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Property of Corroded Concrete under Compressive Uniaxial Loads

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Journal of Wuhan University of Technology(Materials Science) 2008年第2期23卷 276-280页

作者： fan yingfang HU Zhiqiang ZHOU Jing LI Xin Institute of Road and Bridge Engineering Dalian Maritime University Dalian 116026 China State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China

In order to study the compressive property of corroded concrete, accelerated corrosion test were performed on concrete C30.6 corrosive solutions, including hydraulic acid solution （pH=2）, hydraulic acid solution （pH=3） were applied as the corrosive medium. 6 series of corrosion tests, including 111 specimens, were carried out. Mechanical properties of all the corroded specimens were tested respectively. Compressive properties of the corroded specimens （e.g. compressive strength, stress-strain relation, elastic modulus etc.） were achieved. Taking the strength degradation ratio and strain energy loss as damage index, effects of the corrosion solution on the compressive property of corroded concrete were discussed in detail. Relationship between the damage index and corrosion state of specimens were achieved.

关键词： concrete corrosion compressive strength elastic modulus stress-strain curve strain energy loss

Study on the interactions between anti-tumor metal complexes and mononucleotides using trans-[en_(2)Os(h^(2)-H_(2))(CF_(3)SO_(3))](CF_(3)SO_(3))as a^(1)H NMR probe in a competitive mode

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Science China Chemistry 2005年第3期48卷 227-239页

作者： YANG Pin CHEN Huili fan yingfang YUE Lijun MENG Xiangli Institute of Molecular Science Chemical Biology and Molecular Engineering Laboratory of Education MinistryShanxi UniversityTaiyuan 030006China

The interaction of several anti-tumor metal complexes with dGMP have been investigated using trans-[en_(2)Os(h^(2)-H_(2))]^(2+)as a ^(1)H NMR probe in a competitive ***_(2)SnCl_(2),Bu_(2)SnCl_(2),Et_(2)Sn(phen)Cl_(2) and Et_(2)SnCl_(2) can bind to dGMP mainly via phosphate;Cp_(2)TiCl_(2) binds to dGMP mainly via phosphate and N_(7).The binding constant for(CH_(3))_(2)SnCl_(2) binding to phos-phate of dGMP exceeds 2.71×10^(4).The binding constant for Cp_(2)TiCl_(2) to phosphate is even greater than that of Sn(IV).Cis-platin has high affinity for both N_(7) and phosphate,but mainly for N_(7).Binding of the probe to N_(7) of dGMP reduces the binding affinity for phosphate of the same dGMP molecule by a factor of 5 to *** the same factor is expected to apply to other metals containing agents interacting with dGMP.

关键词： trans-[en_(2)Os(h^(2)-H_(2))]^(2+) dGMP,anti-tumor metal complex competitive mode.

The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo

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Acta Pharmaceutica Sinica B 2019年第2期9卷 316-323页

作者： Yan Wen Ruiqiang Zhao Pranav Gupta yingfang fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang Department of Pharmaceutical Sciences College of Pharmacy and Health Sciences St.John's University Department of Pharmacy the First Affiliated Hospital of Guangxi Medical University Guangxi Colleges and Universities Key Laboratory of Biological Molecular Medicine Research Guangxi Medical University Department of Biochemistry and Molecular Biology School of Preclinical Medicine Guangxi Medical University Department of Hepatobiliary Surgery Zhujiang Hospital Southern Medical University Department of Biotechnology School of Preclinical Medicine Guangxi Medical University The Affiliated Tumor Hospital of Guangxi Medical University College of Pharmacy Guangxi Medical University

Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function.

关键词： Epigallocatechin gallate(EGCG) 5,3’,4’,3″,4″,5″-6-O-ethylEGCG(Y6) Drug resistance Resistance reversal ABCB1 P-gp

The efficacy of vitamin E in preventing arthrofibrosis after joint replacement

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Animal Models and Experimental Medicine 2024年第2期7卷 145-155页

作者： yingfang fan Jean Yuh Sashank Lekkala Mehmet D.Asik Andrew Thomson Madeline McCanne Mark A.Randolph Antonia F.Chen Ebru Oral Harris Orthopaedic Laboratory Department of Orthopaedic SurgeryMassachusetts General HospitalBostonMassachusettsUSA Department of Orthopaedic Surgery Harvard Medical SchoolBostonMassachusettsUSA Department of Surgery Harvard Medical SchoolBostonMassachusettsUSA Department of Orthopaedic Surgery Brigham and Women's HospitalBostonMassachusettsUSA

