检索结果-南通市图书馆

HIV-1 DNA levels in peripheral blood mononuclear cells of patients with HIV-related non-Hodgkin’s lymphoma

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2023年第22期136卷 2741-2743页

作者： Zhenyan Wang Jingna Xun Zichen Song yinzhong shen Li Liu Jun Chen Tangkai Qi Jianjun Sun Wei Song Yang Tang Shuibao Xu Junyang Yang Bihe Zhao Renfang Zhang Department of Infection and Immunity Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China

To the Editor:Human immunodeficiency virus(HIV)patients have an increased risk of non-Hodgkin’s lymphoma(NHL),even in the era of antiretroviral therapy(ART).[1]The specific mechanisms of HIVrelated NHL(HIV-NHL)remain unclear.It is currently thought that HIV causes lymphoma primarily through chronic immune activation and an increased risk of infection with oncoviruses.In addition,HIV may have some other mechanisms that directly contribute to the occurrence of lymphoma.[2]Even with sustained ART,HIV-DNA remains in infected cells,creating a persistent reservoir of HIV infection.It is not known whether HIV reservoirs are involved in the development of HIV-NHL.In the present study,we detected HIV-1 DNA levels in peripheral blood mononuclear cells(PBMCs)and plasma inflammatory cytokines levels in HIV-NHL,and then evaluated their effects on HIV-NHL development and prognosis.

关键词： lymphoma patients sustained

Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2022年第1期11卷 47-55页

作者： Jingjing Hu Ling Gu Yueming Shao Renfang Zhang Tangkai Qi Jianjun Sun Zhenyan Wang Wei Song Yang Tang Jiangrong Wang Shuibao Xu Junyang Yang yinzhong shen Li Liu Jun Chen Hongzhou Lu School of Public Health Bengbu Medical CollegeBengbu233000AnhuiChina Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan University2901 Caolang RoadJinshan DistrictShanghai201508China shenzhen Third People’s Hospital The Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen518000China

Background:Few data are available regarding the long-term case-fatality rate(CFR)among people living with HIV(PLWH)with nontuberculous mycobacteria(NTM)disease.The aim of this study is to analyze the long-term CFR in patients with NTM disease and to identify risk factors for their death.Methods:A retrospective cohort study of 379 cases of microbiologically confirmed NTM disease in PLWH was conducted from January 1,2012,to December 31,2020,in Shanghai,China.We used Kaplan-Meier survival analysis and the log-rank test to compare the long-term CFR in patients with disseminated NTM(DNTM)and localized NTM disease.Univariate Cox proportional hazards regression analysis and a stepwise Cox proportional hazards regression model were used to estimate the predictors of long-term CFR.Results:The cohort was followed up for a median of 26 months.The total CFR was 15.7%by one year and increased to 22.6%at 5 years after the diagnosis of NTM disease.The 5-year CFR of PLWH with DNTM was significantly higher than that of PLWH with localized NTM(26.7%vs 19.6%for DNTM and localized NTM disease,respectively).Older age[hazard ratio(HR)=1.04,95%confidence interval(CI):1.02-1.06,P<0.001],comorbidity(HR=2.05,95%CI:1.21-3.49,P<0.01),DNTM(HR=2.08,95%CI:1.17-3.68,P<0.05),and HIV viral load(HR=1.32,95%CI:1.12-1.55,P<0.001)were all independent risk factors for long-term CFR.In the subgroup analysis,time to culture positivity was negatively correlated with CFR in patients with DNTM(HR=0.90,95%CI:0.82-0.98,P<0.05).Conclusions:NTM was associated with a high long-term CFR in PLWH.Further approaches to prevent NTM disease in PLWH are urgently needed.

关键词： HIV/AIDS Nontuberculous mycobacteria Case-fatality rate Risk factor

Antiretroviral therapy-naïve people living with HIV tend to have more severe symptoms of COVID-19

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2023年第22期136卷 2753-2755页

作者： Jinfeng Sun Rui Jiang Yueming Shao Jingjing Hu Zhihang Zheng Luling Wu Li Liu Junyang Yang yinzhong shen Renfang Zhang Tangkai Qi Jianjun Sun Zhenyan Wang Yang Tang Wei Song Shuibao Xu Bihe Zhao Jun Chen Department of Infection and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China

To the Editor:Coronavirus disease 2019(COVID-19),instigated by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has manifested as a formidable global pandemic,precipitating significant economic implications and leading to extensive mortalities.Simultaneously,the acquired immune deficiency syndrome(AIDS)epidemic caused by the human immunodeficiency virus(HIV)persists as a salient global health exigency.Cumulatively by the termination of 2022,AIDS-related pathologies accounted for approximately 40.4 million fatalities,with an extant global HIV population of roughly 39 million people living with HIV(PLWH),as a potentially immunocompromised population,have received limited attention in the realm of COVID-19 research.

