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High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells

World Journal of Stem Cells 2024年第2期16卷 176-190页

作者： Yu-Su wang wen-Hui Chu Jing-Jie Zhai wen-ying wang Zhong-Mei He Quan-Min Zhao Chun-Yi Li Institute of Antler Science and Product Technology Changchun Sci-Tech UniversityChangchun 130000Jilin ProvinceChina College of Chinese Medicinal Materials Jilin Agricultural UniversityChangchun 130118Jilin ProvinceChina School of Life Science Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina Department of Oral Implantology Hospital of StomatologyJilin UniversityChangchun 130000Jilin ProvinceChina

BACKGROUND Cartilage defects are some of the most common causes of *** lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral *** studies have shown that decellularized extracellular matrix(ECM)derived from autologous,allogenic,or xenogeneic mesenchymal stromal cells(MSCs)can effectively restore osteochondral *** To determine whether the decellularized ECM of antler reserve mesenchymal cells(RMCs),a xenogeneic material from antler stem cells,is superior to the currently available treatments for osteochondral *** We isolated the RMCs from a 60-d-old sika deer antler and cultured them in vitro to 70%confluence;50 mg/mL L-ascorbic acid was then added to the medium to stimulate ECM *** sheets of adipocyte-derived MSCs(aMSCs)and antlerogenic periosteal cells(another type of antler stem cells)were used as the *** weeks after ascorbic acid stimulation,the ECM sheets were harvested and applied to the osteochondral defects in rat knee *** The defects were successfully repaired by applying the *** highest quality of repair was achieved in the RMC-ECM group both in vitro(including cell attachment and proliferation),and in vivo(including the simultaneous regeneration of well-vascularized subchondral bone and avascular articular hyaline cartilage integrated with surrounding native tissues).Notably,the antler-stem-cell-derived ECM(xenogeneic)performed better than the aMSC-ECM(allogenic),while the ECM of the active antler stem cells was superior to that of the quiescent antler stem *** Decellularized xenogeneic ECM derived from the antler stem cell,particularly the active form(RMC-ECM),can achieve high quality repair/reconstruction of osteochondral defects,suggesting that selection of decellularized ECM for such repair should be focused more on bioactivity rather than kinship.

关键词： Osteochondral defect repair Mesenchymal stem cells Extracellular matrix Decellularization Antler stem cells Reserve mesenchymal cells Xenogeneic

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Current Mycoplasma pneumoniae epidemic among children in Shanghai:unusual pneumonia caused by usual pathogen

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World Journal of Pediatrics 2024年第1期20卷 5-10页

作者： Xiao-Bo Zhang wen He Yong-Hao Gui Quan Lu Yong Yin Jian-Hua Zhang Xiao-Yan Dong ying-wen wang ying-Zi Ye Hong Xu Jia-Yu wang Bing Shen Dan-Ping Gu Li-Bo wang Yi wang Department of Respiratory Medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China State Key Laboratory of Genetic Engineering at School of Life Sciences Institute of Reproduction&DevelopmentChildren's Hospital of Fudan UniversityShanghaiChina Department of Respiratory Medicine Children's Hospital of Shanghai Jiao Tong UniversityShanghaiChina Department of Respiratory Medicine Shanghai Children's Medical CenterAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Pediatric Respiratory Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Nursing Children's Hospital of Fudan UniversityShanghaiChina Department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina Department of Nephrology Children's Hospital of Fudan UniversityShanghaiChina NHC Key Laboratory of Neonatal Diseases Children's Hospital of Fudan UniversityShanghaiChina Shanghai Shenkang Hospital Development Center ShanghaiChina Center for Medical Quality Control Management of Shanghai ShanghaiChina Department of Neurology Children's Hospital of Fudan University399Wanyuan RoadShanghai 201102China

Mycoplasma pneumoniae(***),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and *** infection occurs endemically with an epidemic peak every few *** worldwide incidence confirmed by direct test methods was reported to be 8.61%between 2017 and 2020 across all age groups[1].

