检索结果-南通市图书馆

中医药治疗新冠病毒轻型感染用药规律及疗效分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华中医药学刊 2024年第5期42卷 8-13,I0004页

作者：王誉儒王亚勤李英杰王琳琳臧凝子王梅吕晓东庞立健辽宁中医药大学辽宁沈阳110847 辽宁中医药大学附属医院辽宁沈阳110032

目的研究辽宁丹东83例新型冠状病毒轻型感染者的用药规律及疗效分析。方法收集2022年6月5日—2022年6月18日收住入丹东市第六人民医院、丹东结核病医院及职专方舱的83例新冠病毒轻型感染者。基于Excel及SPSS对资料进行频数分析、关联分... 详细信息

目的研究辽宁丹东83例新型冠状病毒轻型感染者的用药规律及疗效分析。方法收集2022年6月5日—2022年6月18日收住入丹东市第六人民医院、丹东结核病医院及职专方舱的83例新冠病毒轻型感染者。基于Excel及SPSS对资料进行频数分析、关联分析、聚类分析及回归分析。结果共收录83首处方,涉及103味中药,共1523味次。使用频次前10位的药物分别为蒲公英、柴胡、甘草、苦杏仁、桔梗、薏苡仁、黄芩、麦冬、金银花、木香。药物四气频数前3位分别为寒性、温性、平性。药物五味频数前3位分别为苦味、甘味、辛味。药物归经频数前3位分别为肺经、胃经、脾经。药物功效频数前3位分别为清热解毒、利尿通淋、利水渗湿。对处方高频中药进行关联规则分析,剔出甘草对关联药物的影响,结果显示柴胡、蒲公英、苦杏仁、桔梗之间存在显著关联。经聚类分析,得出5类药物。经回归分析,显示服药前核酸阳性天数每增加1d,服用中药后核酸阳性天数≥4d的可能性将增加37.4%。结论新型冠状病毒轻型感染的中医药治疗,应从肺、胃、脾入手,以清热解毒为主,兼以清利湿热、理气化痰、宣肺止咳、固护气阴,早期及时干预是疗效的关键。

关键词：新型冠状病毒感染用药规律关联规则系统聚类临床疗效

大兴安岭中南段查布其日上侏罗统玛尼吐组火山岩地质及年代学特征

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

地质论评 2024年第3期70卷 996-1012页

作者：陈显婷董培培李英杰孟广安林敏王帅赵东芳刘晶晶刘志斌河北地质大学地球科学学院石家庄050031 河北地质大学河北省战略性关键矿产研究协同创新中心石家庄050031 河北地质大学蛇绿岩带成矿理论与找矿技术创新基地石家庄050031 河北省地质矿产研究中心石家庄050031 福建省地质调查研究院福州350013 中国地质大学(北京) 北京100083

通过1∶5万区域地质调查,运用“火山构造—岩性岩相—火山地层”三重填图方法,对大兴安岭中南段内蒙古查布其日地区上侏罗统玛尼吐组火山岩进行了系统的野外地质特征、岩石学、地球化学和锆石U-Pb年代学研究,分析玛尼吐组火山岩形成时... 详细信息

