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Heterogeneity of aberrant immunoglobulin expression in cancer cells

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Cellular & Molecular Immunology 2011年第6期8卷 479-485页

作者： Duosha Hu Zhi Duan Ming Li yiqun Jiang Haidan Liu Hui Zheng Lili Li Ann M Bode Zigang Dong Ya cao Key Laboratory of Ministry of Education Key Laboratory of Ministry of HealthLaboratory of Tumor Molecular BiologyCancer Research InstituteXiangya School of MedicineCentral South UniversityChangshaChina Department of Immunology Xiangya School of MedicineCentral South UniversityChangshaChina Center of Clinical Gene Diagnosis and Therapy Department of Cardiothoracic SurgeryThe Second Xiangya HospitalCentral South UniversityChangshaChina The Hormel Institute University of MinnesotaAustinMNUSA

Accumulating evidence has shown that immunoglobulin(Ig)is‘unexpectedly’expressed by epithelial cancer cells and that it can promote tumor *** main purpose of this study was to explore the components of the cancerous Ig and its possible *** presence of cancerous Ig in the Golgi apparatus was confirmed by immunofluorescence,indirectly suggesting that the cancerous Ig was processed and packaged in cancer *** blot analysis and ELISA results indicated that cancer cells produced membrane Ig and secreted Ig into the supernatant *** cancerous Ig consists of an a heavy chain and a k light ***,by analyzing the Ig components pulled down by protein A beads,the cancerous Ig was found to be structurally distinct from normal *** cancerous Ig was truncated or *** the underlying mechanism that causes the abnormalities has not been determined,our current discoveries strengthen our previous findings and promise fruitful future explorations.

关键词： immunoglobulin truncated immunoglobulin tumor immunology

Study on the application of reinforcement learning in the operation optimization of HVAC system

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Building Simulation 2021年第1期14卷 75-87页

作者： Xiaolei Yuan yiqun Pan Jianrong Yang Weitong Wang Zhizhong Huang School of Mechanical Engineering Tongji University4800 Cao’an RoadShanghai201804China Shanghai Research Institute of Building Sciences ShanghaiChina Kuaishou Co.Ltd. BeijingChina Sino-German College of Applied Sciences Tongji UniversityShanghai201804China

Supervisory control can be used to optimize the HVAC system operation and achieve building energy conservation,while reinforcement learning(RL)is considered as a promising model-free supervisory control *** this paper,we apply RL algorithm to the operation optimization of air-conditioning(AC)system and propose an innovative RL-based model-free control strategy combining rule-based and RL-based control algorithm as well as complete application *** use a variable air volume(VAV)air-conditioning system for a single-storey office building as a case study to validate the optimization performance of the RL-based *** select control strategies with the rule-based control controller(RBC)and proportional-integral-derivative(PID)controller respectively as the reference *** results show that,for the air supply of single zone,the RL controller performs the best in terms of both non-comfortable time and energy costs of AC system after one-year exploration *** total energy consumption of AC system reduced by 7.7%and 4.7%,respectively compared with RBC and PID *** the air supply of multi-zone,the performance of RL controller begins to outperform the reference strategies after two-year exploration learning and two-year buffer *** the seventh year on,RL controller performs much better in terms of both non-comfortable time and operating costs of AC system,while the operating cost of AC system is reduced by 2.7%to 4.6%compared with the reference *** addition,RL controller is more suitable for small-scale operation optimization problems.

