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Aquaporin 1 overexpression may enhance glioma tumorigenesis by interacting with the transcriptional regulation networks of Foxo4,Maz,and E2F families

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Chinese Neurosurgical Journal 2024年第1期10卷 20-27页

作者： ying guan Jinhua Han Die Chen Yuefu Zhan Jianqiang Chen Department of Ultrasound The First Affiliated Hospital of Hainan Medical CollegeHaikou City 570102Hainan ProvinceChina Department of Radiology The First Affiliated Hospital of Hainan Medical CollegeHaikou City 570102Hainan ProvinceChina Department of Radiology Hainan Children’s HospitalHaikou City 571103Hainan ProvinceChina

Background The glioblastoma has served as a valuable experimental model system for investigating the growth and invasive properties of ***-1(AQP1)in facilitating cell migration and potentially contributing to tumor *** this study,we analyzed the role of AQP1 overexpression in glioblastoma and elucidated the main mechanisms *** AQP1 overexpression recombinant vector was introduced into C6 rat glioma cells to construct an AQP1 overexpression C6 cell line,and its effect on cell viability and migration ability was detected by MTT and *** was extracted by Trizol method for gene sequencing and transcriptomics analysis,and the differentially expressed genes(DEGs)were enriched for up-and downregulated genes by Principal component analysis(PCA),and the molecular mechanism of AQP1 overexpression was analyzed in comparison with the control group using the NCBI GEO *** analysis was performed using Mann-Whitney paired two tailed t *** The cell viability of AQP1-transfected cell lines increased by 23%and the mean distance traveled increased by 67%compared with the control *** analysis of gene expression showed that there were 12,121 genes with an average transcripts per million(TPM)value greater than *** accounted for 13%of the genes expressed,with the highest correlation with upregulated genes being FOXO4 and MAZ,and the highest with down-regulated genes being E2F *** AQP1 may be implicated in glioma formation by interacting with the transcriptional regulation networks involving the FOXO4,MAZ,and E2F1/*** findings shed light on the potential significance of AQP1 in glioma pathogenesis and warrant further investigations to unravel the underlying molecular mechanisms.

关键词： C6 cell line Aquaporin 1 Gioma Migration

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Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca^(2+)-dependent AMPK/mTOR pathway

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 420-434页

作者： Liu-Hui Huang Jiao Lyu Sheng Chen Ting-Yi Liang Yu-Qing Rao ping Fei Jing Li Hai-ying Jin Pei-Quan Zhao Department of Ophthalmology Shanghai Xinhua Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Ophthalmology Shanghai Tenth People’s Hospital Affiliated with Shanghai Tongji University School of MedicineShanghai 200072China Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVictoria 3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVictoria 3002Australia Shenzhen Eye Hospital Shenzhen Key Laboratory of OphthalmologyAffiliated Shenzhen Eye Hospital of Jinan UniversityShenzhen 518040Guangdong ProvinceChina Department of Ophthalmology Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

●AIM:To explore whether autophagy functions as a cellular adaptation mechanism in lens epithelial cells(LECs)under hyperosmotic stress.●METHODS:LECs were treated with hyperosmotic stress at the concentration of 270,300,400,500,or 600 mOsm for 6,12,18,24h in *** chain reaction(PCR)was employed for the mRNA expression of autophagyrelated genes,while Western blotting detected the targeted protein *** transfection of stub-RFP-sens-GFPLC3 autophagy-related double fluorescence lentivirus was conducted to detect the level of autophagy *** electron microscopy was used to detect the existence of *** interfering RNA of autophagy-related gene(ATG)7,transient receptor potential vanilloid(TRPV)1 overexpression plasmid,related agonists and inhibitors were employed to their influence on autophagy related *** cytometry was employed to test the apoptosis and intracellular Ca^(2+)*** membrane potential was measured by JC-1 *** cell counting kit-8 assay was used to calculate the cellular *** wound healing assay was used to evaluate the wound closure *** 6.0 software was utilized to evaluate the data.●RESULTS:The hyperosmotic stress activated autophagy in a pressure-and time-dependent manner in *** 1 protein expression and conversion of LC3B II to LC3B I increased,whereas sequestosome-1(SQSTM1)protein expression *** Ca^(2+)influx was stimulated caused by hyperosmotic stress,levels of mammalian target of rapamycin(mTOR)phosphorylation decreased,and the level of AMP-activated protein kinase(AMPK)phosphorylation increased in the early *** on this evidence,autophagy activation through the Ca^(2+)-dependent AMPK/mTOR pathway might represent an adaptation process in LECs under hyperosmotic *** stress decreased cellular viability and accelerated apoptosis in LECs and cellular migration *** of autophagy by ATG7 knockdown had sim

