检索结果-南通市图书馆

Highly efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by heteropoly acids in water

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2010年第7期21卷 778-781页

作者： yingxiao Zong Yan Zhao WenCai Luo Xing Hai Yu Jun Ke Wang Yi Pan Key Laboratory of Resources and Environment Chemistry of West ChinaHexi UniversityZhangye 734000China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210093China

Heteropoly acids efficiently catalyzed the cyclocondensation reaction of anthranilamide with aldehydes in water at ambient temperature and afforded the corresponding 2,3-dihydro-4（1H）-quinazolinones compounds in good to excellent *** method provides mild reaction conditions and clean reaction profiles,using a small quantity of catalyst and a simple workup procedure.

关键词： Heteropoly acid 2 3-Dihydroquinazolin-4(1H)-ones Water

Writing and erasing MYC ubiquitination and SUMOylation

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2019年第4期6卷 359-371页

作者： yingxiao Chen Xiao-Xin Sun Rosalie C.Sears Mu-Shui Dai Departments of Molecular&Medical Genetics School of MedicineOHSU Knight Cancer InstituteOregon Health&Science University3181 SW Sam Jackson Park RoadPortlandOR 97239USA

The transcription factor c-MYC(MYC thereafter)controls diverse transcription programs and plays a key role in the development of many human *** develop multiple mechanisms to ensure that MYC levels and activity are precisely controlled in normal physiological *** a short half-lived protein,MYC protein levels are tightly regulated by the ubiquitin proteasome *** a dozen of ubiquitin ligases have been found to ubiquitinate MYC whereas a number of deubiquitinating enzymes counteract this *** studies show that SUMOylation and deSUMOylation can also regulate MYC protein stability and ***,evidence suggests an intriguing crosstalk between MYC ubiquitination and *** of the MYC ubiquitination-SUMOylation regulatory network may contribute to *** review is intended to provide the current understanding of the complex regulation of the MYC biology by dynamic ubiquitination and SUMOylation and their crosstalk.

关键词： deSUMOylating enzymes Deubiquitinating enzymes MYC SUMO SUMOylation Ubiquitination

Oral glucose tolerance test in diabetes,the old method revisited

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2021年第6期12卷 786-793页

作者： Feng Yu Kuo Kai-Chun Cheng yingxiao Li Juei-Tang Cheng Cardiovascular Center Veterans General HospitalKaohsiung 82445Taiwan Department of Pharmacy College of Pharmacy and Health CareTajen UniversityPingtung 90741Taiwan Pharmacological Department of Herbal Medicine and Department of Psychosomatic Internal Medicine Graduate School of Medical and Dental SciencesKagoshima UniversityKagoshima 890-8544Japan Department of Nursing Tzu Chi University of Science and TechnologyHualien 973302Taiwan Department of Medical Research Chi-Mei Medical CenterTainan 71004Taiwan

The oral glucose tolerance test(OGTT)has been widely used both in clinics and in basic research for a long *** is applied to diagnose impaired glucose tolerance and/or type 2 diabetes mellitus in ***,it has been employed in research to investigate glucose utilization and insulin sensitivity in *** main aim of each was quite different,and the details are also somewhat ***,the time or duration of the OGTT was the same,using the 2-h post-glucose load glycemia in both,following the suggestions of the American Diabetes ***,the use of 30-min or 1-h post-glucose load glycemia in clinical practice has been recommended by several *** this review article,we describe this new view and suggest perspectives for the ***,quantification of the glucose curve in basic research is also *** in clinical practice,the incremental area under the curve is not suitable for use in the studies involving animals receiving repeated treatments or chronic *** discuss the potential mechanisms in ***,variations between bench and bedside in the application of the OGTT are ***,the newly identified method for the OGTT must achieve a recommendation from the American Diabetes Association or another official unit *** conclusion,we summarize the recent reports regarding the OGTT and add some of our own perspectives,including machine learning and others.