关键词： acute termination living

Neutralization of five SARS-CoV-2 variants of concern by convalescent and BBIBP-CorV vaccinee serum

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2022年第6期37卷 831-841页

作者： Yuqi Zhu Xinyi Yang Jingna Xun Jun Liu Qing Wen Yixiao Lin Xiaoting shen Jun Chen Songhua Yuan Xiaying Zhao Jing Wang Hanyu Pan Jinlong Yang Zhiming Liang Yue Liang Qinru Lin Huitong Liang Min Li Jianping Liu yinzhong shen Xiaoyan Zhang Pengfei Wang Daru Lu Chunhua Yin Jianqing Xu Shibo Jiang Hongzhou Lu Huanzhang Zhu State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology Ministry of EducationInstitute of GeneticsSchool of Life SciencesFudan UniversityShanghai200438China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Fubio(Suzhou)Biomedical Technology Co. LtdSuzou215300China Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesFudan UniversityShanghai200032China Department of Infectious Diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People's Hospital of ShenzhenShenzhen518112China

The prevalence of SARS-CoV-2 variants of concern(VOCs) is still escalating throughout the world. However, the level of neutralization of the inactivated viral vaccine recipients’ sera and convalescent sera against all VOCs,including B.1.1.7(Alpha), B.1.351(Beta), P.1(Gamma), B.1.617.2(Delta), and B.1.1.529(Omicron) remains to be lack of comparative analysis. Therefore, we constructed pseudoviruses of five VOCs using a lentiviral-based system and analyzed their viral infectivity and neutralization resistance to convalescent and BBIBP-CorV vaccinee serum at different times. Our results show that, compared with the wild-type strain(WT), five VOC pseudoviruses showed higher infection, of which B.1.617.2 and B.1.1.529 variant pseudoviruses exhibited higher infection rates than wild-type or other VOC strains, respectively. Sera from 10 vaccinated individuals at the 1, 3and 5-month post second dose or from 10 convalescent at 14 and 200 days after discharge retained neutralizing activity against all strains but exhibited decreased neutralization activity significantly against the five VOC variant pseudoviruses over time compared to WT. Notably, 100%(30/30) of the vaccinee serum samples showed more than a 2.5-fold reduction in neutralizing activity against B.1.1.529, and 90%(18/20) of the convalescent serum samples showed more than 2.5-fold reduction in neutralization against B.1.1.529. These findings demonstrate the reduced protection against the VOCs in vaccinated and convalescent individuals over time, indicating that it is necessary to have a booster shot and develop new vaccines capable of eliciting broad neutralization antibodies.

关键词： SARS-CoV-2 Variants of concern(VOCs) Convalescent BBIBP-CorV vaccine Neutralization

2014 update of the Chinese guidelines for diagnosis and treatment of avian influenza A（H7N9） virus infection

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2014年第13期127卷 2543-2547页

作者： shen yinzhong Lu Hongzhou Department of Infectious Diseases Shanghai Public Health ClinicalCenter Fudan University Shanghai 201508 China

The National Health and Family Planning Commission of China published an updated guidance （2014 version） on clinical management in Chinese on January 26, 2014.The guidelines come as human cases of avian influenza A... 详细信息

关键词： avian influenza A（H7N9） virus diagnosis antiviral treatment guideline

Human infection with avian influenza A（H7N9） virus in Shanghai： current status and future trends

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2014年第10期127卷 1973-1976页

作者： shen yinzhong Lu Hongzhou Department of Infectious Diseases Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China

Avian influenza A（H7N9） virus is one subgroup among the larger group of H7 viruses,which normally circulate among birds.The H7N9 subtype of avian influenza viruses has not been known to infect humans until only recently.On March 31,2013,China confirmed the first three human cases of novel avian influenza A（H7N9）infection in Shanghai and Anhui,two of these patients died.1 As of February 27,2014,367 laboratory-confirmed human cases have been reported from 15 provinces/municipalities in China's Mainland,

