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终末期患者居家社会照护需求评估工具的构建及信效度检验

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中华护理杂志 2025年第1期60卷 99-105页

作者：肖瑶张晓天魏永婷马迎辉龚霓杨晶王梓珅岳鹏首都医科大学护理学院北京市100069 北京大学第三医院护理部宜昌市中心人民医院护理部首都医科大学附属北京安贞医院护理部暨南大学护理学院中日友好医院北区心脏科

目的构建终末期患者居家社会照护需求评估工具,并检验其信效度。方法以社会生态系统理论为框架,基于终末期患者居家社会照护需求的半结构式访谈、参与式观察及文献分析结果,形成条目池。通过3轮专家函询,形成初始版评估工具。采用方便... 详细信息

目的构建终末期患者居家社会照护需求评估工具,并检验其信效度。方法以社会生态系统理论为框架,基于终末期患者居家社会照护需求的半结构式访谈、参与式观察及文献分析结果,形成条目池。通过3轮专家函询,形成初始版评估工具。采用方便抽样法,于2023年4月—12月,选取5个省(市)22所医院收治的504例终末期患者作为调查对象,对评估工具进行信效度检验。结果终末期患者居家社会照护需求评估工具包括微观、中观、宏观3个维度,共34个条目。评估工具的Cronbach’sα系数为0.966、折半信度系数为0.877;条目水平的内容效度指数为0.875~1.000,量表水平的平均内容效度指数为0.989;探索性因子分析结果显示,各维度下条目的因子载荷值均>0.4;验证性因子分析结果显示,模型拟合度较好。结论该研究构建的终末期患者居家社会照护需求评估工具的信度与效度较好,可为医护人员评估终末期患者的居家社会照护需求提供有效工具。

关键词：居家终末期社会照护需求评估工具信效度安宁疗护

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基于深度强化学习的共享单车调度优化方法

信息技术与信息化 2025年第1期 193-196页

作者：李晓丹李冉马迎辉郑州经贸学院大数据与人工智能学院河南郑州450000 河南省多模态感知与智能交互技术工程研究中心河南郑州450000

共享单车因其流动特性,常呈现车辆流动的马太效应,部分区域单车堆积,其他区域却单车匮乏,严重影响车辆周转率,致使单车分布失衡。这种不均衡分布让传统调度方法难以依据实时交通流量、用户需求分布和单车分布等复杂因素动态地选择最优站... 详细信息

共享单车因其流动特性,常呈现车辆流动的马太效应,部分区域单车堆积,其他区域却单车匮乏,严重影响车辆周转率,致使单车分布失衡。这种不均衡分布让传统调度方法难以依据实时交通流量、用户需求分布和单车分布等复杂因素动态地选择最优站点,造成调度成本高、效率低。鉴于此,设计一种基于深度强化学习的共享单车调度优化方法。综合步行距离、单车电量和支付费用构建用于评估共享单车调度效果的效用函数。借助构建的效用函数,运用深度强化学习模型在多个调度站点中选择最优站点,并将其作为优化模型的输入。设定用户满意度最大化和调度成本最小化的目标函数,同时考虑供需平衡和调度能力等约束条件来建立调度优化模型。通过迭代算法求解此模型得到Pareto最优解集,再用加权求和法根据实际需求选择Pareto最优解集中的最优解,生成最优的调度方案。实验结果表明,共享单车调度成本降低幅度随迭代次数增多而增大,证明该方法在降本增效方面的可行性与有效性。

关键词：深度强化学习共享单车调度优化调度站点用户需求

Qualitative and Quantitative Analysis of Drug Interactions： Fritillary Mediating the Transport of Alkaloids in Caco-2 Cells by P-Glycoprotein

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Chemical Research in Chinese Universities 2014年第5期30卷 731-737页

作者： ma Jingwei KAN Hong ma yinghui MEN Lihui PI Zifeng LIU Zhiqiang LIU Zhongying College of Pharmacy Jilin University Changchun 130021 P. R. China Changchun Center of mass Spectrometry Changehun Institute of Applied ChemistryChinese Academy of Sciences Changchun 130022 P. R. China