关键词： pneumonia epidemic respiratory

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Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 304-310页

作者： Yuan-Zhang Zhu Zhi-Zhi Dou wen-ying wang Qing-Yue Ma wen-Dan Yi Ning-Ning Yao Yi-Chong Liu Xiao-Di Gao Qian Zhang wen-Juan Luo Department of Ophthalmology the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

AIM:To observe the therapeutic effect of conbercept on diabetic macular edema(DME)complicated with diabetic nephropathy(DN).METHODS:In this retrospective study,54 patients(54 eyes)that diagnosed as DME from January 2017 to October 2021 were *** patients were divided into two groups:DME patients with DN(25 eyes),and DME patients without DN(29 eyes).General conditions were collected before treatment,laboratory tests include fasting blood glucose,HbA1c,microalbumin/creatinine,serum *** coherence tomography(OCT)was used to check the ellipsoidal zone(EZ)and external limiting membrane(ELM)*** macular thickness(CMT),best corrected visual acuity(BCVA),and retinal hyperreflective foci(HF)as well as numbers of injections were ***:There were significant differences between fasting blood glucose,HbA1c,serum creatinine,urinary microalbumin/creatinine,and estimated glomerular filtration rate(eGFR)between the two groups(all P<0.05).EZ and ELM continuity in the DME+DN group was worse than that in the DME group(P<0.05).BCVA(logMAR)in the DME group was significantly better than that in the DME+DN group at the same time points during treatment(all P<0.05).CMT and HF values were significantly higher in the DME+DN group than that in the DME group at the all time points(all P<0.05)and significantly decreased in both groups with time during *** 6mo after treatment,the mean number of injections in the DME+DN and DME group was 4.84±0.94 and 3.79±0.86,***:Conbercept has a significant effect in short-term treatment of DME patients with or without DN,and can significantly ameliorate BCVA,CMT and the number of HF,treatment efficacy of DME patients without DN is better than that of DME patients with DN.

关键词： conbercept diabetic nephropathy diabetic macular edema optical coherence tomography

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Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis in vitro and in vivo: From biological characteristics to therapeutic mechanisms

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World Journal of Stem Cells 2019年第8期11卷 548-564页

作者： Fei Yin wen-ying wang wen-Hua Jiang Department of Histology and Embryology Basic Medical College of Jilin University

Liver fibrosis is a wound-healing response to chronic injuries, characterized by the excessive accumulation of extracellular matrix or scar tissue within the liver;in addition, its formation is associated with multiple cytokines as well as several cell types and a variety of signaling pathways. When liver fibrosis is not well controlled, it can progress to liver cirrhosis, but it is reversible in principle. Thus far, no efficient therapy is available for treatment of liver fibrosis. Although liver transplantation is the preferred strategy, there are many challenges remaining in this approach, such as shortage of donor organs, immunological rejection, and surgical complications. Hence, there is a great need for an alternative therapeutic strategy. Currently, mesenchymal stem cell (MSC) therapy is considered a promising therapeutic strategy for the treatment of liver fibrosis;advantageously, the characteristics of MSCs are continuous self-renewal, proliferation, multipotent differentiation, and immunomodulatory activities. The human umbilical cord-derived (hUC)-MSCs possess not only the common attributes of MSCs but also more stable biological characteristics, relatively easy accessibility, abundant source, and no ethical issues (e.g., bone marrow being the adult source), making hUC-MSCs a good choice for treatment of liver fibrosis. In this review, we summarize the biological characteristics of hUC-MSCs and their paracrine effects, exerted by secretion of various cytokines, which ultimately promote liver repair through several signaling pathways. Additionally, we discuss the capacity of hUC-MSCs to differentiate into hepatocyte-like cells for compensating the function of existing hepatocytes, which may aid in amelioration of liver fibrosis. Finally, we discuss the current status of the research field and its future prospects.