关键词： avian influenza A（H7N9） virus epidemiology diagnosis treatment Shanghai

比克恩丙诺片与拉米夫定多替拉韦片对初治艾滋病期患者的疗效及安全性分析

在线全文

学校读者我要写书评

暂无评论

中华传染病杂志 2024年第3期42卷 147-153页

作者：王江蓉孙建军杨君洋张仁芳刘莉陈军汤阳齐唐凯宋炜王珍燕沈银忠上海市(复旦大学附属)公共卫生临床中心感染与免疫科上海201508

目的评价并比较含整合酶抑制剂的单片制剂方案比克恩丙诺片(B/F/TAF)与拉米夫定多替拉韦片(3TC/DTG)用于初治艾滋病期患者的临床疗效及安全性。方法本研究为一项回顾性队列研究,通过收集2020年10月至2023年7月在上海市(复旦大学附属)公... 详细信息

目的评价并比较含整合酶抑制剂的单片制剂方案比克恩丙诺片(B/F/TAF)与拉米夫定多替拉韦片(3TC/DTG)用于初治艾滋病期患者的临床疗效及安全性。方法本研究为一项回顾性队列研究,通过收集2020年10月至2023年7月在上海市(复旦大学附属)公共卫生临床中心使用B/F/TAF或3TC/DTG作为初始抗反转录病毒治疗方案且持续用药时间≥24周的艾滋病期患者的临床资料,比较B/F/TAF组与3TC/DTG组基线人类免疫缺陷病毒(HIV)-1 RNA,基线和治疗12周的CD4+T淋巴细胞计数,治疗24周的病毒学抑制率和病毒学失败率,以及治疗前后总胆固醇、血肌酐、尿酸等指标变化。统计学分析采用独立样本t检验、校正t检验、曼-惠特尼U检验、威尔科克森符号秩检验、χ^(2)检验。结果189例初治艾滋病期患者中,B/F/TAF组141例,3TC/DTG组48例。B/F/TAF组患者基线HIV-1 RNA为1.77(0.78,4.52)×10^(5)拷贝/mL,3TC/DTG组为0.97(0.24,2.20)×10^(5)拷贝/mL,差异有统计学意义(U=2221.00,P=0.006)。B/F/TAF组治疗24周病毒学抑制率为77.3%(109/141),无病毒学失败的患者;3TC/DTG组治疗24周病毒学抑制率为85.4%(41/48),1例(2.1%)病毒学失败。治疗12周时,B/F/TAF组CD4+T淋巴细胞计数较基线升高30%以上的患者占92.2%(130/141),3TC/DTG组为85.4%(41/48);B/F/TAF组CD4+T淋巴细胞计数较基线升高>100.00/μL的比例为67.4%(95/141),3TC/DTG组为52.1%(25/48);两组间差异均无统计学意义(χ^(2)=1.91、3.61,P=0.167、0.733)。B/F/TAF组和3TC/DTG组患者治疗24周时总胆固醇(W=2036.00,t=-5.42)、血肌酐(W=1098.00、234.00)、尿酸(W=2188.00、299.00)水平均较治疗前升高,轻中度肾功能不全患者比例(χ^(2)=22.29、8.22)均较治疗前增加,差异均有统计学意义(均P<0.01)。结论B/F/TAF与3TC/DTG用于初治艾滋病期患者具有良好的病毒学、免疫学疗效和安全性。

关键词：获得性免疫缺陷综合征安全性有效性比克恩丙诺片拉米夫定多替拉韦片

Discovery process, clinical characteristics, and treatment of patients infected with avian influenza virus （H7N9） in Shanghai

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2014年第1期127卷 185-186页

作者： Sun Yang shen yinzhong Lu Hongzhou Department of Infectious Diseases Shanghai Public Health ClinicalCenter Fudan University Shanghai 201508 China Institute of Medicine Science Shanghai Tongji Hospital ShanghaiTongji University School of Medicine Shanghai 200065 China

During the spring of 2013,a novel avian-origin influenza A （H7N9） virus emerged and spread in Shanghai.On May 9,2013,33 lab-confirmed cases （2 children and 31 adults） have been reported,among whom 13 died.Among the 31 adult cases of H7N9 avian influenza A virus infections in humans,80.6% （25/31） were older men （average age 65 years）.Clear history of poultry exposure was found in eight patients （8/33,24.3%） and the remaining 21 cases had been suspected poultry exposure.Clustered cases were found in two families （two cases from a father and his son,and the other two cases from a wife and her husband）.However,no evidence of human-to-human transmission had been identified.Avian influenza is one of the most dangerous contagions in poultry worldwide,and avian influenza A virus is the major pathogen responsible.Transmission from poultry to humans has now been proven.Some gene segments of the strain have mutated,and further mutations might result in human-to-human transmission.

关键词： discovery process avian influenza virus H7N9 clinical characteristics treatment

Human infection with avian influenza A(H7N9) virus in Shanghai:current status and future trends

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human infection with avian influenza A(H7N9) virus in Shangh...