检索结果-南通市图书馆

Nano Research 2019年第8期12卷 1959-1966页

作者： Bo Dai Xingyu Wu Christopher J. Butch Jianquan wang Ziyang wang yisheng wang Shuming Nie Qian Lu Yiqing wang Yitao Ding Drum Tower Clinical Medical College Nanjing Medical UniversityNanjing 210008China Department of Biomedical Engineering College of Engineering and Applied SciencesNanjing UniversityNanjing 210008China Department of Biomedical Engineering University of Illinois at Urbana-ChampaignIllinois 61801USA

The clinical translation of nanomedicine is hindered by the low delivery efficiency, and consequently drug concentration in tumor sites falls short of the therapeutic effective range which leads to poor clinical outcomes. One important lesson learned from the development of antibody-drug-conjugates (ADCs) is that to achieve significant clinical benefits, extremely potent cytotoxic agents and cleavable linkers should be used. By encapsulating maytansinoid, AP3, which is 100-1,000 times more potent than most conventional small molecule anticancer drugs, in pH-sensitive acetalated dextran-polyethylene glycol (PEG)(ADP) nanocarriers, even with only 1% drug loading, we were able to eradicate tumors in 50% of tested animals with negligible side effects, while free AP3 only showed marginal efficacy and severe liver damages. This study suggests that besides improving the low efficiency of nano-delivery systems, the potency of drug to be delivered is also critical to the clinical outcomes of nanomedicine. Our results also showed that ADP nanoparticles (NPs) were able to expand the narrow therapeutic window of maytansinoids in a similar manner to the ADCs.

关键词： nanomedicine drug delivery maytansinoid extremely potent drug pH-sensitive nanocarrier

Residents’ Willingness to Pay for Improving Air Quality in Jinan, China

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Chinese Journal of Population,Resources and Environment 2007年第2期5卷 12-19页

作者： wang Yan, Zhang yisheng, wang Qian, wang Wei School of Environmental Science and Engineering, Shandong University, Jinan Shandong 250100, China School of Environmental Science and Engineering Shandong University

Along with the progress of urbanization and environ- mental deterioration, residents’ desire for improved air quality is increasing. In order to quantify an individual’s willingness-to-pay (WTP) for improved air quality in Jinan of eastern China, a contingent valuation method (CVM) was employed. A sample of 1,500 residents was chosen on the basis of multistage sampling methods with face-to-face interviews by using a series of hypo-thetical, open-ended scenario questions which were designed to elicit the respondents’ WTP. Results showed that 59.7% of respondents were able to express their WTP and the mean WTP is 100 Chinese Yuan (CNY) per person per year. A probit model on the probability of a positive WTP and a regression model were developed to find the relationship between endogenous variables and WTP. Most parameters in the econometric analysis had the expected sign. Annual household income and expenditure on treating respiratory diseases significantly influence WTP. The rates of positive WTP and the monetary amount are larger for men than for women. Results also showed that people who lived in more polluted areas were willing to pay more for clean air. Unlike developed countries, clean air may only be considered as a public good in China in that more than 40% of respondents had no incen- tive to bear the costs of attempting to achieve better air quality, which indicates the relatively low environmental consciousness.

关键词： air quality willingness to pay contingent valuation method Jinan

CHANGES IN LIPIDS OF MUSSEL DURING STORAGE

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中国水产科学 1995年第4期 56-63页

作者： Xue Changhu, wang yisheng, Li Zhaojie, Lou Weifeng(Ocaan University of Qingdao 266003)

ＣＨＡＮＧＥＳＩＮＬＩＰＩＤＳＯＦＭＵＳＳＥＬＤＵＲＩＮＧＳＴＯＲＡＧＥＸｕｅＣｈａｎｇｈｕ，ＷａｎｇＹｉｓｈｅｎｇ，ＬｉＺｈａｏｊｉｅ，ＬｏｕＷｅｉｆｅｎｇ（ＯｃａａｎＵｎｉｖｅｒｓｉｔｙｏｆＱｉｎｇｄａｏ２６６０... 详细信息

ＣＨＡＮＧＥＳＩＮＬＩＰＩＤＳＯＦＭＵＳＳＥＬＤＵＲＩＮＧＳＴＯＲＡＧＥＸｕｅＣｈａｎｇｈｕ，ＷａｎｇＹｉｓｈｅｎｇ，ＬｉＺｈａｏｊｉｅ，ＬｏｕＷｅｉｆｅｎｇ（ＯｃａａｎＵｎｉｖｅｒｓｉｔｙｏｆＱｉｎｇｄａｏ２６６００３）ＣＨＡＮＧＥＳＩＮＬＩＰＩＤ...