Ultra performance liquid chromatographic-electrospray ionization-mass spectrometry（UPLC-ESI-MS） was used to investigate the potential interaction between selected ingredients of Aconitum and fritillary. The efflux ratios of 14-benzoylmesaconine（BM）, 14-benzoylaconine（BC）, 14-benzoylhypaconine（BH）, mesaconitine（ma）, aco- nitine（AC） and hypaconitine（HA） was 11.16, 12.53, 11.69, 12.8, 11.03 and 6.15, respectively, and the secretion of them was inhibited by Veraparnil, which means they are the substrates of permeability-glycoprotein（P-gp）. The transport of Aconitum alkaloids extract through a Caco-2 cell monolayer was determined in the absence and presence of fritillary extract. And the fritillary extract increased the absorption of Aconitum alkaloids. Peimine（PE） and peimi- nine（PEN） in fritillary increased the absorption of pure Aconitum alkaloids. The transport of digoxin was respectively enhanced by PE and PEN, which means they are the inhibitors of P-gp. PEN showed more effective inhibition than PE at the same concentration. The in vitro data suggest that the compounds such as fritillary present in alkaloids were able to inhibit the P-gp activity and lead modifying the transport of alkaloids.

关键词： Aconitum alkaloid Fritillary Caco-2 cell Permeability-glycoprotein(P-gp) Ultra performance liquidchromatographic-electrospray ionization-mass spectrometry(UPLC-ESI-MS)

Studies on Intestinal Transport of Ginsenoside Compatibility with Veratrum nigrum via Caco-2 Cell Monolayer Model Coupled with UPLC-ESI-MS Method

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Chemical Research in Chinese Universities 2015年第6期31卷 914-918页

作者： ma yinghui LIU Yuanyuan WEI Mengying SONG Fengrui LIU Zhongying PI Zifeng College of Pharmacy Jilin University Changchun 130021 P. R. China Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China

The Caco-2 cells have been recognized as effective tools to be applied to imitating the drug absorption in human intestine for the transport of drug. Herein, Caco-2 cell monolayer model was used to study the transport of the ginsenoside compatibility with Veratrum nigrum in different proportions. A specific high performance liquid chro- matography-electrospray ionization-mass spectrometry（HPLC-ESI-MS） method was developed for the semiquantita- tive determination of ginsenoside in intestinal transport with Dioscin as an internal standard. For the Caco-2 model constructed, two influencing factors were investigated, including time and concentration. The results suggest that the absorption of ginsenoside Re, Rgl, Rbl, Rc, Rb2 and Rd are time- and concentration-dependent and the excretions of Rbl, Rc, Rb2 and Rd have a relatronship with some transport proteins. The bioavailability of the ginsenosides has reduced compared to the single Panax ginseng extract when compatibility with a certain amount of Veratrum nigrum.

关键词： High performance liquid chromatography-electrospray ionization-mass spectroscopy(HPLC-ESI-MS) Panax ginseng Ginsenoside Veratrum nigrum Transport Caco-2 cell monolayer model

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基于电容原理的边坡监测倾角传感器设计

电子设计工程 2025年第05期33卷 70-74页

作者：任建超马英辉刘茂福赵燚陕西陕煤曹家滩矿业有限公司

针对现有电子式倾角传感器在电磁干扰或温度升高情况下测量精度较差的问题，采用电容液态介质倾斜后导致介电常数变化的原理，设计了一种新型电容式倾角传感器，通过试验对传感器进行标定、误差检验和温度稳定性测试，结果表明，传感器... 详细信息

针对现有电子式倾角传感器在电磁干扰或温度升高情况下测量精度较差的问题，采用电容液态介质倾斜后导致介电常数变化的原理，设计了一种新型电容式倾角传感器，通过试验对传感器进行标定、误差检验和温度稳定性测试，结果表明，传感器具有良好的线性关系，工作温度范围为0～100℃且在0～90°量程范围内的测量误差为±3%，由此证明了传感器在电磁干扰的矿山采空区边坡稳定性监测中具有应用潜力。

