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Microstructure and properties of 35 kg large aluminum alloy flywheel housing components formed by squeeze casting with local pressure compensation

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China Foundry 2024年第5期21卷 563-576页

作者： Ju-fu Jiang Jing Yan ying-ze liu Ning Ge ying Wang Chang-jie Ding De-chao Zou School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China Dalian Innovation Die-casting Co. Ltd.Dalian 116600LiaoningChina

The squeeze casting method with local pressure compensation was proposed to form a flywheel housing component with a weight of 35 *** numerical simulation,microstructure observation and phase characterization were performed,and the influence of local pressure compensation on feeding of thick-wall position,microstructure and mechanical properties of the formed components were *** show that the molten metal keeps a good fluidity and the filling is complete during the filling *** the solidification at thick-wall positions of the mounting ports is slow,the local pressure compensation effectively realizes the local forced feeding,significantly eliminating the shrinkage cavity *** the microstructure of AlSi9Mg alloy,α-Al primarily consists of fragmented dendrites and rosette grains,while eutectic Si predominantly comprises needles and short *** impact of local pressure compensation on strength is relatively minimal,yet its influence on elongation is *** local pressure compensation,the average elongation at the compensated areas is 9.18%,which represents a 44.90%higher than that before *** average tensile strength is 209.1 MPa,and the average yield strength is 100.6 *** local pressure compensation can significantly reduce or even eliminate the internal defects in the 35 kg large-weight components formed by squeeze casting.

关键词： squeeze casting local pressure compensation aluminum alloy microstructure mechanical properties large flywheel housing components

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Microstructure and property of the Ti-24Al-15Nb-1.5Mo/TC11 joint welded by electron beam welding

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International Journal of Minerals,Metallurgy and Materials 2009年第5期16卷 568-575页

作者： ying-ying liu ze-kun Yao Hong-zhen Guo Hang-hang Yang College of Materials Science and Engineering Northwestern Polytechnical University Xi＇an 710072 China

The Ti-24Al-15Nb-1.5Mo alloy, in the as-forged and heat-treated states, was joined to the as-forged TC 11 titanium alloy by electron beam welding with the heat inputs of 135 and 150 kJ/m. Then the microstructure and property of the Ti-24Al-15Nb- 1.5Mo/TC 11 welding interface were investigated. The results show that the phase constitution of the weld is not related to the heat input, and is mainly composed of α＇ phase. Moreover, the intermetallic phases of TiEAlNb, MoNb, NbaAl, and TiAl3 are formed in the weld zone. Therefore, the microhardness value of the weld zone is higher than that of the other portions in the same sample. The profile of the weld is asymmetrically fimnel-like. The grain sizes of the weld and its heat-affected zones are increased with increasing heat input. There is an obvious difference in the element content of the welding interface; only the alloying elements in the fusion zone reach a new balance during solidification.

关键词： titanium alloys electron beam welding heat input microstructure property

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High temperature deformation behavior and microstructure evolution of wrought nickel-based superalloy GH4037 in solid and semi-solid states

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Transactions of Nonferrous Metals Society of China 2020年第3期30卷 710-726页

作者： Ju-fu JIANG Guan-fei XIAO ying WANG ying-ze liu ying ZHANG School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China

Cylindrical samples of Ni-based GH4037 alloy were compressed at solid temperatures(1200,1250 and 1300℃) and semi-solid temperatures(1340,1350,1360,1370 and 1380℃) with different strain rates of 0.01,0.1 and 1 *** temperature deformation behavior and microstructure evolution of GH4037 alloy were *** results indicated that flow stress decreased rapidly at semi-solid temperatures compared to that at solid ***,the flow stress continued to increase after reaching the initial peak stress at semi-solid temperatures when the strain rate was 1 *** increasing the deformation temperature,the size of initial solid grains and recrystallized grains *** semi-solid temperatures,the grains were equiaxed,and liquid phase existed at the grain boundaries and inside the *** dynamic recrystallization(DDRX) characterized by grain boundary bulging was the main nucleation mechanism for GH4037 alloy.

