Mesoporous silica nanoparticles for drug and gene delivery

作     者：Yixian Zhou Guilan Quan Qiaoli Wu Xiaoxu Zhang Boyi Niua Biyuan Wu Ying Huang Xin Pan Chuanbin Wu 

作者机构：School of Pharmaceutical Sciences Sun Yat-Sen University Zengcheng District People's Hospital of Guangzhou Qingdao Huanghai University Guangdong Research Center for Drug Delivery Systems 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2018年第8卷第2期

页      面：165-177页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financial support from the National Natural Science Foundation of China (81473155) the Natural Science Fund Project of Guangdong Province (Grant No. 2016A030312013) the Science and Technology Plan Projects of Guangdong Province (Grant No. 2015B020232010) the Science and Technology Foundation Guangzhou (201707010103) 

主　　题：Mesoporous silica nanoparticles Poorly soluble drug Cancer therapy Multidrug resistance Gene delivery 

摘      要：Mesoporous silica nanoparticles(MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume,selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug bioavailability, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly,the exciting progress in the development of MSNs-based effective delivery systems for poorly soluble drugs, anticancer agents, and therapeutic genes are highlighted.