 602.9 mAh g^(-1)is ***,the good cycling performance is maintained under poor electrolyte conditions with sulfur loading of 4.8 mg cm^(-2)and electrlyte/sulfur ratio of 5µL mg^(-1).This work provides a positive solution to achieve the suppression of shuttle effect,the regulation of LiPSs redox and the stabilization of Li anodes.

关键词： Li-S batteries electrolyte additive nickel bromide dimethoxyethane regulating LiPSs redox stabilizing Li anode

卵巢恶性生殖细胞肿瘤患者的预后分析:一项基于数据库的回顾性研究

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中华生殖与避孕杂志 2018年第5期38卷 375-379页

作者：纪逸萱盛菲马妍丁海遐章青李文第二军医大学长征医院生殖医学中心上海200003

目的分析不同临床病理特征的卵巢恶性生殖细胞肿瘤(MOGCTs)患者预后。方法选取监测、流行病学和结果数据库(SEER)中MOGCTs的患者的临床病理数据共2 801例进行分析。用Kaplan-Meier法绘出生存曲线,log-rank检验单因素分析预后影响因素,Co... 详细信息

目的分析不同临床病理特征的卵巢恶性生殖细胞肿瘤(MOGCTs)患者预后。方法选取监测、流行病学和结果数据库(SEER)中MOGCTs的患者的临床病理数据共2 801例进行分析。用Kaplan-Meier法绘出生存曲线,log-rank检验单因素分析预后影响因素,Cox回归模型进行多因素分析。结果单因素分析显示:MOGCTs预后与年龄(c^2=93.119,P=0.000)、种族(c^2=12.894,P=0.002)、病理类型(c^2=316.287,P=0.000)、肿瘤分化(c^2=27.476,P=0.000)、国际妇产科联盟(FIGO)分期(c^2=187.837,P=0.000)、肿瘤位置(c^2=36.959,P=0.000)、肿瘤大小(c^2=319.981,P=0.000)、淋巴结转移(c^2=20.849,P=0.000)和手术方式(c^2=170.370,P=0.000)等有关。多因素分析显示MOGCTs预后与FIGO分期(P=0.004,95%CI=1.204~2.603)、病理类型(P=0.010,95%CI=1.109~2.144)、发病年龄(P=0.009,95%CI=1.340~7.584)有关。结论 FIGO分期、病理类型和发病年龄高是MOGCTs其预后的独立危险因素。

关键词：卵巢卵巢恶性生殖细胞肿瘤(MOGCTs) 预后

基于测速测距激光雷达的飞行器地形匹配导航方法

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中国惯性技术学报 2024年第1期32卷 8-15页

作者：桑洋纪新春魏东岩尤逸轩张文超袁洪中国科学院空天信息创新研究院北京100094 中国科学院大学电子电气与通信工程学院北京100049 西北工业大学电子信息学院西安710129

针对中低空飞行器地形匹配与惯导组合中惯导误差累积导致高程图变形限制地形匹配精度、二维地形匹配运算量大和地形匹配失效时定位可用性差的问题,提出一种基于测速测距激光雷达的地形匹配导航方法。利用激光测速信息辅助构建高程图,减... 详细信息

针对中低空飞行器地形匹配与惯导组合中惯导误差累积导致高程图变形限制地形匹配精度、二维地形匹配运算量大和地形匹配失效时定位可用性差的问题,提出一种基于测速测距激光雷达的地形匹配导航方法。利用激光测速信息辅助构建高程图,减小高程图变形从而提高匹配精度,同时降低匹配结果与惯导的相关性;设计集成尺度不变特征变换(SIFT)特征与分步核验的地形匹配算法,提高匹配的实时性;采用激光测速信息辅助校正惯导,提高地形匹配失效时定位的可用性。典型场景地形数据的测试结果表明,基于激光测速辅助构建的高程图较基于惯导构建的高程图的地形匹配定位精度提高了36.6%,所提的卡方初始化随机抽样一致性地形特征误匹配检测算法(TCI-RANSAC)相比于RANSAC算法缩短了55.6%的核验时间,且测速信息的引入将组合定位精度提高了65.9%,具备较高的工程应用价值。

