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Tau truncation in the pathogenesis of Alzheimer's disease:a narrative review

Neural Regeneration Research 2024年第6期19卷 1221-1232页

作者： Dandan Chu Xingyue Yang jing Wang Yan Zhou jin-Hua Gu jin Miao Feng Wu Fei Liu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsCoinnovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Department of Biochemistry and Molecular Biology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Clinical Pharmacy Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong UniversityNantongJiangsu ProvinceChina Laboratory of Animal Center Nantong UniversityNantongJiangsu ProvinceChina Department of Neurochemistry Inge Grundke-Iqbal Research FloorNew York State Institute for Basic Research in Developmental DisabilitiesStaten IslandNYUSA

Alzheimer's disease is characterized by two major neuropathological hallmarks—the extracellularβ-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau *** studies suggest that dysregulation of the microtubuleassociated protein Tau,especially specific proteolysis,could be a driving force for Alzheimer's disease *** physiologically promotes the assembly and stabilization of microtubules,whereas specific truncated fragments are sufficient to induce abnormal hyperphosphorylation and aggregate into toxic oligomers,resulting in them gaining prion-like *** addition,Tau truncations cause extensive impairments to neural and glial cell functions and animal cognition and behavior in a fragment-dependent *** review summarizes over 60 proteolytic cleavage sites and their corresponding truncated fragments,investigates the role of specific truncations in physiological and pathological states of Alzheimer's disease,and summarizes the latest applications of strategies targeting Tau fragments in the diagnosis and treatment of Alzheimer's disease.

关键词： Alzheimer's disease cleavage site diagnosis marker neurofibrillary tangles phosphorylation Tau Tau aggregation therapy truncation

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Nearly lattice-defect-free MOF membranes

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Science China Chemistry 2024年第3期67卷 741-743页

作者： Yuzhang Zhu Yang Liu Jian jin i-Lab Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Membrane technology has widely accepted as the most energy efficient technology for the separation of ions or molecules. As the core of the membrane technology, the chemical and structure nature of membrane materials determines the application and energy-efficiency of the technology. An advanced membrane that has a remarkable ability to selectively differentiate ions and molecules can significantly enhance the separation technology and revolutionize industrial separation processes.

关键词： processes. separation defect

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Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences

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Science China(Life Sciences) 2024年第9期67卷 2045-2047页

作者： Bing-Zhi Li Ying-jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Frontiers Research Institute for Synthetic Biology Tianjin UniversityTianjin 300072China

Genomic rearrangements play a significant role in disease,evolution,and tumorigenesis(Mani and Chinnaiyan,2010).While single nucleotide polymorphisms(SNPs)and small insertions/deletions contribute substantially to gen... 详细信息

关键词： insertion sequences

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Special Issue: Functional Polymer Materials

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Chinese Journal of Polymer Science 2024年第7期42卷 895-896,I0004页

作者： Gu, Jun-Wei Wang, Du-jin Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical Engineering Northwestern Polytechnical University Xi’an China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Engineering Plastics Institute of Chemistry Chinese Academy of Sciences Beijing China

The rapid development of science has led to a significant role for polymer materials in multitude fields,including industry,medicine,energy,and the environment,*** a leading academic journal in the field of polymer,Chinese Journal of Polymer Science has been dedicated to fostering the advancement and utilization of polymer science.

关键词： polymer Polymer Functional

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Turning point of organoid transplantation:first-in-human trial of iPSC-derived retinal organoid grafting in patients with retinitis pigmentosa

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Science China(Life Sciences) 2024年第5期67卷 1082-1084页

作者： Chang-Jun Zhang Zi-Bing jin Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

The discovery of induced pluripotent stem cells(iPSCs)has revolutionized the field of disease research,providing a promising platform for studying various *** the last decade,significant progress has been made in combining iPSCs with other cutting-edge technologies to investigate disease mechanisms and develop potential treatments.

关键词： conditions patients retinitis

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Research on Sarcasm Detection Technology Based on Image-Text Fusion

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Computers, Materials & Continua 2024年第6期79卷 5225-5242页

作者： Xiaofang jin Yuying Yang YinanWu Ying Xu School of Information and Communication Engineering Communication University of ChinaBeijing100024China Cable Television Technology Research Institute Academy of Broadcasting ScienceBeijing100053China

The emergence of new media in various fields has continuously strengthened the social aspect of social *** tend to express emotions in social interactions,and many people even use satire,metaphors,and other techniques to express some negative emotions,it is necessary to detect sarcasm in social comment *** sarcasm,the more reference data modalities used,the better the experimental *** paper conducts research on sarcasm detection technology based on image-text fusion *** effectively utilize the features of each modality,a feature reconstruction output algorithm is *** algorithm is based on the attention mechanism,learns the low-rank features of another modality through cross-modality,the eigenvectors are reconstructed for the corresponding modality through weighted *** only the image modality in the dataset is used,the preprocessed data has outstanding performance in reconstructing the output model,with an accuracy rate of 87.6%.When using only the text modality data in the dataset,the reconstructed output model is optimal,with an accuracy rate of 85.2%.To improve feature fusion between modalities for effective classification,a weight adaptive learning algorithm is *** algorithm uses a neural network combined with an attention mechanism to calculate the attention weight of each modality to achieve weight adaptive learning purposes,with an accuracy rate of 87.9%.Extensive experiments on a benchmark dataset demonstrate the superiority of our proposed model.

