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两种血吸虫病免疫诊断试剂盒现场筛查效果的对比研究

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中国血吸虫病防治杂志 2006年第3期18卷 192-196页

作者：孙乐平洪青标黄轶昕梁幼生徐明张联恒高扬周明杨坤朱荫昌江苏省血吸虫病防治研究所无锡214064 江苏省镇江市疾病预防控制中心江苏省扬州市血吸虫病防治所江苏省无锡市疾病预防控制中心

目的评价胶体染料试纸条法（DDIA）和酶联免疫吸附试验（ELISA）两种试剂盒在血吸虫病现场防治中的筛查价值. 方法受检对象采取整群抽样,按照单盲试验的原则,先同时进行DDIA和ELISA血清学检测,再对血清学阳性者采用粪便尼龙绢集卵孵化法... 详细信息

目的评价胶体染料试纸条法（DDIA）和酶联免疫吸附试验（ELISA）两种试剂盒在血吸虫病现场防治中的筛查价值. 方法受检对象采取整群抽样,按照单盲试验的原则,先同时进行DDIA和ELISA血清学检测,再对血清学阳性者采用粪便尼龙绢集卵孵化法（1送1检）进行病原学检查,配对比较两种试剂盒的筛查效果和效率.结果在11个流行村配对检测12 881人, ELISA阳性912例,平均阳性率为7.08%（0.84%～21.50%）;DDIA阳性707例,平均阳性率为5.49%（0.44%～17.83%）,ELISA法显著高于DDIA法（χ^2=27.698,P〈0.01）;两法双阳性383例,双阴性11 645例,总符合率为93.38%,检出结果呈中度一致（kappa=0.438）.两种试剂盒在未控制地区筛出的阳性数差异无显著性（χ^2=3.498,P =0.061）,在已控制地区筛出的阳性数ELISA明显高于DDIA（χ^2=33.393,P〈0.01）.在血清学阳性的885例（ELISA）和615例（DDIA）中分别查出粪孵阳性病人25例和27例,用DDIA法筛查减少粪检270人,却多查出2例粪阳病人.DDIA和ELISA法每人每日完成检测样本数分别为473份和174份,DDIA法的检测工作效率是ELISA法的2.72倍. 结论两种试剂盒均可用于血吸虫病现场筛查,但DDIA试剂盒的筛查效率优于ELISA试剂盒.

关键词：日本血吸虫病胶体染料试纸条法酶联免疫吸附试验筛查效果配对比较

基于网络药理学和分子对接研究红花治疗阿尔茨海默病的作用机制

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中医药信息 2023年第2期40卷 53-60页

作者：谭冬娴陈棉海郭晋言黄一兴肖越陈倩文周玉其张维炊杜以宽杨春广东医科大学东莞市干细胞与再生组织重点实验室广东东莞523808 东莞市人民医院广东东莞523059

目的:运用网络药理学和分子对接的方法研究红花治疗阿尔茨海默病(AD)的作用机制。方法:通过查阅文献和数据库获取红花的有效药物成分,利用数据库预测红花的成分靶点与AD的靶点,并对红花靶标基因进行标准化。运用Cytoscape 3.7.2软件构... 详细信息

目的:运用网络药理学和分子对接的方法研究红花治疗阿尔茨海默病(AD)的作用机制。方法:通过查阅文献和数据库获取红花的有效药物成分,利用数据库预测红花的成分靶点与AD的靶点,并对红花靶标基因进行标准化。运用Cytoscape 3.7.2软件构建“红花-成分-靶点”网络,利用红花的靶标基因与AD的靶标基因的交集基因构建蛋白相互作用(PPI)网络。通过DAVID数据库进行GO分析和KEGG富集分析,最后利用Ledock软件对关键成分与核心靶点进行分子对接。结果:获得21种红花有效成分和391个作用靶点,AD的疾病靶点535个,其中红花与AD的共同作用靶点有94个。共得到535个GO分析,43个KEGG通路,主要涉及阿尔茨海默病信号通路、ErbB信号通路、5-羟色胺能突触、癌症中的蛋白多糖等;分子对接结果显示,核心成分与关键靶点具有良好的结合能力。结论:红花治疗由微循环障碍引起的AD的潜在作用机制,且具有多成分、多靶点、多通路的特点。

