检索结果-南通市图书馆

Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

引用

World Journal of Gastroenterology 2024年第12期30卷 1751-1763页

作者： Ting Yang Kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan Yan-ping guan Jing Mao Pan Li Shao-Xing guan Wen Xie Xiang Gao Min Huang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Institute of Clinical Pharmacology Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States

BACKGROUND Thiopurine-induced leucopenia significantly hinders the wide application of *** optimization guided by nudix hydrolase 15(NUDT15)has significantly reduced the early leucopenia rate,but there are no definitive biomarkers for late risk leucopenia *** To determine the predictive value of early monitoring of DNA-thioguanine(DNATG)or 6-thioguanine nucleotides(6TGN)for late leucopenia under a NUDT15-guided thiopurine dosing strategy in patients with Crohn’s disease(CD).METHODS Blood samples were collected within two months after thiopurine initiation for detection of metabolite *** leucopenia was defined as a leukocyte count<3.5×10^(9)/L over two *** Of 148 patients studied,late leucopenia was observed in 15.6%(17/109)of NUDT15/thiopurine methyltransferase(TPMT)normal and 64.1%(25/39)of intermediate *** patients suffering late leucopenia,early DNATG levels were significantly higher than in those who did not develop late leucopenia(P=4.9×10^(-13)).The DNATG threshold of 319.43 fmol/μg DNA could predict late leucopenia in the entire sample with an area under the curve(AUC)of 0.855(sensitivity 83%,specificity 81%),and in NUDT15/TPMT normal metabolizers,the predictive performance of a threshold of 315.72 fmol/μg DNA was much more remarkable with an AUC of 0.902(sensitivity 88%,specificity 85%).6TGN had a relatively poor correlation with late leucopenia whether in the entire sample(P=0.021)or NUDT15/TPMT normal or intermediate metabolizers(P=0.018,P=0.55,respectively).CONCLUSION Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD,especially the former.

关键词： Thiopurine-induced late leucopenia DNA-thioguanine 6-thioguanine nucleotide Proactive therapeutic drug monitoring Crohn’s disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In-plane isotropic separator-induced highly efficient sodium plating for unlocking the fast-charging capability of anode-free sodium battery at practical conditions

引用

Journal of Materiomics 2024年第3期10卷 643-651页

作者： Haocheng Yuan Kaihua Wen Shundong guan ying Liang Yu-Hsien Wu Sijie Liu Dengfeng Yu Liangliang Li Ce-Wen Nan State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China

Ether-based electrolytes with excellent reductive stability are compatible with sodium(Na)metal an-odes,which enables stable cycling for Na metal batteries even in an anode-free ***,the practical applications of anode-free sodium batteries(AFSBs)with a high theoretical energy density are restricted by the low-rate capability and limited cycle *** we demonstrate that the mechanical properties of the separators,which have been overlooked in previous studies,can significantly affect the cycling stability of AFSBs due to the intrinsic softness of Na and the large volume variation of AFSBs during Na plating/*** using various separators including polypropylene(PP),polyethylene(PE),PP/PE/PP tri-layer,and aluminum oxide-coated separators,we find that the balanced elastic moduli of the separator along the machine direction and transverse direction are crucial for enabling highly effi-cient Na plating and unlocking the 4 C fast-charging capability of the AFSBs at practical conditions including a high cathode active mass loading(13.5 mg/cm^(2)),lean electrolyte addition(8.8 mL/cm^(2)),and no pre-sodiation *** study provides an important separator design principle for the develop-ment of high-rate and long-cycle-life AFSBs.

关键词： Sodium metal Elastic modulus Ether electrolyte Sodium battery Short circuit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Perinatal prevalence of birth defects in the Mainland of China,2000–2021:a systematic review and meta-analysis

引用

World Journal of Pediatrics 2024年第7期20卷 669-681页

作者： Liang-Yu Kang Zi-Rui Guo Wei-Jing Shang Gui-ying Cao Yi-ping Zhang Qiao-Mei Wang Hai-ping Shen Wan-Nian Liang Min Liu Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityNo.38Xueyuan RoadHaidian DistrictBeijing100191China Vanke School of Public Health Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Department of Maternal and Child Health National Health Commission of the People’s Republic of ChinaNo.1Xizhimenwai South RoadXicheng DistrictBeijingChina Institute of Healthy China Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of Education BeijingNo.38Xueyuan RoadHaidian DistrictBeijing100191China