关键词： reinforcement learning HVAC system operation optimization control strategy VAV system energy saving

Characterization of a novel gene, BcMF7,that is expressed preferentially in pollen of Brassica campestris L. ssp. chinensis Makino

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Science China(Life Sciences) 2007年第4期50卷 497-504页

作者： HUANG Li, cao JiaShu, ZHANG YuChao & YE yiqun Laboratory of Cell & Molecular Biology, Institute of Vegetable Science, Zhejiang University, Hangzhou 310029, China Laboratory of Cell & Molecular Biology Institute of Vegetable Science Zhejiang University Hangzhou China

Pollen formation is important for plant sexual reproduction. To identify the genes that are involved in pollen formation, we performed the genome-wide transcriptional profiling in the flower buds of both male meiotic cytokinesis (mmc) mutant and its wild-type plants of Brassica campestris L. ssp. chinen-sis, syn. B. rapa L. ssp. chinensis. cDNA-amplified fragment length polymorphism (cDNA-AFLP) analy-sis showed that the mmc mutation resulted in changes in expression of a variety of genes. BcMF7, a transcript-derived fragment (TDF) accumulated in the wild-type flower buds was further characterized. The BcMF7 gene has 1161 bp in length with two introns. The full-length BcMF7 cDNA has 609 bp in length and encodes a protein of 129 amino acids. The deduced amino acid sequence of BcMF7 protein shares no similarity to any function-known protein in Swiss-Prot database, but has 8 protein kinase C phosphorylation sites, 2 casein kinase II phosphorylation sites, 2 tyrosine kinase phosphorylation sites, 2 N-glycosylation sites and 2 N-myristoylation sites. Spatial and temporal expression patterns analysis showed that BcMF7 was expressed exclusively in pollen. The expression signal of BcMF7 was first detected at the tetrad stage of microspore development, reached a peak level at the uninucleate stage, and decreased to a slightly low level at the mature pollen stage. All these results show that BcMF7 may play a certain role in the signal transduction during pollen development.

关键词： Brassica campestris ssp. chinensis differentially expressed pollen development flower buds signal transduction

Activation of the Ig la I promoter by the transcription factor Ets-1 triggers Ig lal-Cal germline transcription in epithelial cancer cells

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Cellular & Molecular Immunology 2014年第2期11卷 197-205页

作者： Zhi Duan Hui Zheng San Xu yiqun Jiang Haidan Liu Ming Li Duosha Hu Wei Li Ann M. Bode Zigang Dong Ya cao Laboratory of Tumor Molecular Biology Cancer Research Institute Central South University Changsha China Key Laboratory of Carcinogenesis andCancer Invasion Ministry of Education Changsha China Key Laboratory of Carcinogenesis Ministry of Health Changsha China Center of Clinical Gene rDiagnosis and Theralav Department of Cardiothoracic Surgery The Second Xian~:ya Hospital Central South University Changsha China Department ofimmunology Xiangya Medical College Central South University Changsha China The Hormel Institute University of Minnesota Austin MN USACorrespondence: Dr Y Cao Laboratory of Tumor Molecular Biology Cancer Research Institute Central South University Changsha 410078 China.

Immunoglobulins （Igs） are known to be synthesized and secreted only by B lymphocytes. Class switch recombination （CSR） is a key event that enables B cells to express Igs, and one of the crucial steps for CSR initiation is the germline transcription of Iggenes. Surprisingly, recent studies have demonstrated that the Iggenes are also expressed in some epithelial cancer cells; however, the mechanisms underlying how cancer cells initiate CSR and express Igs are still unknown. In this study, we confirmed that the Ig la I promoter in cancer cell lines was activated by the Ets- 1 transcription factor, and the activity of the Ig la I promoter and ig lal-C^l germiine transcription were attenuated after knockdown of Ets-1 by specific small interfering RNAs （siRNA）. Furthermore, the expression of Ets-1 and Iga heavy chain in cancer cells was dose dependently upregulated by TGF-I^I. These results indicate that activation of the Ig lal promoter by the transcriotion factor Ets-1 is a critical Dathwav and orovides a novel mechanism for le exoression in non-B cell cancers.

