Writing and erasing MYC ubiquitination and SUMOylation

作     者：Yingxiao Chen Xiao-Xin Sun Rosalie C.Sears Mu-Shui Dai 

作者机构：Departments of Molecular&Medical GeneticsSchool of MedicineOHSU Knight Cancer InstituteOregon Health&Science University3181 SW Sam Jackson Park RoadPortlandOR 97239USA 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2019年第6卷第4期

页      面：359-371页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：We thank members of the Dai and Sears laboratories for active discussion.This work was supported by NIH/NCI grant R01 CA186241 to M-S.D.and R.S 

主　　题：deSUMOylating enzymes Deubiquitinating enzymes MYC SUMO SUMOylation Ubiquitination 

摘      要：The transcription factor c-MYC(MYC thereafter)controls diverse transcription programs and plays a key role in the development of many human *** develop multiple mechanisms to ensure that MYC levels and activity are precisely controlled in normal physiological *** a short half-lived protein,MYC protein levels are tightly regulated by the ubiquitin proteasome *** a dozen of ubiquitin ligases have been found to ubiquitinate MYC whereas a number of deubiquitinating enzymes counteract this *** studies show that SUMOylation and deSUMOylation can also regulate MYC protein stability and ***,evidence suggests an intriguing crosstalk between MYC ubiquitination and *** of the MYC ubiquitination-SUMOylation regulatory network may contribute to *** review is intended to provide the current understanding of the complex regulation of the MYC biology by dynamic ubiquitination and SUMOylation and their crosstalk.