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Chinese Journal of Chemistry 2011年第1期29卷 165-170页

作者： liu, Xia li, ying lin, zhao College of Food Science and Technology Hunan Agricultural University Hunan Provincial Key Laboratory of Food Science and Biotechnology Changsha Hunan 410128 China

A surface plasmon resonance （SPR） biosensor based on wavelength modulation technology was developed and validated for the kinetic analysis of the interactions between two nonsteroidal anti-inflammatory drugs （NSAIDs） and cyclooxygenase-2 （COX-2）. After the effect of different concentration COX-2 on the binding capacity of the SPR biosensor surface was studied, the COX-2 was immobilized covalently onto the biosensor surface using a standard amine coupling method. The affinity constants for indomethacin, ketoprofen binding to COX-2 are 7.5× 10^3 L/tool and 9.25 × 10^3 L/mol, respectively. The biosensor surface can be regenerated after being rinsed with 0.01 mol/L NaOH, and the biosensor can be used repeatedly. These indicated that the wavelength modulation SPR biosensor has the potential application in the fields of pharmacokinetics, pharmacodynamics and drug discovery.

关键词： surface plasmon resonance biosensor cyclooxygenase drug affinity

Fast segmentation approach for SAR image based on simple Markov random field

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Journal of Systems Engineering and Electronics 2010年第1期21卷 31-36页

作者： Xiaogang Lei ying li Na zhao Yanning Zhang Department of Computer Science Northwestern Polytechnical University Xi'an 710072 E R. China

Traditional image segmentation methods based on MRF converge slowly and require pre-defined weight. These disadvantages are addressed, and a fast segmentation approach based on simple Markov random field （MRF） for SAR image is proposed. The approach is firstly used to perform coarse segmentation in blocks. Then the image is modeled with simple MRF and adaptive variable weighting forms are applied in homogeneous and heterogeneous regions. As a result, the convergent speed is accelerated while the segmentation results in homogeneous regions and boarders are improved. Simulations with synthetic and real SAR images demonstrate the effectiveness of the proposed approach.

关键词： SAR image segmentation simple Markov random field coarse segmentation maximum a posterior iterated condition mode.

Association of chronic obstructive pulmonary disease with mild cognitive impairment and dementia risk:A systematic review and meta-analysis

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World Journal of Clinical Cases 2022年第11期10卷 3449-3460页

作者： li-ying zhao Xue-Lai Zhou Department of Geriatrics Traditional Chinese Medical Hospital of ZhujiZhuji 311800Zhejiang ProvinceChina Department of Respiratory Medicine Traditional Chinese Medical Hospital of ZhujiZhuji 311800Zhejiang ProvinceChina

BACKGROUND Chronic obstructive pulmonary disease(COPD)is a common public health issue that has been linked to cognitive *** To investigate the relationship between COPD and a risk of mild cognitive impairment(MCI)and *** A comprehensive literature search of the PubMed,Embase,Google Scholar,and Cochrane library electronic databases was *** odds ratios(OR)and mean differences(MD)with 95%confidence intervals(CIs)were calculated using a random or fixed effects *** that met the inclusion criteria were assessed for quality using the Newcastle Ottawa *** Twenty-seven studies met all the inclusion ***-analysis yielded a strong association between COPD and increased risk of MCI incidence(OR=2.11,95%CI:1.32-3.38).It also revealed a borderline trend for an increased dementia risk in COPD patients(OR=1.16,95%CI:0.98-1.37).Pooled hazard ratios(HR)using adjusted confounders also showed a higher incidence of MCI(HR=1.22,95%CI:-1.18 to-1.27)and dementia(HR=1.32,95%CI:-1.22 to-1.43)in COPD patients.A significant lower mini-mental state examination score in COPD patients was noted(MD=-1.68,95%CI:-2.66 to-0.71).CONCLUSION Our findings revealed an elevated risk for the occurrence of MCI and dementia in COPD *** clinical management and attention are required to prevent and control MCI and dementia incidence in COPD patients.

关键词： Mild cognitive impairment Chronic obstructive pulmonary disease Dementia Meta-analysis

MECHANICAL PROPERTIES AND CURING KINETICS OF EPOXY RESINS CURED BY VARIOUS AMINO-TERMINATED POLYETHERS

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Chinese Journal of Polymer Science 2010年第6期28卷 961-969页

作者： li-ying zhao Jian-guo Guan Hui-ru Ma Zhi-gang Sun State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

