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Sequentially bridged MXene platelets for strong high‐temperature EM‐IR bi‐stealth sheets

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SmartMat 2024年第1期5卷 121-134页

作者： Yushan Yang Kaicong Chen yipeng Chen Chao Wang Baokang Dang Yingying Li Ming liu Qingfeng sun College of Chemistry and Materials Engineering Zhejiang A&F UniversityHangzhouChina Guangxi Fenglin Wood Industry Group Co.Ltd NanningChina

Combination of flexible multifunctional stealth technology properties such as electromagnetic(EM)and infrared(IR)stealth is crucial to the development of aerospace,military,and electronic fields,but the synthesis technology still has a significant ***,we have successfully designed and synthesized highly flexible MXene@cellulose lamellae/borate ion(MXCB)sheets with strong high‐temperature EM‐IR bi‐stealth through sequential bridging of hydrogen and covalent *** resultant MXCB sheets display high conductivity and good mechanical features such as flexibility,stretchability,fatigue resistance,and ultrasonic *** sheets have a high tensile strength of 795 ***,MXCB sheets with different thicknesses indicate exceptional high‐temperature thermal‐camouflage *** reduces the radiation temperature of the target object(>300°C)to 100°*** conductivity of MXCB sheet with 3μm thickness is 6108 S/cm and the EM interference(EMI)shielding value is 39.74 *** normalized surface‐specific EMI SE absolute shielding effectiveness(SSE/t)is as high as 39312.78 dB·cm2/g,which remained 99.39%even after 10,000 times repeated *** multifunctional ultrathin MXCB sheets can be arranged by vacuum‐assisted induction to develop EM‐IR bi‐stealth sheet.

关键词： cellulose lamellae EM‐IR bi‐stealth mechanically strong MXene platelets transition metal carbides

Dopamine Inhibits the Expression of Hepatitis B Virus Surface and e Antigens by Activating the JAK/STAT Pathway and Upregulating Interferon-stimulated Gene 15 Expression

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 443-456页

作者： Xiaoquan liu Xiuqing Pang Zhiping Wan jinhua Zhao Zhiliang Gao Hong Deng Department of Infectious Diseases Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Key Laboratory of Liver Disease Research Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou GuangdongChina Key Laboratory of Tropical Disease Control(sun Yat-sen University) Ministry of EducationGuangzhouGuangdongChina

Background and Aims:Hepatitis B virus(HBV)infection is a major risk factor for cirrhosis and liver cancer,and its treatment continues to be *** previously demonstrated that a dopamine analog inhibited the packaging of pregenomic RNA into *** present study aimed to determine the effect of dopamine on the expressions of hepatitis B virus surface and e antigens(HBsAg and HBeAg,respectively)and to elucidate the underlying ***:We used dopamine-treated HBVinfected HepG2.2.15 and NTCP-G2 cells to monitor HBsAg and HBeAg expression *** analyzed interferon-stimulated gene 15(ISG15)expression in dopamine-treated *** knocked down ISG15 and then monitored HBsAg and HBeAg expression *** analyzed the expression of Janus kinase(JAK)/signal transducer and activator of transcription(STAT)pathway factors in dopamine-treated *** used dopamine hydrochloride-treated adeno-associated virus/HBV-infected mouse model to evaluate HBV DNA,HBsAg,and HBeAg *** virus was collected from HepAD38.7 cell culture ***:Dopamine inhibited HBsAg and HBeAg expression and upregulated ISG15 expression in HepG2.2.15 and HepG2-NTCP cell ***15 knockdown increased HBsAg and HBeAg expression in HepG2.2.15 ***-treated cells activated the JAK/STAT pathway,which upregulated ISG15 *** the adeno-associated virus-HBV murine infection model,dopamine downregulated HBsAg and HBeAg expression and activated the JAK-STAT/ISG15 ***:Dopamine inhibits the expression of HBsAg and HBeAg by activating the JAK/STAT pathway and upregulating ISG15 expression.