关键词： nickel-based superalloy high temperature deformation semi-solid microstructure evolution dynamic recrystallization

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Microstructure and mechanical properties of 7005 aluminum alloy processed by one-pass equal channel reciprocating extrusion

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Transactions of Nonferrous Metals Society of China 2021年第3期31卷 609-625页

作者： Ju-fu JIANG ying WANG ying-ze liu Guan-fei XIAO Hua LI School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China

An equal channel reciprocating extrusion(ECRE)was proposed first to obtain a severe plastic deformation(SPD)of 7005 *** microstructure and mechanical properties of one-pass ECREed(ECRE processed)7005 alloy were *** results show that SPD occurring in ECRE leads to a mixed *** 7005 alloy exhibits a significant improvement of ultimate tensile strength(UTS)and *** properties in the region undergoing a complete ECRE process are higher than those in the region undergoing an incomplete ECRE process due to larger dislocation strengthening *** strength(YS)and UTS first decrease and then increase with an increase of extrusion *** YS of 359.2 MPa,UTS of 490 MPa and elongation of 17.7%are obtained after T6 ***-grain strengthening,dislocation strengthening and precipitation strengthening in the T6-treated ECREed sample all play important roles in improving the mechanical properties.

关键词： 7005 aluminum alloy equal channel reciprocating extrusion microstructure mechanical properties

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Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 968-978页

作者： ying-Qiao Zhang Qing-Hao liu Lu liu Peng-Yu Guo Run-ze Wang Zhi-Chang Ba Department of Radiology Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina Department of Digestive Internal Medicine Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina

BACKGROUND Traditional treatments for pancreatic cancer(PC)are *** therapy(PDT)is non-invasive,and proven safe to kill cancer cells,including ***,the mitochondrial concentration of the photosensitizer,such as verteporfin,is *** To investigate the distribution of fluorescence of verteporfin in PC cells treated with antitumor drugs,*** Workable survival rates of PC cells(AsPC-1,BxPC-3)were determined with chemotherapy[doxorubicin(DOX)and gemcitabine(GEM)]and non-chemotherapy[sirolimus(SRL)and cetuximab(CTX)]drugs in vitro,with or without verteporfin,as measured via MTT,flow cytometry,and laser confocal *** cell proliferation was associated with GEM that was more enduring compared with *** laser microscopy allowed observation of GEM-and verteporfin-treated PC cells co-stained with 4’,6-diamidino-2-phenylindole and MitoTracker Green to differentiate living and dead cells and subcellular localization of verteporfin,*** Cell survival significantly dropped upon exposure to either chemotherapy drug,but not to SRL or *** cell lines responded similarly to *** intensity of fluorescence was associated with the concentration of *** experiments using GEM showed that survival rates of the PC cells treated with 10μmol/L verteporfin(but not less)were significantly lower relative to nil *** and dead stained cells treated with GEM were *** GEM treatment,verteporfin was observed primarily in the *** Verteporfin was observed in living *** GEM-treated human PC cells,verteporfin was particularly prevalent in the *** study supports further study of PDT for the treatment of PC after neoadjuvant chemotherapy.

关键词： Photodynamic therapy Pancreatic cancer Verteporfin Mitochondria Chemotherapy Gemcitabine

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Effects of temperature and time on three-dimensional microstructural evolution of semi-solid 2A14 aluminum alloy during short process preparation of semi-solid billets

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Transactions of Nonferrous Metals Society of China 2022年第7期32卷 2091-2109页

作者： ying-ze liu Ju-fu JIANG Guan-fei XIAO ying ZHANG Min-jie HUANG ying WANG School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China