关键词： Mussel Lipid Oxidation

Inhibition of peroxisome proliferator-activated receptor-γ in steroid-induced adipogenic differentiation of the bone marrow mesenchymal stem cells of rabbit using small interference RNA

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Chinese Medical Journal 2014年第1期127卷 130-136页

作者： wang yisheng Li Jinfeng Liu Ming Zhao Guoqiang Hao Lanyu Li Yuebai Department of Orthopaedic Surgery the First Affiliated Hospital ofZhengzhou University Zhengzhou Henan 450052 China Department of Microbiology & Immunology Basic Medical College Zhengzhou University Zhengzhou Henan 450001 China Department of Biochemistry and Molecular Biology Basic Medical College Zhengzhou University Zhengzhou Henan 450001 China SIAS International College Zhengzhou University ZhengzhouHenan 450000 China

Background Steroids inhibit osteogenic differentiation and decrease bone formation while concomitantly inducing adipose deposition in *** leads to the fatty degeneration and necrosis of bone cells commonly seen in osteonecrosis of the femoral *** peroxisome proliferator-activated receptor-γ （PPARγ） is an adipogenic transcription factor linked to the development of this disease and responsible for inducing adipogenesis over osteogenesis in bone marrow mesenchymal stem cells （BMSCs）.The aim of this study was to assess whether adipogenic differentiation could be suppressed,and thus osteogenic potential retained,by inhibiting PPARy expression in *** Cells from the bone marrow of New Zealand rabbits were treated with 10-7 mol/L dexamethasone and infected with one of three small interference RNA （siRNA） adenovirus vectors （S1,S2,and S3） or non-targeting control siRNA （Con） and compared with dexamethasone-treated （model） and untreated （normal） *** were grown for 21 days and stained with Sudan Ⅲ for adipocyte *** various time points,cells were also assessed for changes in PPARγ,osteocalcin （OC）,Runx2,alkaline phosphatase （ALP） activity,and triglyceride （TG） *** Dexamethasone-treated model and control groups showed a significant increase in fatty acid-positive staining,which was inhibited in cells treated with PPARγ siRNA-treated,similar to normal untreated *** three siRNA groups significantly inhibited PPARγ mRNA and protein,adipocyte number,and TG content compared with the dexamethasonetreated model and control groups,matching that seen in normal *** and Runx2 mRNA and protein,as well as ALP activity,were significantly higher in cells treated with siRNA against PPARγ,similar to that seen in the normal *** osteogenic markers were significantly lower in the dexamethasone-treated cell *** The siRNA adenovirus vector targeting PPARγ can efficiently inhibit steroid-induced adipogenic dif

关键词： RNA interference adenovirus vector steroid peroxisome proliferator-activated receptor-γ adipogenic differentiation

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宋代经济的现代韵味

浙江学刊 2022年第1期 29-34页

作者：王一胜浙江省社会科学院杭州310007

宋代社会的变革,使宋代经济具有了某些现代的因素,主要包括劳动者人身依附的减弱与租佃雇佣经营的盛行,商品经济的市场化发展,产业分工程度的提高与生产技术的进步。宋代经济不仅对中国历史产生重大影响,也对世界现代社会的产生有重大... 详细信息

宋代社会的变革,使宋代经济具有了某些现代的因素,主要包括劳动者人身依附的减弱与租佃雇佣经营的盛行,商品经济的市场化发展,产业分工程度的提高与生产技术的进步。宋代经济不仅对中国历史产生重大影响,也对世界现代社会的产生有重大的影响。宋代经济结构也发生了显著的变革:国家调控经济能力增强与国营经济的经营方式的变革,公共组织与公共经济的兴起,民营经济的不断成长。这些变革都是受商品经济刺激的结果,因此也透露出独具特色的现代韵味。

关键词：宋代经济市场化公共经济现代化宋韵文化

基于专利计量的广东高水平大学科研竞争力评价研究

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重庆大学学报（社会科学版） 2016年第6期22卷 128-132页

作者：余以胜王宇华南师范大学经济与管理学院广东广州510006

文章采用专利计量方法,对广东七所建设中的高水平大学的科研竞争力进行评价研究。项目研究主要从专利申请数量、年代分布、有效数、领域分布、专利转化率、被引率等方面进行多维探讨,最后对高校科研水平提升、科研评价体系的完善提出了... 详细信息

文章采用专利计量方法,对广东七所建设中的高水平大学的科研竞争力进行评价研究。项目研究主要从专利申请数量、年代分布、有效数、领域分布、专利转化率、被引率等方面进行多维探讨,最后对高校科研水平提升、科研评价体系的完善提出了相应建议。

关键词：高水平大学专利分析竞争力评价

基于GPU的大规模多阶段任务系统可靠性并行计算方法

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系统工程与电子技术 2019年第1期41卷 215-222页

