Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice

作     者：Li Xu Qiankun Zhang Xiaowei Dou Yipeng Wang Jianwei Wang Yong Zhou Xingyin Liu Jing Li Li Xu;Qiankun Zhang;Xiaowei Dou;Yipeng Wang;Jianwei Wang;Yong Zhou;Xingyin Liu;Jing Li

作者机构：State Key Laboratory of Reproductive MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Pathogen Biology-Microbiology DivisionState Key Laboratory of Reproductive MedicineNanjing Medical UniversityNanjingJiangsu 211166China Shanghai Personal BiotechnologyShanghai 200231China Department of Obstetrics and GynecologyThe Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210003China Institute of Pediatric ResearchChildren's Hospital of Soochow UniversitySuzhouJiangsu 215003China Fertility Preservation LaboratoryReproductive Medicine CenterGuangdong Second Provincial General HospitalGuangzhouGuangdong 510317China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2022年第49卷第11期

页      面：1042-1052页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(2018YFC1003703-1) the National Natural Science Foundation of China(81871628,82172288,81902027) 

主　　题：Ovarian aging Gut microbiota Inflammatory cytokines Ovarian microenvironment 

摘      要：Advanced maternal age is characterized by declines in the quantity and quality of oocytes in the ovaries,and the aging process is accompanied by changes in gut microbiota ***,little is known about the relationship between gut microbiota and ovarian *** using fecal microbiota transplantation(FMT)to transplant material from young(5-week-old)into aged(42-week-old)mice,we find that the composition of gut microbiota in FMT-treated mice presents a“younger-like phenotypeand an increase of commensal bacteria,such as Bifidobacterium and ***,the FMT-treated mice show increased anti-inflammatory cytokine IL-4 and decreased pro-inflammatory cytokine IFN-γ.Fertility tests for assessing ovarian function reveal that the first litter size of female FMT-treated mice is significantly higher than that of the non-FMT *** analysis demonstrates a dramatic decrease in follicle atresia and apoptosis as well as an increase in cellular proliferation in the ovaries of the FMT-treated *** results also show that FMT improves the immune microenvironment in aged ovaries,with decreased macrophages and macrophage-derived multinucleated giant cells(MNGCs).These results suggest that FMT from young donors could be a good choice for delaying ovarian aging.