检索结果-南通市图书馆

Acta Pharmaceutica Sinica B 2020年第11期10卷 2198-2211页

作者： Biyuan Wu Jintao Fu yixian zhou Sulan Luo Yiting Zhao Guilan Quan Xin Pan Chuanbin Wu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 510632China

Malignant tumor has become an urgent threat to global public *** of the heterogeneity of tumor,single therapy presents great limitations while synergistic therapy is arousing much attention,which shows desperate need of intelligent carrier for co-delivery.A core-shell dual metaleorganic frameworks(MOFs)system was delicately designed in this study,which not only possessed the unique properties of both materials,but also provided two individual specific functional zones for co-drug *** indocyanine green(ICG)and chemotherapeutic agent doxorubicin(DOX)were stepwisely encapsulated into the nanopores of MIL-88 core and ZIF-8 shell to construct a synergistic photothermal/photodynamic/chemotherapy *** for efficient drug delivery,the MIL-88 could be functioned as a nanomotor to convert the excessive hydrogen peroxide at tumor microenvironment into adequate oxygen for photodynamic *** DOX release from MIL-88-ICG@ZIF-8-DOX nanoparticles was triggered at tumor acidic microenvironment and further accelerated by near-infrared(NIR)light *** in vivo antitumor study showed superior synergistic antitumor effect by concentrating the nanoparticles into dissolving microneedles as compared to intravenous and intratumoral injection of nanoparticles,with a significantly higher inhibition *** is anticipated that the multi-model synergistic system based on dual-MOFs was promising for further biomedical application.

关键词： Metaleorganic frameworks Core-shell structure Synergistic therapy Photothermal therapy Photodynamic therapy Fenton-like reaction

“Pincer movement”:Reversing cisplatin resistance based on simultaneous glutathione depletion and glutathione S-transferases inhibition by redox-responsive degradable organosilica hybrid nanoparticles

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第4期12卷 2074-2088页

作者： Boyi Niu yixian zhou Kaixin Liao Ting Wen Sixian Lao Guilan Quan Xin Pan Chuanbin Wu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 510632China

The therapeutic efficacy of cisplatin has been restricted by drug resistance of *** glutathione(GSH)detoxification of cisplatin under the catalysis of glutathione S-transferases(GST)plays important roles in the development of cisplatin ***,a strategy of“pincer movement”based on simultaneous GSH depletion and GST inhibition is proposed to enhance cisplatin-based ***,a redox-responsive nanomedicine based on disulfide-bridged degradable organosilica hybrid nanoparticles is developed and loaded with cisplatin and ethacrynic acid(EA),a GST *** to high level of intracellular GSH,the hybrid nanoparticles can be gradually degraded due to the break of disulfide bonds,which further promotes drug ***,the disulfide-mediated GSH depletion and EA-induced GST inhibition cooperatively prevent cellular detoxification of cisplatin and reverse drug ***,the nanomedicine is integrated into microneedles for intralesional drug delivery against cisplatin-resistant *** in vivo results show that the nanomedicine-loaded microneedles can achieve significant GSH depletion,GST inhibition,and consequent tumor growth ***,this research provides a promising strategy for the construction of new-type nanomedicines to overcome cisplatin resistance,which extends the biomedical application of organosilica hybrid nanomaterials and enables more efficient chemotherapy against drug-resistant cancers.

关键词： Cancer therapy Cisplatin Drug resistance Glutathione depletion Glutathione Stransferases Disulfide bonds Organosilica hybrid nanoparticles Ethacrynic acid

A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2020年第12期10卷 2404-2416页

作者： yixian zhou Boyi Niu Biyuan Wu Sulan Luo Jintao Fu Yiting Zhao Guilan Quan Xin Pan Chuanbin Wu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 510632China

Pulmonary drug delivery has attracted increasing attention in biomedicine,and porous particles can effectively enhance the aerosolization performance and bioavailability of ***,the existing methods for preparing porous particles using porogens have several drawbacks,such as the inhomogeneous and uncontrollable pores,drug leakage,and high risk of *** this study,a series of cyclodextrin-based metal-organic framework(CD-MOF)particles containing homogenous nanopores were delicately engineered without *** with commercial inhalation carrier,CDMOF showed excellent aerosolization performance because of the homogenous nanoporous *** great biocompatibility of CD-MOF in pulmonary delivery was also confirmed by a series of experiments,including cytotoxicity assay,hemolysis ratio test,lung function evaluation,in vivo lung injury markers measurement,and histological *** results of ex vivo fluorescence imaging showed the high deposition rate of CD-MOF in ***,all results demonstrated that CD-MOF was a promising carrier for pulmonary drug *** study may throw light on the nanoporous particles for effective pulmonary administration.

