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Studies Directed toward Synthesis of the Structure Proposed for Stereocalpin A

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Chinese Journal of Chemistry 2011年第6期29卷 1185-1191页

作者： Huang, yixian wu, Yikang State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

Some synthetic efforts directed to the proposed structure of stereocalpin A are disclosed. The stereogenic centers in the aldol unit were installed using the method of Evans and the intermediates obtained through a reliable route helped to reveal that the spectroscopic data reported earlier in the literature for the same structures were either erroneous or irrelevant.

关键词： peptide natural product aldol reaction amino acid condensation

Slippery hydrogel with desiccation-tolerant‘skin’for high-precision additive manufacturing

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International Journal of Extreme Manufacturing 2024年第2期6卷 486-500页

作者： Desheng Liu Pan Jiang Yue Hu Yaozhong Lu yixian Wang Jiayu wu Danli Hu Tao wu Xiaolong Wang State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China CAS Key Laboratory of Chemistry of Northwestern Plant Resources Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai 264006People’s Republic of China Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003People’s Republic of China

Hydrogels inevitably undergo dehydration,structural collapse,and shrinkage deformation due to the uninterrupted evaporation in the atmosphere,thereby losing their flexibility,slipperiness,and manufacturing ***,we propose a novel bioinspired strategy to construct a spontaneously formed‘skin’on the slippery hydrogels by incorporating biological stress metabolites trehalose into the hydrogel network,which can generate robust hydrogen bonding interactions to restrain water *** contents of trehalose in hydrogel matrix can also regulate the desiccation-tolerance,mechanical properties,and lubricating performance of slippery hydrogels in a wide *** vat photopolymerization three-dimensional printing and trehalose-modified slippery hydrogels enables to achieve the structural hydrogels with high resolution,shape fidelity,and sophisticated architectures,instead of structural collapse and shrinkage deformation caused by *** thus,this proposed functional hydrogel adapts to manufacture large-scale hydrogels with sophisticated architectures in a long-term *** a proof-of-concept demonstration,a high-precision and sophisticated slippery hydrogel vascular phantom was easily fabricated to imitate guidewire ***,the proposed protocol is universally applicable to diverse types of hydrogel *** strategy opens up a versatile methodology to fabricate dry-resistant slippery hydrogel for functional structures and devices,expanding their high-precision processing and broad applications in the atmosphere.

关键词： slippery hydrogel trehalose desiccation tolerance vat photopolymerization 3D printing hydrogen bonding

Ultrasound-driven BaTiO_(3) nanorobots patching immunologic barrier to cure chronic rheumatoid arthritis

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Journal of Advanced Ceramics 2023年第5期12卷 1105-1117页

作者： Le Jiang Yifan Wang Chunlin Liu Nan Xu Wenshuo Li Lei Wang yixian wu Jingyun Wang Zhijun He Fengbo Sun Lingyun Zhao Qiong wu Xiumei Wang Huihui Yuan Xiaohui Wang Xiaodan Sun State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China MOE Key Lab.Bioinformatics School of Life SciencesTsinghua UniversityBeijing 100084China Department of Immunology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

The disruption and reconstruction of the TREM2^(+) tissue resident macrophage(TRM)barrier on the surface of synovial lining play a key role in the activation and"remission"of rheumatoid arthritis(RA),which engender the prediction of this immunologic barrier as a potential driver for the achievement of"cure"in ***,strategies to promote the reconstruction of this barrier have not been reported,and the effect of patching this barrier remains *** the other hand,appropriate piezoelectric stimulation can reprogram macrophages,which has never been exerted on this barrier TRM ***,we design piezoelectric tetragonal BaTiO_(3)(BTO)ultrasound-driven nanorobots(USNRs)by the solvothermal synthesis method,which demonstrates satisfactory electro-mechanical conversion effects,paving the way to generate controllable electrical stimulation under ultrasound to reprogram the barrier TRM by minimally invasive injection into joint *** is demonstrated that the immunologic barrier could be patched by this USNR effectively,thereby eliminating the hyperplasia of vessels and nerves(HVN)and ***,TREM2 deficiency serum-transfected arthritis(STA)mice models are applied and proved the indispensable role of TREM2 in RA curing mediated by *** all,our work is an interesting and important exploration to expand the classical tetragonal BTO nanoparticles in the treatment of autoimmune diseases,providing a new idea and direction for the biomedical application of piezoelectric ceramics.