Background Although birth defects are of great concern globally,the latest national prevalence has not yet been quantified in *** conducted a systematic review and meta-analysis to estimate the perinatal prevalence of birth defects in the Mainland of China between 2000 and *** We performed a systematic literature search of six databases for relevant articles published between January 1,2000,and March 1,*** included published studies that reported data on the perinatal prevalence of birth defects in the Mainland of *** DerSimonian and Laird random-effects models were used to estimate the pooled prevalence and its 95%confidence interval(CI).We also conducted subgroup analyses and univariable meta-regressions to explore differences in prevalence by time period,geographic region,and other *** We included 254 studies reporting the perinatal prevalence of birth defects and 86 studies reporting only the prevalence of specific types of birth *** on 254 studies covering 74,307,037 perinatal births and 985,115 cases with birth defects,the pooled perinatal prevalence of birth defects was 122.54(95%CI 116.20–128.89)per 10,000 perinatal births in the Mainland of China during 2000–***,the perinatal prevalence of birth defects increased from 95.60(86.51–104.69)per 10,000 in 2000–2004 to 208.94(175.67–242.22)per 10,000 in 2020–*** were also significant disparities among different geographical *** heart defects(33.35 per 10,000),clefts of the lip and/or palate(13.52 per 10,000),polydactyly(12.82 per 10,000),neural tube defects(12.82 per 10,000),and inborn errors of metabolism(11.41 per 10,000)were the five most common types of birth *** perinatal prevalence among males was significantly higher than that among females(β=2.44×10^(−3),P=0.003);a higher perinatal prevalence of birth defects was observed among perinatal births whose mothers were≥35 years(β=4.34×10^(−3),P<0.001).Conclusion Compreh

关键词： Birth defects China Perinatal Prevalence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

毕达哥拉斯犹豫模糊集多属性决策研究

引用

系统工程与电子技术 2024年第3期46卷 982-991页

作者：关欣刘赢海军航空大学山东烟台264000

针对属性间相互关联,评价信息为毕达哥拉斯犹豫模糊信息的多属性决策问题,首先通过研究犹豫度对决策结果的影响,提出一种新的毕达哥拉斯犹豫模糊集得分函数,解决了现有得分函数中存在的不足。其次,提出一种最小公倍数规范化原则,解决了... 详细信息

针对属性间相互关联,评价信息为毕达哥拉斯犹豫模糊信息的多属性决策问题,首先通过研究犹豫度对决策结果的影响,提出一种新的毕达哥拉斯犹豫模糊集得分函数,解决了现有得分函数中存在的不足。其次,提出一种最小公倍数规范化原则,解决了现有方法容易引入误差的缺陷。最后,针对属性关联的多属性决策问题,基于λ-模糊测度与Choquet积分,提出了一种拓展交互式多准则决策(interative multi-criteria decision-making,TODIM)方法,既解决了属性关联的问题,又通过前景理论反映了决策者的心理行为特征。实例分析与敏感性分析验证了所提算法的正确性与有效性。

关键词：毕达哥拉斯犹豫模糊集得分函数最小公倍数规范化原则属性关联交互式多准则决策方法

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Rapidly growing primordial black holes as seeds of the massive high-redshift JWST Galaxies

引用

Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 139-146页

作者： guan-Wen Yuan Lei Lei Yuan-Zhu Wang Bo Wang Yi-ying Wang Chao Chen Zhao-Qiang Shen Yi-Fu Cai Yi-Zhong Fan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Deep Space Exploration Laboratory/Department of Astronomy School of Physical SciencesUniversity of Science and Technology of ChinaHefei 230026China Jockey Club Institute for Advanced Study The Hong Kong University of Science and TechnologyHong KongChina

A group of massive galaxies at redshifts of z■7 have been recently detected by the James Webb Space Telescope(JWST),which were unexpected to form at such an early time within the standard Big Bang *** this work,we propose that this puzzle can be explained by the presence of some primordial black holes(PBHs)with a mass of~1000M_(⊙).These PBHs act as seeds for early galaxy formation with masses of~10^(8)-10^(10)M_(⊙)at high redshift,hence accounting for the JWST *** use a hierarchical Bayesian inference framework to constrain the PBH mass distribution models,and find that the Lognormal model with the M_(c)~750M_(⊙)is preferred over other *** rapidly growing BHs are expected to have strong radiation and may appear as high-redshift compact objects,similar to those recently discovered by *** we focused on PBHs in this work,the bound on the initial mass of the seed black holes remains robust even if they were formed through astrophysical channels.