Background:Arthrofibrosis is a joint disorder characterized by excessive scar formation in the joint *** E is an antioxidant with potential anti-fibroblastic *** aim of this study was to establish an arthrofibrosis rat model after joint replacement and assess the effects of vitamin E supplementation on joint ***:We simulated knee replacement in 16 male Sprague–Dawley *** immobilized the surgical leg with a suture in full *** control groups were killed at 2 and 12 weeks(n=5 per group),and the test group was supplemented daily with vitamin E(0.2 mg/mL)in their drinking water for 12 weeks(n=6).We performed histological staining to investigate the presence and severity of *** staining andα2-macroglobulin(α2M)enzyme-linked immunosorbent assay(ELISA)were used to assess local and systemic *** weight bearing(total internal reflection)and range of motion(ROM)were collected for functional ***:The ROM and weight-bearing symmetry decreased after the procedure and recovered slowly with still significant deficit at the end of the study for both *** analysis confirmed fibrosis in both lateral and posterior periarticular *** E supplementation showed a moderate anti-inflammatory effect on the local and systemic *** vitamin E group exhibited significant improvement in ROM and weight-bearing symmetry at day 84 compared to the control ***:This model is viable for simulating arthrofibrosis after joint *** E may benefit postsurgical arthrofibrosis,and further studies are needed for dosing requirements.

关键词： arthrofibrosis range of motion total knee arthroplasty vitamin E

3D腹腔镜胆囊切除术治疗胆囊结石1例并文献复习

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南方医科大学学报 2013年第12期33卷 1856-1857页

作者：范应方项楠南方医科大学珠江医院肝胆一科广东广州510282

目的报道3D腹腔镜胆囊切除术1例并文献复习。方法采用德国Stroze公司3D腹腔镜为1例胆囊结石患者实施腹腔镜胆囊切除术。结果 3D腹腔镜下术野呈现纵深感,真实呈现腹腔及胆囊三角区的三维解剖结构,手术操作更加精准。成功实施了3D腹腔镜... 详细信息

目的报道3D腹腔镜胆囊切除术1例并文献复习。方法采用德国Stroze公司3D腹腔镜为1例胆囊结石患者实施腹腔镜胆囊切除术。结果 3D腹腔镜下术野呈现纵深感,真实呈现腹腔及胆囊三角区的三维解剖结构,手术操作更加精准。成功实施了3D腹腔镜胆囊切除术,历时32 min,无手术并发症。结论 3D腹腔镜下深度感的出现,使得解剖更清楚,操作更精准,有利于减少并发症、缩短手术时间、完成更为复杂的腹腔镜手术。

关键词： 3D腹腔镜胆囊切除术

纳米偏高岭土水泥浆在水化早期的内部结构建立

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湖南大学学报（自然科学版） 2023年第12期50卷 102-111页

作者：李秋超范颖芳大连海事大学土木工程系辽宁大连116026

考虑水胶比(0.40、0.45、0.50)、NMK掺量(0、1%、3%、5%、7%)、减水剂掺量(0、0.04%、0.08%,0.12%)及温度(10℃、20℃、30℃、40℃)的影响,采用静态屈服应力试验方法和小振幅振荡剪切试验方法获得了纳米偏高岭土(NMK)水泥浆静态屈服应... 详细信息

考虑水胶比(0.40、0.45、0.50)、NMK掺量(0、1%、3%、5%、7%)、减水剂掺量(0、0.04%、0.08%,0.12%)及温度(10℃、20℃、30℃、40℃)的影响,采用静态屈服应力试验方法和小振幅振荡剪切试验方法获得了纳米偏高岭土(NMK)水泥浆静态屈服应力、储能模量等参数,通过静态屈服应力和储能模量随时间的演变规律讨论了水化早期(10~90 min)NMK水泥浆内部结构的建立过程.试验结果表明:NMK能够促进水泥浆在水化早期的内部结构建立.在水化90 min内,掺3%NMK水泥浆静态屈服应力的平均增长速率约为普通水泥浆的2倍;掺7%NMK水泥浆储能模量的平均增长速率约为普通水泥浆的4倍.水胶比越高、减水剂掺量越大,NMK水泥浆内部结构建立速率越低;NMK加速了不同温度环境中水泥浆内部结构的建立;温度升高,NMK水泥浆静态屈服应力和储能模量的增长速率增大.

