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Saddlepoint Approximation Method in Reliability Analysis:A Review

Computer Modeling in Engineering & Sciences 2024年第6期139卷 2329-2359页

作者： Debiao Meng yipeng Guo Yihe xu Shiyuan Yang Yongqiang Guo Lidong Pan Xinkai Guo School ofMechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu611731China Institute of Electronic and Information Engineering of UESTC in Guangdong Dongguan523808China Glasgow College University of Electronic Science and Technology of ChinaChengdu611731China Beijing Research Institute of Mechanical&Electrical Technology Ltd.Beijing100083China

The escalating need for reliability analysis(RA)and reliability-based design optimization(RBDO)within engineering challenges has prompted the advancement of saddlepoint approximationmethods(SAM)tailored for such *** article offers a detailed overview of the general SAM and summarizes the method characteristics ***,recent enhancements in the SAM theoretical framework are ***,the mean value first-order saddlepoint approximation(MVFOSA)bears resemblance to the conceptual framework of the mean value second-order saddlepoint approximation(MVSOSA);the latter serves as an auxiliary approach to the *** distinction is rooted in the varying expansion orders of the performance function as implemented through the Taylor *** the saddlepoint approximation and third-moment(SATM)and saddlepoint approximation and fourth-moment(SAFM)strategies model the cumulant generating function(CGF)by leveraging the initial random moments of the *** their optimal application domains diverge,each method consistently ensures superior relative precision,enhanced efficiency,and sustained *** method elucidated is exemplified through pertinent RA or RBDO *** juxtaposing them against alternative strategies,the efficacy of these methods becomes *** outcomes proffered are subsequently employed as a foundation for contemplating prospective theoretical and practical research endeavors concerning *** main purpose and value of this article is to review the SAM and reliability-related issues,which can provide some reference and inspiration for future research scholars in this field.

关键词： Reliability analysis reliability-based design optimization saddlepoint approximation

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Cross-media Hot Topic Auto-tracking Model Based on Semantics and Temporal Context

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Chinese Journal of Electronics 2015年第3期24卷 529-534页

作者： LIANG Meiyu DU Junping ZHOU yipeng Beijing Key Lab of Intelligent Telecommunication Software and Multimedia School of Computer ScienceBeijing University of Posts and Telecommunications School of Computer and Information Engineering Beijing Technology and Business University

As the Internet multimedia information grows explosively, seeking an automatic technology to realize the effective organization and management of crossmedia emergency information is significantly necessary. A novel cross-media hot topic auto-tracking model based on semantics and temporal context is proposed in this paper. According to the semantic correlations of cross-media information, we learn the image visual semantics by the text semantics based on the Latent Dirichlet Allocation probability model, and establish the unified cross-media information description on the same semantic level. Also a semantics-based two-step feature dimension-reduction scheme is proposed to establish the efficient semantic feature space. The self-adaptive learning of topic model is realized to track the dynamic changes in the topic. Experimental results demonstrate that the proposed method outperforms the existing methods, which further improves the effect of hot topic auto-tracking.

关键词： Cross-media data mining Topic autotracking Semantic model Latent dirichlet allocation(LDA) Temporal context

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Inputs and outputs of insulin receptor

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Protein & Cell 2014年第3期5卷 203-213页

作者： yipeng Du Taotao Wei National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

The insulin receptor （IR） is an important hub in insulin signaling and its activation is tightly regulated. Upon insulin stimulation, IR is activated through autophos- phorylation, and consequently phosphorylates several insulin receptor substrate （IRS） proteins, including IRS1- 6, Shc and Gab1. Certain adipokines have also been found to activate IR. On the contrary, PTP, Grb and SOCS proteins, which are responsible for the negative regu- lation of IR, are characterized as IR inhibitors. Addi- tionally, many other proteins have been identified as IR substrates and participate in the insulin signaling path- way. To provide a more comprehensive understanding of the signals mediated through IR, we reviewed the upstream and downstream signal molecules of IR, summarized the positive and negative modulators of IR, and discussed the IR substrates and interacting adaptor proteins. We propose that the molecular events associ- ated with IR should be integrated to obtain a better understanding of the insulin signaling pathway and diabetes.

关键词： insulin insulin receptor signaling

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H9N2 influenza virus in China： a cause of concern

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Protein & Cell 2015年第1期6卷 18-25页

作者： yipeng Sun Jinhua Liu Key Laboratory of Animal Epidemiology and Zoonosis Ministry of Agriculture College of Veterinary MedicineChina Agricultural University Beijing 100083 China

The recent human infection with avian influenza virus revealed that H9N2 influenza virus is the gene donor for H7N9 and H10N8 viruses infecting humans. The crucial role of H9N2 viruses at the animal-human interface might be due to the wide host range, adaptation in both poultry and mammalian, and extensive gene reassortment. As the most prevalent subtype of influenza viruses in chickens in China, H9N2 also causes a great economic loss for the poultry industry, even under the long-term vaccination programs. The history, epidemiology, bio- logical characteristics, and molecular determinants of H9N2 influenza virus are reviewed in this paper. The contribution of H9N2 genes, especially RNP genes, to the infection of humans needs to be investigated in the future.

