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Development and validation of a nomogram to predict failure of 14-day negative nucleic acid conversion in adults with non-severe COVID-19 during the Omicron surge: a retrospective multicenter study

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Infectious Diseases of Poverty 2023年第1期12卷 36-46页

作者： Honglian Gui Zhenglan Zhang Bin Chen Yaoxing Chen Yue wang Zhuo Long Chuanwu Zhu yinling wang Zhujun Cao Qing Xie Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Diseases Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghaiChina Department of Hepatology Wuwei People’s HospitalGansuChina Department of Infectious Diseases The Affiliated Infectious Diseases Hospital of Soochow UniversitySuzhouChina Department of Endocrine and Metabolic Diseases Fengcheng Hospital of Fengxian DistrictShanghaiChina

Background With the variability in emerging data,guidance on the isolation duration for patients with coronavirus disease 2019(COVID-19)due to the Omicron variant is controversial.This study aimed to determine the predictors of prolonged viral RNA shedding in patients with non-severe COVID-19 and construct a nomogram to predict patients at risk of 14-day PCR conversion failure.Methods Adult patients with non-severe COVID-19 were enrolled from three hospitals of eastern China in Spring 2022.Viral shedding time(VST)was defined as either the day of the first positive test or the day of symptom onset,whichever was earlier,to the date of the first of two consecutively negative PCR tests.Patients from one hospital(Cohort I,n=2033)were randomly grouped into training and internal validation sets.Predictors of 14-day PCR conversion failure were identified and a nomogram was developed by multivariable logistic regression using the training dataset.Two hospitals(Cohort II,n=1596)were used as an external validation set to measure the performance of this nomogram.Results Of the 2033 patients from Cohort I,the median VST was 13.0(interquartile range:10.0-16.0)days;716(35.2%)lasted>14 days.In the training set,increased age[per 10 years,odds ratio(OR)=1.29,95%confidence interval(CI):1.15-1.45,P14 days,whereas full or boosted vaccination(OR=0.63,95%CI:0.42-0.95,P=0.028)and antiviral therapy(OR=0.56,95%CI:0.31-0.96,P=0.040)were protective factors.These predictors were used to develop a nomogram to predict VST>14 days,with an area under the ROC curve(AUC)of 0.73 in the training set(AUC,0.74 in internal validation set;0.76 in external validation set).Conclusions Older age,increasing comorbidities,incomplete vaccinations,and lack of antiviral therapy are risk factors for persistent infection with Omicron variant for>14 days.A nomogram based on these predictors could be used as a prediction tool to guide treatment and isola

关键词： Nomogram Viral shedding time Prediction Omicron variant COVID-19

Redox-neutral photocatalytic strategy for selective C–C bond cleavage of lignin and lignin models via PCET process

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Science Bulletin 2019年第22期64卷 1658-1666页

作者： yinling wang Yue Liu Jianghua He Yuetao Zhang State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University

It remains challenging to achieve the selective cleavage of C–C bonds in lignin or lignin model compounds to produce aromatic products in high yield and selectivity.We have developed a redox-neutral photocatalytic strategy to accomplish this goal in both b-O-4 and b-1 lignin models at room temperature(RT)via proton-coupled electron transfer(PCET)process without any pretreatments of substrate,by adjusting the alkalinity of base to obtain a lignin models/base PCET pair with a bond dissociation free energy close to 102 kcal/mol.Without breaking down C_b–Ccbond and any C–O bonds,this PCET method is 100%atom economy and produces exclusive Ca–C_bbond cleavage products,such as benzaldehydes(up to 97%)and phenyl ethers(up to 96%),in high to excellent yields and selectivities.Preliminary studies indicated that the PCET strategy is also effective for the depolymerization of native lignin at RT,thus providing significantly important foundation to the depolymerization of lignin.

关键词： C–C bond cleavage Lignin depolymerization Photocatalysis Proton-coupled electron transfer Redox-neutral

基于络病理论运用络虚通补法治疗糖尿病骨质疏松

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世界中医药 2024年第4期19卷 514-518页

作者：王寅翎王彬天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津300381

糖尿病骨质疏松(DOP)作为糖尿病(DM)主要慢性并发症,起病隐匿,发病机制复杂,与高血糖状态、氧化应激、相关细胞因子、激素水平变化、降糖药物的使用等多种因素综合作用有关,病情缠绵难愈,严重影响患者生命质量。中医学认为DOP病位在骨,... 详细信息