关键词：纳米偏高岭土水泥浆结构建立静态屈服应力储能模量

维普期刊数据库博看期刊

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偏高岭土对水泥砂浆中钢筋钝化的影响

复合材料学报 2020年第11期37卷 2917-2927页

作者：李闯范颖芳李秋超大连海事大学交通运输工程学院大连116026

利用电化学阻抗谱、循环动电位极化、阴极极化、热重和XRD等方法,研究了偏高岭土(MK)掺量(占MK/水泥总质量的20wt%、30wt%、40wt%)对钢筋-MK/水泥砂浆中钢筋钝化膜形成及其耐蚀性能的影响。结果表明:在一般环境中,钢筋在不同MK掺量的钢... 详细信息

利用电化学阻抗谱、循环动电位极化、阴极极化、热重和XRD等方法,研究了偏高岭土(MK)掺量(占MK/水泥总质量的20wt%、30wt%、40wt%)对钢筋-MK/水泥砂浆中钢筋钝化膜形成及其耐蚀性能的影响。结果表明:在一般环境中,钢筋在不同MK掺量的钢筋-MK/水泥砂浆中均可以形成稳定的钝化膜;在质量分数为3.5wt%的NaCl溶液环境中,MK掺量过多会使钢筋-MK/水泥砂浆中钢筋的钝化膜稳定性降低,耐蚀性能下降。从钢筋钝化膜稳定角度考虑,在氯盐环境中,水泥基材料中MK掺量应予以限制。

关键词：偏高岭土水泥砂浆钢筋钝化电化学阻抗谱极化曲线

粗糙度对CFRP-混凝土界面剪切黏结性能的影响

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建筑材料学报 2018年第2期21卷 202-207页

作者：殷雨时范颖芳徐义洪大连海事大学土木工程系辽宁大连116026

针对3种强度、6种界面粗糙度的54块混凝土试件,采用单向剪切试验,研究了表面粗糙度对碳纤维增强复合材料(CFRP)-混凝土梁界面黏结性能的影响.结果表明:6种界面中,粗糙度为0.44的混凝土试件界面黏结性能最佳,CFRP-混凝土的极限荷载和黏... 详细信息

针对3种强度、6种界面粗糙度的54块混凝土试件,采用单向剪切试验,研究了表面粗糙度对碳纤维增强复合材料(CFRP)-混凝土梁界面黏结性能的影响.结果表明:6种界面中,粗糙度为0.44的混凝土试件界面黏结性能最佳,CFRP-混凝土的极限荷载和黏结强度较粗糙度为0.25的试件分别提高36%~51%,124%~221%;粗糙度对混凝土界面有效黏结长度影响较大,与现有模型中的有效黏结长度计算值相比,考虑粗糙度和黏结树脂后的有效黏结长度最高可提高273%;6种界面的有效黏结长度随粗糙度的提高,总体呈现减小趋势;粗糙度为0.25~0.44的混凝土界面τ-s曲线在脆性区域上的刚度相差无几,界面越粗糙,脆性区间越短;进入塑性阶段后,6种界面的CFRP-混凝土梁黏结滑移曲线均以不同斜率下降,最终以0.04~0.35mm的滑移值剥离破坏.

关键词：混凝土碳纤维增强复合材料界面黏结滑移关系单剪试验黏结应力

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基于电化学阻抗谱的偏高岭土水泥性能研究

建筑材料学报 2020年第4期23卷 755-762页

作者：李闯范颖芳李秋超大连海事大学交通运输工程学院辽宁大连116026

利用电化学阻抗谱、压汞法和抗压强度试验研究了偏高岭土(MK)水泥净浆从早期水化到养护28d的性能发展规律,分析了MK水泥净浆的电化学参数随养护龄期的变化规律,提出了1种同时考虑弥散效应和水泥净浆/电极界面扩散过程的等效电路模型,分... 详细信息

利用电化学阻抗谱、压汞法和抗压强度试验研究了偏高岭土(MK)水泥净浆从早期水化到养护28d的性能发展规律,分析了MK水泥净浆的电化学参数随养护龄期的变化规律,提出了1种同时考虑弥散效应和水泥净浆/电极界面扩散过程的等效电路模型,分析了电化学参数与抗压强度、孔结构参数的关系.结果表明:MK能够促进水泥净浆的水化进程;利用等效电路模型得到的MK水泥净浆电荷转移电阻Rct1能够很好地反映MK水泥净浆的抗压性能;MK水泥净浆的孔隙率与电荷转移电阻Rct1、高频区阻抗模数|Z|1呈负相关关系.

关键词：偏高岭土水泥净浆电化学阻抗谱等效电路孔隙抗压强度