关键词：飞行器测速测距激光雷达地形匹配导航组合导航高程图构建特征匹配核验

Distributed intelligent self-organized mission planning of multi-UAV for dynamic targets cooperative search-attack

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Chinese Journal of Aeronautics 2019年第12期32卷 2706-2716页

作者： Ziyang ZHEN Ping ZHU yixuan XUE Yuxuan ji College of Automation Engineering Nanjing University of Aeronautics and Astronautics

This article studies the cooperative search-attack mission problem with dynamic targets and threats, and presents a Distributed Intelligent Self-Organized Mission Planning(DISOMP)algorithm for multiple Unmanned Aerial Vehicles(multi-UAV). The DISOMP algorithm can be divided into four modules: a search module designed based on the distributed Ant Colony Optimization(ACO) algorithm, an attack module designed based on the Parallel Approach(PA)scheme, a threat avoidance module designed based on the Dubins Curve(DC) and a communication module designed for information exchange among the multi-UAV system and the dynamic environment. A series of simulations of multi-UAV searching and attacking the moving targets are carried out, in which the search-attack mission completeness, execution efficiency and system suitability of the DISOMP algorithm are analyzed. The simulation results exhibit that the DISOMP algorithm based on online distributed down-top strategy is characterized by good flexibility, scalability and adaptability, in the dynamic targets searching and attacking problem.

关键词： Ant Colony Optimization(ACO) Cooperative control Mission planning Search-attack integration Self-organized Unmanned Aerial Vehicle(UAV)

新辅助免疫联合治疗在局部晚期头颈部鳞状细胞癌的应用进展

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中华肿瘤防治杂志 2024年第15期31卷 968-974页

作者：马艺轩李晓娟靳晴纪鸾乔俏中国医科大学第二临床学院中国医科大学第一临床学院中国医科大学附属第一医院放疗科

目的总结新辅助免疫联合治疗方式在局部晚期头颈部鳞状细胞癌(LA-HNSCC)中的最新研究成果与临床应用现状，为优化综合治疗方案、改善LA-HNSCC患者的治疗效果和生活质量提供参考依据。方法以“头颈部肿瘤、鳞状细胞癌、新辅助治疗、免... 详细信息

目的总结新辅助免疫联合治疗方式在局部晚期头颈部鳞状细胞癌(LA-HNSCC)中的最新研究成果与临床应用现状，为优化综合治疗方案、改善LA-HNSCC患者的治疗效果和生活质量提供参考依据。方法以“头颈部肿瘤、鳞状细胞癌、新辅助治疗、免疫治疗、新辅助联合治疗、生物标志物、毒副反应”为中文关键词，以“head and neck neoplasm、squamous cell carcinoma、neoadjuvant therapy、Immunotherapy、neoadjuvant combination therapy、biomarkers、toxic and side effects”为英文关键词，检索PubMed数据库和维普数据库2010年10月-2023年8月发表的关于LA-HNSCC新辅助免疫联合治疗方面的文献。纳入标准：(1)LA-HNSCC;(2)新辅助联合免疫治疗。排除标准：(1)会议性、评论类等文献；(2)鼻咽癌相关的文献。共纳入47篇文献，其中中文文献5篇，英文文献42篇。结果基于新辅助免疫治疗的联合治疗有利于LA-HNSCC患者实现病理缓解，3个周期后病理完全缓解(pCR)率为37.0%～100%,主要病理缓解(MPR)率为40%～100%。实现病理缓解的HNSCC患者较非病理缓解者的无病生存期和总生存期更长，且差异均有统计学意义。程序性死亡配体1(PD-L1)高表达和HPV相关HNSCC作用更为明显，PD-L1高表达者客观缓解率为68.2%～100%,HPV相关HNSCC患者pCR率和MPR率分别为90%和100%。从新辅助免疫联合治疗HNSCC的毒副作用来看，3～4级治疗相关不良事件偶见，未见治疗相关死亡病例，整体可控。结论新辅助免疫联合治疗LA-HNSCC可有效提高肿瘤的客观反应率，且对PD-L1高表达及HPV相关HNSCC作用更为明显。然而新辅助免疫联合治疗对LA-HNSCC长期生存的益处有待进一步研究。

关键词：头颈部肿瘤鳞状细胞癌新辅助治疗免疫治疗新辅助联合治疗生物标志物毒副作用综述文献