糖尿病骨质疏松(DOP)作为糖尿病(DM)主要慢性并发症,起病隐匿,发病机制复杂,与高血糖状态、氧化应激、相关细胞因子、激素水平变化、降糖药物的使用等多种因素综合作用有关,病情缠绵难愈,严重影响患者生命质量。中医学认为DOP病位在骨,与肾脾肝脏腑功能失常,进而导致气虚血瘀密切相关,治疗多立足于调补脏腑、行气化瘀,使骨得其养从而改善症状。本文基于络病理论,针对DOP骨络脏腑亏虚、邪瘀阻络的主要病机,探讨络虚通补法在防治糖尿病骨质疏松DOP中的应用,以期为临床防治DOP提供更多思路与理论参考。

关键词：糖尿病骨质疏松症络病理论络虚通补法中医微循环络脉骨络

The application and perspective of NMR and MS based strategies for functional compounds mining in medicinal and dietary plants

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Food Science and Human Wellness 2024年

作者： Bodou Zhang Sheng Li Zhenzhen Liang yinling Wei Jing Dong Hongyan Wen Lingli Guo Xiaojiang Hao Yu Zhang University of Chinese Academy of Sciences State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Medicinal and dietary plants provide numerous nutritional and functional compounds and also have various potential health benefits to humanity. The specific and efficient techniques for accurate identification of nutritional compounds and functional metabolites is crucial for the development of functional foods from medicinal and dietary plants. Nuclear magnetic resonance (NMR) and mass spectrometry (MS) are indispensable and essential technologies that provide an unsurpassed wealth of untargeted identification， quantitative and qualitative analysis， and structural information in the study of food and plant products. In the past decade， the rapid development of modern analytical technology has led to the emergence of new approaches and strategies for natural products discovery. Especially the application of novel NMR- and MS-based identification and dereplication strategies aided by artificial intelligence and machine learning algorithms have brought about a significant shift in the natural products discovery process. These developments and changes in the natural products filed have given us insights into how to accurately target and mining nutritional， functional， and bioactive compounds. Thus， we have summarized recent research on novel NMR and MS based strategies and methods focusing on functional compounds， accurate identification and efficient discovery mainly in medicinal and dietary plants. This review could provide a comprehensive perspective for a better understanding of novel strategies and methods based on NMR and MS technologies， which could provide valuable insights and ideas for functional compounds mining.

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美国关于《国际卫生条例》修订提案的规制俘获策略及其因应

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国际经济合作 2024年第3期 68-80,94页

作者：周银玲武汉大学国际法研究所/国际法治研究院

美国有关国际卫生法的主张呈现出信息俘获、代表性俘获、资源俘获三方面特点,其在议题设置、规则内容和保障机制等方面的扩权倾向,对《国际卫生条例(2005)》的修订谈判产生深刻影响。美国的立场反映了国家中心主义的价值观,偏离了全球... 详细信息

美国有关国际卫生法的主张呈现出信息俘获、代表性俘获、资源俘获三方面特点,其在议题设置、规则内容和保障机制等方面的扩权倾向,对《国际卫生条例(2005)》的修订谈判产生深刻影响。美国的立场反映了国家中心主义的价值观,偏离了全球公域、全球公共产品相关国际造法所根植的全球主义价值观。中国有必要对美国变革国际卫生法的做法加以审视,在推进全球卫生治理法治化过程中提升国际法话语表达能力,充分兼顾本国利益和国际社会共同利益,审慎预防和应对他国提案中基于国家单方利益的规制俘获风险,加快提升中国的国际话语权和规则制定权,促进公平公正的国际卫生法秩序。

关键词：《国际卫生条例》规制俘获国际话语权全球卫生治理对外援助

CeCl_(3)-Promoted Simultaneous Photocatalytic Cleavage and Amination of C_(α)–C_(β)Bond in Lignin Model Compounds and Native Lignin

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CCS Chemistry 2020年第3期2卷 107-117页

作者： yinling wang Jianghua He Yuetao Zhang State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchunJilin 130012

It remains challenging to achievevaluableplatformchemicals from lignin because of itscomplicated polymeric structure and inherent inert chemical activities.So far,only a fewexamples have been reported for the selective cleavage of C–C bonds in lignin due to their intrinsic inertness and ubiquity.Here,we present a simple and commercially available cerium(Ⅲ)chloride(CeCl_(3))-promoted photocatalytic depolymerization strategy to realize the simultaneous cleavage and amination ofC_(α)–C_(β)bond in a variety of lignin model compounds at room temperature.This procedure does not require any pretreatments and breakdown of C–O bonds or loss ofγ-CH_(2)OHgroup to generate aldehydes(up to 97%)and N-containing products(up to 95%)in good to excellent yields.Additionally,this CeCl_(3)-based photocatalyst system could maintain excellent catalytic performance even after 10 sequential cycles with newstarting materials.Moreover,this approach realizes the precise control over the reaction via switching the external light stimuli on/off.Further,this method is effective for the depolymerization of real lignin,thus affording the corresponding cleavage and amination products of C_(α)–C_(β)bonds.