关键词： Human umbilical cord mesenchymal stem cells Liver fibrosis Hepatocytelike cells Mechanism Cell therapy Paracrine effect Exosome Transdifferentiation

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GaAs pHEMT multi-band/multi-mode SP9T switch for quad-band GSM and UMTS handsets applications

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第4期12卷 317-322页

作者： Xiao-ying wang wen-ting GUO Yang-yang PENG wen-quan SUI Zhejiang California International Nanosystems Institute (ZCNI) Zhejiang University Hangzhou 310029 China

A multi-band/multi-mode single-pole nine-throw (SP9T) switch for GSM/UMTS (global system for mobile communications/universal mobile telecommunication system) systems is *** switch consists of a GaAs 0.5μm pseudomorphic high-electron mobility transistor (pHEMT) radio frequency (RF) switches module and Si complementary metal-oxide-semiconductor (COMS) digital module with an encoder and a DC boost *** isolation and high linearity are achieved by a series-shunt switch structure and the DC boost circuit,*** switch shows a measured insertion loss of 0.4 dB at 0.8 GHz for GSM transmit arms,0.7 dB at 0.9 GHz and 0.9 dB at 1.8 GHz for GSM receive arms,and 0.6 dB at 1.8 GHz for UMTS *** switch introduces 2nd and 3rd harmonic suppression levels less than 64 dBc at 37 dBm input *** between transmit and receive terminals are more than 48 dB when one transmit arm is *** size of the RF switches module is 1.5 mm×1.1 mm,and the size of the digital module is 1.3 mm×0.63 mm with gold bonding wires connecting these two modules.

关键词： GSM UMTS Single-pole nine-throw (SP9T) pHEMT Encoder DC boost

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Retinal vascular diameter changes assessed with a computer-assisted software after strabismus surgery

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 620-624页

作者： Jin-Qiong Zhou Jing Fu Ji-Peng Li Xiao-Zhen wang wen-ying wang Bo-wen Zhao Meng Qi Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing 100730China

AIM: To quantitatively investigate the retinal vascular diameter changes, analyzing the early and long-term effects on the retinal circulation, with 6-month follow-up. METHODS: Patients underwent horizontal strabismus surger y were enrolled prospectively. Retinal vessel diameters on color fundus photographs were assessed before and 1, 7 d, 6 mo after surgery, using a computerassisted quantitative assessment software. To evaluate the retinal vascular caliber changes, retinal vascular diameters were calculated by means of the Parr–Hubbard formula as the central retinal arteriolar equivalent(CRAE) and central retinal venular equivalent(CRVE). The arteriovenous ratio(AVR) was calculated as CRAE divided by CRVE. RESULTS: A total of 154 eyes of 104 consecutive patients were included. Compared with the data before surgery(121.55±24.67), the mean CRAE(131.18±28.29) significantly increased 1 d af ter surger y(P=0.003), but went back to baseline level at 7 d(118.89±30.35, P=0.15), and 6 mo(123.22±15.32, P=0.60), so did the AVR(P<0.001, P=0.08, P=0.07). As for the mean CRVE, there was no significant difference between those four time points(172.43±33.25, 175.57±36.98, 174.03±40.18, 174.86±20.46, P=1.00). CONCLUSION: Strabismus surgery on both lateral and media rectus muscles, or single media rectus muscle may increase retinal blood flow during the early postoperative period, but would return to normal later. The number of transected anterior ciliary arteries rather might be the main cause of retinal hemodynamic changes early after strabismus surgery.