关键词： cataract posterior capsular opacification lens epithelial cell hyperosmotic stress autophagy apoptosis transient receptor potential vanilloid 1

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Oat avenanthramide B alleviates high-fat diet-induced obesity via regulating fatty acid metabolism involved in gut bacteria and fungi remodeling

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Food Science and Human Wellness 2024年

作者： Yongyong Liu Kai Huang Xiao guan Sen Li Hongdong Song ying Zhang Yu Zhang Zhu Sun Zhiquan Yu School of Health Science and Engineering， University of Shanghai for Science and Technology National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center Inner Mongolia Yangufang Whole Grain Industry Development Co.， Ltd.

Oat avenanthramides (AVNs) have been found to exhibit novel lipid-lowering effects. However， the mechanism remains unclear. In this study， the effect of avenanthramide B (AVN B)， as one of the major AVNs， on high-fat diet (HFD)-induced mice was investigated. Results showed that AVN B significantly inhibited weight gain and improved hepatic and serum lipid biochemical indices. Hepatic RNA-Sequencing analysis suggested that AVN B significantly modulates fatty acid (FA) metabolism. Hepatic real-time qualitative polymerase chain reaction (RT-qPCR) and Western blot results indicated that AVN B could alleviate FA synthesis by activating the AMPK- SREBP1c-FAS， and increase FA oxidation by activating the AMPK/CPT1A and PPARα. Additionally， AVN B had a regulating effect on ileum lipid metabolism by inhibiting intestinal cell differentiation and down-regulating the expression levels of FA absorption-related protein and gene. Moreover， AVN B promoted the growth of beneficial bacteria and fungi such as Coriobacteriaceae＿UCG-002， Parvibacter， Enterococcus， and Aspergillus， while decreasing the abundance of Roseburia， unclassified＿f＿Lachnospiraceae Cladosporium， Eurotium， unclassified＿f＿Aspergillaceae and unclassified＿f＿Ceratocystidaceae. All these results provided new points of the lipid-lowing mechanism of AVNs and oats via the gut-liver axis.

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Amorphous NiMo_(3)S_(13)/nickel foam integrated anode for lithium-ion batteries

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Tungsten 2024年第2期6卷 438-446页

作者： Ming-Xin Shi Min Wu Shan-Shan Xiao Shan-ping Liu Rui-Qi Yao ying-Qi Li Yong-Hui Wang Yang-guang Li Hua-Qiao Tan Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Faculty of ChemistryNortheast Normal UniversityChangchun 130024China School of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130118China Institute Charles Gerhardt Montpellier Universite de MontpellierCentre National de la Recherche Scientifi quePlace E.Bataillon34095 Montpellier Cedex 05France

Although crystalline anode materials with long-range ordered lattice structure are in favor of facilitating the electron transfer,their structures are easily disrupted during long-term cycling due to the continuous embedding/de-embedding of lithium *** contrast,the amorphous materials have abundant defects and lithium ion storage sites,refl ecting a superior reaction kinetics and long-term cycling ***,we synthesize an integrated hybrid anode by in-situ loading amorphous NiMo_(3)S_(13)nanosheets on nickel foam *** ting from the introduction of Ni^(2+)that amorphizes the molybdenumsulfur clusters,the assembled lithium ion battery based on the integrated NiMo_(3)S_(13)/nickel foam anode delivers a specifi c capacity up to 1659 mA·h·g^(−1)at a current density of 0.6 A·g^(−1)and exhibits superior rate/cycling performance.