关键词：红花阿尔茨海默病网络药理学作用机制分子对接

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江滩地区人畜血吸虫病流行因素定量研究

中国血吸虫病防治杂志 1997年第3期9卷 143-145页

作者：孙乐平周晓农洪青标曹奇黄轶昕吴久东万立新江苏省血吸虫病防治研究所无锡214064 江苏省江浦县血吸虫病防治站

本文对江滩地区6个自然村的血吸虫病流行因素进行了定量研究，结果表明：江滩野粪密度与耕牛感染率和居民感染率呈正相关，相关系数检验结果非常显著（r1＝0．9344，r2＝0．8183，P值均＜0．01），其回归方程为：y1＝6．7808＋25．6486x... 详细信息

本文对江滩地区6个自然村的血吸虫病流行因素进行了定量研究，结果表明：江滩野粪密度与耕牛感染率和居民感染率呈正相关，相关系数检验结果非常显著（r1＝0．9344，r2＝0．8183，P值均＜0．01），其回归方程为：y1＝6．7808＋25．6486x1；y2＝2．1998＋3．3386x2；钉螺自然感染率与居民感染率呈正相关，相关系数检验结果亦非常显著（r3＝0．9540，P＜0．01），其回归方程为y3＝1．3743＋2．6255x3。提示江滩型地区控制居民血吸虫感染率，首先应消灭阳性钉螺，其次为减少滩地人畜粪便污染。

关键词：日本血吸虫感染率相关系数

全球气候变暖对中国血吸虫病传播影响的研究 II.钉螺越夏致死高温与夏蛰的研究

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中国血吸虫病防治杂志 2003年第1期15卷 24-26页

作者：洪青标周晓农孙乐平杨国静杨坤黄轶昕江苏省血吸虫病防治研究所无锡214064 中国疾病预防控制中心寄生虫病预防控制所

目的　研究全球气候变暖对中国大陆钉螺分布的潜在影响 ,探讨钉螺适生性中的生态因子之一的越夏致死高温和夏蛰现象。方法　对采自江苏省江滩地区的湖北钉螺指名亚种 (***-sis hupensis) ,采用实验室模拟自然环境逐步改变温度的方法 ,... 详细信息

目的　研究全球气候变暖对中国大陆钉螺分布的潜在影响 ,探讨钉螺适生性中的生态因子之一的越夏致死高温和夏蛰现象。方法　对采自江苏省江滩地区的湖北钉螺指名亚种 (***-sis hupensis) ,采用实验室模拟自然环境逐步改变温度的方法 ,测定钉螺的越夏致死高温 ,并观察其夏蛰现象等。结果　钉螺在干燥和潮湿环境中的半数致死高温 (L T50 )分别为 4 0 .0 1℃ (95 %可信区间为 39.76 - 4 0 .2 7℃ )和 4 2 .13℃ (95 %可信区间为 4 1.5 9- 4 2 .6 8℃ )。高温和钉螺死亡率的回归趋势可分别拟合 logistic方程为 :Y干 =10 1/ (1+e6 1 .4 0 2 2 6 9- 1 .5350 58X) (F=6 9.997,P<0 .0 0 1) 潮 =10 1/ (1+e76 .4 4582 5- 1 .84 2 0 6 8X) (F=2 4 .6 99,P<0 .0 0 1)高温对钉螺的活动抑制较明显 ,39℃时 10 0 %钉螺呈闭厣状态 ,但仅有 14 .94 %的钉螺出现夏蛰现象 ;即使温度上升至 4 0℃ ,也仅为 2 7.78%的钉螺表现出夏蛰状态。结论　部分钉螺可表现出夏蛰现象 ,但似乎没有冬眠现象普遍 ;处于潮湿环境中的钉螺比在干燥环境中 ,对极限高温的耐受性更强些。

关键词：全球气候变暖中国血吸虫病传播钉螺

全球气候变暖对中国血吸虫病传播影响的研究 Ⅰ.钉螺冬眠温度与越冬致死温度的测定

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中国血吸虫病防治杂志 2002年第3期14卷 192-195页

作者：洪青标周晓农孙乐平杨国静黄轶昕杨坤江苏省血吸虫病防治研究所无锡214064 中国预防医学科学院寄生虫病研究所

目的　研究气候变暖对中国大陆钉螺分布的潜在影响 ,实验测定钉螺适生性中的重要因子冬眠温度和越冬致死温度。方法　现场采集江苏省湖沼地区的湖北钉螺指名亚种 (***) ,在实验室采用模拟自然环境逐步改变温度的方法分别进行实验测定。... 详细信息