作者：闫华汪贻生王锐淇刘波郭立卿肖骅陆军勤务学院军事物流系重庆401311

针对大规模多阶段任务系统(phased-mission system,PMS)的可靠性求解,引入并行计算思想,通过分析传统的一致化方法(uniformization method,UM),基于Nvidia提出的CUDA(compute unified device architecture)架构,实现了基于图形处理器(graphics processing unit,GPU)的UM并行算法(GPU-UM),并采用合并访问和共享内存技术,提高了GPU中数据负载的利用率;PMS中不同阶段参与任务的设备及其数量通常会发生变化,导致阶段间依赖性处理困难。通过对新设备加入、已有设备暂时退出任务或完全退出任务等3种基本情况的分析,提出了阶段间状态映射机制,实际中的阶段变化情况更加复杂,可综合上述3种基本情况进行处理。通过算例对比了GPU-UM、CUDA-UM、传统UM和Krylov子空间等4种算法的计算时间和可靠性结果,分析表明GPU-UM算法的计算耗时优于其他方法,且结果精度也能满足可靠性计算需求;同时,通过对比分析UM算法和Krylov子空间算法与仿真方法的结果误差,表明提出的阶段间映射机制能够正确处理PMS中阶段间的复杂依赖关系。

关键词：多阶段任务系统任务可靠性并行计算图形处理器一致化方法

惠州25-8DPP组块横向装船及动力定位浮托安装关键技术

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中国造船 2016年第3期57卷 198-203页

作者：许南王奕晟王飚秦立成周昕达海洋石油工程股份有限公司天津300457 北京大学物理学院北京100871

动力定位浮托安装技术是将动力定位技术与浮托安装技术相结合的一种新型浮托安装技术,国内首次利用动力定位船成功地完成了惠州25-8DPP组块的动力定位浮托安装。论文归纳了动力定位船舶进行浮托安装的优势,并以惠州25-8DPP组块浮托安装... 详细信息

动力定位浮托安装技术是将动力定位技术与浮托安装技术相结合的一种新型浮托安装技术,国内首次利用动力定位船成功地完成了惠州25-8DPP组块的动力定位浮托安装。论文归纳了动力定位船舶进行浮托安装的优势,并以惠州25-8DPP组块浮托安装为例,提出了从装船到海上浮托安装的关键技术点,并给出了惠州25-8DPP组块动力定位浮托安装的关键设计与结果。论文的研究对动力定位浮托安装大型组块具有一定借鉴意义,填补了国内海洋工程技术的一项空白。

关键词：惠州25-8DPP 组块横向装船动力定位浮托安装安装时间窗口

Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei wang Chi Zhang Jinghua wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding yisheng wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even *** has the largest population of patients with traumatic spinal cord *** studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been *** the best of our knowledge,no national-level study of treatment status and economic burden has been *** retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national *** included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of *** epidemiological and clinical features,treatment status,and total and daily costs were *** in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression *** percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent *** 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 *** total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 ho

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

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鼻腔非何杰金淋巴瘤的CT诊断

中华放射学杂志 2000年第2期34卷 103-105页

作者：唐光健王仪生北京医科大学第一医院医学影像科 100034

目的　研究鼻腔淋巴瘤的CT影像 ,发现鼻腔淋巴瘤相对特异的CT表现。方法　分析10例病理证实的鼻腔淋巴瘤的CT材料 ,结合文献复习 ,评价其影像表现的诊断意义。结果　 10例鼻腔淋巴瘤病理均为T细胞非何杰金淋巴瘤 (NHL) ,9例为AnnArborI... 详细信息

目的　研究鼻腔淋巴瘤的CT影像 ,发现鼻腔淋巴瘤相对特异的CT表现。方法　分析10例病理证实的鼻腔淋巴瘤的CT材料 ,结合文献复习 ,评价其影像表现的诊断意义。结果　 10例鼻腔淋巴瘤病理均为T细胞非何杰金淋巴瘤 (NHL) ,9例为AnnArborI～II期 ,1例AnnArborIV期。 10例病变均发生于一侧鼻腔前部 ,沿下鼻甲向后呈不同程度蔓延。 9例I期病变均无骨质破坏 ,相邻鼻背侧皮肤不同程度肿胀 ,皮下脂肪消失 ,1例IV期病变可见患侧中鼻甲及钩突骨质部分吸收 ,同侧眶内肿瘤侵犯。结论　CT发现鼻腔前部肿物 ,不伴骨结构破坏或变形 ,相邻鼻背皮肤肿胀或皮下脂肪消失。

关键词：淋巴瘤鼻肿瘤 NHL CT 诊断