关键词： Hepatitis B virus Dopamine JAK-STAT/ISG15 axis HBV surface antigen HBV e antigen HepG2.2.15 cell line Human NTCP-expressing HepG2 cell line HepAD38 cell line

Partial oxidation of methane by photocatalysis

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Chinese Chemical Letters 2024年第1期35卷 153-168页

作者： Zhongshan Yang Qiqi Zhang Hui Song Xin Chen Jiwei Cui Yanhui sun Lequan liu jinhua Ye TJU-NIMS International Collaboration Laboratory School of Materials Science and EngineeringTianjin UniversityTianjin 300072China International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)1-1 NamikiIbaraki 3050047Japan Zhejiang LAMP Co. Ltd.Wenzhou 325206China

Methane chemistry is one of the“Holy Grails of catalysis”.It is highly desirable but challenge to transform methane into value-added chemicals,because of its high C-H bonding energy(435 kJ/mol),lack ofπbonding or unpaired ***,commercial methane conversion is usually carried out in harsh conditions with enormous energy *** partial oxidation of methane to liquid oxygenates(PPOMO)is a future-oriented technology towards realizing high efficiency and high selectivity under mild *** selection of oxidant is crucial to the PPOMO ***,attentions are paid to the research progress of PPOMO with various oxidants(O_(2),H_(2)O,H_(2)O_(2)and other oxidants).Moreover,the activation of the selected oxidants is also highly ***,we summarized the methane activation mechanisms focusing on the C-H bond that was broken mainly by·OH radical,O-specie or photogenerated hole(h+).Finally,the challenges and prospects in this subject are briefly discussed.

关键词： Partial oxidation of methane Photocatalysis Liquid oxygenates Oxidants C-H activation

大采高综采工作面切顶留巷矸石帮变形控制技术研究

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煤炭工程 2024年第8期56卷 78-85页

作者：孙闯刘义鹏煤炭科学研究总院有限公司矿山大数据研究院北京100083 天地科技股份有限公司北京技术研究分公司北京100083 中国矿业大学(北京)深部岩土力学与地下工程国家重点实验室北京100010

为解决厚煤层大采高综采工作面切顶留巷矸石帮围岩控制难题,首先利用理论分析建立了不同挡矸支护条件下矸石帮位移变化的力学公式,以此为基础提出矸石帮变形控制双策略,减弱矸石帮变形压力和增强矸石帮的抗变形能力;其次利用现场实验设... 详细信息

为解决厚煤层大采高综采工作面切顶留巷矸石帮围岩控制难题,首先利用理论分析建立了不同挡矸支护条件下矸石帮位移变化的力学公式,以此为基础提出矸石帮变形控制双策略,减弱矸石帮变形压力和增强矸石帮的抗变形能力;其次利用现场实验设计两种类别共4组挡矸支护方案,探讨不同支护方案的矸石帮控制效果,验证理论研究成果。结果表明:①增强矸石帮侧顶板支护强度,能减弱矸石帮变形压力;②增架卡兰个数、增加卡兰预紧力、增加卡兰个数、增强U型钢之间的摩擦力等能增加U型钢滑移初始滑移应力,增强矸石帮的抗变形能力;③挡矸支护控制效果为:2副卡兰+单体支柱<2副卡兰+单元支架<2副卡兰+单元支架+呛柱<3副卡兰+单元支架。该研究可为同类条件下切顶留巷矸石帮变形控制提供参考。

关键词：厚煤层切顶留巷矸石帮挡矸支护

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H3亚型禽流感流行的潜在危害和防控建议

科学通报 2024年第10期69卷 1315-1319页

作者：刘金华孙洪磊高福中国农业大学动物医学院兽医公共卫生安全全国重点实验室农业农村部禽流感等家禽重大疾病防控重点实验室北京100193 中国科学院微生物研究所病原微生物与免疫学重点实验室北京100101 中国疾病预防控制中心病毒病预防控制所中国国家流感中心北京102206