关键词： Influenza Poultry H9N2 Evolution,Virulence Antigenic drift

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褐飞虱KCTD3基因克隆、序列分析及其时空表达研究

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中国计量大学学报 2022年第3期33卷 423-431页

作者：姬金亮张瑞娟李雅彬余建斌俞晓平许益鹏中国计量大学生命科学学院浙江省生物计量及检验检疫技术重点实验室浙江杭州310018

目的:克隆褐飞虱钾通道蛋白KCTD3基因,并研究其序列特征和时空表达情况,以更好地了解褐飞虱KCTD3在褐飞虱生长发育中的作用,为防治褐飞虱提供理论依据。方法:通过PCR扩增褐飞虱KCTD3基因,运用生物信息学方法对褐飞虱KCTD3基因序列进行分... 详细信息

目的:克隆褐飞虱钾通道蛋白KCTD3基因,并研究其序列特征和时空表达情况,以更好地了解褐飞虱KCTD3在褐飞虱生长发育中的作用,为防治褐飞虱提供理论依据。方法:通过PCR扩增褐飞虱KCTD3基因,运用生物信息学方法对褐飞虱KCTD3基因序列进行分析;之后采用荧光定量PCR(qPCR)检测KCTD3基因在褐飞虱不同生长发育时期(1~5龄若虫和1~9日龄雌成虫)和不同组织(胸部、卵巢、脂肪体、头部和肠道)中的表达情况。结果:褐飞虱KCTD3基因开放阅读框长度为2139 bp,编码712个氨基酸残基,预测蛋白相对分子质量为78200 u,等电点为7.6,包含有一个BTB保守结构域,无信号肽。系统进化树显示,褐飞虱KCTD3与半翅目茶翅蝽Halyomorpha halys和绿盲蝽Apolygus lucorum的KCTD3亲缘关系最近。qPCR结果显示,褐飞虱KCTD3在褐飞虱发育的所有阶段均有表达且在雌成虫中高水平表达,KCTD3在若虫时期表达量较为稳定,而在3日龄成虫中的表达量最高;组织表达分析表明,褐飞虱KCTD3在各组织中均有表达,且在卵巢中的表达量明显高于其他组织,在脂肪体中的表达量最低。结论:本研究成功克隆了褐飞虱KCTD3基因,明确了KCTD3的序列特征和时空表达模式,结果暗示KCTD3在褐飞虱的生长发育和生殖中起重要作用。

关键词：褐飞虱 KCTD3 基因克隆序列分析组织表达

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Cesium lead halide perovskite nanocrystals for ultraviolet and blue light blocking

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Chinese Chemical Letters 2019年第5期30卷 1021-1023页

作者： Guihua Huang yipeng Huang Wei xu Qiuhong Yao Xiaofang Liu Caifeng Ding Xi Chen Institute of Analytical Technology and Smart Instruments College of Environment and Public HealthXiamen Huaxia UniversityXiamen 361024China State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361005China Department of Anesthesiology Xiamen Maternal and Children HospitalXiamen 361003China Key Laboratory of Sensor Analysis of Tumor Marker Ministry of EducationCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China

Using cesium lead halide perovskite nanocrystals, CsPb(Cl/Br)3, as a light absorber, we report a highly effective UV and blue light blocking film. The CsPb(Cl/Br)3 nanocrystals are well dispersed in the ethyl cellulose(EC) matrix to compose a UV and blue light shielding film, and the absorption edge of the film is tunable by adjusting Cl to Br ratio using anion exchange. The CsPbCl2 Br-EC film exhibits a transmittance of 5% at 459 nm, 90% at 478 nm and 95% in the range of 500–800 nm, which makes it excellent for UV and blue light shielding. In addition, the as-prepared EC-CsPb(Cl/Br)3 film shows excellent photostability under UV irradiation. Results demonstrate that this EC-CsPb(Cl/Br)3 based materials with sharp absorbance edges, tunable blocking wavelength, and high photostability can be useful for the applications in UV and blue light blocking and optical filters.

关键词： Perovskite nanocrystals UV blocking Blue light blocking Cesium lead halide nanocrystals Tunable adsorption edge

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Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice

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Journal of Genetics and Genomics 2022年第11期49卷 1042-1052页

作者： Li xu Qiankun Zhang Xiaowei Dou yipeng Wang Jianwei Wang Yong Zhou Xingyin Liu Jing Li State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjingJiangsu 211166China Department of Pathogen Biology-Microbiology Division State Key Laboratory of Reproductive MedicineNanjing Medical UniversityNanjingJiangsu 211166China Shanghai Personal Biotechnology Shanghai 200231China Department of Obstetrics and Gynecology The Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210003China Institute of Pediatric Research Children's Hospital of Soochow UniversitySuzhouJiangsu 215003China Fertility Preservation Laboratory Reproductive Medicine CenterGuangdong Second Provincial General HospitalGuangzhouGuangdong 510317China