关键词： ultrasound-driven BaTiO_(3)nanorobots(BTO NRs) immunologic barrier upstream driver rheumatoid arthritis(RA)

Mechanochemical route to fabricate an efficient nitrate reduction electrocatalyst

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Nano Research 2024年第6期17卷 4889-4897页

作者： Yunliang Liu Zhiyu Zheng Sobia Jabeen Naiyun Liu yixian Liu Yuanyuan Cheng Yaxi Li Jingwen Yu Xin wu Nina Yan Lei Xu Haitao Li Institute for Energy Research School of Energy and Power EngineeringJiangsu UniversityZhenjiang 212013China Jiangsu Engineering Technology Research Center of Biomass Composites and Addictive Manufacturing Institute of Agricultural Facilities and EquipmentJiangsu Academy of Agricultural SciencesNanjing 210014China Key Laboratory for Protected Agricultural Engineering in the Middle and Lower Reaches of Yangtze River Ministry of Agriculture and Rural AffairsNanjing 210014China

The electrochemical nitrate reduction reaction(NO_(3)RR)to ammonia under ambient conditions is a promising approach for addressing elevated nitrate levels in water bodies,but the progress of this reaction is impeded by the complex series of chemical reactions involving electron and proton transfer and competing hydrogen evolution ***,it becomes imperative to develop an electro-catalyst that exhibits exceptional efficiency and remarkable selectivity for ammonia synthesis while maintaining long-term *** the magnetic biochar(Fe-C)has been synthesized by a two-step mechanochemical route after a pyrolysis treatment(450,700,and 1000℃),which not only significantly decreases the particle size,but also exposes more oxygen-rich functional groups on the surface,promoting the adsorption of nitrate and water and accelerating electron transfer to convert it into *** showed that the catalyst(Fe-C-700)has an impressive NH_(3)production rate of 3.5 mol·h^(−1)·gcat^(−1),high Faradaic efficiency of 88%,and current density of 0.37 A·cm^(−2)at 0.8 V *** hydrogen electrode(RHE).In-situ Fourier transform infrared spectroscopy(FTIR)is used to investigate the reaction intermediate and to monitor the *** oxygen functionalities on the catalyst surface activate nitrate ions to form various intermediates(NO_(2),NO,NH_(2)OH,and NH_(2))and reduce the rate determining step energy barrier(*NO_(3)→*NO_(2)).This study presents a novel approach for the use of magnetic biochar as an electro-catalyst in NO_(3)RR and opens the road for solving environmental and energy challenges.

关键词： mechanochemical route magnetic biochar electron transfer nitrate ammonia

Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1380-1399页

作者： yixian Li Peng Yang Ran Meng Shuting Xu Lingling Zhou Kang Qian Pengzhen Wang Yunlong Cheng Dongyu Sheng Minjun Xu Tianying Wang Jing wu Jinxu Cao Qizhi Zhang Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China

Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer’s disease(AD)collectively culminate in neuronal *** the context of AD,autophagy dysfunction,a multi-link obstacle involving autophagy downregulation and lysosome defects in neurons/microglia is highly implicated in intra/extraneuronal pathological ***,multidimensional autophagy regulation strategies co-manipulating“autophagy induction”and“lysosome degradation”in dual targets(neuron and microglia)are more reliable for AD ***,we designed an RP-1 peptide-modified reactive oxygen species(ROS)-responsive micelles(RT-NM)loading rapamycin or gypenoside *** by RP-1 peptide,the ligand of receptor for advanced glycation end products(RAGE),RT-NM efficiently targeted neurons and microglia in AD-affected *** nanocombination therapy activated the whole autophagy-lysosome pathway by autophagy induction(rapamycin)and lysosome improvement(gypenoside XVII),thus enhancing autophagic degradation of neurotoxic aggregates and inflammasomes,and promoting Aβ ***,it decreased aberrant protein burden,alleviated neuroinflammation,and eventually ameliorated memory defects in 3×Tg-AD transgenic *** research developed a multidimensional autophagy nano-regulator to boost the efficacy of autophagy-centered AD therapy.

关键词： Autophagy-lysosome pathway Alzheimer’s disease Proteostasis Neuroinflammation Multi-target therapy Rapamycin Gypenoside XVII Cascade dual-targeting

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汽车安全气囊展开过程的仿真算法

同济大学学报（自然科学版） 2012年第2期40卷 281-285页

作者：吴光强吴奕娴同济大学汽车学院上海201804 东京大学生产技术研究所

对气袋织物的各向异性材料模型进行研究,将织物的拉伸和剪切仿真与试验结果对比,以验证材料模型的准确性.分别采用控制体积法(Control Volume,CV)与近年来新开发的粒子法(Corpuscular Method,CPM),对平铺与折叠气囊展开进行数值模拟,并... 详细信息

对气袋织物的各向异性材料模型进行研究,将织物的拉伸和剪切仿真与试验结果对比,以验证材料模型的准确性.分别采用控制体积法(Control Volume,CV)与近年来新开发的粒子法(Corpuscular Method,CPM),对平铺与折叠气囊展开进行数值模拟,并对比气囊展开形态和压力结果对比.结果表明,CV方法只适用于IP(In-Position)乘员与气囊作用的仿真模拟,而CPM方法可模拟出气囊展开初期的高速气流运动,且计算效率较高,适用于OOP(Out-of-Position)乘员与气囊的相互作用仿真.

关键词：安全气囊展开控制体积法粒子法

综合考虑内外生不确定性的绿色数据中心多域资源协同规划方法

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中国电机工程学报 2024年第12期44卷 4732-4747,I0011页

作者：曾博刘一贤张卫翔罗旸凡吴晨新能源电力系统全国重点实验室(华北电力大学) 北京市昌平区102206

数字经济下,发展以“高能源效率、低环境影响”为主要特征的绿色数据中心(green data center,GDC)是应对碳中和挑战和促进社会可持续发展的重要举措。如何科学配置供需侧资源,在满足服务质量约束的前提下,充分利用数据用户的互动响应潜... 详细信息

数字经济下,发展以“高能源效率、低环境影响”为主要特征的绿色数据中心(green data center,GDC)是应对碳中和挑战和促进社会可持续发展的重要举措。如何科学配置供需侧资源,在满足服务质量约束的前提下,充分利用数据用户的互动响应潜力促进系统提质增效,是未来公有型GDC规划面临的难点。为此,该文基于信息-物理-社会耦合视角,在深入分析不同类型数据负载运行特性的基础上,引入后悔度匹配方法模拟数据用户参与GDC需求响应(GDC demand response,GDC-DR)意愿的中长期动态演化。基于动态预想场景,综合考虑数据用户参与GDC-DR意愿等内生不确定性和可再生能源发电出力、数据负载需求等外生不确定性的影响,提出一种GDC多域资源协同规划模型。模型以系统综合效益最大化为目标,同时考虑设备运行、服务质量等多域约束,通过对GDC设备容量、需求响应激励价格以及各预想场景下系统运行策略进行协同优化,以充分发掘数据负载灵活性潜力,实现系统经济性和碳中和效益的综合趋优。算例仿真结果验证了该文所提模型和方法的有效性。

