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Androgen and meibomian gland dysfunction:from basic molecular biology to clinical applications

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 915-922页

作者： Li-Xiang Wang ying-ping deng Department of Ophthalmology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

Meibomian gland,the largest sebaceous gland of the body,is responsible for the biosynthesis of lipid layer of the tear film to prevent excessive *** loss of normal functions of meibomian gland,known as meibomian gland dysfunction(MGD),is a chronic disease and is the leading cause of dry eye symptoms in the *** have found sex hormones,especially androgen,play vital roles in the regulation of the functions of meibomian ***,androgen has also been preliminarily applied in clinics for the treatment of MGD and showed promising results,especially in people with endogenous androgen *** review summarized the mechanisms of the function of androgen on meibomian gland based on molecular,animal,and clinical studies,and proposed evidence-based views about its potential applications for the treatment of MGD.

关键词： meibomian gland dysfunction androgen dry eye disease

Transgenic dry eye mouse models: powerful tools to study dry eye disease

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International Journal of Ophthalmology(English edition) 2022年第4期15卷 635-645页

作者： Dan-Yi Qin Li-Xiang Wang ying-ping deng Department of Ophthalmology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

Dry eye disease(DED) is one of the most common chronic multifactorial ocular surface diseases with high prevalence and complex pathogenesis. DED results in several ocular discomforts, vision fluctuation, and even potential damage of the ocular surface, bringing heavy burdens both on individuals and the society. The pathology of DED consists of tear film hyperosmolarity and immune responses on the ocular surface. Mice are widely used for developing models that simulate human DED features for investigating its pathogenesis and treatment. DED can be classified into aqueous-deficiency dry eye(ADDE) and evaporative dry eye(EDE). ADDE can be further divided into Sj?gren syndrome dry eye(SSDE) and non-Sj?gren syndrome dry eye(NSSDE). SSDE mouse models include natural strains, typified by non-obese diabetic(NOD) mice, and genetically engineered ones, like Aire-/-and Id3 knockout mice. Intrinsic EDE mainly refers to meibomian gland dysfunction(MGD). Eda-/-Tabby, Sod1-/-, Elovl1-/-are the most common transgenic MGD mouse models. Transgenic mouse models provide useful tools for studying the pathogenesis of DED and evaluating its novel therapies. This review compares the major transgenic dry eye mouse models and discusses their applications in DED research.

关键词： dry eye disease transgenic mouse models ocular surface pathology

Effect of body position on the pathogenesis of asymmetric primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 94-100页

作者： Jing Tang Ni Li ying-ping deng Le-Mei Qiu Xiao-Ming Chen Department of Ophthalmology West China Hospital of Sichuan University

AIM： To explore the pathogenesis of asymmetric primary open angle glaucoma（POAG） in both eyes by comparing the intraocular pressure（IOP） of patients who sleep in different positions and to investigate the relationship between IOP variations and sleep ***： One hundred and thirty-one patients with asymmetric POAG and forty-six healthy volunteers were enrolled. All participants completed a questionnaire that provided information about their sleep laterality. The cup disc ratio（C/D） and visual field defect established binocular asymmetry. The IOP of both eyes was measured using i Care parameters after the patients were asked to change body position. The ＂worse＂ and ＂better＂ eyes were identified according to the diagnosis, whereas the ＂dependent＂ and ＂independent＂ eyes were defined according to the lateral position. RESULTS： No significant difference in sleep laterality was observed between healthy people and patients with POAG（F=3.195, P=0.362）. Among the enrolled patients, the IOP of the dependent eye was always greater than that of the independent eye in the lateral position（P〈0.05）. In the patients with binocular asymmetric POAG, the questionnaire clearly showed that 85.7% of left side preferences were found their left eyes to be the worse eyes and the right eyes of 71.4% patients with a right side preference were the more serious. When the asymmetric C/D ratio was greater than or equal to 0.2, the worse eye of patients with POAG and a preferred sleeping position was the dependent eye（χ~2=16.762, P=0.001）.CONCLUSION： A higher IOP was measured in the dependent eye in the lateral position. The long-term tendency to choose a lateral sleeping position might lead the dependent eye to manifest more severe symptoms than the independent eye. Thus, the lateral sleeping position might be one cause of asymmetric POAG.