关键词： primordial black hole dark matter halo black hole accretion primordial galaxies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于数据驱动信息间隙理论的风光水储聚合商多元市场竞标决策模型

引用

电网技术 2024年第3期48卷 979-989页

作者：谭颖管霖华南理工大学电力学院广东省广州市510641

随着电力系统中可再生能源(renewable energy sources,RESs)比例不断增加,新能源参与能量市场和备用市场在技术上和经济上的重要性不断凸显。研究了含有风、光、水、储资源的RES聚合商在日前市场、备用市场及实时平衡市场等多个市场的... 详细信息

随着电力系统中可再生能源(renewable energy sources,RESs)比例不断增加,新能源参与能量市场和备用市场在技术上和经济上的重要性不断凸显。研究了含有风、光、水、储资源的RES聚合商在日前市场、备用市场及实时平衡市场等多个市场的综合竞价策略。针对北欧顺序交易市场框架,提出了一套考虑备用资源和波动补偿耦合的数据驱动信息间隙理论(data-driven information gap theory,DIGDT)决策模型解决RES聚合商的多阶段竞价优化问题。在DIGDT中采用基于置信区间的模糊集构造方法(confidence interval-based ambiguity set,CIAS)估计风、光的预测误差,通过机会约束对水电和储能(batteryenergy storage,BES)补偿出力偏差的可能性进行建模,并考虑备用资源与补偿容量的多时间尺度耦合。在备用市场中,利用基于备用调用场景的随机优化确保日前备用计划的可行性。通过案例分析验证了所提出模型的有效性。

关键词：新能源聚合商能量和备用市场数据驱动信息间隙理论波动补偿多时间尺度耦合

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer

引用

World Journal of Gastrointestinal Surgery 2024年第5期16卷 1395-1406页

作者： Qiu-Xiao Yu ping-ying Fu Chi Zhang Li Li Wen-Ting Huang Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer and the second most common cause of cancer-related mortality ***-epithelial transition factor(MET)gene participates in multiple tumor biology and shows clinical potential for pharmacological manipulation in tumor *** amplification has been reported in CRC,but data are very *** pathological values of MET in CRC may provide new therapeutic and genetic screening options in future clinical *** To determine the pathological significance of MET amplification in CRC and to propose a feasible screening *** A number of 205 newly diagnosed CRC patients undergoing surgical resection without any preoperative therapy at Shenzhen Cancer Hospital of Chinese Academy of Medical Sciences were *** patients were without RAS/RAF mutation or microsatellite *** amplification and c-MET protein expression were analyzed using fluorescence in situ hybridization(FISH)and immunohistochemistry(IHC),*** between MET aberration and pathological features were detected using the chi-squared *** free survival(PFS)during the two-year follow-up was detected using the Kaplan-Meier method and log rank *** results of MET FISH and IHC were com pared using one-way *** Polysomy-induced MET amplification was observed in 14.4%of cases,and focal MET amplification was not ***-induced MET amplification was associated with a higher frequency of lymph node metastasis(LNM)(P<0.001)and higher tumor budding grade(P=0.02).In the survival analysis,significant difference was detected between patients with amplified-and non-amplified MET in a two-year follow-up after the first diagnosis(P=0.001).C-MET scores of 0,1+,2+,and 3+were observed in 1.4%,24.9%,54.7%,and 19.0%of tumors,respectively.C-MET overexpression correlated with higher frequency of LNM(P=0.002),but no significant difference of PFS was dete

关键词： Colorectal cancer MET Amplification Pathological features Prognosis Fluorescence in situ hybridization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

动态人工模拟海水环境下两种B10铜镍合金腐蚀行为

引用

材料工程 2024年第6期52卷 201-210页

作者：苏英管勇中国科学技术大学材料科学与工程学院合肥230026 中国科学院金属所沈阳110016

采用动电位极化曲线和电化学阻抗谱测试并结合XPS测试和SEM/EDS微观表征,通过自制的冲刷腐蚀实验装置研究了两种B10铜镍合金在不同流速和不同时间下的冲刷腐蚀行为,比较了两种铜镍合金在不同冲刷条件下的腐蚀差异。结果表明,两种铜镍合... 详细信息

