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Expression of IL-10 and TNF-α in Rats with Cerebral Infarction after Transplantation with Mesenchymal Stem Cells

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Cellular & Molecular Immunology 2009年第3期6卷 207-213页

作者： Nan Liu Ronghua Chen Houwei Du Jiehua Wang yixian zhang Jinsen Wen Department of Neurology Union Hospital Fujian Medical University Fuzhou 350001 China

We investigated the effects of bone marrow-derived mesenchymal stem cells （MSCs） transplantation on the recovery of neurological functions in rat＇s MCAO （middle cerebral artery occlusion） model and its mechanism. MSCs were isolated from bone marrow of male Sprague Dawley （SD） rats. Female adult SD rats were randomly assigned into 4 groups： sham-operated group, MCAO group, vehicle group and MCAO ＋ MSCs-treated group. MSCs were injected into the lateral ventricle of rats in the MSCs-treated group and the same volume of PBS was given to the vehicle group. The expressions of IL-10 and TNF-α were assayed by RT-PCR and ELISA detections at day 1 and 4 after MCAO. The infarction volume was measured by TTC-staining. All rats underwent behavioral tests before, as well as 1, 4, and 14 days after MCAO. MSCs significantly improved functional recovery compared with the control at day 14 after transplantation. Compared with the MCAO group and the vehicle group, the expression of IL-10 mRNA and its protein level in the MSCs group significantly upregulated. However, the expression of TNF-α at day 4 after MCAO in the MSCs group significantly decreased compared with that of the MCAO group and the vehicle group. As a result, transplantation with MSCs significantly decreased infarct volume at day 1 and 4. This study strongly suggested transplantation with MSCs could reduce neuronal injury post focal cerebral ischemia in rats partly by regulating the expressions of IL-10 and TNF-α in the brain.

关键词： Cerebral infarction MSC IL-10 TNF-α

COVID-19 Public Opinion and Emotion Monitoring System Based on Time Series Thermal New Word Mining

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Computers, Materials & Continua 2020年第9期64卷 1415-1434页

作者： yixian zhang Jieren Cheng Yifan Yang Haocheng Li Xinyi Zheng Xi Chen Boyi Liu Tenglong Ren Naixue Xiong School of Information and Communication Engineering Hainan UniversityHaikou570100China School of Computer Science and Cyberspace Security Hainan UniversityHaikou570100China University of Chinese Academy of Sciences Shenzhen518000China National University of Defense Technology Changsha410000China Department of Mathematics and Computer Science Northeastern State UniversityTahlequahUSA

With the spread and development of new epidemics,it is of great reference value to identify the changing trends of epidemics in public *** designed and implemented the COVID-19 public opinion monitoring system based on time series thermal new word mining.A new word structure discovery scheme based on the timing explosion of network topics and a Chinese sentiment analysis method for the COVID-19 public opinion environment are *** a“Scrapy-Redis-Bloomfilter”distributed crawler framework to collect *** system can judge the positive and negative emotions of the reviewer based on the comments,and can also reflect the depth of the seven emotions such as Hopeful,Happy,and ***,we improved the sentiment discriminant model of this system and compared the sentiment discriminant error of COVID-19 related comments with the Jiagu deep learning *** results show that our model has better generalization ability and smaller discriminant *** designed a large data visualization screen,which can clearly show the trend of public emotions,the proportion of various emotion categories,keywords,hot topics,etc.,and fully and intuitively reflect the development of public opinion.

关键词： COVID-19 public opinion monitoring data mining Chinese sentiment analysis data visualization

Experimental measurements of surgical microenvironments in two operating rooms with laminar airflow and mixing ventilation systems

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Energy and Built Environment 2021年第2期2卷 149-156页

作者： Guangyu Cao Ingeborg Kvammen Thea Amalie Solberg Hatten yixian zhang Liv-Inger Stenstad Gabriel Kiss Jan Gunnar Skogås Department of Energy and Process Engineering Norwegian University of Science and TechnologyKolbjørn Hejes Vei 1B7491 TrondheimNorway Faculty of Urban Construction and Environmental Engineering Chongqing UniversityChongqing 40045China Operating Room of the Future at St.Olavs Hospital St.Olavs HospitalOlav Kyrres Gate 107030 TrondheimNorway

At present,laminar airflow(LAF)systems and mixing ventilation(MV)systems are two commonly used ventila-tion solutions for operating rooms(ORs)to ensure the required indoor air ***,recent studies have shown that there is little difference in the prevalence of surgical site infection(SSI)for the LAF systems and MV *** objective of this study was to compare the performance of an LAF system with an MV system in ORs at *** hospital,*** this study,all the experimental measurements were conducted in real ORs with LAF and MV *** study found that the air velocity above the surgical incision is approximately two times higher in the OR with LAF than that in the OR with *** use of surgical lamps and different airflow patterns may contribute to the different surgical microenvironment of ORs with LAF and MV.