关键词： asymmetric primary open angle glaucoma intraocular pressure body position

Comment on:Optic neuropathy and increased retinal glial fibrillary acidic protein due to microbead-induced ocular hypertension in the rabbit

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 992-994页

作者： Meng-Zhen Xie Yao Zhang ying-ping deng Li Tang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina

Dear Editor,W e read with great interest the study by Zhao et al[1],which evaluated optic neuropathy and changes in the amount of glial fibrillary acidic protein in the retina with intracameral injection of microbeads into *** objective was to investigate whether the injection of microbeads into the anterior chamber can induce chronic intraocular hypertension in a glaucoma model in rabbits.

关键词： rabbit hypertension neuropathy

Comparisons of morphologic characteristics between thin-flap LASIK and SBK

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 338-342页

作者： Yi Sun ying-ping deng Lin Wang Yong-Zhi Huang and Le-Mei Qiu Department of Ophthalmology West Hospital of China Chengdu 610041 Sichuan Province China

AIM: To compare the morphologic characteristics between thin-flap laser in situkeratomileusis (LASIK) and Sub-Bowman keratomileusis (SBK), and to evaluate the uniformity of flap and to explore the correlative factors of corneal flap thickness. METHODS: A prospective, randomized, comparative clinical study was performed in Department of Ophthalmology, West Hospital of China, Chengdu, Sichuan Province, China. Totally 59 patients 114 eyes underwent LASIK or SBK to correct myopia, 29 patients 57 eyes underwent SBK, 30 patients 57 eyes underwent LASIK. Anterior optical coherence tomography (OCT) was used to measure corneal flap thickness in all the patients 1 week after surgeries, 16 positions were set to be measured in each eye. Comparisons of flap thickness in each group and between 2 groups were evaluated. Correlative factors of flap thickness were evaluated. RESULTS: Coefficient of variation(CV, s/((X) over bar)x%)in SBK group were lesser than that in LASIK group, ttest showed there was significant statistical difference between 2 groups (P=0.000). Comparisons of the difference of 2 paired positions (temporal-nasal; superior-inferior) showed there were no significant differences in each group, but between 2 groups, there were statistical significance of value of difference (D-value) of superior and inferior positions between SBK and LASIK group (P =0.036). Linear regression analysis of correlative factors of flap thickness showed there were no statistic significances related to central corneal thickness(CCT) (P =0.060, t=1.921)and corneal curvature( P=0.083, t=1.766). CONCLUSION: SBK is better than LASIK in a-eating much uniform corneal flap. There was no evidence showing correlations between flap thickness and CCT or corneal curvature.

关键词： Sub-Bowman keratomileusis flap thickness

A 3-month comparison study of subjective and objective visual quality of small incision lenticule extraction and transepithelial photorefractive keratectomy in patients with low and moderate myopia

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 608-615页

作者： Li-Xiang Wang Xiao-Li Wang Jing Tang Ke Ma Hong-Bo Yin ying-ping deng Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Ophthalmology the People’s Hospital of Jianyang CityChengdu 641400Sichuan ProvinceChina

AIM:To compare the subjective and objective visual quality between small incision lenticule extraction(SMILE)and transepithelial photorefractive keratectomy(t PRK)in patients with low and moderate ***:Patients undertaking SMILE or t PRK for the correction of low and moderate myopia were consecutively recruited in this prospective cohort study with a 3-month follow-up *** evaluation[visual acuity test,manifest refraction,wavefront aberrations,the total cut-off value of the total modulation transfer function(MTFcut-off),and Strehl ratio(SR)]and subjective evaluation of visual quality(quality-of-life questionnaire)were conducted before surgery and at days 1,7,30,and 90 after ***:A total of 47 patients(94 eyes)with SMILE and 22 patients(22 eyes)with t PRK were *** uncorrected visual acuity(UCVA)was better in SMILE patients on day 7 after surgery(1.13±0.13 vs 0.99±0.17,t=4.85,P<0.001)but was comparable at days 30 and *** day 90,the SMILE group had a lower spherical equivalent(SE)than the t PRK group(0.04±0.31 vs 0.19±0.43,t=2.08,P=0.042).Total higher order aberrations(HOAs)were induced in both surgical types,which were more evident in the t PRK group with 3-mm pupil diameter(0.16±0.07 vs0.11±0.05,t=4.27,P<0.001)and 5-mm pupil diameter(0.39±0.17 vs 0.36±0.11,t=2.33,P=0.022).The MTFcut-offand SR showed a trend of improvement in both SMILE and t PRK patients but were statistically better in the SMILE group with both pupil *** was a significant improvement of contrast sensitivity(CS)over baseline levels at the spatial frequency of 18 cycles/degree(c/d)in the SMILE group(F=2.72,P=0.033)and at 3 c/d(F=3.03,P=0.031),12 c/d(F=3.72,P=0.013),and 18 c/d(F=4.62,P=0.004)in the t PRK *** subjective quality of life questionnaire showed a steady improvement in the SMILE group(F=8.31,P<0.001)but not the t PRK ***:SMILE and t PRK are both safe and effective ways to correct low and moderate myopia.A generally bet