关键词： amination C–C bond cleavage CeCl_(3) lignin depolymerization photocatalytic strategy

社区老年人社会隔离的潜在剖面分析及影响因素研究

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护理学杂志 2024年第2期39卷 14-18页

作者：王佩王青赵翠芬李欣张银玲空军军医大学护理系陕西西安710032 空军军医大学第一附属医院风湿免疫科空军军医大学第二附属医院风湿免疫科西安交通大学第一附属医院风湿免疫科

目的分析社区老年人社会隔离特征及影响因素,为制定干预措施以促进积极老龄化提供参考。方法采取便利抽样法,随机选取渭南市3所社区卫生服务中心接受健康体检的老年人308人为调查对象。采用一般资料调查表、Lubben社交网络量表-6、老年... 详细信息

目的分析社区老年人社会隔离特征及影响因素,为制定干预措施以促进积极老龄化提供参考。方法采取便利抽样法,随机选取渭南市3所社区卫生服务中心接受健康体检的老年人308人为调查对象。采用一般资料调查表、Lubben社交网络量表-6、老年人社会参与能力评估标准、日常生活活动能力量表进行调查。结果社区老年人社会隔离得分为(11.26±4.74)分,老年人中51.62%存在社会隔离。社区老年人社会隔离可划分为高朋友隔离组(52.92%)和低朋友隔离组(47.08%)2个潜在剖面。logistic回归分析显示,日常生活自理能力、社会参与能力、退休前职业、患病年限、年均住院次数是老年人社会隔离潜在剖面类别的影响因素(均P<0.05)。结论社区老年人社会隔离现象严重,且存在明显的分类特征,可针对不同类型特征老年人实施个体化干预,改善老年人社会隔离情况。

关键词：老年人社会隔离日常生活活动能力社会参与能力潜在剖面分析积极老龄化社区护理

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混合所有制改革的治理效应研究:综述与展望

重庆理工大学学报（社会科学） 2024年第4期38卷 157-166页

作者：王攀娜吴银玲兰鹏飞重庆理工大学会计学院重庆400054

坚持以“混”促“改”为方向的所有制改革是新一轮国企改革成功的关键,混合所有制改革过程中如何发挥异质性股东的治理效应,成为当下重要的议题。从混改的动因、混改与公司治理、混改的经济后果,以及影响因素4个方面,对混合所有制改革... 详细信息

坚持以“混”促“改”为方向的所有制改革是新一轮国企改革成功的关键,混合所有制改革过程中如何发挥异质性股东的治理效应,成为当下重要的议题。从混改的动因、混改与公司治理、混改的经济后果,以及影响因素4个方面,对混合所有制改革的现有研究进行梳理,发现现有研究存在不足,遂提出未来进一步研究的方向:不同类型的国有企业混改动机的差异,党组织参与治理与公司治理的关系及其效果,“反向混改”中委派高层参与治理的效果,制度环境、市场化程度、行业竞争程度、信息披露机制等对混合所有制改革的影响。该研究可以为混合所有制改革的相关研究和实践提供有益的启示。

关键词：所有制改革混合所有制改革国企改革公司治理治理效应

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零航速下的船用多功能翼水动力分析

船舶工程 2024年第3期46卷 55-62页

作者：姜寅令李洋张强竺可东北石油大学电气信息工程学院黑龙江大庆163318 哈尔滨工程大学智能学院黑龙江大庆163318 东北石油大学机械科学与工程学院哈尔滨150001

为了研究船用多功能翼在零航速下水动力特性和展弦比效应,采用计算流体力学(CFD)软件和动网格技术对其进行三维水动力仿真。船用多功能翼根据荷兰Rotor Swing公司推出的可伸缩尾翼稳定器产品WING Stabilizer建立的几何模型,分析其在不... 详细信息

为了研究船用多功能翼在零航速下水动力特性和展弦比效应,采用计算流体力学(CFD)软件和动网格技术对其进行三维水动力仿真。船用多功能翼根据荷兰Rotor Swing公司推出的可伸缩尾翼稳定器产品WING Stabilizer建立的几何模型,分析其在不同展弦比、攻角和摆动周期下的升/阻力特性。仿真结果表明,对于翼面积为0.5 m^(2)的船用多功能翼,在3~5内选择其展弦比,能在提高升力的同时,产生较小的阻力。因此可以认为多功能翼与常规减摇鳍对不同,过大的展弦比会降低鳍的升阻比。

关键词：多功能翼船舶减摇升/阻力特性计算流体力学零航速