关键词： Pulmonary drug delivery Metal-organic framework Inhalable dry powder Nanoporous particle

Mesoporous silica nanoparticles for drug and gene delivery

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2018年第2期8卷 165-177页

作者： yixian zhou Guilan Quan Qiaoli Wu Xiaoxu Zhang Boyi Niua Biyuan Wu Ying Huang Xin Pan Chuanbin Wu School of Pharmaceutical Sciences Sun Yat-Sen University Zengcheng District People's Hospital of Guangzhou Qingdao Huanghai University Guangdong Research Center for Drug Delivery Systems

Mesoporous silica nanoparticles(MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume,selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug bioavailability, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly,the exciting progress in the development of MSNs-based effective delivery systems for poorly soluble drugs, anticancer agents, and therapeutic genes are highlighted.

关键词： Mesoporous silica nanoparticles Poorly soluble drug Cancer therapy Multidrug resistance Gene delivery

A triple-enhanced chemodynamic approach based on glucosepowered hybrid nanoreactors for effective bacteria killing

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第2期16卷 2682-2694页

作者： Jintao Fu yixian zhou Ting Liu Wenhao Wang Yiting Zhao Ying Sun Yiming Zhang Wenxuan Qin Zhongwei Chen Chao Lu Guilan Quan Chuanbin Wu Xin Pan School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 511443China

Rapid evolution of multidrug resistance in bacterial pathogens is outpacing the development of new antibiotics,and chemodynamic therapy(CDT)provides an excellent ***,achieving highly efficient CDT is still a great challenge,since the pH in the infection site is close to neutral and the supply of H_(2)O_(2)is *** herein constructed the antibacterial *** green(ICG)and glucose oxidase(GOx)were incorporated into homologous zeolitic imidazolate framework-8(ZIF-8)nanoparticles coating with metal polyphenol network(MPN)composed by Fe^(3+)and tannic acid(TA).The well-designed nanoreactors could simultaneously break the pH and H_(2)O_(2)limitations,and generate hyperthermia under irradiation,thus realizing a triple-enhanced CDT for high-efficiency ***,the nanoreactors could combine CDT with photothermal therapy(PTT)and photodynamic therapy(PDT),which not only improved the bactericidal efficiency and broadened the antibacterial spectrum,but also alleviated the antibiotics resistance ***,the proposed nanoreactors achieved a robust in vitro bacterial killing against Gram-positive methicillin-resistant Staphylococcus aureus(MRSA)and Gram-negative Pseudomonas *** nanoreactors achieved an 99.7%MRSA reduction in an MRSA-induced murine abscess model accompanied with negligible ***,this study provides a promising strategy for multiple-enhanced CDT and multimodal combined therapy for pathogenic infections.

关键词： metal-organic frameworks glucose oxidase photothermal therapy photodynamic therapy localized bacterial infection

The fate of eclogites in the lithosphere

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第3期67卷 879-884页

作者： Zhensheng WANG yixian XU State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China Key Laboratory of Geoscience Big Data and Deep Resource of Zhejiang Province School of Earth SciencesZhejiang UniversityHangzhou 310058China

1. Eclogites and the concept of viscous drainage Eclogites are a distinctive rock type, mainly composed of garnet and omphacite and formed through ultra-high-pressure metamorphism, wherein oceanic or continental crust... 详细信息

关键词： crustal garnet rock

Secure state estimation for cyber-physical systems with unknown input sliding mode observer

在线全文

学校读者我要写书评

暂无评论

Control Theory and Technology 2024年第2期22卷 244-253页

作者： Panpan Zhang Yuwei Ren yixian Fang Ang Liu School of Information Science and Engineering Shandong Normal UniversityJinan250358ShandongChina School of Information Engineering Shandong Management UniversityJinan250357ShandongChina

In recent years, cyber attacks have posed great challenges to the development of cyber-physical systems. It is of great significance to study secure state estimation methods to ensure the safe and stable operation of the system. This paper proposes a secure state estimation for multi-input and multi-output continuous-time linear cyber-physical systems with sparse actuator and sensor attacks. First, for sparse sensor attacks, we propose an adaptive switching mechanism to mitigate the impact of sparse sensor attacks by filtering out their attack modes. Second, an unknown input sliding mode observer is designed to not only observe the system states, sensor attack signals, and measurement noise present in the system but also counteract the effects of sparse actuator attacks through an unknown input matrix. Finally, for the design of an unknown input sliding mode state observer, the feasibility of the observing system is demonstrated by means of Lyapunov functions. Additionally, simulation experiments are conducted to show the effectiveness of this method.