关键词： corneal refractive surgery small incision lenticule extraction transepithelial photorefractive keratectomy myopia visual quality

Stromal lenticule addition keratoplasty with corneal crosslinking for corneal ectasia secondary to FS-LASIK:a case series

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 596-602页

作者： Li-Xiang Wang ying-ping deng Meng-Zhen Xie Ke Ma Hong-Bo Yin Qiong Wang Rui Gong Jing Tang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina

●AIM:To explore the clinical efficacy and safety of stromal lenticule addition keratoplasty(SLAK)with corneal crosslinking(CXL)on patients with corneal ectasia secondary to femtosecond laser-assisted in situ keratomileusis(FS-LASIK).●METHODS:A series of 5 patients undertaking SLAK with CXL for the treatment of corneal ectasia secondary to FS-LASIK were followed for *** lenticules were collected from patients undertaking small incision lenticule extraction(SMILE)for the correction of *** a stromal lenticule was aimed at improving the corneal thickness for the safe application of crosslinking and compensating for the thin cornea to improve its mechanical strength.●RESULTS:All surgeries were conducted successfully with no significant *** best corrected visual acuity(BCVA)ranged from 0.05 to 0.8-2 before *** pre-operational total corneal thickness ranged from 345-404μm and maximum keratometry(Kmax)ranged from 50.8 to *** the combination surgery,both the corneal keratometry(range 55.9 to 92.8)and total corneal thickness(range 413-482μm)significantly *** out of 5 patients had improvement of corneal biomechanical parameters(reflected by stiffness parameter A1 in Corvis ST).However,3 patients showed decreased BCVA after surgery due to the development of irregular astigmatism and transient *** the onset of corneal edema right after SLAK,the corneal topography and thickness generally stabilized after 3mo.●CONCLUSION:SLAK with CXL is a potentially beneficial and safe therapy for advanced corneal *** work needs to address the poor predictability of corneal refractometry and compare the outcomes of different surgical modes.

关键词： corneal ectasia femtosecond laserassisted in situ keratomileusis stromal lenticule addition keratoplasty corneal crosslinking corneal thickness corneal biomechanics

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Q值引导LASIK术后对比敏感度的变化

国际眼科杂志 2009年第4期9卷 746-748页

作者：周李邓应平四川大学华西医院眼科中国四川省成都市610041

目的:对比Q值引导的LASIK与常规LASIK治疗近视术后术眼对比敏感度的变化差异。方法:选择27例近视度数在-2.50～-9.25D,散光度0.05)。术后1mo,F-CAT组Q值引导眼在3c/d时对比敏感度高于对照组(P<0.05)。结论:用Q值引导的LASIK矫正近视,在... 详细信息

目的:对比Q值引导的LASIK与常规LASIK治疗近视术后术眼对比敏感度的变化差异。方法:选择27例近视度数在-2.50～-9.25D,散光度0.05)。术后1mo,F-CAT组Q值引导眼在3c/d时对比敏感度高于对照组(P<0.05)。结论:用Q值引导的LASIK矫正近视,在提高术后CS方面比常规LASIK有优势。

关键词：准分子激光角膜原位磨镶术角膜非球面系数对比敏感度

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性激素与眼表及角膜相关疾病的研究进展

国际眼科杂志 2012年第5期12卷 872-875页

作者：罗畅邓应平四川大学华西医院眼科中国四川省成都市610041

性别差异是当今流行病学研究中的常见现象之一。这种现象的发生,除了与男女基因表达差异有关以外,更与性激素的调控有着密不可分的联系。在已知的各类眼科疾病中也存在着性别差异的现象。随着生物学相关研究的进展,研究人员在包括眼表... 详细信息

性别差异是当今流行病学研究中的常见现象之一。这种现象的发生,除了与男女基因表达差异有关以外,更与性激素的调控有着密不可分的联系。在已知的各类眼科疾病中也存在着性别差异的现象。随着生物学相关研究的进展,研究人员在包括眼表及角膜在内的眼部组织中发现了越来越多的性激素受体,暗示性激素对眼表及角膜正常功能的维持有着十分重要的作用。在此,我们将对目前已知的性激素和眼表及角膜间的关系的相关报道进行综述和讨论,并对未来的相关研究进行展望。

关键词：性激素受体性激素干眼角膜圆锥角膜