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Carbonic anhydrase 2 mediates anti-obesity effects of black tea as thermogenic activator

Food Science and Human Wellness 2024年第5期13卷 2917-2936页

作者： Peng Ma Jie Xiao Biyu Hou Ping He Xinyu Yang yisa wang Zijing wang Tianshu Xu Xiuying Yang Xuan Zhu Shasha Xiang Song Li Guanhua Du Jian Ying Guifen Qiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening ResearchBeijing 100050China COFCO Nutrition and Health Research Institute Beijing 102209China Department of Pharmacy The Eighth Affiliated HospitalSun Yat-sen UniversityShenzhen 518000China Faculty of Biology Medicine and Health SciencesThe University of ManchesterManchester M139PLUnited Kingdom Changchun University of Chinese Medicine Changchun 130117China School of Food Science and Biotechnology Zhejiang Gongshang UniversityHangzhou 310018China China Tea Technology(Beijing)Co. Ltd.Beijing 102209China Beijing Key Laboratory of Nutrition Health and Food SafetyBeijing 102209China

Obesity is a metabolic disorder due to over-accumulation of adipose tissue and ultimately becomes a“disease”.Brown adipose tissue(BAT)thermogenesis and white adipose tissue(WAT)browning emerge as a potential strategy of anti-obesity by dissipating energy as ***,drugs based on adipose tissue thermogenesis have not been successfully approved *** current study,we found that black tea extract(BTE)obtained by patentauthorized manufacturing process prevented body weight gain as novel thermogenic activator with reduction of adiposity,improvement of adipose distribution,and glucose metabolism improvement in diet-induced obesity ***,anti-obesity effect of BTE depends on promoting BAT thermogenesis and WAT browning with upregulation of uncoupling protein 1(UCP1),especially visceral adipose tissue(VAT)with browning ***,utilizing in silico approach of network pharmacology and molecular docking,we identified carbonic anhydrase 2(CA2)in nitrogen metabolism as anti-obesity target of BTE and further elucidated that protein kinase B(AKT)signaling pathway linked CA2 and *** gut microbiota regulation may prompt the CA2-dependent thermogenesis *** findings demonstrated anti-obesity effect of BTE as thermogenic activator through CA2-mediated BAT thermogenesis and WAT browning via CA2-AKT-UCP1 signaling pathway,which could be developed as promising anti-obesity agent with good safety and efficacy.

关键词： Obesity Black tea Thermogenesis Browning Adipose tissue

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Effect of Calcium Carbonate Whisker on Impact Toughness of Precast Concrete

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Journal of Wuhan University of Technology(Materials Science) 2021年第3期36卷 374-380页

作者： LV Linnv wang yisa HE Yongjia wang Fazhou HU Shuguang School of Science Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Silicate Materials for Architec-tures(Wuhan University of Technology) Wuhan 430070China School of Materials Science and Engineering Wuhan University of Tech-nologyWuhan 430070China

The impact toughness and compressive strength of concrete added with calcium carbonate whisker are *** is found that calcium carbonate whisker can significantly improve the impact energy consumption at failure of 55℃steam cured concrete,but has limited impact on 90℃steam cured *** the same time,SEM,XRD and LF-NMR were used to study the micro morphology,hydration product components and pore structure of the concrete,and the mechanism of the influence of calcium carbonate whisker on the impact toughness and compressive strength of concrete was analyzed.

关键词： calcium carbonate whisker concrete products impact toughness compressive strength

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Effect of Calcium Silicate Hydrate Seeds on Hydration and Mechanical Properties of Cement

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Journal of Wuhan University of Technology(Materials Science) 2021年第1期36卷 103-110页

作者： wang yisa LÜLinnü HE Yongjia wang Fazhou HU Shuguang Hubei Key laboratory of Theory and Application of Advanced Materials Mechanics(School of Science Wuhan University of Technology)Wuhan 430070China State Key Laboratory of Silicate Materials for Architectures(Wuhan University of Technology) Wuhan 430070China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