Advanced maternal age is characterized by declines in the quantity and quality of oocytes in the ovaries,and the aging process is accompanied by changes in gut microbiota ***,little is known about the relationship between gut microbiota and ovarian *** using fecal microbiota transplantation(FMT)to transplant material from young(5-week-old)into aged(42-week-old)mice,we find that the composition of gut microbiota in FMT-treated mice presents a“younger-like phenotype”and an increase of commensal bacteria,such as Bifidobacterium and ***,the FMT-treated mice show increased anti-inflammatory cytokine IL-4 and decreased pro-inflammatory cytokine IFN-γ.Fertility tests for assessing ovarian function reveal that the first litter size of female FMT-treated mice is significantly higher than that of the non-FMT *** analysis demonstrates a dramatic decrease in follicle atresia and apoptosis as well as an increase in cellular proliferation in the ovaries of the FMT-treated *** results also show that FMT improves the immune microenvironment in aged ovaries,with decreased macrophages and macrophage-derived multinucleated giant cells(MNGCs).These results suggest that FMT from young donors could be a good choice for delaying ovarian aging.

关键词： Ovarian aging Gut microbiota Inflammatory cytokines Ovarian microenvironment

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Smartphone-based bridge frequency identification using vehicle contact-point response

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Earthquake Engineering and Engineering Vibration 2023年第4期22卷 1031-1043页

作者： Liu Chengyin Zhu yipeng Zeng Qing Wu Xiaodong Shenzhen Key Laboratory of Intelligent Structure System in Civil Engineering Harbin Institute of TechnologyShenzhen 518055China

Bridge frequency(BF)identification using the vehicle scanning method has attracted considerable attention during the last two ***,most previous studies have adopted unrealistic vehicle models,thus finding limited practical *** study proposes a smartphone-based BF identification method that uses the contact-point acceleration response of a four degree-of-freedom vehicle *** said response can be inferred from the vehicle body response measured by a *** realizing practical applications,this method is incorporated into a self-developed smartphone app to obtain data smoothly and identify BFs in a timely *** and experimental investigations are performed to verify the effectiveness of the proposed *** particular,the robustness of this method is investigated numerically against various factors,including the vehicle speed,bridge span,road roughness,and bridge ***,laboratory calibration tests are performed to investigate the accuracy of the smartphone gyroscope in measuring the angular velocity,where anomalous data are detected and *** experiment results for a simply supported bridge indicate that the proposed method can be used to identify the first two BFs with acceptable accuracy.

关键词： bridge frequency(BF)identification vehicle–bridge interaction four degree-of-freedom(DOF)vehicle model contact-point response smartphone

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Construction of transposon-mediated baculovirus vector and expression of green fluorescent protein in insect cells and larvae

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Chinese Science Bulletin 1999年第2期44卷 158-163页

作者： Ying Zhu yipeng Qi Wuhan Univ Inst Virol Wuhan 430072 Peoples R China

A transposon-shuttle vector Hanpvid was constructed by using wild-type genomic DNA from Heliothis armigera nuclear polyhedrosis virus (HaNPV). lt could replicate in E. coli cells as a large plasmid and remain infectious when being induced into insect *** comprises HaNPV DNA and a transposon cassette which includes a miniF replicon, a kanamycin resistance gene (kan), lacZa and an attachment site for Tn7 (attTn7). Recombinant virus rHa-FaGP was obtained after transposition of a donor plasmid carrying green fluorescent protein gene (gfp) and polyhedrin gene (ocu) into ***-PAGE analysis shows that both gfp and ocu genes were highly expressed in Heliothis armigera cells. Green Hemolymphocytes can be seen under a fluorescent microscope 4 d after recombinant virus rHa-FaGP infected the third-instar larvae. The infected larvae show strong green fluorescence 6 d post infection.

关键词： HaNPV transposon-shuttle vector recombinant virus green fluorescent protein.

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Properties of Resistivity, Reflection and Absorption Related to Structure of ITO Films

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Journal of Materials Science & Technology 2012年第4期28卷 325-328页

作者： yipeng Chao Wu Tang xuehui Wang State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technologyof ChinaChengdu 610054China

Indium tin oxide （ITO） films were fabricated on polyethylene terephthalate （PET） substrate at room temperature using dc magnetron sputtering technique with different sputtering powers. The structural, electrical and optical properties were investigated by X-ray diffraction （XRD）, Hall effect, reflection and transmission, respectively. XRD patterns show gradual enhancement of crystalline quality with increasing sputtering power. Significant improvement of Hall mobility due to the reduction of defects was observed though the carrier density varied slightly. Simultaneously, the mean transmission in visible light range decreased severely with increasing sputtering power. Slight move toward shorter-wavelength side of absorption peak was due to the variation of plasma wavelength. The reflection increase of near-infrared light originated from the decrease of resistivity. Finally, band gap was obtained using Tauc＇s relation and it was consistent with Burstein-Moss shift.

关键词： Crystalline quality Hall mobility Absorption

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