关键词： Oral glucose tolerance test Impaired glucose tolerance Glucose Utilization Type 2 diabetes Area under the curve

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

粉丝经济下品牌企业的信号传递策略研究

系统工程学报 2022年第1期37卷 88-103页

作者：周建亨李颖潇东华大学旭日工商管理学院上海200051

本文研究粉丝经济下,当企业类型信息不对称时,品牌企业的最优策略.考虑包含两种类型的企业(原创性品牌或模仿型企业)与两种类型的消费者群体(粉丝或一般消费者)的两级供应链,构建两种信息结构下的企业与消费者之间的策略性竞争博弈模型... 详细信息

本文研究粉丝经济下,当企业类型信息不对称时,品牌企业的最优策略.考虑包含两种类型的企业(原创性品牌或模仿型企业)与两种类型的消费者群体(粉丝或一般消费者)的两级供应链,构建两种信息结构下的企业与消费者之间的策略性竞争博弈模型,得出分离均衡及混同均衡下企业的最优决策.探索了品牌企业是否应该向消费者披露企业真实类型,若披露,则如何通过价格及质量进行信号传递;进一步研究了研究消费者群体中粉丝比例与粉丝行为模式对企业决策的影响.结果表明:完全信息下,粉丝比例越大对品牌企业越有利;不完全信息下,若品牌企业选择分离均衡,当粉丝对模仿产品厌恶心理强烈时,粉丝比例越大对品牌企业却并非总是有利;即使品牌企业因前期投入大量筹建成本而导致收益低于模仿型企业,当粉丝比例足够大时,其收益终将高于模仿型企业;无论何种企业,其收益与粉丝心理收益总呈现出单调非递减性.

关键词：粉丝经济信号传递不完全信息

Single-atom cobalt catalysts for chemoselective hydrogenation of nitroarenes to anilines

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第12期34卷 183-188页

作者： Xiaochun Liu Chaoyue Wang Jiaolong Meng Xiaodong Yue Qingyun Wang Jiatian Lu Junke Wang Xicun Wang yingxiao Zong Xuefeng Jjiang Gansu Key Laboratory of Polymer Materials College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China Key Laboratory of Hexi Corridor Resources Utilization of Gansu College of Chemistry and Chemical EngineeringHexi UniversityZhangye 734000China Shanghai Key Laboratory of Green Chemistry and Chemical Process Department of ChemistryEast China Normal UniversityShanghai 200062China School of Materials Design&Engineering Beijing Institute of Fashion TechnologyBeijing 100000China

Single-atomic catalysts(SACs)caught considerable attention due to their unique structural properties,complete exposed active site,and 100%atom utilization efficiency with remarkable catalytic *** single-atomic cobalt catalyst with Co-N_(4) active sites was synthesized by using nitrogen-doped graphene derived from ***-atomic cobalt was observed by aberration-corrected high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)in Co@***,the density functional theory(DFT)calculation and the extended X-ray absorption fine structures(EXAFS)fitting results indicate that the coordination structure of Co-N is *** this work,the practical hydrogenation of nitroarenes to anilines enabled by Co@Nx-C-800 was established with excellent yields and selectivity,which proved its advantages and potential applications.

关键词： Cobalt catalyst Heterogeneous catalysis Nitro reduction Single-atom catalysts Chemoselective hydrogenation

Epigenetic regulation and mechanobiology

在线全文

学校读者我要写书评

暂无评论

Biophysics Reports 2020年第Z1期6卷 33-48页

作者： Shitian Li Dingyi Yang Li Gao yingxiao Wang Qin Peng Department of Bioengineering and Whitaker Institute of Biomedical Engineering University of California Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University) Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital School of Chemical Engineering and Technology North University of China

Mechanical force regulates a variety of cellular functions through inducing modulations in nuclear chromatin structures and epigenetic landscapes(outside in). The epigenetic modifications, in turn,regulate gene expressions and affect phenotypic outcomes, including cytoskeletal organization and cell–cell/cell–ECM interactions(inside out). While there have been significant advances in the understanding of mechanotransduction in the nucleus, there is still a lack of knowledge on the potential mechanisms through which mechanical cues affect epigenetic and chromatin regulations to determine genetic outcomes. This review firstly focuses on the current understanding of epigenetic regulations and then summarizes how mechanotransduction and epigenetic modification couple together to regulate molecular and cellular functions, eventually causing functional phenotype changes e.g., ***, we introduce related technologies for mechanistic studies, particularly fluorescence resonance energy transfer(FRET) biosensors for the visualization of dynamic epigenetic regulations in single living cells, as well as the applications of FRET biosensors to visualize mechanotransduction events occurring in the nucleus. These studies could provide new insights into epigenetics in regulating the physiological and pathological processes in living cells under different mechanical environments.