C-S-H series are synthesized at different temperatures and ages by pozzolanic *** change of particle size distribution,phase composition,morphology and nanostructure of C-S-H with temperatures and ages,and the effects of C-S-H seeds and seeds parameters on the hydration behavior and mechanical properties development of cement were investigated by DLS,XRD,SEM,^(29)Si NMR,TAM-air isothermal calorimeter and mechanical properties *** results show that the particle size,crystallinity,basal spacing and Q^(2)/Q^(1) ratio of C-S-H increases with the increase of synthesis temperature and *** addition of synthesized C-S-H seeds to cement pastes results in the strong acceleration effect on cement hydration and significant improvement of the early strength of cement paste and *** 1 day-C-S-H seeds synthesized at room temperature can increase the strength of cement paste by about 30 MPa at 12 *** effect does not show a very regular change with the increase of the temperature and age of seeds *** the effect of C-S-H seeds on the hydration and mechanical properties of cement,and economy and short cycle of seeds synthesis,the C-S-H seeds synthesized at room temperature for 1 day or 55 ℃ water bath for 12 hours is recommended..

关键词： calcium silicate hydrate(C-S-H) seeds hydration mechanical property temperature

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Phase-transfer-shuttle generated in situ enables novel S1-type fluorination of sulfonium ylide with hydrofluoric acid

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Science China Chemistry 2024年

作者： yisa Xiao Rui wang Zhaoxuan Xu Qunchao Zhao Renyi Pang Tao Dong Long Lu Qilong Shen Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy Sciences Chinese Academy of Sciences

The development of a nucleophilic fluorination protocol using hydrofluoric acid as the fluoride source represents a long-sought goal in the field of organofluorine chemistry. We report herein the realization of such a reaction that employed alkyl-substituted sulfonium ylides as the substrates. The key to the success of the protocol was attributed to two factors: First, as a Br?nsted base,the ylide was able to be protonated by HFaq, thus serving as a phase-transfer shuttle generated in situ to bring F-from aqueous phase to the organic phase promoting desolvation of fluoride ion. Second, after protonation, a sulfonium salt, a good leaving group, was generated and subsequent attacked by the fluoride to afford the alkyl fluoride. Mechanistic investigation indicates that the reaction occurs via an SN1 pathway. Because of the nature of the cationic intermediate in the reaction, two attractive rearrangement-fluorination approaches including 1,2-aryl migration fluorination and ring-expansion fluorination were disclosed.

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安徽繁昌癞痢山东裂隙早更新世异仓鼠

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第四纪研究 2022年第2期42卷 592-602页

作者：王一飒王元黄柏挺徐繁金昌柱中国科学院古脊椎动物与古人类研究所中国科学院脊椎动物演化与人类起源重点实验室北京100044 中国科学院生物演化与环境卓越创新中心北京100044 中国科学院大学北京100049 安徽省芜湖市繁昌区文物保护中心安徽芜湖241200

文章详细记述了产自安徽繁昌癞痢山东裂隙堆积的异仓鼠化石。化石产地位于长江下游南岸的繁昌,与著名的人字洞古人类活动遗址相距仅数米,2020年我们首次对该裂隙堆积进行了系统发掘,已采集到数百件哺乳动物化石标本,其中异仓鼠属(Allocr... 详细信息

文章详细记述了产自安徽繁昌癞痢山东裂隙堆积的异仓鼠化石。化石产地位于长江下游南岸的繁昌,与著名的人字洞古人类活动遗址相距仅数米,2020年我们首次对该裂隙堆积进行了系统发掘,已采集到数百件哺乳动物化石标本,其中异仓鼠属(Allocricetus)化石居多。异仓鼠属在我国最早的地史记录为上新世早期,最晚则延续到中更新世的周口店期,而且常与重要的古人类遗存伴生。东裂隙的标本依臼齿尺寸较大,M1的前边尖从前面二分且唇侧者稍大、无前小脊刺发育且中脊较短,m1缺失下中脊,m2下中脊发育较差,m3发育下中脊并伸至齿缘且m3长于m2等特征最相似于早更新世的艾克氏异仓鼠(***);然而,周口店第十八地点的艾克氏异仓鼠的M1发育前小脊刺,湖北建始龙骨洞的m2下中脊较明显等形态特征比东裂隙的标本稍显原始,因此暂定为艾克氏异仓鼠(相似种)Allocricetus ***。鉴于繁昌东裂隙动物群兼具有早更新世—中更新世过渡的性质且出现Allocricetus ***,推测东裂隙动物群的地质时代为早更新世晚期。东裂隙的异仓鼠很可能是该种在我国的末现位。

