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A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models

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Signal Transduction and Targeted Therapy 2021年第10期6卷 2954-2956页

作者： Jian sheng Fan Xinlei Zhuang Xiaoyue Yang yingchun xu Zhan Zhou Liqiang Pan Shuqing Chen Institute of Drug Metabolism and Pharmaceutical Analysis College of Pharmaceutical SciencesZhejiang UniversityHangzhouChina

Dear Editor,The epidermal growth factor receptor(EGFR),one member of the ErbB family of receptor tyrosine kinases,has been implicated in various epithelial *** a clinically validated target,both small-molecule tyrosine kinase inhibitors and antibody-based drugs have been approved by regulatory ***-EGFR antibodyci rug conjugates(ADCs)could kill target tumor cells irrespective of EGFR ***,cancer patients treated with EGFR-targeted antibody therapy eventually develop acquired epitope substitutions such as S492R,G465R,G465E,and 1491M.

关键词： drugs conjugate eventually

Rational Construction of Hierarchically Porous Fe–Co/N-Doped Carbon/rGO Composites for Broadband Microwave Absorption

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Nano-Micro Letters 2019年第4期11卷 337-352页

作者： Shanshan Wang yingchun xu Ruru Fu Huanhuan Zhu Qingze Jiao Tongying Feng Caihong Feng Daxin Shi Hansheng Li Yun Zhao School of Chemistry and Chemical Engineering Beijing Institute of TechnologyZhuhai 100081People’s Republic of China School of Materials and the Environment Beijing Institute of TechnologyZhuhai 519085People’s Republic of China

Developing lightweight and broadband microwave absorbers for dealing with serious electromagnetic radiation pollution is a great ***,a novel Fe-Co/N-doped carbon/reduced graphene oxide(Fe-Co/NC/rGO)composite with hierarchically porous structure was designed and synthetized by in situ growth of Fe-doped Cobased metal organic frameworks(Co-MOF)on the sheets of porous cocoon-like rGO followed by *** Fe-Co/NC composites are homogeneously distributed on the sheets of porous *** Fe-Co/NC/rGO composite with multiple components(Fe/Co/NC/rGO)causes magnetic loss,dielectric loss,resistance loss,interfacial polarization,and good impedance *** hierarchically porous structure of the Fe-Co/NC/rGO enhances the multiple reflections and scattering of *** with the Co/NC and Fe-Co/NC,the hierarchically porous Fe-Co/NC/rGO composite exhibits much better microwave absorption performances due to the rational composition and porous structural *** minimum reflection loss(RLmin)reaches?43.26 dB at 11.28 GHz with a thickness of 2.5 mm,and the effective absorption frequency(RL≤?10 dB)is up to 9.12 GHz(8.88-18 GHz)with the same thickness of 2.5 ***,the widest effective bandwidth of 9.29 GHz occurs at a thickness of 2.63 *** work provides a lightweight and broadband microwave absorbing material while offering a new idea to design excellent microwave absorbers with multicomponent and hierarchically porous structures.

关键词： Fe-doped Co-MOF Hierarchically porous rGO Broadband Microwave absorption performance

Arterial spin labeling perfusion MRI applications in drug‑resistant epilepsy and epileptic emergency

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Acta Epileptologica 2023年第3期6卷 139-147页

作者： yingchun xu Ge Tan Deng Chen Jiao Liu Zixian Zhou Ling Liu Department Neurology Sichuan UniversityWest China HospitalGuo Xue Lane 37Chengdu 610041SichuanPR China

Epilepsy affects all age groups and is one of the most common and disabling neurological disorders ***-resistant epilepsy(DRE),status epilepticus(SE),and sudden unexpected death in epilepsy(SUDEP),which are associated with considerable healthcare costs and mortality,have always been difficult to address and become the focus of clinical *** rapid identification of seizure onset and accurate localization of epileptic foci are crucial for the treatment and prognosis of people with DRE,SE,or ***,most of the conventional neuroimaging techniques for assessing cerebral blood flow of people with epilepsy are restricted by time consumption,limited resolution,and ionizing *** spin labeling(ASL)is a newly powerful non-contrast magnetic resonance imaging technique that enables the quantitative evaluation of brain perfusion,characterized by its unique advantages of reproducibility and easy *** studies have demonstrated the potential advantages of ASL for the diagnosis and evaluation of ***,in this review,we discussed the complementary value of ASL in evaluating and characterizing the basic substrates underlying refractory epilepsy and epileptic emergencies.