关键词： Operating room Laminar airflow Mixing ventilation Surgical microenvironment Thermal environment

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上海郊区宅基地置换试点模式及案例研究

城市规划 2010年第5期34卷 59-65,96页

作者：张娴中国城市规划设计研究院城市规划师

2004年7月开始实施的上海郊区宅基地置换试点,是促进郊区城市化发展的具有试验性的公共政策。按照试点选择及运作特点,将宅基地置换试点归纳为四类模式并选择其中的典型案例进行比较研究,有利于分析置换试点在不同社会经济条件下的运行... 详细信息

2004年7月开始实施的上海郊区宅基地置换试点,是促进郊区城市化发展的具有试验性的公共政策。按照试点选择及运作特点,将宅基地置换试点归纳为四类模式并选择其中的典型案例进行比较研究,有利于分析置换试点在不同社会经济条件下的运行机制、政策绩效和面临的问题,总结试点经验并提出可行建议。

关键词：上海郊区城市化宅基地置换试点模式

Orthogroup and phylotranscriptomic analyses identify transcription factors involved in the plant cold response:Acase study of Arabidopsis BBX29

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Plant Communications 2023年第6期4卷 148-162页

作者： Shuo Wang Yirong Shen Deyin Deng Liangyu Guo yixian zhang Yuqi Nie Yunfei Du Xijuan Zhao Xiaoxue Ye Jianqin Huang Huahong Huang Jian-Kang Zhu Wenwu Wu State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityLin’an 311300HangzhouChina Institute of Tropical Biosciences and Biotechnology Chinese Academy of Tropical Agricultural SciencesHaikou 571101China Institute of Advanced Biotechnology and School of Life Sciences Southern University of Science and TechnologyShenzhen 518055China Center for Advanced Bioindustry Technologies Chinese Academy of Agricultural SciencesBeijing 100081China

C-repeat binding factors(CBFs)are well-known transcription factors(TFs)that regulate plant cold *** sequencing(RNA-seq)data from diverse plant species provide opportunities to identify other TFs involved in the cold ***,this task is challenging because gene gain and loss has led to an intertwined community of co-orthologs and in-paralogs between and within *** orthogroup(closely related homologs)analysis,we identified 10,549 orthogroups in five representative eudicots.A phylotranscriptomic analysis of cold-treated seedlings from eudicots identified 35 high-confidence conserved cold-responsive transcription factor orthogroups(CoCoFos).These 35 CoCoFos included the well-known cold-responsive regulators CBFs,HSFC1,ZAT6/10,and CZF1 among *** used Arabidopsis BBX29 for experimental *** and genetic analyses showed that cold-induction of BBX29 is CBF-and abscisic acid-independent,and BBX29 is a negative regulator of cold *** RNA-seq and Cleavage Under Targets and Tagmentation followed by sequencing analyses revealed that BBX29 represses a set of cold-induced TFs(ZAT12,PRR9,RVE1,MYB96,etc.).Altogether,our analysis yielded a library of eudicot CoCoFos and demonstrated that BBX29 is a negative regulator of cold tolerance in Arabidopsis.

关键词： phylogenomics phylotranscriptomics orthogroup cold acclimation BBX29 CBF-independent pathway

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基于灰色方法与结构距离的飓风轨迹聚类算法

系统工程理论与实践 2017年第4期37卷 1046-1055页

作者：江艺羡张岐山福州大学经济与管理学院福州350108 福建医科大学公共卫生学院福州350108

飓风轨迹的聚类分析以轨迹间的相似性为基础.但是目前轨迹相似距离研究主要仅针对一个或两个轨迹属性,使得得到的聚类结果无法充分体现轨迹的运动特征.为充分利用轨迹的属性特征,结合灰色相关理论,提出将位置、方向、速度三个属性融合... 详细信息

飓风轨迹的聚类分析以轨迹间的相似性为基础.但是目前轨迹相似距离研究主要仅针对一个或两个轨迹属性,使得得到的聚类结果无法充分体现轨迹的运动特征.为充分利用轨迹的属性特征,结合灰色相关理论,提出将位置、方向、速度三个属性融合为结构相似距离,并以此作为轨迹间相似距离度量函数进行聚类分析,以达到更全面了解轨迹运动特点的目的.实例分析表明该算法能充分体现轨迹运动特征,聚类结果更具有实际意义.