关键词： Sparse attacks Cyber-physical systems Unknown input sliding mode Secure state estimation Adaptive switching mechanism

PARE:Privacy-Preserving Data Reliability Evaluation for Spatial Crowdsourcing in Internet of Things

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第8期80卷 3067-3084页

作者： Peicong He Yang Xin yixian Yang School of Cyberspace Security Beijing University of Posts and TelecommunicationsBeijing100876China

The proliferation of intelligent,connected Internet of Things(IoT)devices facilitates data ***,task workers may be reluctant to participate in data collection due to privacy concerns,and task requesters may be concerned about the validity of the collected ***,it is vital to evaluate the quality of the data collected by the task workers while protecting privacy in spatial crowdsourcing(SC)data collection tasks with *** this end,this paper proposes a privacy-preserving data reliability evaluation for SC in IoT,named ***,we design a data uploading format using blockchain and Paillier homomorphic cryptosystem,providing unchangeable and traceable data while overcoming privacy ***,based on the uploaded data,we propose a method to determine the approximate correct value region without knowing the exact ***,we offer a data filtering mechanism based on the Paillier cryptosystem using this value *** evaluation and analysis results show that PARE outperforms the existing solution in terms of performance and privacy protection.

关键词： Spatial crowdsourcing privacy-preserving data evaluation IoT blockchain

Temperature is a cryptic factor shaping the geographical pattern of genetic variation in Ceratophyllum demersum across a subtropical freshwater lake

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Diversity 2024年第5期46卷 630-639页

作者： yixian Li Xuyao Zhao Manli Xia Xinzeng Wei Hongwei Hou The State Key Laboratory of Freshwater Ecology and Biotechnology The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of SciencesInstitute of HydrobiologyChinese Academy of SciencesWuhan 430072HubeiChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074HubeiChina

Macrophyte habitats exhibit remarkable heterogeneity,encompassing the spatial variation of abiotic and biotic components such as changes in water conditions and weather as well as anthropogenic *** factors are thought to be important drivers shaping the genetic and epigenetic variation of aquatic ***,the links among genetic diversity,epigenetic variation,and environmental variables remain largely unclear,especially for clonal aquatic ***,we performed population genetic and epigenetic analyses in conjunction with habitat discrimination to elucidate the environmental factors driving intraspecies genetic and epigenetic variation in hornwort(Ceratophyllum demersum)in a subtropical *** factors were highly correlated with the genetic and epigenetic variation of ***,with temperature being a key driver of the genetic *** temperature was detected to be correlated with greater genetic and epigenetic *** and epigenetic variation were positively driven by water temperature,but were negatively affected by ambient air *** findings indicate that the genetic and epigenetic variation of this clonal aquatic herb is not related to the geographic feature but is instead driven by environmental conditions,and demonstrate the effects of temperature on local genetic and epigenetic variation in aquatic systems.

关键词： Genetic diversity Epigenetic variation Temperature Macrophyte Restoration

Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第3期14卷 1380-1399页

作者： yixian Li Peng Yang Ran Meng Shuting Xu Lingling zhou Kang Qian Pengzhen Wang Yunlong Cheng Dongyu Sheng Minjun Xu Tianying Wang Jing Wu Jinxu Cao Qizhi Zhang Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China

Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer’s disease(AD)collectively culminate in neuronal *** the context of AD,autophagy dysfunction,a multi-link obstacle involving autophagy downregulation and lysosome defects in neurons/microglia is highly implicated in intra/extraneuronal pathological ***,multidimensional autophagy regulation strategies co-manipulating“autophagy induction”and“lysosome degradation”in dual targets(neuron and microglia)are more reliable for AD ***,we designed an RP-1 peptide-modified reactive oxygen species(ROS)-responsive micelles(RT-NM)loading rapamycin or gypenoside *** by RP-1 peptide,the ligand of receptor for advanced glycation end products(RAGE),RT-NM efficiently targeted neurons and microglia in AD-affected *** nanocombination therapy activated the whole autophagy-lysosome pathway by autophagy induction(rapamycin)and lysosome improvement(gypenoside XVII),thus enhancing autophagic degradation of neurotoxic aggregates and inflammasomes,and promoting Aβ ***,it decreased aberrant protein burden,alleviated neuroinflammation,and eventually ameliorated memory defects in 3×Tg-AD transgenic *** research developed a multidimensional autophagy nano-regulator to boost the efficacy of autophagy-centered AD therapy.

关键词： Autophagy-lysosome pathway Alzheimer’s disease Proteostasis Neuroinflammation Multi-target therapy Rapamycin Gypenoside XVII Cascade dual-targeting