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Metabolomics for the diagnosis of bladder cancer: A systematic review

Asian Journal of Urology 2024年第2期11卷 221-241页

作者： Herney Andrés García-Perdomo angélica María Dávila-Raigoza Fernando Korkes Division of Urology/Urooncology Department of SurgerySchool of MedicineUniversidad del ValleCaliColombia UROGIV Research Group School of MedicineUniversidad del ValleCaliColombia Urologic Oncology Division of UrologyABC Medical SchoolSao PauloBrazil

Objective: Metabolomics has been extensively utilized in bladder cancer (BCa) research, employing mass spectrometry and nuclear magnetic resonance spectroscopy to compare various variables (tissues, serum, blood, and urine). This study aimed to identify potential biomarkers for early BCa ***: A search strategy was designed to identify clinical trials, descriptive and analytical observational studies from databases such as Medline, Embase, Cochrane Central Register of Controlled Trials, and Latin American and Caribbean Literature in Health sciences. Inclusion criteria comprised studies involving BCa tissue, serum, blood, or urine profiling using widely adopted metabolomics techniques like mass spectrometry and nuclear magnetic resonance. Primary outcomes included description of metabolites and metabolomics profiling in BCa patients and the association of metabolites and metabolomics profiling with BCa diagnosis compared to control patients. The risk of bias was assessed using the Quality Assessment of studies of Diagnostic ***: The search strategy yielded 2832 studies, of which 30 case-control studies were included. Urine was predominantly used as the primary sample for metabolite identification. Risk of bias was often unclear inpatient selection, blinding of the index test, and reference standard assessment, but no applicability concerns were observed. Metabolites and metabolomics profiles associated with BCa diagnosis were identified in glucose, amino acids, nucleotides, lipids, and aldehydes ***: The identified metabolites in urine included citric acid, valine, tryptophan, taurine, aspartic acid, uridine, ribose, phosphocholine, and carnitine. Tissue samples exhibited elevated levels of lactic acid, amino acids, and lipids. Consistent findings across tissue, urine, and serum samples revealed downregulation of citric acid and upregulation of lactic acid, valine, tryptophan, taurine, glutamine, aspartic acid, uridine, rib

关键词： Metabolite Metabolomics Bladder cancer Metabolomicsprofile

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status and trends of carbon emissions research at the county level in China

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Advances in Climate Change Research 2024年第2期15卷 338-352页

作者： ang-Zu CAI Ru GUO Yu-Hao ZHang Jiang WU College of Environmental science and Engineering Institute of Environmental Planning and ManagementTongji UniversityShanghai 200092China Institute of Carbon Neutrality Tongji UniversityShanghai 200092China s.anghai Institute of Pollution Control and Ecological security Shanghai 200092China College of Architecture and Urban Planning Tongji UniversityShanghai 200092China Megacity Elaborated Urban Governance Institute Tongji UniversityShanghai 200092China

This study provides a comprehensive overview of the challenges to achieving carbon neutrality at the county level in China and offers targeted recommendations,laying the groundwork for future specialized research in this area.A total of 283 relevant studies(2004-2023)were analyzed to assess county-level carbon emissions through three phases:bibliometric analysis,frontier analysis,and future *** findings reveal that publication trends were largely influenced by domestic and foreign *** cluster discerns ten primary themes,ranging from conceptual frameworks to research *** frontier analysis of the literature highlights the leading research areas,which include carbon neutrality pathway,driving factors,spatiotemporal variation of carbon emissions,the co-effects of pollutants and carbon reduction,and carbon emissions in China's rural *** from the results of bibliometric and frontier analyses,this study elucidates the recommendations for achieving carbon neutrality at the county level from three perspectives:effective regional policy guidance,emphasis on ecological conservation,and the deployment of advanced carbon reduction and sequestration *** study enriches the body of knowledge on carbon emissions at the county level and holds significant implications for China's comprehensive push towards achieving its carbon neutrality objectives.