关键词： Molybdenum-sulfur clusters Amorphous Integrated anode Crystalline Lithium-ion batteries

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基于综合犹豫模糊熵的多属性决策研究

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控制与决策 2024年第6期39卷 2022-2030页

作者：刘赢关欣李易城海军航空大学山东烟台264001 93116部队沈阳110000

针对犹豫模糊集现有熵测度存在的计算过程复杂以及反直觉等现象,提出一种综合犹豫模糊熵,并基于累积前景理论,改进传统的TOPSIS决策方法,构建属性权重未知下的多属性决策模型.首先,在模糊度和非明确度的基础上,给出犹豫模糊熵新的公理... 详细信息

针对犹豫模糊集现有熵测度存在的计算过程复杂以及反直觉等现象,提出一种综合犹豫模糊熵,并基于累积前景理论,改进传统的TOPSIS决策方法,构建属性权重未知下的多属性决策模型.首先,在模糊度和非明确度的基础上,给出犹豫模糊熵新的公理化定义;然后,定义综合犹豫模糊熵,并证明其满足新的公理化定义,与现有犹豫模糊熵的对比分析表明,综合犹豫模糊熵在更为合理表征犹豫模糊元模糊性的同时,也解决了反直觉的问题;最后应用改进TOPSIS方法对所提出的综合性熵测度进行仿真分析,通过实例分析验证所提出的犹豫模糊熵的有效性.相比现有熵测度,综合犹豫模糊熵还具有计算简单和易于理解等优点,改进TOPSIS方法能够考虑决策者的心理偏好,相比传统决策手段,其决策效果更为合理.

关键词：犹豫模糊集犹豫模糊熵模糊度非明确度累积前景理论改进TOPSIS方法

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A contradictory phenomenon of thicken pericardium and cardiac compression without inferior vena cava dilation:sign of IVC escape

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Journal of Geriatric Cardiology 2024年第5期21卷 583-587页

作者： Tie-Nan CHEN Shuang ZHAO Shuai QIAO Yong-Yong HAN Qing LIU Chang-Le LIU guang-ping LI Tong LIU Hua-ying FU Department of Cardiovascular Surgery Second Hospital of Tianjin Medical UniversityTianjinChina Department of Cardiology Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseTianjin Institute of Cardi-ologyThe Second Hospital of Tianjin Medical UniversityTianjinChina Department of Oncology Second Hospital of Tianjin Medical UniversityTianjinPeople's Republic of China

A 77-year-old female presented with shortness of breath and tightness of chest was *** past medical history included hypertension and she has been taking nifedipine *** years before,she was diagnosed with pericardial effusion(Figure 1)and had pericardiocentesis *** physical examination,her blood pressure was 151/100 mm-Hg and her pulse rate was 91 beats/min.

关键词： admitted cardiac thick

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Multilocular thymic cysts can be easily misdiagnosed as malignant tumor on computer tomography:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1474-1480页

作者： Jun Sun Qing-Ning Yang Yi Guo ping Zeng Long-Yan Ma Ling-Wen Kong Bo-ying Zhao Chuan-Ming Li Department of Radiology Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China Department of Pathology Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China Department of Cardiothoracic Surgery Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China

BACKGROUND Multilocular thymic cyst(MTC)is a rare mediastinal lesion which is considered to occur in the process of acquired *** is usually characterized by well-defined cystic density and is filled with transparent *** SUMMARY We report on a 39-year-old male with a cystic-solid mass in the anterior *** tomography(CT)imaging showed that the mass was irregular with unclear *** injection of contrast agent,there was a slight enhancement of stripes and *** to CT findings,it was diagnosed as thymic *** After surgery,MTC accompanied by bleeding and infection was confirmed by pathological *** main lesson of this case was that malignant thymic tumor and MTC of the anterior mediastinum sometimes exhibit similar CT *** is necessary in clinical work to avoid misdiagnosis.