关键词： retinal blood flow retinal vascular diameter strabismus strabismus surgery

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Clinical experiences in the management of critically ill patients with COVID‑19 in a designated children’s hospital in China

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World Journal of Pediatrics 2023年第6期19卷 605-608页

作者： Gong-Bao Liu ying Gu ying-wen wang Chuan-Qing wang Jian Ma Mei Zeng Guo-Ping Lu Zhong-Lin wang Ai-Mei Xia Jin-Hao Tao Xiao-wen Zhai wen-Hao Zhou Hong Xu Yong-Hao Gui Guo-ying Huang Xiao-Bo Zhang Department of Medical Affairs Children’s Hospital of Fudan UniversityShanghaiChina Department of Nursing Children’s Hospital of Fudan UniversityShanghaiChina Department of Nosocomial Infection Prevention and Control Children’s Hospital of Fudan UniversityShanghaiChina Department of Infectious Disease Children’s Hospital of Fudan UniversityShanghaiChina Department of Critical Medicine Children’s Hospital of Fudan UniversityShanghaiChina Department of Hematology Children’s Hospital of Fudan UniversityShanghaiChina Department of Neonate Children’s Hospital of Fudan UniversityShanghaiChina Department of Nephrology Children’s Hospital of Fudan UniversityShanghaiChina Department of Key Laboratory of Ministry of Health for Neonatal Disease Children’s Hospital of Fudan UniversityShanghaiChina Department of Cardiology Children’s Hospital of Fudan UniversityWanyuan RdNo.399ShanghaiChina Department of Respiratory Children’s Hospital of Fudan UniversityWanyuan RdNo.399ShanghaiChina

Omicron variant has been the dominant epidemic variant of novel coronavirus in the world since *** have shown that the incidence of severe or critical cases with coronavirus disease 2019(COVID-19)is much lower than that of the previous novel coronavirus variants[1,2];however,it is still a major challenge to treat critical pediatric patients with COVID-19,especially for those with underlying diseases.

关键词： patients Clinical cases

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Low-viscosity oligoether esters(OEEs)as high-efficiency lubricating oils:Insight on their structure‒lubricity relationship

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Friction 2024年第6期12卷 1133-1153页

作者： Hanwen wang ying wang Ping wen Lin MA Mingjin FAN Rui DONG Chunhua ZHANG Shaanxi Key Laboratory of Phytochemistry College of Chemistry&Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China Key Laboratory of Shaanxi Province for Development and Application of New Transportation Energy Chang’an UniversityXi’an 710064China

Development of energy-efficient lubricants is a way to reduce energy consumption for transportation,with the tendency to design molecules that are beneficial in reducing the viscosity of synthetic *** esters(OEEs),as a low-viscosity ester base oil,have characteristics such as simple synthesis and excellent lubrication effect;however,the application of OEEs in tribology field has rarely been *** objective of the present study is to investigate the effect of structure on the lubricating performance of OEEs and to develop a predictive model for OEEs based on quantitative structure‒property relationship(QSPR)through a combination of experiment and statistical *** showed that glycol chains contribute positively to lubrication with the ether functional groups increasing the sites of *** to branched-chain OEEs,straight-chain OEEs exhibited reduced wear,which was mainly due to the thicker adsorption film formed by the straight-chain ***,carbon films were detected on lightly worn surfaces,indicating that OEEs underwent oxidation during the friction *** on the results of principal component analysis(PCA)and partial least squares(PLS),it could be found that the predictive models of viscosity‒temperature performance,thermal stability performance,coefficient of friction(COF),and wear volume(WV)performed well and *** them,COF and WV can be best predicted with an R^(2) of about 0.90.

关键词： oligoether esters(OEEs) low-viscosity ester friction wear quantitative structure-property relationship(QSPR)

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Contrast-enhanced ultrasound using SonoVue mixed with oral gastrointestinal contrast agent to evaluate esophageal hiatal hernia: Report of three cases and a literature review

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World Journal of Clinical Cases 2021年第11期9卷 2679-2687页