关键词：聚类轨迹灰色GM(1 1)模型结构距离

Long term monitoring of urban subsidence by Permanent Scatterer DInSAR

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Progress in Natural Science:Materials International 2007年第1期17卷 107-111页

作者： TANG yixian, zhang Hong and WANG Chao ( The Chinese Remote Sensing Satellite Ground Station, Chinese Academy of Sciences, Beijing 100086, China State Key Laboratory of Remote Sensing IRSA, Chinese Academy of Sciences, Beijing 100101, China) Chinese Remote Sensing Satellite Ground Station Chinese Academy of Sciences Beijing 100086 China State Key Laboratory of Remote Sensing IRSA Chinese Academy of Sciences Beijing 100101 China

When using differential SAR interferometry (DInSAR) to monitor the surface deformation over a long time scale, it is often strongly affected by the spatial and temporal decorrelations and atmospheric dishomogeneities. The recently developed Permanent Scatterers (PS) technique proposed by Fertti et al. can overcome these difficulties by interpreting time-series of interferometric phase only at coherent point scatterers. In this study, we apply this PS technique using 25 ERS-1/2 scenes from 1992 to 2000 to monitor the subsidence in Suzhou. By using the linear deformation model, the deformation map in Suzhou urban area over the eight years is obtained. And the calculated results are in good agreement with the measurements of leveling.

关键词： Permanent Scatterer differential SAR interferometry urban subsidence.

当代俄罗斯摇滚诗歌与东方哲学以格列宾希科夫作品为例

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外国文学动态研究 2024年第5期 111-126页

作者：张宜先青岛大学外语学院

俄罗斯摇滚诗歌是复杂而多元的文化和文学产物,其中不乏从东方哲学中撷取的成分。摇滚诗人格列宾希科夫对以佛禅和道学为代表的东方哲学颇多借鉴和吸纳,后者构成其思想体系的重要一环。白银时代的文学传统、欧美流行文化掀起的佛禅潮流... 详细信息

俄罗斯摇滚诗歌是复杂而多元的文化和文学产物,其中不乏从东方哲学中撷取的成分。摇滚诗人格列宾希科夫对以佛禅和道学为代表的东方哲学颇多借鉴和吸纳,后者构成其思想体系的重要一环。白银时代的文学传统、欧美流行文化掀起的佛禅潮流、诗人对俄罗斯社会和西方现代文明的客观审视及其兼收并蓄的多元文化观念,都促成了格列宾希科夫对东方哲学的承袭,其作品的互文性特征、意象体系建构和折中主义诗学,诗人对传统二元对立的反叛,对生命自由和自然本真的追求,都与诗人对东方哲学的研究有着紧密关联。

关键词：俄罗斯摇滚诗歌格列宾希科夫佛禅道学多元

Suppression of Radioactive Strontium Absorption by Sodium Alginate in Animals and Human Subjects

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Biomedical and Environmental Sciences 1991年第3期4卷 273-282页

作者： GONG YIFENG, HUANG ZHAOJIAN, QIANG MEIYU, LAN FUXING,BAI GUANG, MAO yixian MA XlNPEl AND zhang FENGGE The Institute of Radiation Medicine, Beijing, China and The Institute of Atomic Energy, Beijing, China Institute of Radiation Medicine Beijing China.

The effect of 23 sodium alginate preparations from different species of algae (Sargassum sp.) and kelp (Laminaria sp.) on reducing the absorption of strontium was studied in detail. A pilot production procedure has been established. Na alginate from S. siliquastrum was proven to be a potent agent for reducing Sr absorption, with high efficiency and virtually no toxicity. It reduced the body burden of strontium 3.3-4.2 fold in rats. Strontium absorption in human subjects was reduced by 78% ( ±8.9) or completely suppressed the increase of serum Sr at 2 h after ingestion of stable Sr in volunteers and decrease 24 h urine Sr to similar extent. No undesirable effects on gastrointestinal function was observed nor were Ca, Fe, Cu and Zn metabolism changed, both in the animal experiments and in human. It was concluded that alginate preparations derived from Sargassum species are a suitable antidote against radiostrontium absorption on a long-term basis, when added to bread at a 6% level. In cases of emergency, an alginate syrup preparation appears to be more suitable because of its rapid action.

关键词： Suppression of Radioactive Strontium Absorption by Sodium Alginate in Animals and Human Subjects