采用动电位极化曲线和电化学阻抗谱测试并结合XPS测试和SEM/EDS微观表征,通过自制的冲刷腐蚀实验装置研究了两种B10铜镍合金在不同流速和不同时间下的冲刷腐蚀行为,比较了两种铜镍合金在不同冲刷条件下的腐蚀差异。结果表明,两种铜镍合金的腐蚀速率随时间的变化规律相似,在不同的流速下冲刷2 h后腐蚀速率较高,冲刷8 h后腐蚀速率较低。在低于4 m/s的流速冲刷不同时间后,A合金的耐蚀性整体上高于B合金的耐蚀性;当流速高于3 m/s且较长时间冲刷后,B合金的耐蚀性更好。这与钝化膜中Ni,Fe的化学态无关而与晶粒尺寸和孪晶数量以及Ni,Fe元素的富集有关。长时间高流速冲刷会促进钝化膜中Ni和Fe元素的富集,有利于增强钝化膜的耐蚀性。

关键词： B10铜镍合金电化学技术冲刷腐蚀钝化膜腐蚀形貌

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Altered interaction network in the gut microbiota of current cigarette smokers

引用

Engineering Microbiology 2024年第2期4卷 44-50页

作者： Zhouhai Zhu Meng Wang ying guan Meng Li Qiyuan Peng Ning Zheng Wenbin Ma Joint Institute of Tobacco and Health Kunming 650106China State Key Laboratory of Microbial Technology Institute of Microbial TechnologyShandong UniversityQingdao 266237China Department of Neurology Binzhou Medical University HospitalBinzhou 256600China

The association between cigarette smoking and the gut microbiota remains unclear,and there is no agreement on how smoking affects the composition of gut *** this study,the relationship between smoking status and gut microbial composition was investigated by performing 16S rRNA gene amplicon sequencing anal-ysis of stool samples from 80 healthy Chinese *** results showed that smoking did not cause significant changes to the composition and microbial functional pathways of the gut ***,smoking altered the relative abundance of several specific taxa,where Phascolarctobacterium and Fusobacterium increased and Dialister ***,our analysis revealed that smoking introduced more microbial interactions to the interaction network and decreased its ***,this study provides new insights into the association between smoking status and the gut microbiota.

关键词： Cigarette smoking Gut microbiota China Co-occurrence network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SP-141 targets Trs85 to inhibit rice blast fungus infection and functions as a potential broadspectrum antifungal agent

引用

Plant Communications 2024年第2期5卷 169-184页

作者： Xi-Yu Wu Bo Dong Xue-Ming Zhu ying-ying Cai Lin Li Jian-ping Lu Bin Yu Jing-Li Cheng Fei Xu Jian-Dong Bao ying Wang Xiao-Hong Liu Fu-Cheng Lin State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of BiotechnologyZhejiang UniversityHangzhou 310058Zhejiang ProvinceChina State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Plant Protection and MicrobiologyZhejiang Academy of Agricultural SciencesHangzhou 310058Zhejiang ProvinceChina Department of Pharmacology and Nutritional Science College of MedicineThe University of KentuckyLexingtonKY 40506USA Markey Cancer Center College of MedicineThe University of KentuckyLexingtonKY 40506USA College of Life Sciences Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina Institute of Pesticide and Environmental Toxicology Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and InsectsZhejiang UniversityHangzhou 310058Zhejiang ProvinceChina Institute of Edible Fungi Shanghai Academy of Agricultural SciencesShanghai 201106ShanghaiChina

Rice blast is a devastating disease worldwide,threatening rice production and food *** blast fun-gus Magnaporthe oryzae invades the host via the appressorium,a specialized pressure-generating struc-ture that generates enormous turgor pressure to penetrate the host ***,owing to ongoing evolution of fungicide resistance,it is vitally important to identify new targets and ***,we show that Trs85,a subunit of the transport protein particle III complex,is essential for appressorium-mediated infection in *** explain how Trs85 regulates autophagy through Ypt1(a small guano-sine triphosphatase protein)in *** then identify a key conserved amphipathic a helix within Trs85 that is associated with pathogenicity of *** computer-aided screening,we identify a lead compound,SP-141,that affects autophagy and the Trs85–Ypt1 ***-141 demonstrates a substantial capacity to effectively inhibit infection caused by the rice blast fungus while also exhibiting wide-ranging potential as an antifungal agent with broad-spectrum *** together,our data show that Trs85 is a potential new target and that SP-141 has potential for the control of rice *** thus provide a novel strategy that may help in thefight against rice blast.

关键词： Magnaporthe oryzae rice blast TRAPPIII complex trs85 fungicide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：