关键词：安徽繁昌癞痢山东裂隙堆积早更新世艾克氏异仓鼠

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广西扶绥岩亮洞与巨猿伴生的鼠亚科及其动物群的层序对比

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人类学学报 2021年第6期40卷 1041-1054页

作者：王元王一飒王奕迪秦超秦大公金昌柱中国科学院古脊椎动物与古人类研究所中国科学院脊椎动物演化与人类起源重点实验室北京100044 中国科学院生物与环境卓越中心北京100044 中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学北京100049 沈阳师范大学古生物学院沈阳110034 北京大学生命科学学院北京100871

本文系统研究了产自广西扶绥岩亮洞与步氏巨猿下颌骨伴生的鼠亚科化石,包括:锡金小鼠(相似种)(Mus ***)、小巢鼠(Micromys minutus)、亚洲姬鼠(Apodemus asianicus)、细狨鼠(Hapalomys gracilis)、原始笔尾树鼠(Chiropodomys primitivus)、先社鼠(Niviventer preconfucianus)、安氏白腹鼠(Niviventer andersoni)、拟爱氏巨鼠(Leopoldamys edwardsioides)和始家鼠(相似种)(Rattus ***),共计8属9种,其中包括了6个绝灭种,鼠亚科绝灭种的比例高达67%。研究表明,岩亮洞鼠亚科动物群的性质比重庆巫山龙骨坡的相关鼠类显得稍进步,但比湖北建始龙骨洞以及广西崇左泊岳山巨猿洞和三合大洞的鼠亚科组合都要原始,因此推测其时代为早更新世早期(可能距今约200万年)。此外,依据主要属种的形态差异和演化水平,本文还初步建立了广西左江流域更新世鼠亚科动物群的层序,从早到晚依次为:扶绥岩亮洞(距今约200万年)—崇左泊岳山巨猿洞(距今约180万年)—崇左三合大洞(距今约160-120万年)—木榄山智人洞(距今约11万年),这对于深入研究我国南方早更新世巨猿—中华乳齿象动物群的系统演化,以及探讨我国南方第四纪生物地层的划分具有积极的意义。

关键词：广西左江流域早更新世扶绥岩亮洞鼠亚科动物群层序对比

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天然产物抗肥胖活性的研究进展

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中药药理与临床 2021年第3期37卷 235-240页

作者：王以撒李文兰孙加琳强桂芬杜冠华哈尔滨商业大学哈尔滨150028 中国医学科学院药物研究所北京100050 青岛大学附属医院药学部青岛266000

肥胖严重影响健康,我国是肥胖人群数量增长最迅速的国家之一。目前抗肥胖药物非常有限,且常见停药反弹或多种不良反应,因此,寻找安全有效的抗肥胖药物是目前药物及健康产品研发的重要方向。多种天然产物被发现可通过抑制脂肪组织形成、... 详细信息

肥胖严重影响健康,我国是肥胖人群数量增长最迅速的国家之一。目前抗肥胖药物非常有限,且常见停药反弹或多种不良反应,因此,寻找安全有效的抗肥胖药物是目前药物及健康产品研发的重要方向。多种天然产物被发现可通过抑制脂肪组织形成、增加脂肪组织产热、诱导白色脂肪组织(WAT)褐变等途径发挥抗肥胖作用,是开发抗肥胖药物的重要来源。本文对见诸文献的具有抗肥胖活性的天然产物研究现状作一综述,为抗肥胖药物研发提供参考。

关键词：天然产物肥胖脂肪

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述情障碍对脑出血患者愤怒倾向的影响

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护理学杂志 2015年第2期30卷 4-6页

作者：王一飒金搏温岭市第一人民医院脑外科二病区

目的了解脑出血患者述情障碍和愤怒倾向现状,探讨述情障碍对脑出血患者愤怒倾向的影响。方法采用多伦多述情障碍量表和特质愤怒量表对230例脑出血患者进行调查。结果脑出血患者述情障碍发生率为40.87%,述情障碍总分为(62.51±7.31)分;... 详细信息