关键词： Arterial spin labeling Cerebral blood flow Drug-resistant epilepsy Epileptic emergency Status epilepticus SUDEP

TCR-mimic antibody-drug conjugates targeting intracellular tumor-specific mutant antigen KRAS G12V mutation

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Asian Journal of Pharmaceutical Sciences 2020年第6期15卷 777-785页

作者： Ying Shen Xiaoyue Wei Shijie Jin Yue Wu Wenbin Zhao yingchun xu Liqiang Pan Zhan Zhou Shuqing Chen College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Huabo Biopharm Co. Ltd.Shanghai 201203China

Limited clinical application of antibody-drug conjugates(ADCs)targeting tumor associated antigens(TAAs)is usually caused by on-target off-tumor side ***-specific mutant antigens(TSMAs)only expressed in tumor cells which are ideal targets for *** addition,intracellular somatic mutant proteins can be presented on the cell surface by human leukocyte antigen class I(HLA I)molecules forming tumor-specific peptide/HLA I *** G12 V mutation frequently occurred in varied cancer and was verified as a promising target for cancer *** this study,we generated two TCR-mimic antibodydrug conjugates(TCRm-ADCs),2E8-MMAE and 2 A5-MMAE,targeting KRAS G12 V/HLAA*0201 complex,which mediated specific antitumor activity in vitro and in vivo without obvious *** findings are the first time validate the strategy of TCRm-ADCs targeting intracellular TSMAs,which improves the safety of antibody-based drugs and provides novel strategy for precision medicine in cancer therapy.

关键词： TCR-mimic antibody-drug conjugates Tumor-specific mutant antigens KRAS G12V Human leukocyte antigen classⅠ

Numerical simulation of liquid core reduction in thin-slab continuous casting

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Baosteel Technical Research 2009年第1期3卷 15-21页

作者： WANG yingchun ZHANG Li xu Rongjun xu Hongwei Metallurgical Process Division Baosteel Research Institute Baoshan Iron ＆ Steel Co. Ltd. Shanghai 201900 China

Thin-slab continuous casting and rolling technology is a process integrating casting and plastic deformation. In this study,targeting actions such as slab deformation and liquid core flows during the process of liquid core reduction on thin-slab continuous casting, suggests the fluid-solid coupling method should be used to research the characteristic and patterns of slab deformation during the liquid core reduction process, as well as research liquid core backflows. A material model of the slab shell was obtained through the high-temperature compression test of the cast steel. The analysis of the fluid-solid coupling simulation for liquid core reduction shows that slab deformation concentrates on the narrow side due to the existence of the liquid core. Meanwhile,the stress and strain increases with the increase of the reduction rate and slab thickness. The changing trends of stress and strain are identical under various conditions. The results demonstrate that using greater reduction at the upper part of the slab, which has a higher temperature and thinner slab,is beneficial to the quality of the slab. Moreover,the liquid core is extruded as the reduction is implemented. The quantity of the extrusion increases with the increase of reduction rate and the thickness of thinner shell, which leads to fluctuation of the mould level, making the operation more difficult.