关键词： Sentiment analysis sarcasm detection feature fusion feature reconstruction

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Coordinate Rule of Law Efforts in Both Domestic and Foreign-Related Matters

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Social Sciences in China 2024年第1期45卷 71-88页

作者： Huang jin Academy for the Rule of Law China University of Political Science and Law

Taking a coordinated approach to promoting the rule of law at home and in matters involving foreign parties stands as one of the essentials of Xi jinping Thought on the Rule of *** profound essence of this concept is predominantly articulated through the dialectic nexus between the rule of law at home and in matters involving foreign parties and the foundational necessities and underlying principles for their coordinated *** concept is intellectually rooted in the legal theory of socialist rule of law with Chinese characteristics,the theory of major-country diplomacy with Chinese characteristics,modern progressive theories of international law,and the exemplary facets of traditional Chinese *** is aligned with contemporary trends and in harmony with the need to take a holistic approach to imperatives at home and *** philosophy underscores the approach to building a human community with a shared future through the rule of law,guaranteeing the fruition of national strategic *** resonates with profound contemporary,integrative,international,and strategic ***,the focus should be on fostering the development of foreign-related rule of law,maintaining the correct equilibrium between the dyad of rule of law in domestic and foreign-related *** is imperative to augment strategic design and institutional construction in the realm of rule of law on issues related to foreign parties,step up research on and practical application of international law,and reinforce the cultivation of legal professionals in this area to take a coordinated approach to advance the rule of law at home and in matters involving foreign parties.

关键词： comprehensive law-based governance rule of law in domestic matters foreignrelated rule of law rule of law in international matters

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Revisiting Enlightenment Universalism:18th-Century Lessons on Nonliteral Translations and Transcultural Storytelling

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Journal of Foreign Languages and Cultures 2024年第1期8卷 68-79页

作者： Wen jin East China Normal University

A large number of transcultural fictions appeared in the 18th century,providing us with an important entry into discussing the task of comparative literature *** 18th-century Oriental tales,stories authored by European writers that adapted from or modeled themselves after loose translations of folk tales from the East,practiced a kind of mental shapeshifting,blurring the boundaries between East and *** same kind of cross-cultural identification is visible in many other literary narratives from the same period,indicative of a fluid,universalist politics regarding Europe's relations with the Orient that requires reevaluation.18th-century transcultural fictions suggest a few tactics for mediating between the necessity of establishing grounds of comparison and the need to draw *** its search for ways of breaking through the stronghold of cultural nationalism,comparative literature in its contemporary incarnation does well to rethink Enlightenment universalism as encoded in the literary landscape of 18th century Europe.

关键词： 18th century Enlightenment universalism translation

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RNA interference in insects:the link between antiviral defense and pest control

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Insect Science 2024年第1期31卷 2-12页

作者： jinzhi Niu Ruoyu Chen jin-Jun Wang Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Southwest UniversityChongqingChina

RNA interference(RNAi)is a form of gene silencing triggered by double-stranded RNA(dsRNA)that operates in all eukaryotic *** has been widely investigated in insects to determine the underlying molecular mechanism,to investigate its role in systemic antiviral defense,and to develop strategies for pest *** insect cells are infected by viruses,viral dsRNA signatures trigger a local RNAi response to block viral replication and generate virus-derived DNA that confers systemic ***-based insect pest control involves the application of exogenous dsRNA targeting genes essential for insect development or survival,but the efficacy of this approach has limited potency in many pests through a combination of rapid dsRNA degradation,inefficient dsRNA uptake/processing,and ineffective RNAi *** could be addressed by dsRNA screening and evaluation,focusing on dsRNA design and off-target management,as well as dsRNA production and *** review summarizes recent progress to determine the role of RNAi in antiviral defense and as a pest control strategy in insects,addressing gaps between our fundamental understanding of the RNAi mechanism and the exploitation of RNAi-based pest control strategies.

关键词： RNAi response systemic RNAi insecticidal dsRNA biological control off-targets

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Pion-photon and kaon-photon transition distribution amplitudes in the Nambu–Jona-Lasinio model

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Chinese Physics C 2024年第8期48卷 94-103页

作者： jin-Li Zhang Jun Wu Department of Mathematics and Physics Nanjing Institute of TechnologyNanjing 211167China National Laboratory of Solid State Microstructures Department of PhysicsNanjing UniversityNanjing 210093China

The Nambu–Jona-Lasinio model is utilized to investigate the pion-and kaon-photon leading-twist transition distribution amplitudes using proper time ***,the properties of the vector and axial vector pion-photon transition distribution amplitudes are examined,and the results meet the desired *** study involves sum rule and polynomiality *** vector and axial vector pion-photon transition form factors that are present in theπ^(+)→γe^(+)νprocess are the first Mellin moments of the pion-photon transition distribution *** vector transition form factor originates from the internal structure of hadrons,the axial current can be coupled to a pion,this pion is virtual,and its contribution will be present independently of the external *** kaon transition form factors are *** vector form factor's value at zero momentum transfer is determined by the axial anomaly,while this is not the case for the axial *** vector and axial form factors,as well as the neutral pion vector form factor F_(πγγ)(t),are *** to our findings,the pion axial transition form factor is harder than the vector transition form factor and harder than the electromagnetic form *** also discuss the link betweenπ−γandγ−πtransitions distribution amplitudes.

关键词： transition form factors NJL model transition distribution amplitudes

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