目的　研究气候变暖对中国大陆钉螺分布的潜在影响 ,实验测定钉螺适生性中的重要因子冬眠温度和越冬致死温度。方法　现场采集江苏省湖沼地区的湖北钉螺指名亚种 (***) ,在实验室采用模拟自然环境逐步改变温度的方法分别进行实验测定。结果　钉螺半数冬眠温度 (ET50 )为 5 .87℃ (95 %可信区间为 5 .3 2 -6.2 3℃ ) ;13℃以下温度与钉螺冬眠率间的 logistic回归方程为 :Y=10 1/(1+ e0 .83 73 0 4x-5.44 2 476) (F =3 5 7.85 4,P<0 .0 0 1)。钉螺在干燥和潮湿环境中的低温半数致死温度 (L T50 )分别为 -2 .3 4℃ (95 %可信区间为 -2 .19℃至 -2 .5 1℃ )和 -2 .72℃ (95 %可信区间为 -2 .5 4℃至 -2 .91℃ ) ,低温和钉螺死亡率间的 logistic回归方程分别为 :Y干 =10 1/(1+e1 .3 3 54 99x+3 .3 3 8748) (F =5 7.677,P<0 .0 0 1) ;Y潮 =10 1/(1+ e0 .92 1 0 3 4 x+2 .763 1 0 2 ) (F =69.866,P<0 .0 0 1)。结论　 11℃以下钉螺开始出现冬眠现象 ;

关键词：全球气候变暖中国血吸虫病钉螺冬眠温度越冬致死温度

A near-complete genome assembly of the allotetrapolyploid Cenchrus fungigraminus(JUJUNCAO)provides insights into its evolution and C4 photosynthesis

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Plant Communications 2023年第5期4卷 324-341页

作者： Huakun Zheng Baiyu Wang Xiuting Hua Ruiting Gao Yuhao Wang Zixin Zhang yixing Zhang Jing Mei Yongji huang Yumin huang Hui Lin Xingtan Zhang Dongmei Lin Siren Lan Zhongjian Liu Guodong Lu Zonghua Wang Ray Ming Jisen Zhang Zhanxi Lin National Engineering Research Center of JUNCAO Technology College of Life ScienceFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources Guangxi Key Laboratory of Sugarcane BiologyGuangxi UniversityNanning 530004GuangxiChina Center for Genomics Fujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyKey Laboratory of GeneticsBreeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350002China Fuzhou Institute of Oceanography Minjiang UniversityFuzhou 350108China

JUJUNCAO(Cenchrus fungigraminus;2n=4x=28)is a Cenchrus grass with the highest biomass production among cultivated plants,and it can be used for mushroom cultivation,animal feed,and biofuel ***,we report a nearly complete genome assembly of JUJUNCAO and reveal that JUJUNCAO is an allopolyploid that originated2.7 million years ago(mya).Its genome consists of two subgenomes,and subgenome A shares high collinear synteny with pearl *** also investigated the genome evolution of JUJUNCAO and suggest that the ancestral karyotype of Cenchrus split into the A and B ancestral karyotypes of *** transcriptome and DNA methylome analyses revealed functional divergence of homeologous gene pairs between the two subgenomes,which was a further indication of asymmetric DNA *** three types of centromeric repeat in the JUJUNCAO genome(CEN137,CEN148,and CEN156)may have evolved independently within each subgenome,with some introgressions of CEN156 from the B to the A *** investigated the photosynthetic characteristics of JUJUNCAO,revealing its typical C4 Kranz anatomy and high photosynthetic ***-ME and PEPCK appear to cooperate in the major C4 decarboxylation reaction of JUJUNCAO,which is different from other C4 photosynthetic subtypes and may contribute to its high photosynthetic efficiency and biomass *** together,our results provide insights into the highly efficient photosynthetic mechanism of JUJUNCAO and provide a valuable reference genome for future genetic and evolutionary studies,as well as genetic improvement of Cenchrus grasses.

关键词： genome assembly allotetrapolyploid centromere architecture evolutionary trajectory photosynthetic efficiency Cenchrus grass

Developmental systems biology flourishing on new technologies

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Journal of Genetics and Genomics 2008年第10期35卷 577-584页

作者： Jing-Dong J. Han Yi Liu Huiling Xue Kai Xia Hong Yu Shanshan Zhu Zhang Chen Wei Zhang Zheng huang Chunyu Jin Bo Xian Jing Li Lei Hou yixing Han Chaoqun Niu Timothy C. Alcon Chinese Academy of Sciences Key Laboratory of Molecular Developmental Biology Center for Molecular Systems Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Machine Perception （Ministry of Education） Peking University Beijing 100871 China Bioinformatics and Computational Biology Graduate Program Iowa State University Ames IA 50011-1040 USA

Organism development is a systems level process. It has benefited greatly from the recent technological advances in the field of systems biology. DNA microarray, phenome, interactome and transcriptome mapping, the new generation of deep sequencing technologies, and faster and better computational and modeling approaches have opened new frontiers for both systems biologists and developmental biologists to reexamine the old developmental biology questions, such as pattern formation, and to tackle new problems, such as stem cell reprogramming. As showcased in the International Developmental Systems Biology Symposium organized by Chinese Academy of Sciences, developmental systems biology is flourishing in many perspectives, from the evolution of developmental systems, to the underlying genetic and molecular pathways and networks, to the genomic, epigenomic and noncoding levels, to the computational analysis and modeling. We believe that the field will continue to reap rewards into the future with these new approaches.