关键词：绿色数据中心多域资源规划需求响应不确定性信息物理社会系统碳中和

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绿色轮胎用高性能丁二烯基橡胶合成技术进展

科学通报 2016年第31期61卷 3326-3337页

作者：朱寒张树吴一弦北京化工大学化工资源有效利用国家重点实验室北京100029

绿色轮胎在节能、环保、安全方面的优势使其成为当今世界轮胎的发展趋势.稀土(钕系)顺丁橡胶(Nd-BR)和溶聚丁苯橡胶(SSBR)是制造绿色轮胎胎面重要的合成橡胶原材料.本文主要介绍绿色轮胎发展现状、Nd-BR合成技术进展、工业化产品及新型... 详细信息

绿色轮胎在节能、环保、安全方面的优势使其成为当今世界轮胎的发展趋势.稀土(钕系)顺丁橡胶(Nd-BR)和溶聚丁苯橡胶(SSBR)是制造绿色轮胎胎面重要的合成橡胶原材料.本文主要介绍绿色轮胎发展现状、Nd-BR合成技术进展、工业化产品及新型丁二烯基共聚橡胶合成技术进展,着重介绍微观结构、拓扑结构及共聚组成对其加工性能、物理机械性能及动态力学性能的重要贡献,为制造绿色轮胎用高性能合成橡胶原材料提供参考.顺式结构含量在98%以上的Nd-BR具有更加优异的物理机械性能及动态力学性能,可有效降低轮胎生热、滚动功率损耗、压缩永久变形及终动压缩率,降低轮胎磨耗并延长轮胎寿命,更适用于制造绿色轮胎.长链支化结构Nd-BR可以改善生胶的抗冷流性能、加工性能及与填料的混合性能,进一步提高硫化胶的物理机械性能和动态力学性能.高顺式含量丁苯无规共聚弹性体及立构规整丁二烯/苯乙烯共聚物集高顺式聚丁二烯橡胶、丁苯橡胶的优异性能于一体,综合性能提高,冰雪路面抓着力提高,滚动阻力下降,符合高性能绿色轮胎对合成橡胶原材料的要求.

关键词：绿色轮胎顺丁橡胶稀土催化剂配位聚合丁苯橡胶

先进催化剂及其用于乙烯/丙烯配位共聚的研究进展

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科学通报 2018年第34期63卷 3530-3545页

作者：张树张志乾吴一弦北京化工大学化工资源有效利用国家重点实验室北京100029

乙烯-丙烯共聚物及乙烯-丙烯-少量二烯烃共聚物(简称乙丙橡胶)只能通过催化剂作用下烯烃配位共聚方法来合成,其微观结构、共聚组成、序列分布及拓扑结构等与催化剂密切相关.乙丙橡胶是世界上七大通用合成橡胶品种之一,具有优异的弹性、... 详细信息

乙烯-丙烯共聚物及乙烯-丙烯-少量二烯烃共聚物(简称乙丙橡胶)只能通过催化剂作用下烯烃配位共聚方法来合成,其微观结构、共聚组成、序列分布及拓扑结构等与催化剂密切相关.乙丙橡胶是世界上七大通用合成橡胶品种之一,具有优异的弹性、耐臭氧、耐热、耐候及耐老化性能等,应用广泛.本文分别论述了乙烯/丙烯配位共聚中所用催化剂的研究进展、催化特性及工业应用情况,主要包括齐格勒-纳塔催化剂、茂金属催化剂和非茂金属配合物催化剂,探讨主催化剂中金属的种类与价态、主催化剂中配体的结构、助催化剂、添加剂等因素对催化活性、共聚组成、分子量、分子量分布及序列分布等的影响规律.采用先进催化剂,可提高催化活性及丙烯插入率,调控共聚物的分子量及其分布,调控共聚物的序列分布与拓扑结构,设计合成高性能乙丙橡胶.

关键词：乙丙橡胶催化剂配位聚合烯烃共聚