关键词： Carbon emissions Emission reduction County Carbon neutrality sustainability

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Lightweight and high-security laser-based cotton tip pruning robot

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 98-108页

作者： Xuan'ang Guo Ziyang Mao Zedong shi Wei Lu school of Artificial Intelligence Nanjing Agricultural UniversityNanjing 210031China

Considering the current environmental pollution caused by chemical topping,plant damage caused by mechanical topping,and the high cost of manual topping,a laser-based cotton-tip pruning robot for field cotton was designed in this *** main advantages of this robot include its safety,light weight,low cost,and environmental ***,the structural design,measurement,and corresponding control system design of the robot were ***,a precise laser control method based on Yolov5 cotton top identification and the inverse kinematic solution of parallel robot rapid positioning were ***,the optimal laser irradiation wavelength and duration were ***,a laser-topping experiment was conducted,and the overall accuracy and recall rates for cotton identification were 98.3%and 99.3%,*** AP and mAP at the threshold value of 0.5 reached 99.3%and 78.8%,*** maximum positioning error of the jacking system is 2.6 mm,and the repeated positioning error is within±1.2 cm,which meets the accuracy requirements of laser ***-purple laser irradiation at 15 W and 405 nm for 22 s was the best topping *** the effects of cotton topping with and without manual topping,it can be seen that laser topping significantly improved the yield and *** with the photothermal response of the cotton topping,the feasibility of laser topping was verified both theoretically and *** laser-topping scheme proposed in this study exhibits high efficiency,environmental protection,and safety,as well as good application prospects.

关键词： laser topping parallel manipulator photothermal response object detection

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sCIRD: Revealing Infection of Malicious software in Edge Computing-Enabled IoT Networks

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Computers, Materials & Continua 2024年第5期79卷 2743-2769页

作者： Jiehao Ye Wen Cheng Xiaolong Liu Wenyi Zhu Xuan’ang Wu shigen shen school of Information Engineering Huzhou UniversityHuzhou313000China

The Internet of Things(IoT)has characteristics such as node mobility,node heterogeneity,link heterogeneity,and topology *** the face of the IoT characteristics and the explosive growth of IoT nodes,which brings about large-scale data processing requirements,edge computing architecture has become an emerging network architecture to support IoT applications due to its ability to provide powerful computing capabilities and good service ***,the defense mechanism of Edge Computing-enabled IoT Nodes(ECIoTNs)is still weak due to their limited resources,so that they are susceptible to malicious software spread,which can compromise data confidentiality and network service *** this situation,we put forward an epidemiology-based susceptible-curb-infectious-removed-dead(sCIRD)***,we analyze the dynamics of ECIoTNs with different infection levels under different initial conditions to obtain the dynamic differential ***,we establish the presence of equilibrium states in the sCIRD ***,we conduct an analysis of the model’s stability and examine the conditions under which malicious software will either spread or disappear within Edge Computing-enabled IoT(ECIoT)***,we validate the efficacy and superiority of the sCIRD model through MATLAB *** research findings offer a theoretical foundation for suppressing the propagation of malicious software in ECIoT *** experimental results indicate that the theoretical sCIRD model has instructive significance,deeply revealing the principles of malicious software propagation in ECIoT *** study solves a challenging security problem of ECIoT networks by determining the malicious software propagation threshold,which lays the foundation for buildingmore secure and reliable ECIoT networks.

关键词： Edge computing Internet of Things malicious software propagation model heterogeneity

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Proposal for valleytronic materials:Ferrovalley metal and valley gapless semiconductor

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Frontiers of physics 2024年第2期19卷 131-139页

作者： san-Dong Guo Yu-Ling Tao Guangzhao Wang shaobo Chen Dong Huang Yee sin ang school of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology of Chongqing School of Electronic Information EngineeringYangtze Normal UniversityChongqing 408100China College of Electronic and Information Engineering Anshun UniversityAnshun 561000China science Mathematics and Technology(SMT)Singapore University of Technology and Design(SUTD)8 Somapah RoadSingapore 487372Singapore