通过1∶5万区域地质调查,运用“火山构造—岩性岩相—火山地层”三重填图方法,对大兴安岭中南段内蒙古查布其日地区上侏罗统玛尼吐组火山岩进行了系统的野外地质特征、岩石学、地球化学和锆石U-Pb年代学研究,分析玛尼吐组火山岩形成时代和构造背景。将内蒙古查布其日地区玛尼吐组划分为2个岩性段,一段为火山碎屑沉积岩和少量中性、中酸性火山碎屑岩,二段为中性火山熔岩、火山碎屑岩和少量火山碎屑沉积岩、酸性火山碎屑岩,构成一个完整的沉积喷发旋回;划分出爆发相(碎屑流堆积相、空落堆积相)、溢流相、火山通道相、喷发—沉积相等火山岩相,并圈出4个V级火山机构。获得查布其日玛尼吐组二段安山岩的LA-ICP-MS锆石U-Pb年龄为157.8±1.4 Ma,表明其形成时代为晚侏罗世。岩石地球化学特征为,玛尼吐组二段粗安岩的SiO_(2)为64.04%~65.40%,高Al_(2)O_(3)(16.02%~16.96%),岩石富碱(K_(2)O+Na_(2)O=8.07%~8.38%),低TFe_(2)O_(3)(1.38%~4.43%),贫TiO_(2)(0.6%~0.81%),A/CNK值介于1.02~1.12之间;稀土丰度总量ΣREE为177.60×10^(-6)~254.61×10^(-6),轻、重稀土分异较明显,(La/Yb)N=8.13~12.63,具弱负Eu异常(δEu=0.71~0.78);微量元素以富集大离子亲石元素(Rb、Ba、Th、U、K)和相对亏损高场强元素(Nb、Ta、P、Ti)为特征。主量元素、微量元素地球化学特征显示查布其日玛尼吐组二段粗安岩为钾玄质岩。研究区玛尼吐组火山岩岩浆来源于伸展作用触发先前俯冲板片释放流体交代的大陆岩石圈地幔发生部分熔融,且受地壳混染影响较小,可能形成于蒙古—鄂霍次克洋造山后的伸展构造环境。

关键词：上侏罗统玛尼吐组火山作用 LA-ICP-MS锆石U-Pb定年大兴安岭蒙古—鄂霍次克洋内蒙古查布其日

浮动花键接触有限元模型及不对中接触特性研究

在线全文

学校读者我要写书评

暂无评论

科学技术创新 2024年第9期 63-66页

作者：朱晔李坚孙继堂李英杰赵广袁运博洪琪琛中国航发湖南动力机械研究所湖南株洲大连理工大学能源与动力学院辽宁大连大连理工大学控制科学与工程学院辽宁大连

针对浮动花键进行有限元建模,分析不同扭矩、不同齿侧间隙等对航空花键接触特性的影响。结果表明:花键Mises应力值、齿面压力、整体变形都随着扭矩的增大,近似线性增大;随着不对中角度的增大,齿侧间隙大的花键的Mises应力增速快;齿侧间... 详细信息

针对浮动花键进行有限元建模,分析不同扭矩、不同齿侧间隙等对航空花键接触特性的影响。结果表明:花键Mises应力值、齿面压力、整体变形都随着扭矩的增大,近似线性增大;随着不对中角度的增大,齿侧间隙大的花键的Mises应力增速快;齿侧间隙对花键的Mises应力及齿面压力的影响是非线性变化。

关键词：浮动花键有限元不对中齿侧间隙接触特性

Effect of biochar application on rice,wheat,and corn seedlings in hydroponic culture

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第1期135卷 379-390页

作者： yingjie Yin Jikai li Sihang Zhu Qing Chen Chong Chen Yukui Rui Jianying Shang College of Land Science and Technology China Agricultural UniversityKey Laboratory of Plant-Soil InteractionsMinistry of Educationand Key Laboratory of Arable Land Conservation in North ChinaMinistry of Agriculture and Rural AffairsBeijing 100193China Agricultural Management Institute Ministry of Agriculture and Rural AffairsBeijing 102208China College of Resources and Environmental Sciences China Agricultural UniversityBeijing Key Laboratory of Farmland Soil Pollution Prevention and RemediationBeijing 100193China

In recent years,biochar has attracted considerable attention for soil quality improvement and carbon sequestration due to its unique physicochemical ***,the mechanism by which biochar application negatively affects the growth of crop seedlings has not been fully *** this study,a hydroponic experiment was conducted to evaluate the response of rice,wheat,and corn seedlings to biochar application(CK,0 g/L;BC1,0.5 g/L;and BC2,1.0 g/L).Compared with the CK treatment,the BC1 and BC2 treatments decreased the fresh shoot and root weights of rice and corn seedlings(Plings(P>0.05).For the contents of nutrient elements in seedlings,both BC1 and BC2 treatments hindered the roots from absorbing Fe and Cu and increased the uptake of Ca and *** with the CK treatment,the translocation factor(TF)values of Ca,Mn,and Zn were significantly decreased especially in rice seedlings(35.3%-36.8%,68.7%-76.5%,and 29.8%-22.0%,respectively)under the BC1 and BC2 treatments,while only Mn was significantly decreased in wheat and corn seedlings(Plication can reduce nutrient absorption and translocation,and hinder rice,wheat,and corn seedlings,particularly rice seedling,in hydroponic system.