关键词： Multilocular thymic cyst Computer tomography Misdiagnosis Hemorrhage Infection Case report

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Bone marrow-derived mesenchymal stem cell-derived exosomeloaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage

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World Journal of Diabetes 2024年第9期15卷 1979-2001页

作者： Yue-ying Wang Ke Li Jia-Jun Wang Wei Hua Qi Liu Yu-Lan Sun Ji-ping Qi Yue-Jia Song Department of Pathology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Endocrinology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of *** role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are *** this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced *** To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral *** BMSC-exo were isolated from mouse BMSC *** was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro *** dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of *** Our findings indicated that BMSC-exo can promote neuroinflammation and functional *** chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in *** of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH ***,we found that miR-129-5p had a targeted binding relationship with HMGB1 *** We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain.

关键词： Bone marrow mesenchymal stem cells Exosome Diabetic cerebral hemorrhage Neuroinflammation MicroRNA-129-5p High mobility group box 1

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Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma Shu-ping Yang ying Li Tian-tian Xu Ya-lin Yang Hui-yong Yang Heng-bing Li Le-jin Zhou Yong Diao Su-yun Li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea Surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

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Study on blood pressure rhythm in hypertensive patients with Yin deficiency syndrome and a random forest model for predicting hypertension with Yin deficiency syndrome

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Journal of Traditional Chinese Medicine 2024年第3期44卷 564-571页

作者： ZHOU ying LI ping LUAN Jianwei SHEN Rui WU yinglan XU Qiwen WANG Xinyue ZHU Yao XU Xiangru LIU Zitian JIANG Yuning ZHONG Yong HE Yun JIANG Weimin Department of Cardiology the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China Department of Health Management Centre Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Emergency Department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of General Internal Medicine the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China

OBJECTIVE: To investigate blood pressure rhythm(BPR)in Yin deficiency syndrome of hypertension(YDSH)patients and develop a random forest model for predicting ***: Our study was consistent with technical processes and specification for developing guidelines of Evidence-based Chinese medicine clinical practice(T/CACM 1032-2017). We enrolled 234 patients who had been diagnosed with primary hypertension without antihypertensive medications prior to the enrollment. All participants were divided into Yin deficiency group(YX, n = 74) and non-Yin deficiency group(NYX, n = 160).Participants were professionally grouped by three experienced chief Traditional Chinese Medicine(TCM)physicians according to four examinations(i.e.,inspection, listening and smelling, inquiry and palpation).We collected data on 24 h ambulatory blood pressure monitoring(ABPM) and YDSH rating scale. We divided 24 h of a day into 12 two-hour periods [Chen-Shi(7:00-9:00), Si-Shi(9:00-11:00), Wu-Shi(11:00-13:00), Wei-Shi(13:00-15:00), Shen-Shi(15:00-17:00), You-Shi(17:00-19:00), Xu-Shi(19:00-21:00), Hai-Shi(21:00-23:00), ZiShi(23:00-1:00), Chou-Shi(1:00-3:00), Yin-Shi(3:00-5:00), Mao-Shi(5:00-7:00)] according to the theory of “midnight-midday ebb flow”. We used random forest to build the diagnostic model of YDSH, with whether it was Yin deficiency syndrome as the outcome. RESULTS: Compared with NYX group, YX group had more female participants with older age, lower waist circumference, body mass index(BMI), diastolic blood pressure(DBP), and smoking and drinking rate(all P < 0.05). The YDSH rating scores of YX group [28.5(21.0-36.0)] were significantly higher than NYX group [13.0(8.0-22.0)](P < 0.001), and the typical symptoms of YX group included vexing heat in the chest, palms and soles, dizziness, dry eyes, string-like and fine pulse, soreness and weakness of lumbus and knees, palpitations, reddened cheeks, and tinnitus(all P < 0.05). The ratio of non-dipper hypertension in YX group was higher t

关键词： hypertension Yin deficiency syndrome random forest blood pressure rhythm blood pressure variability

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