关键词： epithelial cancer cells Ets-1 Ig I^1 promoter

基于HPLC⁃DAD指纹图谱结合化学模式识别的红糖产地溯源方法

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食品研究与开发 2024年第8期45卷 149-158页

作者：张雅淑黄美婷吕仕军陆莉莉曹轶群谢彩锋陆海勤黎庆涛黄智广西大学轻工与食品工程学院广西南宁530004 广西壮族自治区产品质量检验研究院广西南宁530200

红糖作为一种功能食品,近年来需求量不断增长,然而市场上红糖的品质却良莠不齐,且缺乏科学的鉴别和评估方法来确保红糖的品质。该研究以我国5个红糖主产地(广西、广东、云南、贵州和香港地区)的55批红糖作为研究对象,通过构建高效液相色... 详细信息

红糖作为一种功能食品,近年来需求量不断增长,然而市场上红糖的品质却良莠不齐,且缺乏科学的鉴别和评估方法来确保红糖的品质。该研究以我国5个红糖主产地(广西、广东、云南、贵州和香港地区)的55批红糖作为研究对象,通过构建高效液相色谱⁃二极管阵列检测器(high⁃performance liquid chromatography⁃diode array detector,HPLC⁃DAD)指纹图谱并结合共有模式法、相似度评价法和化学计量学法,建立一种能够准确追溯红糖产地的方法。研究发现,不同产地的红糖既有特有的HPLC⁃DAD指纹图谱也有共有的HPLC⁃DAD指纹图谱,特有的HPLC⁃DAD指纹图谱显示产地特有峰的保留时间具有明显的地域特性,与产地区分密切相关。产地共有指纹图谱共标定出9个共有峰,指纹图谱的相似度为0.473~0.915,表明虽然存在共有峰但共有峰峰面积存在明显差异(例如广东、广西、云南、贵州和香港地区的S2号共有峰的平均相对峰面积分别为47.592%、26.873%、814.853%、8.683%和3.111%)。共有峰峰面积的聚类热图显示不同地区的样品存在明显差异。此外,共有峰峰面积的主成分分析发现前3个主成分对产地区分的贡献率分别为59.9%、17.1%和11.6%,累计贡献率为88.6%,可以作为鉴别红糖产地的特征性指标。

关键词：红糖高效液相色谱⁃二极管阵列检测器指纹图谱聚类分析主成分分析产地溯源

Assessment of Adaptive Rate Response Provided by Accelerometer, Minute Ventilation and Dual Sensor Compared with Normal Sinus Rhythm During Exercise： A Self-controlled Study in Chronotropically Competent Subjects

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Chinese Medical Journal 2015年第1期128卷 25-31页

作者： Yuanyuan cao yiqun Zhang Yangang Su Jin Bai Wei Wang Junbo Ge Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai 200032 China Institute of Advancing Science Boston Scientific-China Shanghai 200032 China

Background：Dual sensor （DS） for rate adaption was supposed to be more *** evaluate its superiority,the DS （accelerometer [ACC] and minute ventilation [MV]） and normal sinus rate response were compared in a self-controlled way during exercise treadmill testing.Methods：This self-controlled study was performed in atrioventricular block patients with normal sinus function who met the indications of pacemaker ***-one patients came to the 1-month follow-up *** performed a treadmill test 1-month post implant while programmed in DDDR and sensor passive *** these patients,sensor response factors were left at default settings （ACC =8,MV =3） and sensor indicated rates （SIRs） for DS,ACC and MV sensor were retrieved from the pacemaker memories,along with measured sinus node （SN） rates from the beginning to 1-minute after the end of the treadmill test,and compared among study *** measures analysis of variance and profile analysis,as well as variance analysis of randomized block designs,were used for statistical analysis.Results：Fifteen patients （15/2 l） were determined to be chronotropically *** mean differences between DS SIRs and intrinsic sinus rates during treadmill testing were smaller than those for ACC and MV sensor （mean difference between SIR and SN rate：ACC ***,MV ***,DS ***,respectively,34.84,17.60,16.15 beats/min）,though no sensors could mimic sinus rates under the default settings for sensor response factor （ACC *** P-adjusted 〈 0.001; MV *** P-adjusted =0.002; DS *** P-adjusted =0.005）.However,both in the range of 1st minute and first 3 minutes of exercise,only the DS SIR profile did not differ from sinus rates （P-adjusted =0.09,0.90,respectively）.Conclusions：The DS under default settings provides more physiological rate response during physical activity than the corresponding single sensors （ACC or MV sensor）.Further study is needed to determine if individual optimization would further