关键词： Epigenetic modification Mechanobiology Live cell imaging Fluorescence resonance energy transfer (FRET)

Strontium ranelate incorporated 3D porous sulfonated PEEK simulating MC3T3-E1 cell differentiation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2021年第1期8卷 43-51页

作者： yingxiao Sunt Xingdan Liu Ji Tan Dan Lv Wengang Song Rui Su Ling Li Xuanyong Liu Liping Ouyang Yun Liao Department of Pharmacy Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200336China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesChangning DistrictShanghai 200050China Graduate School of Beihua University Beihua UniversityFengman District Jilin 132013China

Polyetheretherketone(PEEK)has been used as an implant material because it has similar mechani-cal properties to natural ***,inferior osseointegration and bioinertness hamper the clinical application of *** this study,the surfaces of sulfonated three-dimensional(3D)PEEK porous structures were loaded with different concentrations of strontium ranelate,a compound commonly used in the treatment or prevention of osteoporosis by promoting bone formation and inhibiting bone ***-emission scanning electron microscopy was used to characterize the topography of the structures,elemental carbon,oxygen and strontium contents were mea-sured by X-ray photoelectron spectroscopy,and surface zeta potentials and water-contact angle were also *** results indicated that strontium ranelate was successfully loaded onto the 3D porous *** vitro cellular results showed that strontium ranelate-treated sulfonated PEEK(SP-SR)strengthened the adhesion of MC3T3-E1 *** activity of alkaline phosphatase,collagen secretion and extracellular matrix mineralization deposition of MC3T3-E1 cells were also improved on the surface of *** results indicate that SP-SR could serve a new implant candidate for surgical treatment.

关键词： polyetheretherketone sufonation strontium ranelate osseointegr ation

Atomic Fe-N4 sites on electrospun hierarchical porous carbon nanofibers as an efficient electrocatalyst for oxygen reduction reaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2020年第6期31卷 1588-1592页

作者： Ruiqin Zhong Chenxu Zhi yingxiao Wu Zibin Liang Hassina Tabassum Hao Zhang Tianjie Qiu Song Gao Jinming Shi Ruqiang Zou State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Beijing Key Laboratory for Theory and Technology of Advanced Battery Materials Department of Materials Science and EngineeringCollege of EngineeringPeking UniversityBeijing J00871China

Porous carbon materials doped with atomically dispersed metal sites(ADMSs)are promising electrocatalysts for oxygen reduction reaction(ORR)*** this work,we fabricated hierarchical porous nitrogen-doped carbon nanofibers with atomically dispersed Fe-N4 sites by carbonization of electrospinning iron-based metal-organic frameworks(MOFs)/polyacrylonitrile nanofibers for ORR ***,the re sultant carbon nanofibers with atomically dispersed FeN4 sites exhibit extraordinary electrochemical performance with an onset potential of 0.994 V and a halfwave potential of 0.876 V in alkaline electrolyte,comparable to the benchmark commercial Pt/C *** high catalytic performance is originated from the unique hierarchically porous 1 D carbon structure and abundant highly active atomically dispersed Fe-N4 sites.

关键词： Atomically dispersed metal sites Metal-organic frameworks Electrospinning Oxygen reduction reaction Electrocatalysis

在线全文

学校读者我要写书评

暂无评论

卫姒簋的自名修饰语研究

民俗典籍文字研究 2022年第1期 129-135,283页

作者：王英霄北京语言大学北京100083

西周晚期的卫姒簋为豆形簋,其铭文释文为“衛(卫)始(姒)乍(作)■?(簋)”。研究表明:簋前修饰语有表示特征、饮食、荐献祭祀、媵嫁、出行或随葬、数量等多种类别,卫姒簋中的■字应隶定为■,表荐献义;■字为“深”的简写,其顶部■形或为... 详细信息

西周晚期的卫姒簋为豆形簋,其铭文释文为“衛(卫)始(姒)乍(作)■?(簋)”。研究表明:簋前修饰语有表示特征、饮食、荐献祭祀、媵嫁、出行或随葬、数量等多种类别,卫姒簋中的■字应隶定为■,表荐献义;■字为“深”的简写,其顶部■形或为倒置器皿的构件的一部分,或为羡符“一”。“深”“覃”“寻”三者关系密切,“深”有“温”义,“■(簋)”意思即为“盛放荐献熟食/温食之簋”,青铜器中类似动宾结构的自名修饰语有很多。

关键词：卫姒簋荐献 ■ 深温