关键词：倾角传感器电容温漂电磁干扰边坡监测

Growth and wood properties of a 38-year-old Populus simonii 3 *** plantation established with different densities in semi-arid areas of northeastern China

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Journal of Forestry Research 2020年第2期31卷 497-506页

作者： Ammar Khalil Mohamed Ahmed Zhixiang Fu Changjun Ding Luping Jiang Xidong Han Aiguo Yang yinghui ma Xiyang Zhao State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040People’s Republic of China Baicheng Academy of Forestry Baicheng 137000People’s Republic of China State Key Laboratory of Tree Genetics and Breeding Research Institute of ForestryChinese Academy of ForestryBeijing 100091People’s Republic of China Key Laboratory of Tree Breeding and Cultivation National Forestry and Grassland AdministrationBeijing 100091People’s Republic of China Baicheng Forestry Bureau Baicheng 137000People’s Republic of China Faculty of Forest Science and Technology University of Gezira22212 MadaniAbu HarazSudan

To characterize the effects of plantation densities on the growth characteristics(diameter at breast level,tree height and volume)and the common wood properties,38-year-old Populus simonii 9 *** clones planted with four levels of spacing(2 m 92 m,3 m 93 m,4 m 94 m,and 5 m 95 m)in a semi-arid area in northeastern China were *** results of ANOVA showed significant differences(P\0.01)for all the investigated growth traits and wood properties under different plantation densities,except for the chemical composition of *** repeatability and phenotypic variations of all the traits varied from 0.34 to 0.99 and from 13.45 to 59.65%,*** for wood density,which was significantly negatively correlated with the growth traits,a positive correlation was observed between the growth traits and all the other wood mechanical ***,most of the correlations between the growth traits and the chemical composition of the wood were not *** path analysis for the wood mechanical characteristics and the growth in the prediction of volume were significant and ranged from 0.18 to 0.72 for wood density and diameter at breast height,respectively,while those for the chemical composition of wood ranged from 0.001 to 0.336,which showed a low impact on the *** highest stand volume(610 m3)per hectare was observed with the 2 m 92 m spacing,which consequently provided a high total price and income,while a high individual volume growth per tree was observed with the 5 m 95 m *** results suggested that for the poplar trees younger than 40 years in a semi-arid area in China,2 m 92 m spacing is suitable for obtaining a high volume per hectare,while 5 m 95 m spacing is best for obtaining a high individual volume per tree.

关键词： Fiber length Hemicellulose content Lignin content Planting spacing Poplar Wood density

Hot-melt extrusion promotes dissolution,extends“spring-parachute”process and inhibits crystallization in supersaturating microparticle systems

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Particuology 2023年第7期78卷 35-48页

作者： Yanfei Zhang Huifeng Zhang Huan Yu yinghui ma Chengyi Hao Xiaoying Lin Yong Zhang Zhengqiang Li Xianrong Qi Jia Zeng Nianqiu Shi School of Pharmacy jilin Medical University Jilin132013jilin ProvinceChina Collge of Life Science Jilin UniversityChangchun130012jilin ProvinceChina Department of Pharmaceutics School of Pharmaceutical SciencePeking UniversityBeijing100191China College of Pharmaceutical Sciences Yanbian UniversityYanji133002jilin ProvinceChina