关键词： Biochar Toxicity Seedling growth Hydroponic cultivation

在线全文

学校读者我要写书评

暂无评论

20世纪以来全球气象干旱时空变化研究

河南科技 2024年第4期51卷 98-103页

作者：刘巧妙李英杰麻庆苗缪紫露乔家轩江苏师范大学地理测绘与城乡规划学院江苏徐州221116

【目的】气象干旱是四种干旱类型中最先发生的,探明气象干旱发生的特征及规律对其他几种类型干旱的早期预警和防灾减灾具有重要意义。【方法】基于CRU TS数据集中长系列气象数据,采用标准化降雨蒸散发指数(SPEI)表征气象干旱情势,采用Ma... 详细信息

【目的】气象干旱是四种干旱类型中最先发生的,探明气象干旱发生的特征及规律对其他几种类型干旱的早期预警和防灾减灾具有重要意义。【方法】基于CRU TS数据集中长系列气象数据,采用标准化降雨蒸散发指数(SPEI)表征气象干旱情势,采用Mann-Kendall趋势检验和最小二乘回归分析法研究1901—2021年全球气象干旱变化,并分析其时空变化特征,引入湿润指数(HI)探究干湿状况变化对干旱历时的影响。【结果】20世纪以来全球气象干旱整体呈现加重趋势,尤其是在2001年以后。全球大部分流域的平均干旱历时在13至16个月之间,大部分流域的干旱持续时间没有显著变化。【结论】流域尺度下的干旱历时与区域干湿状况密切相关,累计湿度越大,干旱持续时间越长。

关键词：气象干旱累计湿度流域时空特征

In-situ polymerized PEO-based solid electrolytes contribute better li metal batteries:Challenges,strategies,and perspectives

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第5期92卷 548-571页

作者： Zhihui Jia Yong liu Haoming li Yi Xiong yingjie Miao Zhongxiu liu Fengzhang Ren School of Materials Science and Engineering Henan Key Laboratory of Non-Ferrous Materials Science&Processing TechnologyHenan University of Science and TechnologyLuoyang 471023HenanChina Provincial and Ministerial Co-construction of Collaborative Innovation Center for Non-ferrous Metal new Materials and Advanced Processing Technology Henan University of Science and TechnologyLuoyang 471023HenanChina

Polyethylene oxide(PEO)-based solid polymer electrolytes(SPEs)with good electrochemical stability and excellent li salt solubility are considered as one of the most promising SPEs for solid-state lithium metal batteries(SSLMBs).However,PEO-based SPEs suffer from low ionic conductivity at room temperature and high interfacial resistance with the electrodes due to poor interfacial contact,seriously hindering their practical *** an emerging technology,in-situ polymerization process has been widely used in PEO-based SPEs because it can effectively increase li-ion transport at the interface and improve the interfacial contact between the electrolyte and ***,we review recent advances in design and fabrication of in-situ polymerized PEO-based SPEs to realize enhanced performance in *** merits and current challenges of various SPEs,as well as their stabilizing strategies are ***,various in-situ polymerization methods(such as free radical polymerization,cationic polymerization,anionic polymerization)for the preparation of PEO-based SPEs are *** addition,the application of in-situ polymerization technology in PEO-based SPEs for adjustment of the functional units and addition of different functional filler materials was systematically discussed to explore the design concepts,methods and working ***,the challenges and future prospects of in-situ polymerized PEO-based SPEs for SSLMBs are also proposed.