关键词： Accelerometer Adaptive Rate Pacing Dual Sensor Minute Ventilation

Research on power electronic transformer applied in AC/DC hybrid distribution networks

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Global Energy Interconnection 2018年第3期1卷 396-403页

作者： yiqun Miao Jieying Song Haijun Liu Zhengang Lu Shufan Chen Chun Ding Tianzhi cao Linhai Cai Yuzhong Gong State Grid Shanghai Municipal Electric Power Company State Key Laboratory of Advanced Power Transmission Technology Global Energy Interconnection Research Institute State Grid Jibei Electric Power Company Department of Electrical and Computer Engineering University of Saskatchewan

The AC/DC hybrid distribution network is one of the trends in distribution network development, which poses great challenges to the traditional distribution transformer. In this paper, a new topology suitable for AC/DC hybrid distribution network is put forward according to the demands of power grid, with advantages of accepting DG and DC loads, while clearing DC fault by blocking the clamping double sub-module(CDSM) of input stage. Then, this paper shows the typical structure of AC/DC distribution network that is hand in hand. Based on the new topology, this paper designs the control and modulation strategies of each stage, where the outer loop controller of input stage is emphasized for its twocontrol mode. At last, the rationality of new topology and the validity of control strategies are verified by the steady and dynamic state simulation. At the same time, the simulation results highlight the role of PET in energy regulation.

关键词： AC/DC hybrid distribution network Power electronic transformer(PET) Clamping double sub-module(CDSM) Energy router

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On-chip spiking neural networks based on add-drop ring microresonators and electrically reconfigurable phase-change material photonic switches

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Photonics Research 2024年第4期12卷 755-766页

作者： QIANG ZHANG NING JIANG yiqun ZHANG ANRAN LI HUANHUAN XIONG GANG HU YONGSHENG cao KUN QIU School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

We propose and numerically demonstrate a photonic computing primitive designed for integrated spiking neural networks (SNNs) based on add-drop ring microresonators (ADRMRs) and electrically reconfigurable phasechange material (PCM) photonic switches. In this neuromorphic system, the passive silicon-based ADRMR,equipped with a power-tunable auxiliary light, effectively demonstrates nonlinearity-induced dual neural dynamics encompassing spiking response and synaptic plasticity that can generate single-wavelength optical neural spikes with synaptic weight. By cascading these ADRMRs with different resonant wavelengths, weighted multiple-wavelength spikes can be feasibly output from the ADRMR-based hardware arrays when external wavelengthaddressable optical pulses are injected;subsequently, the cumulative power of these weighted output spikes is utilized to ascertain the activation status of the reconfigurable PCM photonic switches. Moreover, the reconfigurable mechanism driving the interconversion of the PCMs between the resonant-bonded crystalline states and the covalent-bonded amorphous states is achieved through precise thermal modulation. Drawing from the thermal properties, an innovative thermodynamic leaky integrate-and-firing (TLIF) neuron system is proposed. With the TLIF neuron system as the fundamental unit, a fully connected SNN is constructed to complete a classic deep learning task:the recognition of handwritten digit patterns. The simulation results reveal that the exemplary SNN can effectively recognize 10 numbers directly in the optical domain by employing the surrogate gradient algorithm. The theoretical verification of our architecture paves a whole new path for integrated photonic SNNs, with the potential to advance the field of neuromorphic photonic systems and enable more efficient spiking information processing.

关键词： neural networks precise

Regulation of cytokinesis by exocyst subunit SEC6 and KEULE in Arabidopsis thaliana

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Regulation of cytokinesis by exocyst subunit SEC6 and KEULE ...