To shorten the preparation process of semi-solid billets,semi-solid billets of 2A14 aluminum alloy were prepared by wrought aluminum directly semi-solid isothermal treatment(WADSSIT)***-dimension(3D)combined microstructure evolution,namely transverse direction(TD)surface,rolling direction(RD)surface,and normal direction(ND)surface,was *** of temperature and holding time on average grain size and average shape factor were *** results showed that the optimum conditions for preparation of 2A14 semi-solid billets by this process were 615℃ and 20 min(average grain size of 124μm and shape factor of 0.81).Electron backscatter diffraction(EBSD)observations indicated that the microstructure was completely recrystallized when it was heated to 600℃.Grain size was increased with the increase of temperature and grew up slowly with the holding time *** was increased with increase of holding time but was not sensitive to temperature.

关键词： 2A14 aluminum alloy three-dimensional microstructure semi-solid billet microstructure evolution

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GAMYB transcription factor LoMYB65 from lily plays a vital role in pollen development

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Horticultural Plant Journal 2024年第1期10卷 223-238页

作者： Xinyue liu Ling He ze Wu Nianjun Teng Key Laboratory of Landscaping Agriculture Ministry of Agriculture and Rural AffairsCollege of HorticultureNanjing Agricultural UniversityNanjingJiangsu 210095China Key Laboratory of Biology of Ornamental Plants in East China National Forestry and Grassland AdministrationCollege of HorticultureNanjing Agricultural UniversityNanjingJiangsu 210095China Jiangsu Graduate Workstation of Nanjing Agricultural University and Nanjing Oriole Island Modern Agricultural Development Co. Ltd.NanjingJiangsu 210043China

Lily(Lilium spp.)is an important horticultural crop,but its use is limited due to serious pollen contamination *** are many studies on pollen development in model plants,but few on flower crops such as ***(GA)is a large class of hormones and plays an important role in plant vegetative growth and reproductive *** is a group of the R2R3-MYB family upregulated by gibberellin,and plays an important role in anther ***,we isolated a novel GAMYB,named LoMYB65,from lily,which was closely related to the AtMYB65 and AtMYB33 in *** quantitative PCR results showed that LoMYB65 was mainly expressed in lily ***65 could be activated by 288μmol·L^(-1)GA3treatment and the LoMYB65 protein was located in the nucleus and cytoplasm,and had transactivation in yeast and tobacco leaf *** conserved motif within 226 amino acids of the C-terminal of LoMYB65 contributed to its *** of LoMYB65 caused dwarf phenotype,unnormal tapetum development,less seeds of siliques in transgenic Arabidopsis plants,the transgenic plants showed partly male ***,silencing of LoMYB65 with VIGS(Virus Induced Gene Silencing)in lily anthers caused unnormal pollen development and reduced the pollen *** of LoMYB65 in Arabidopsis and silencing of LoMYB65 in lily resulted in decreased pollen counts,so we speculate that LoMYB65 may be ***,these findings suggest that LoMYB65 may play an important role in anther development and pollen formation in ***65 may provide a useful candidate gene for pollenless breeding of lily.

关键词： Lily Anther development Pollen pollution GAMYB VIGS

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Clinical applications of metagenomics next-generation sequencing in infectious diseases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 471-484页

作者： ying liu Yongjun MA Department of Clinical Laboratory Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000China

Infectious diseases are a great threat to human *** and accurate detection of pathogens is important in the diagnosis and treatment of infectious *** next-generation sequencing(mNGS)is an unbiased and comprehensive approach for detecting all RNA and DNA in a *** the development of sequencing and bioinformatics technologies,mNGS is moving from research to clinical application,which opens a new avenue for pathogen *** studies have revealed good potential for the clinical application of mNGS in infectious diseases,especially in difficult-to-detect,rare,and novel ***,there are several hurdles in the clinical application of mNGS,such as:(1)lack of universal workflow validation and quality assurance;(2)insensitivity to high-host background and low-biomass samples;and(3)lack of standardized instructions for mass data analysis and report ***,a complete understanding of this new technology will help promote the clinical application of mNGS to infectious *** review briefly introduces the history of next-generation sequencing,mainstream sequencing platforms,and mNGS workflow,and discusses the clinical applications of mNGS to infectious diseases and its advantages and disadvantages.