21世纪短短的20年间,人类已经历了两次大流行传染病,即2009年甲型H1N1大流行流感和2019年新型冠状病毒感染.另外发生了5次世界卫生组织宣布的“全球关注的公共卫生应急事件”,给全球经济发展、社会稳定和人类健康造成了严重危害(https:/... 详细信息

21世纪短短的20年间,人类已经历了两次大流行传染病,即2009年甲型H1N1大流行流感和2019年新型冠状病毒感染.另外发生了5次世界卫生组织宣布的“全球关注的公共卫生应急事件”,给全球经济发展、社会稳定和人类健康造成了严重危害(https://***/emergencies/situations).大流行传染病的频繁出现警示我们,人兽共患性病毒是引发大流行疫病的重要病原.动物源性流感病毒在历史上导致了至少5次流感大流行,尤其是最近几年,动物流感病毒频繁跨种感染人类的现象让人们担忧其可能催生下一次人类流感大流行[1].

关键词：冠状病毒感染流感病毒防控建议禽流感 H3亚型跨种感染动物源性流感大流行

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng liu Wei liu Peng Zhao Feifei Lv Jie sun Hongjun Li Zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

Persistence of charge density wave against variation of band structures in V_(x)Ti_(1−x)Se_(2)(x=0–0.1)

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Nano Research 2024年第3期17卷 2129-2135页

作者： Zhanfeng liu Tongrui Li Wen Zhu Hongwei Shou Mukhtar Lawan Adam Qilong Cui Yuliang Li Sheng Wang Yunbo Wu Hongen Zhu Yi liu Shuangming Chen Xiaojun Wu Shengtao Cui Li Song Zhe sun National Synchrotron Radiation Laboratory CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230029China CAS Key Laboratory of Strongly-coupled Quantum Matter Physics University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China School of Chemistry and Materials Sciences CAS Key Laboratory of Materials for Energy Conversionand CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230026China School Zhejiang Institute of Photonelectronics Jinhua 321004China

Charge density wave(CDW)is a phenomenon that occurs in materials,accompanied by changes in their intrinsic electronic *** study of CDW and its modulation in materials holds tremendous significance in materials research,as it provides a unique approach to controlling the electronic properties of ***_(2) is a typical layered material with a CDW phase at low *** V substitution for Ti in TiSe_(2),we tuned the carrier concentration in V_(x)Ti_(1-x)Se_(2) to study how its electronic structures ***-resolved photoemission spectroscopy(ARPES)shows that the band-folding effect is sustained with the doping level up to 10%,indicating the persistence of the CDW phase,even though the band structure is strikingly different from that of the parent compound TiSe_(2).Though CDW can induce the band fold effect with a driving force from the perspective of electronic systems,our studies suggest that this behavior could be maintained by lattice distortion of the CDW phase,even if band structures deviate from the electron-driven CDW *** work provides a constraint for understanding the CDW mechanism in TiSe_(2),and highlights the role of lattice distortion in the band-folding effect.

关键词： charge density wave band structure lattice distortion

Insights into the interplay between gut microbiota and lipid metabolism in the obesity management of canines and felines

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1761-1777页

作者： Kaiqi Li Xiangyu Xiao Yuling Li Sichen Lu Jianghang Zi Xiaoqiang sun Jia Xu Hao‑Yu liu Xiaoqiong Li Tongxing Song Demin Cai Laboratory of Animal Physiology and Molecular Nutrition Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular DesignCollege of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China College of Animal Science and Technology Huazhong Agricultural UniversityWuhan 430070China School of Life Science and Engineering Foshan UniversityFoshan 528231China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‑Products Institute of Food ScienceZhejiang Academy of Agricultural SciencesHangzhouZhejiang 310021People’s Republic of China College of Agriculture Jinhua PolytechnicJinhua 321017China

Obesity is a prevalent chronic disease that has significant negative impacts on humans and our companion animals,including dogs and *** occurs with multiple comorbidities,such as diabetes,hypertension,heart disease and osteoarthritis in dogs and cats.A direct link between lipid metabolism dysregulation and obesity-associated diseases has been ***,the understanding of such pathophysiology in companion animals is *** review aims to address the role of lipid metabolism in various metabolic disorders associated with obesity,emphasizing the involvement of the gut ***,we also discuss the management of obesity,including approaches like nutritional interventions,thus providing novel insights into obesity prevention and treatment for canines and felines.