关键词： In-situ polymerization Polyethylene oxide Solid polymer electrolytes lithium metal anodes

Photothermal catalytic C-C coupling to ethylene from CO_(2) with high efficiency by synergistic cooperation of oxygen vacancy and half-metallic WTe_(2)

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第6期93卷 547-556,I0014页

作者： Xiaoyue Zhang Yong Yang yingjie Hu lijun Xiong Tianyu Wang Panjie li Jinyou Shen Key Laboratory of Environmental Remediation and Ecological Health Ministry of Industry and Information TechnologySchool of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094JiangsuChina School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina Nanjing Key Laboratory of Advanced Functional Materials Nanjing Xiaozhuang UniversityNanjing 210094JiangsuChina Jiangsu Environmental Engineering Technology Co.Ltd Nanjing 210019JiangsuChina

Photothermal catalytic CO_(2) conversion provides an effective solution targeting carbon neutrality by synergistic utilization of photon and ***,the C-C coupling initiated by photothermal catalysis is still a big ***,a three-dimensional(3D)hierarchical W_(18)O_(49)/WTe_(2) hollow nanosphere is constructed through in-situ embodying of oxygen vacancy and tellurium on the scaffold of WO_(3).The light absorption towards near-infrared spectral region and CO_(2) adsorption are enhanced by the formation of half-metal WTe_(2) and the unique hierarchical hollow *** with the generation of oxygen vacancy with strengthened CO_(2) capture,the photothermal effect on the samples can be sufficiently exploited for activating the CO_(2) *** particular,the close contact between W_(18)O_(49)and WTe_(2) largely promotes the photoinduced charge separation and mass transfer,and thus the~*CHO intermediate formation and fixedness are *** a result,the C-C coupling can be evoked between tungsten and tellurium atoms on WTe_(2).The ethylene production by optimized W_(18)O_(49)/WTe_(2) reaches 147.6μmol g^(-1)with the selectivity of 80%.The in-situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)and density functional theory(DFT)calculations are performed to unveil the presence and significance of aldehyde intermediate groups in C-C *** half-metallic WTe_(2) cocatalyst proposes a new approach for efficient CO_(2) conversion with solar energy,and may especially create a new platform for the generation of multi-carbon products.

关键词： Photothermal catalysis Half-metal WTe_(2) C–C coupling Carbon neutrality

胃癌上皮-间充质转化过程中微小RNA-579-3p/含锌指和BTB域4通路的作用及其机制

在线全文

学校读者我要写书评

暂无评论

中华实验外科杂志 2024年第2期41卷 235-238页

作者：刘文博王冰雨李勇李英杰翟建宁孔凡铭孙楠檀碧波河北医科大学第四医院外三科石家庄050011 北京大学肿瘤医院胃肠肿瘤中心三病区北京100142 天津中医药大学第一附属医院肿瘤科天津300193 河北医科大学第四医院输血科石家庄050011 河北省胃癌精准诊断与综合治疗重点实验室石家庄050011

目的探讨微小RNA-579-3p(miR-579-3p)/含锌指和BTB域4(ZBTB4)通路在胃癌上皮-间充质转化(EMT)中的作用机制。方法生物信息学筛选胃癌与癌旁组织差异表达的微小RNA(miRNA);实时荧光定量聚合酶链反应(RT-qPCR)法检测50例患者胃癌和癌旁癌... 详细信息