关键词： Metagenomics next-generation sequencing(mNGS) Infectious disease Cerebrospinal fluid(CSF) Oxford Nanopore Technologies(ONT) Microbiome

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Neighborhood predictors of short sleep duration and bedtime irregularity among children in the United States: results from the 2019-2020 National Surveyof Children's Health

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World Journal of Pediatrics 2024年第1期20卷 73-81页

作者： ying Dai Jianghong liu School of Nursing University of Pennsylvania418 Curie Blvd.Room 426Claire M.Fagin HallPhiladelphiaPA19104-6096USA

Background Environmental factors may contribute to short sleep duration and irregular bedtime in *** factors and children's sleep duration and bedtime regularity remain a less investigated *** aim of this study was to investigate the national and state-level proportions of children with short sleep duration and irregular bedtime and their neighborhood *** A total of 67,598 children whose parents completed the National Survey of Children's Health in 2019-2020 were included in the ***-weighted Poisson regression was used to explore the neighborhood predictors of children's short sleep duration and irregular *** The prevalence of short sleep duration and irregular bedtime among children in the United States(US)was 34.6%[95%confidence interval(CI)=33.8%-35.4%]and 16.4%(95%CI=15.6%-17.2%)in 2019-2020,*** neighborhoods,supportive neighborhoods,and neighborhoods with amenities were found to be protective factors against children's short sleep duration,with risk ratios ranging between 0.92 and 0.94,P<*** with detracting elements were associated with an increased risk of short sleep duration[risk ratio(RR)=1.06,95%CI=1.00-1.12]and irregular bedtime(RR=1.15,95%CI=1.03-1.28).Child race/ethnicity moderated the relationship between neighborhood with amenities and short *** Insufficient sleep duration and irregular bedtime were highly prevalent among US children.A favorable neighborhood environment can decrease children's risk of short sleep duration and irregular *** the neighborhood environment has implications for children's sleep health,especially for children from minority racial/ethnic groups.

关键词： Child National Survey of Children's Health Neighborhood.Sleep Social determinants of health

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The important role of Turbidity Maximum Zone in sedimentary dynamic of estuarine mangrove swamp

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Frontiers of Earth Science 2024年第1期18卷 219-226页

作者： Tao liu ying liu Baoqing HU Key laboratory of Environment Change and Resources Use in Beibu Gulf(Ministry of Education) Nanning Normal UniversityNanning 530001China School of Civil Engineering and Architecture Guangxi UniversityNanning 530004China

Sedimentation is a key process affecting wetland sustainability and carbon burial *** context of sea level rise,climate change and human activities,further understanding about the sedimentary dynamic in wetland is critical in predicting the landscape evolution or the change in carbon burial *** this study,based on the field hydrological observation in a mangrove system in the Nanliu River estuary,we found the net flux of suspended sediment to mangrove is 39−72 kg/m in tidal cycles with Turbidity Maximum Zone(TMZ)forming in surface layer and only is 9−18 kg/m in tidal cycles without *** higher net flux of suspended sediment to mangrove in tidal cycles with TMZ forming in surface layer is attributed to high SSC in rising tide and intense flocculation in *** significant discrepancy in sedimentation rate in the mangrove patches also can be explained by the probability of TMZ forming in the surface layer of *** future,rapid sea level rising may lead to the change of TMZ pattern in estuary,which will result in non-negligible variation in sedimentation rate in *** to the present data of sedimentation rate in wetlands,the fragility of wetlands in river estuary may be miscalculated.

关键词： mangrove wetland sedimentation Turbidity Maximum Zone Nanliu River

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