关键词： developmental systems biology new technologies symposium

Validation and Scenario Analysis of a Soil Organic Carbon Model

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Agricultural Sciences in China 2002年第4期1卷 417-423页

作者： huang Yao, LIU Shi-Hang, SHEN Qi-rong, ZONG Liang-gang, JIANG Ding-an and huang Hong-guang(College of Resource and Environmental Sciences , Nanjing Agricultural University, Nanjing 210095 , P,R. China Institute of Atmospheric Physics , Chinese Academy of Sciences , Beijing 100029 , P. R . China Agricultural Bureau of yixing City, yixing 214209 , P.R. China ) College of Resource and Environmental Sciences Nanjing Agricultural University Nanjing 210095 P.R. China Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 P.R. China College of Resource and Environmental Sciences Nanjing Agricultural University Nanjing 210095 P.R. China Agricultural Bureau of yixing City Yixing 214209 P. R . China

A model developed by the authors was validated against independent data sets. The data sets were obtained from field experiments of crop residue decomposition and a 7-year soil improvement in yixing City, Jiangsu Province. Model validation indicated that soil organic carbon dynamics can be simulated from the weather variables of temperature, sunlight and precipitation, soil clay content and bulk density, grain yield of previous crops, qualities and quantities of the added organic matter. Model simulation in general a-greed with the measurements. The comparison between computed and measured resulted in correlation coefficient γ2 values of 0.9291* * * (n= 48) and 0.6431* * (n = 65) for the two experiments, respectively. Model prediction under three scenarios of no additional organic matter input, with an annual incorporation of rice and wheat straw at rates of 6.75t/ha and 9.0t/ha suggested that the soil organic carbon in Wanshi Township of yixing City would be from an initial value of 7.85g/kg in 1983 to 6.30g/kg, 11.42g/kg and 13g/kg in 2014, respectively. Consequently, total nitrogen content of the soil was predicted to be respectively 0.49g/kg, 0.89g/kg and 1.01g/kg under the three scenarios.

关键词： Agricultural soils Organic carbon Simulation model Validation Scenario analysis

DeST 3.0:A new-generation building performance simulation platform

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Building Simulation 2022年第11期15卷 1849-1868页

作者： Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei yixing Chen Jinqing Peng Building Energy Research Center School of ArchitectureTsinghua UniversityBeijing 100084China School of Architecture Southeast UniversityNanjingJiangsu 210096China School of Environment and Energy Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China College of Civil Engineering Hunan UniversityChangshaHunan 410082China School of Mechanical Engineering Tongji UniversityShanghai200092China Beijing Key Lab of Heating Gas SupplyVentilating and Air Conditioning EngineeringBeijing University of Civil Engineering and ArchitectureBeijing 100044China China State Construction Technology Center Beijing 101320China School of Architecture Harbin Institute of TechnologyHarbinHeilongjiang 150090China School of Architecture Xi'an University of Architecture and TechnologyXi'anShaanxi 710055China School of Architecture South China University of TechnologyGuangzhouGuangdong 510641China Institute of Building Environment and Energy China Academy of Building ResearchBeijing 100013China Beijing Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China Key Lab of Built Environment and Energy of Tianjin School of Environmental Science and EngineeringTianjin UniversityTianjin 300350China School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Civil Engineering Guangzhou UniversityGuangzhou 510006China Faculty of Computing Harbin Institute of TechnologyHarbinHeilongjiang 150001China Beijing Glory PKPM Technology Co. Ltd.Beijing 100013China Beijing Tangent Software Co. LtdBeijing 100081China Shanghai Huadianyuan Information Technology Co. LtdShanghai200092China Luoyang Hongye Information Technology Co. Ltd.LuoyangHenan 471822China

Buildings contribute to almost 30%of total energy consumption *** building energy modeling programs is of great significance for lifecycle building performance assessment and *** in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and *** meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and *** structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing *** 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation *** 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study *** 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and *** new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization.

关键词： DeST building performance simulation building energy modeling