作者： Jing-Yu wang Yan Luo wen-ying wang Shi-Cheng Zheng Lian He Chun-Yan Xie Li Peng Department of Ultrasound First People's Hospital of Longquanyi DistrictLongquan Hospital of West China Hospital of Sichuan UniversityChengdu 610100Sichuan ProvinceChina Department of Ultrasound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology First People's Hospital of Longquanyi DistrictLongquan Hospital of West China Hospital of Sichuan UniversityChengdu 610100Sichuan ProvinceChina

BACKGROUND Due to a thicker abdominal wall in some patients,ultrasound artifacts from gastrointestinal gas and surrounding tissues can interfere with routine ultrasound examination,precluding its ability to display or clearly show the structure of a hernial sac(HS)and thereby diminishing diagnostic performance for esophageal hiatal hernia(EHH).Contrast-enhanced ultrasound(CEUS)imaging using an oral agent mixture allows for clear and intuitive identification of an EHH sac and dynamic observation of esophageal *** SUMMARY In this case series,we report three patients with clinically-suspected EHH,including two females and one male with an average age of 67.3±16.4 *** was administered with an oral agent mixture(microbubble-based SonoVue and gastrointestinal contrast agent)and identified a direct sign of supradiaphragmatic HS(containing the hyperechoic agent)and indirect signs[e.g.,widening of esophageal hiatus,hyperechoic mixture agent continuously or intermittently reflux flowing back and forth from the stomach into the supradiaphragmatic HS,and esophagus-gastric echo ring(i.e.,the“EG”ring)seen above the diaphragm].All three cases received a definitive diagnosis of EHH by esophageal manometry and *** lesions resolved upon drug treatment and one required *** recurrence rate in follow-up was 0%.The data from these cases suggest that the new non-invasive examination method may greatly improve the diagnosis of *** CEUS with the oral agent mixture can facilitate clear and intuitive identification of HS and dynamic observation of esophageal reflux.

关键词： SonoVue Oral gastrointestinal contrast agent Contrast-enhanced ultrasound Gastrointestinal Hiatal hernia Case report

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Quantitative prediction model for the depth limit of oil accumulation in the deep carbonate rocks:A case study of Lower Ordovician in Tazhong area of Tarim Basin

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Petroleum Science 2024年第1期21卷 115-124页

作者： wen-Yang wang Xiong-Qi Pang Ya-Ping wang Zhang-Xin Chen Fu-Jie Jiang ying Chen State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Research Institute of Exploration and Development PetroChina Southwest Oil&Gas Field CompanyChengdu610041SichuanChina Chemical and Petroleum Engineering Schulich School of EngineeringUniversity of CalgaryCalgaryT2N 1N4Canada

With continuous hydrocarbon exploration extending to deeper basins,the deepest industrial oil accumulation was discovered below 8,200 m,revealing a new exploration ***,the extent to which oil exploration can be extended,and the prediction of the depth limit of oil accumulation(DLOA),are issues that have attracted significant attention in petroleum *** it is difficult to characterize the evolution of the physical properties of the marine carbonate reservoir with burial depth,and the deepest drilling still cannot reach the ***,the DLOA cannot be predicted by directly establishing the relationship between the ratio of drilling to the dry layer and the *** this study,by establishing the relationships between the porosity and the depth and dry layer ratio of the carbonate reservoir,the relationships between the depth and dry layer ratio were obtained *** depth corresponding to a dry layer ratio of 100%is the *** on this,a quantitative prediction model for the DLOA was finally *** results indicate that the porosity of the carbonate reservoir,Lower Ordovician in Tazhong area of Tarim Basin,tends to decrease with burial depth,and manifests as an overall low porosity reservoir in deep *** critical porosity of the DLOA was 1.8%,which is the critical geological condition corresponding to a 100%dry layer ratio encountered in the *** depth of the DLOA was 9,000 *** study provides a new method for DLOA prediction that is beneficial for a deeper understanding of oil accumulation,and is of great importance for scientific guidance on deep oil drilling.

关键词： Deep layer Tarim Basin Hydrocarbon accumulation Depth limit of oil accumulation Prediction model

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