目的了解脑出血患者述情障碍和愤怒倾向现状,探讨述情障碍对脑出血患者愤怒倾向的影响。方法采用多伦多述情障碍量表和特质愤怒量表对230例脑出血患者进行调查。结果脑出血患者述情障碍发生率为40.87%,述情障碍总分为(62.51±7.31)分;愤怒倾向发生率为20.43%。愤怒倾向与述情障碍总分及各维度得分呈显著正相关(P<0.05,P<0.01)。分层回归分析显示,识别情感障碍、描述情感障碍、外向性思维为脑出血患者愤怒倾向的影响因素(P<0.05,P<0.01)。结论脑出血患者愤怒倾向和述情障碍发生率较高,述情障碍是脑出血患者愤怒倾向的影响因素;护士可从述情障碍入手来改善脑出血患者的愤怒倾向。

关键词：脑出血愤怒倾向述情障碍

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The reformation of catalyst:From a trial-and-error synthesis to rational design

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Nano Research 2024年第4期17卷 3261-3301页

作者： Ligang wang Jiabin Wu Shunwu wang Huan Liu Yao wang Dingsheng wang Department of Chemistry Tsinghua UniversityBeijing 100084China

The appropriate catalysts can accelerate the reaction rate and effectively boost the efficient conversion of various molecules,which is of great importance in the study of chemistry,chemical industry,energy,materials and environmental ***,efficient,environmentally friendly,and easy to operate synthesis methods have been used to prepare various types of *** previous studies have reported the synthesis and characterization of the aforementioned catalysts,more still remain in trial and error methods,without in-depth consideration and improvement of traditional synthesis ***,we comprehensively summarize and compare the preparation methods of the trial-and-error synthesis strategy,structure–activity relationships and density functional theory(DFT)guided catalysts rational design for nanomaterials and atomically dispersed *** also discuss in detail the utilization of the nanomaterials and single atom catalysts for converting small molecules(H_(2)O,O_(2),CO_(2),N_(2),etc.)into value-added products driven by electrocatalysis,photocatalysis,and ***,the challenges and outlooks of mass preparation and production of efficient and green catalysts through conventional trial and error synthesis and DFT theory are featured in accordance with its current development.

关键词： trial-and-error synthesis structure–activity relationships density functional theory(DFT)guidance nanomaterials atomically dispersed catalysts

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Numerical Analysis of PRISM-PY Calculations for Hard-and Soft-Core Generic Polymer Models

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Chinese Journal of Polymer Science 2024年第4期42卷 532-543页

作者： Qiang wang Department of Chemical and Biological Engineering Colorado State University1370 Campus DeliveryFort CollinsCO80523-1370USA

Generic polymer models capturing the chain connectivity and excluded-volume interactions between polymer segments can be classified, according to whether or not the 3D integral of the latter diverges, into hard- and soft-core models. Taking homogeneous systems of compressible homopolymer melts (or equivalently homopolymer solutions in an implicit, good solvent) in the continuum as an example, we recently compared the correlation effects on the structural and thermodynamic properties of the hard- and soft-core models given by the polymer reference interaction site model (PRISM) theory with the Percus-Yevick (PY) closure (Polymers 2023, 15, 1180). Here we analyzed in detail the numerical errors and behavior of the interchain pair correlation functions (PCFs) given by the PRISM-PY calculations of these models using an efficient numerical approach that we proposed. Our numerical approach has the least number of independent variables to be iteratively solved, analytically treats the discontinuities caused by the non-bonded pair potential (such as that of the hard spheres) and takes only the inverse Fourier transform of the interchain indirect PCF between polymer segments (which is continuous and decays towards 0 with increasing wavenumber much faster than both the interchain direct and total PCFs), and is essential for us to accurately solve the PRISM-PY theory for chain length N as large as 106. To capture the correlation-hole effect, the real-space cut-off in the PRISM calculations should be proportional to the square root of N.

关键词： Generic polymer models Soft potentials Polymer reference interaction site model theory

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