关键词： Cat Dog Gut microbiota Lipid metabolism Obesity Management

Tildrakizumab for moderate-to-severe plaque psoriasis in Chinese patients:A 12-week randomized placebo-controlled phase III trial with long-term extension

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Chinese Medical Journal 2024年第10期137卷 1190-1198页

作者： Chen Yu Songmei Geng Bin Yang Yunhua Deng Fuqiu Li Xiaojing Kang Mingye Bi Furen Zhang Yi Zhao Weili Pan Zhongwei Tian jinhua Xu Zhenghua Zhang Nan Yu Xinsuo Duan Shuping Guo Qing sun Weiquan Li Juan Tao Zhijun liu Yuanyuan Yin Gang Wang Department of Dermatology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Dermatology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Dermatology Dermatology Hospital of Southern Medical UniversityGuangzhouGuangdong 510091China Department of Dermatology Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Dermatology The Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of Dermatology Wuxi People’s Hospital of Wuxi CityWuxiJiangsu 214023China Department of Dermatology Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and VenereologyShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250022China Department of Dermatology Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Dermatology Zhejiang Provincial People’s HospitalHangzhouZhejiang 310014China Department of Dermatology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiangHenan 453100China Department of Dermatology Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Dermatology General Hospital of Ningxia Medical UniversityYinchuanNingxia 750000China Department of Dermatology Affiliated Hospital of Chengde Medical UniversityChengdeHebei 067000China Department of Dermatology The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China Department of Dermatology Yuebei People’s HospitalShaoguanGuangdong 512026China Department of Dermatology Union Hospital Tongji Medical Collage Huazhong University of Science and TechnologyWuhanHubei 430022China Department of Dermatology and Venereal Diseases The First Affiliated Hospit

Background:There is a need for effective and safe therapies for psoriasis that provide sustained *** aim of this study was to assess the efficacy and safety of tildrakizumab,an anti-interleukin-23p19 monoclonal antibody,for treating moderate-to-severe plaque psoriasis in Chinese ***:In this multi-center,double-blind,phase III trial,patients with moderate-to-severe plaque psoriasis were enrolled and randomly assigned(1:1)to receive subcutaneous tildrakizumab 100 mg or placebo at weeks 0 and *** initially assigned to placebo were switched to receive tildrakizumab at weeks 12,16,and every 12 weeks *** in the tildrakizumab group continued with tildrakizumab at week 16,and every 12 weeks until week *** primary endpoint was the Psoriasis Area and Severity Index(PASI 75)response rate at week ***:At week 12,tildrakizumab demonstrated significantly higher PASI 75 response rates(66.4%[73/110]vs.12.7%[14/110];difference,51.4%[95%confidence interval(CI),40.72,62.13];P<0.001)and Physician’s Global Assessment(60.9%[67/110]vs.10.0%[11/110];difference,49.1%[95%CI,38.64,59.62];P<0.001)compared to *** 75 response continued to improve over time in both tildrakizumab and placebo-switching to tildrakizumab groups,reaching maximal efficacy after 28 weeks(86.8%[92/106]vs.82.4%[89/108])and maintained up to 52 weeks(91.3%[95/104]vs.87.4%[90/103]).Most treatment-emergent adverse events were mild and not related to ***:Tildrakizumab demonstrated durable efficacy through week 52 and was well tolerated in Chinese patients with moderate-to-severe plaque *** registration:***,NCT05108766.

关键词： Tildrakizumab Interleukin 23 Plaque psoriasis Chinese Randomized controlled trial