关键词： thin-slab casting liquid core reduction fluid-solid coupling slab deformation liquid core backflow

Assessment of urinary concentration of cotinine in Chinese pregnant women exposed to environmental tobacco smoke

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Chinese Science Bulletin 2014年第13期59卷 1386-1391页

作者： Yajing Lei Wenhui Liu Lizheng Fang Muhammad Sajid Hamid Akash Kanwal Rehman Hua Narenmandura Weixing Shi Weixian Lu yingchun xu Shuqing Chen Institute of Pharmacology Toxicology and Biochemical Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Sir Run Run Shaw Hospital School of Medicine Zhejiang University College of Pharmacy Government College University Faisalabad Institute of Public Health College of Medical Science Zhejiang University Hangzhou EPIE Bio-detection Technology Limited

Environmental tobacco smoke(ETS)is a wellknown reason of many adverse health consequences in pregnant *** of ETS during pregnancy may increase the risk of some fetal diseases in pregnant women and/or birth defects in *** countries have implemented laws to control smoking and free of second hand smoke in all enclosed *** China,antismoking law was enforced in March *** aimed to assess the exposure of pregnant women to cotinine after anti-smoking law was implemented in *** urine samples were collected from 2,100 volunteers from Zhejiang Province,China and urinary concentration of cotinine was measured using gas chromatography and mass *** was detected in 87%of the pregnant *** GM and 95th percentile concentration inpregnant women were 4.28 and 44.00 lg/L,***,the GM and 95th concentration of cotinine were significantly higher in smoking group than in non-smoking group(P\0.0001).Our results indicate that pregnant women in China are at the high risk of exposure *** attempts are required to make strategies to find out the sources of ETS exposure and prevent smoking at public places especially during pregnancy.

关键词：烟雾浓度烟草烟雾孕妇中国尿液评估环境怀孕期间

Study on the Irreversible Thermodynamics of a Marine Engine Exhaust-powered Adsorption Refrigerating System

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Journal of Ocean University of China 2006年第2期5卷 165-168页

作者： XIE yingchun MEI Ning xu Zhen College of Engineering Ocean University of China Qingdao 266071 P.R. China

This study investigates the heat and mass transfer mechanism of a marine engifie exhaust-powered adsorption refrigerating system by using irreversible thermodynamics. The equations of entropy-production rate and the linear phenomenological equations of thermodynamic flux and force are established. The conventional experimental facilities of unit tube are developed and the phenomenological coefficients are obtained by fitting the experimental data. It is concluded that the thermodynamic process in the adsorbent bed is determined by the coupling effect of the heat and mass transfer; furthermore, the mass transfer is determined by the heat transfer. Taking some measures to increase heat transfer can improve the performance of the adsorption refrigerating system. The conclusions presented in this paper may be of value to the engineering applications of the system.

关键词： adsorption refrigeration irreversible thermodynamics entropy-production rate heat and mass transfer linear phenomenological equations

Endocarditis caused by Arcanobacteriumpyogenes

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Chinese Medical Journal 2014年第19期127卷 3510-3511页

作者： Zhang Hui Shi Zhongkai Yang Qiwen Chen Yu xu yingchun Microbiology Laboratory Peking Union Medical College HospitalChinese Academy of Medical Sciences Beijing 100730 China Department of Clinical Laboratory Heilongjiang Provincial HospitalHaerbin Heilongjiang 150036 China

A21-year-old male farmer was admitted to our hospital n December 28, 2011 with intermittent fever and chills of three months duration. Two weeks previously he had developed chest congestion and shortness of breath. His medical history was unremarkable. On physical examination, his temperature was 37.5℃, pulse 115/ min, and respiratory rate 20/min. His blood pressure was 118/49 mmHg. Cardiac auscultation revealed the presence of a systolic ejection murmur at the left sternal border and diastolic murmur at the right sternal border. A transthoracic echocardiogram performed on December 28 revealed left ventricular hypertrophy, an 8 mm ventricular septum, mild aortic valve stenosis, moderate to severe aortic insufficiency, moderate mitral valve insufficiency, vegetation on the aortic valve （measuring 5 mm×5 mm）, and trace pericardial effusion. The remaining physical examination was unremarkable. The laboratory test results for this patient are shown in the Table 1.

关键词： Arcanobacterium pyogenes endocarditis aortic insufficiency infection penicillin

The first Haematobacter massiliensis caused bacteriamia in China

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The first Haematobacter massiliensis caused bacteriamia in C...