Despite the potential advantages of amorphism-induced supersaturation,the merit of new amorphiza-tion formation methods on the properties of the amorphous drug including the stability of the amor-phous state,dissolution/solubility,supersaturation,and"spring-parachute"process is still poorly understood,particularly for certain amorphous supersaturating drug delivery systems(aSDDS).The present work aimed to explore the detailed merit of current attractive amorphization manufacturing methods(i.g.,hot-melt extrusion(HME)technique)on the property improvement of aSDDS in form of amorphous solid dispersion microparticles by employing a model Bcs II drug nitrendipine and a polyvinylpyrrolidone-based model polymer *** asDDS systems were developed by various methods,and their physicochemical properties were characterized by SEM,PXRD and ***-triggered amorphization induced superior supersaturation by the observation of the highest dissolution and *** induced the optimal supersaturation duration by the observed greatest extension of"spring-parachute"process(e.g,maximum AUCspring-parachute).HME technique is comparable with other techniques for the stabilization of amorphous state during *** aSDDS systems by HME and other methods showed improved long-term stability of the amorphous state in comparison to the pure amorphous *** transformation infrared spectroscopy,Noyes-Whitney equation,nucleation theory and Gibbs free energy of transfer(△G)were used to analyze the underlying ***-lecular mechanism studies indicated that HME caused a stronger crystallization inhibition effect in the asDDS systems than other methods,but molecular interaction is not a dominant mechanism for property enhancement caused by *** the mechanism associated with the polymer itself(PVPVA64),it could inhibit the drug recrystallization,solubilize the drug spontaneously and cause the improved molecular interactions in all aSDDS *** study provided

关键词： Hot-melt extrusion-triggered amorphization Extensionof"spring-parachute"process Promotion of dissolution/solubility Inhibition of crystallization from a supersaturated state Amorphism-based supersaturating drug microparticle systems

基于西门子PLC的以太网开放式通讯分析及应用

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锻压装备与制造技术 2025年第1期60卷 65-70页

作者：鹿德林张怀礼邢向宇马英辉王宣峰封沛石林潇马士尧国机铸锻机械有限公司山东济南250306

西门子设备有多种不同的现场总线协议,如MPI、PROFIBUS、PROFINET、S7协议等,同时也支持开放式以太网通讯。S7-1500系列定义的开放式以太网通讯即OPENE通信,主要有TCP、ISO-n-TCP、UDP三种通讯方式。本文针对该三种基于以太网的开放式通... 详细信息

西门子设备有多种不同的现场总线协议,如MPI、PROFIBUS、PROFINET、S7协议等,同时也支持开放式以太网通讯。S7-1500系列定义的开放式以太网通讯即OPENE通信,主要有TCP、ISO-n-TCP、UDP三种通讯方式。本文针对该三种基于以太网的开放式通讯,详细描述其通讯建立、实现两台设备数据交换的应用方案。

关键词： PLC S7-1500系列以太网开放式通讯电气自动化控制系统

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如何理解胡塞尔:问题的发生、转向与突进

四川大学学报（哲学社会科学版） 2024年第3期 58-67,208,209页

作者：马迎辉浙江大学哲学学院暨现象学与心性思想研究中心杭州310058

理解胡塞尔必须进入胡塞尔本人的运思。《逻辑研究》在拓展范畴直观的同时错失了作为直观之前提的自身被给予性。在1906—1907年间,胡塞尔开始聚焦绝对被给予性(之中的先天)的观念,在随后的内时间意识研究中,他通过对滞留的具体综合样... 详细信息

理解胡塞尔必须进入胡塞尔本人的运思。《逻辑研究》在拓展范畴直观的同时错失了作为直观之前提的自身被给予性。在1906—1907年间,胡塞尔开始聚焦绝对被给予性(之中的先天)的观念,在随后的内时间意识研究中,他通过对滞留的具体综合样式的揭示,为纯粹意识/绝对存在的显现提供了新的意向基础。现象学就此进入超越论阶段。意向流形结构(一维流形构造二维连续统)既是超越论现象学的意向基础,也是现象学对20世纪西方哲学对体验流之内结构的整体探索的回应。只有在此双向交织、多维建基的意向结构中,本质直观与范畴直观的差异、形式化对本质关联的构造、能思/所思的相关性才可能真正得到理解,而超越论现象学从主体性(从能思/所思、本质类型到实显行为)到具体区域的构造也才可能展示自身。

关键词：胡塞尔直观被给予性内时间纯粹意识能思/所思超越论构造