Valleytronic materials can provide new degrees of freedom to future electronic *** this work,the concepts of the ferrovalley metal(FVM)and valley gapless semiconductor(VGs)are proposed,which can be achieved in valleytronic bilayer systems by electric field *** valleytronic bilayer systems,the interaction between out-of-plane ferroelectricity and A-type antiferromagnetism can induce layer-polarized anomalous valley Hall(LP-AVH)*** K and−K valleys of FVM are both metallic,and electron and hole carriers simultaneously *** the extreme case,the FVM can become VGs by analogizing spin gapless semiconductor(sGs).Moreover,it is proposed that the valley splitting enhancement and valley polarization reversal can be achieved by electric field engineering in valleytronic bilayer *** the bilayer RuBr_(2)as an example,our proposal is confirmed by the first-principle *** FVM and VGs can be achieved in bilayer RuBr_(2)by applying electric *** appropriate electric field range,increasing electric field can enhance valley splitting,and the valley polarization can be reversed by flipping electric field *** effectively tune valley properties by electric field in bilayer systems,the parent monolayer should possess out-of-plane magnetization,and have large valley *** results shed light on the possible role of electric field in tuning valleytronic bilayer systems,and provide a way to design the ferrovalley-related material by electric field.

关键词： valleytronics electric field bilayer

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Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma

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Journal of Environmental sciences 2024年第3期137卷 172-180页

作者： Zhiyu Chen Fang Li Lei Fu Yu Xia Ying Luo ang Guo Xiaona Zhu Huifang Zhong Qian Luo Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of sciences Beijing 100049China Rheumatology&Immunology Department of shenzhen Children’s Hospital Shenzhen 518038China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

Lipid metabolism play an essential role in occurrence and development of asthma,and it can be disturbed by phthalate esters(PAEs)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased by PAEs and OPFRs exposure,but it remains not entirely clear how PAEs and OPFRs contribute the onset and progress of the *** have profiled the serum levels of PAEs and OPFRs congeners by liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metabolism in asthmatic,bronchitic(acute infammation)and healthy(non-infammation)*** PAEs and nine OPFRs congeners were found in the serum of children(1–5 years old)from shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,***,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-butyl phosphate(TNBP)were significant higher in asthmatic children than in healthy and bronchitic children as ***-one characteristic lipids and fatty acids of asthma were screened by machine-learning random forest model based on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including palmitic acids,12,13-Di HODE,14,21-Di HDHA,prostaglandin D2 and Lyso PA(18:2)showed significant correlated with high serum levels of MMP,TPP and *** results imply PAEs and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metabolism,and provide a novel sight for better understanding the effects of plastic additives on childhood asthma.

关键词： Phthalate esters Organophosphate fame retardants Childhood asthma Lipid and fatty acid metabolism Machine-learning random forest model Chronic airway infammation

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Adaptive Control of Lower-Limb Exoskeletons for Walking Assistance Based on Inter-Joint Coordination

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Journal of Bionic Engineering 2024年第4期21卷 1775-1787页

作者： Chaoyang Li Lincong Luo Zhi Liu Tianchi Chen songxiang Liu Ye He Xiaoan Chen Lei Li Wei Tech ang school of Mechanical Engineering Chongqing UniversityChongqing400044China Rehabilitation Research Institute of singapore Singapore308232Singapore Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China school of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore639798Singapore

Unilateral motor impairment can disrupt the coordination between the joints,impeding the patient’s normal *** assist such patients to walk normally and naturally,an adaptive control algorithm based on inter-joint coordination was proposed in this work for lower-limb *** control strategy can generate the reference trajectory of the affected leg in real time based on a motion coordination model between the joints,and adopt an adaptive controller with virtual windows to track the reference *** short-Term Memory(LsTM)network was also adopted to establish the coordination model between the joints of both lower limbs,which was optimized by preprocessing angle information and adding gait phase *** the adaptive controller,the virtual windows were symmetrically distributed around the reference trajectory,and its width was adjusted according to the gait phase of the auxiliary *** addition,the impedance parameters of the controller were updated online to match the motion capacity of the affected leg based on the spatiotemporal symmetry factors between the bilateral *** LsTM coordination model demonstrated good accuracy and generality in the gait database of seven individuals,with an average root mean square error of 3.5 and 4.1 for the hip and knee joint angle estimation,*** further evaluate the control algorithm,four healthy subjects walked wearing the exoskeleton while additional weights were added around the ankle joint to simulate an asymmetric *** the experimental results,it was shown that the algorithm improved the gait symmetry of the subjects to a normal level while exhibiting great adaptability to different subjects.