目的探讨微小RNA-579-3p(miR-579-3p)/含锌指和BTB域4(ZBTB4)通路在胃癌上皮-间充质转化(EMT)中的作用机制。方法生物信息学筛选胃癌与癌旁组织差异表达的微小RNA(miRNA);实时荧光定量聚合酶链反应(RT-qPCR)法检测50例患者胃癌和癌旁癌旁组织中miR-579-3p、ZBTB4表达;检测胃上皮细胞株GES-1和胃癌细胞株HGC27、AGS、MKN45中miR-579-3p的表达, 分析miR-579-3p与临床病理特征的关系。生物信息学分析miR-579-3p靶基因。双荧光素酶报告基因验证miR-579-3p与ZBTB4的调控关系。应用miR-579-3p抑制物(inhibitor)干扰HGC27细胞株miR-579-3p表达, 细胞计数试剂盒(CCK-8)法、划痕实验、Transwell小室实验检测细胞增殖、迁移和侵袭能力;RT-qPCR和蛋白质印迹法(Western blot)检测mRNA和蛋白表达水平。采用t检验、χ^(2)检验分析数据。结果生物信息学筛选后RT-qPCR检测结果发现miR-579-3p在胃癌组织中表达显著高于癌旁组织(3.259±1.307比1.326±0.419, t=9.959, P<0.01), miR-579-3p表达与胃癌分化和淋巴结转移明显相关(χ^(2)=4.500、7.714, P<0.05);miR-579-3p在胃癌细胞株表达均高于GES-1(P<0.01)。转染miR-579-3p抑制剂的HGC-27细胞活性(0.500±0.068比1.223±0.089, t=15.780, P<0.01)、迁移率(0.228±0.039比0.533±0.056, t=7.707, P<0.01)和侵袭细胞数[(89.000±7.550)个比(206.700±8.505)个, t=17.92, P<0.01]显著低于对照组。RT-qPCR结果显示miR-579-3p inhibitors组波形蛋白(Vimentin)(0.248±0.030比1.061±0.150, t=9.258, P<0.01)、基质金属蛋白酶-2(MMP-2)(0.178±0.030比1.013±0.195, t=3.320, P<0.01)和连接蛋白细胞黏附分子(Nectin-4)(0.465±0.065比1.042±0.154, t=5.990, P<0.01)的mRNA表达明显低于对照组, 而E-钙黏蛋白(E-cadherin)mRNA(3.249±0.460比1.000±0.175, t=7.990, P<0.01)的表达明显高于对照组, Western blot检测显示抑制miR-579-3p表达后Vimentin(0.420±0.271比1.004±0.095, t=3.528, P<0.05)、MMP-2(0.663±0.119比0.922±0.068, t=3.283, P<0.05)、Nectin-4表达(0.660±0.130比0.919±0.080, t=2.982, P<0.05)低于对照组, 而E-cadherin蛋白表达(1.352±0.113比0.994±0.005, t=5.483, P<0.01)高于对照组。生信分析结果显示ZBTB4是miR-579-3p靶基因;双荧光素酶报告基因分析表明过表达miR-579-3p后野生组中ZBTB4基因活性明显低于对照组(0.323±0.020比1.095±0.131, t=11.690, P<0.01)。RT-qPCR显示ZBTB4在胃癌组织中表达低于癌旁组织(t=7.713, P<0.01);皮尔逊相关分析结果显示ZBTB4与miR-579-3p呈负相关(r=-0.470, P<0.01)。RT-qPCR和Western blot显示抑制miR-579-3p后ZBTB4表达明显增强(P<0.01)。结论 miR-579-3p/ZBTB4通路激活促进胃癌的EMT。

关键词：胃癌微小RNA 上皮-间充质转化生物信息学

Intra-Oceanic Subduction of the Paleo-Asian Oceanic Slab: New Evidence from the Early Carboniferous Quartz Diorite in the Diyanmiao Ophiolite

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2020年第2期94卷 565-567页

作者： WANG Jinfang li yingjie li Hongyang DONG Peipei School of Natural Resources Hebei Geo UniversityShijiazhuang 050031China

Late Paleozoic supra-subduction zone(SSZ)-type ophiolites and intra-oceanic arc igneous petrotectonic assemblages are developed in the Erenhot-Hegenshan suture zone(EHSZ)in the eastern part of the Central Asian Orogenic Belt(CAOB).which contains information about the Late Paleozoic tectonic evolution of the Paleo-Asian Ocean(PAO)in the eastern ***,there are two main views and associated controversies about the closure time of the PAO in the eastern CAOB,which are“collision suture from Late Devonian to Early Carboniferous”and“final suture from Late Permian to Early Triassic”.

关键词： Carboniferous Asian suture