关键词： Lower-limb exoskeleton Adaptive control Gait symmetry Inter-joint coordination Motion estimation

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中美易货借款史研究的基本问题辨析

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上海经济研究 2024年第9期 106-116页

作者：徐昂上海社会科学院经济研究所 200020

基于对学术史与史料的双重分析,本文以抗战时期中美易货借款的合同变化、实际执行与易货贸易全过程为视野,首先辨析了债务统计、合同要件、借款动用、债务清偿以及贸易规定等债务关系问题。其次,本文分析了偿债物资的统购统销、交通运... 详细信息

基于对学术史与史料的双重分析,本文以抗战时期中美易货借款的合同变化、实际执行与易货贸易全过程为视野,首先辨析了债务统计、合同要件、借款动用、债务清偿以及贸易规定等债务关系问题。其次,本文分析了偿债物资的统购统销、交通运输、贸易金融以及大国战略博弈等贸易相关问题,进而构建中美易货借款史研究的理论框架。通过分析史料运用与该专题研究路径变化的关联,本文还指出利用美国典藏相关档案文献是深入研究上述议题的关键转向和必要路径。

关键词：抗日战争中美外债易货贸易海外档案文献研究路径

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Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma(DBA/2J)mice

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Neural Regeneration Research 2024年第1期19卷 220-225页

作者： Yin Yang Zhaoxi Yang Maoxia Lv ang Jia Junjun Li Baitao Liao Jing’an Chen Zhengzheng Wu Yi shi Yang Xia Dezhong Yao Ke Chen Department of Ophthalmology Sichuan Provincial People’s HospitalMedical SchoolUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina The Clinical Hospital of Chengdu Brain science Institute MOE Key Lab for NeuroInformationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit of NeuroInformation Chinese Academy of Medical SciencesChengduSichuan ProvinceChina Institute of Basic Medical sciences Chinese Academy of Medical sciences School of Basic Medicine Peking Union Medical CollegeBeijingChina Health Management Center Sichuan Provincial Key Laboratory for Human Disease Gene StudySichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit for Blindness Prevention of Chinese Academy of Medical sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuan ProvinceChina school of Electrical Engineering Zhengzhou UniversityZhengzhouHenan ProvinceChina

Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the ***,it is not yet clear how the primary visual cortex(V1)is altered in *** study used DBA/2J mice as a model for spontaneous secondary *** aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J *** conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band *** morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue ***-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were *** with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial *** r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J *** findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual *** findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse *** study might offer some innovative perspectives regarding the treatment of glaucoma.

关键词： DBA/2J degeneration gamma band oscillations glaucoma primary visual cortex(V1) retina single-unit recording tuning curve

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生态环境法治视野下工业园区“环保管家”服务模式探析

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水利经济 2024年第4期42卷 59-65页

作者：李昂河海大学法学院江苏南京211100

在分析“环保管家”服务模式的特点、分类及现状的基础上,剖析了制约以工业园区为主的“环保管家”模式的推广和应用发展的法律障碍;建议进一步明确第三方环境保护服务企业的行政和民事责任,完善环境保护法律框架中的相关配套制度,建立... 详细信息

在分析“环保管家”服务模式的特点、分类及现状的基础上,剖析了制约以工业园区为主的“环保管家”模式的推广和应用发展的法律障碍;建议进一步明确第三方环境保护服务企业的行政和民事责任,完善环境保护法律框架中的相关配套制度,建立合理的准入和退出机制,创新监管方法和监督途径,并健全财税支持和金融融资机制,从而促进“环保管家”服务模式在我国得以全面实施和健康发展,充分发挥其污染治理的作用,为我国的生态文明建设提供制度保障。

关键词：环保管家第三方治理生态文明建设服务模式工业园区

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