A high performance thermosetting epoxy resin crosslinkable at room temperature was obtained via directly moulding diglycidyl ether of bisphenol A（DGEBA） and flexibleα,ω-bisamino（n-alkylene）phenyl terminated poly（ethylene glycol）.The influences of the n-alkylene inserted in aminophenyl of flexible amino-terminated polythers（ATPE） on the mechanical properties,fractographs and curing kinetics of the ATPE-DGEBA cured products were *** results show that the insertion of n-alkylene group into the aminophenyl group of the ATPE,on one hand,can significantly increase the strain relaxation rate and decrease glass transition temperature of the ATPE-DGEBA cured products,resulting in slight decrease of the Young’s modulus and tensile strength,and significant increase of the toughness and elongation of the ATPE-DGEBA cured *** the other hand,it can remarkably enhance the reactivity of amine with epoxy,much accelerating the curing rate of the ATPE-DGEBA *** activation energy of DGEBA cured by BAPTPE,BAMPTPE and BAEPTPE was 53.1,28.5 and 25.4 kJ·mol;,*** as-obtained ATPE-DGEBA cured products are homogeneous, transparent,and show excellent mechanical properties including tensile strength and *** they are promising to have important applications in structure adhesives,casting bulk materials,functional coatings,cryogenic engineering, damping and sound absorbing materials.

关键词： Epoxy resin Amine-terminated polyether Fractography Curing kinetics Mechanical properties

APPliCATION OF LYAPUNOV EXPONENT SPECTRUM IN PRESSURE FLUCTUATION OF DRAFT TUBE

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Journal of Hydrodynamics 2009年第6期21卷 856-860页

作者： WANG li-ying zhao Wei-guo WEI De-hua College of Water Conservancy and Hydroelectric Power Hebei University of Engineering Handan 056021 China

The Lyapunov exponent spectrum is firstly applied in the analysis of pressure fluctuation of draft tube and calculated based on the time series of vibration in experiments for different situations. Results shows that the Lyapunov exponent spectrum varies with the setting of guide vane, So the Lyapunov exponent spectrum can be used to judge the pressure fluctuation of draft tube so as to timely adjust the setting of the guide vanes to reduce the damage caused by the vibration.

关键词： Lyapunov exponent spectrum pressure fluctuation setting of guide vanes

Kinetics of austenite grain growth in medium-carbon niobium-bearing steel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第3期12卷 171-176页

作者： ying-li zhao Jie SHI Wen-quan CAO Mao-qiu WANG Gang XIE School of Material and Metallurgy Engineering Kunming University of Science and Technology Kunming 650093 China Institute for Structural Materials Central Iron and Steel Research Institute Beijing 100081 China

In order to locate a reasonable heating system,the austenite grain growth behavior of Nb microalloyed medium carbon steel has been experimentally studied at various austenitizing temperatures and for different holding *** is indicated that austenite grain growth increases with increasing austenitizing temperatures and holding *** when the austenitizing temperature was above 1100 ℃,austenite grains grew rapidly,and an abnormal austenite grain growth was *** the austenitizing temperature was lower than 1100 ℃,austenite grain size and growth rate were *** activation energy of grain growth in the tested steel is 397 679.5 J/*** ensure an absence of coarse grains in microstructures,the heating technology of the tested steel should be controlled for 1 h at 1100 ℃.The relationships of austenite average grain size with soaking temperature and time of tested steel were obtained by mathematical calculation,and austenite average grain size was found to be in agreement with the measured size for different holding times.

关键词： Microalloyed steel Grain growth Modeling

Effect of direct quenching on microstructure and mechanical properties of medium-carbon Nb-bearing steel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第10期11卷 776-781页

作者： ying-li zhao Jie SHI Wen-quan CAO Mao-qiu WANG Gang XIE School of Material and Metallurgy Engineering Kunming U~iversity of Scienee and Technology Kunming 650093 China Institute for Structural Materials Central Iron and Steel Research Institute Beijing 100081 China

The influence of direct quenching (DQ) on microstructure and mechanical properties of 0.19C-1.7Si-1.0 Mn-0.05Nb steel was studied. The microstructure and mechanical properties of reheat quenched and tempered (RQ&T) steel plate were compared with those of direct quenched and tempered (DQ&T) steel plates which were hot rolled at different finish rolling tem-peratures (1173 K and 1123 K), i.e., recrystallization-controlled-rolled direct-quenched (RCR&DQ) and controlled-rolled direct-quenched (CR&DQ), respectively. The strengths generally increased in the following order: RQ&Tling direction, while complete equiaxed grains were visible in RQ&T and RCR&DQ&T steels. Transmission electron microscopy (TEM) and electron backscattering diffraction (EBSD) of the DQ steels showed smaller block width and higher density of dislocations. Inheritance of austenite deformation substructure by the martensite and differences in martensite block width were ruled out as major causes for the strength differences between DQ and RQ steels.

关键词： Direct quenching (DQ) Block Mechanical properties Electron backscattering diffraction (EBSD) Nb steel

Prognostic and predictive blood biomarkers in gastric cancer and the potential application of circulating tumor cells

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World Journal of Gastroenterology 2018年第21期24卷 2236-2246页

作者： Ting-Ting li Hao liu Jiang Yu Guang-Yao Shi li-ying zhao Guo-Xin li Department of General Surgery Nanfang HospitalSouthern Medical University Division of Cardiology Third Affiliated HospitalSun Yat-sen University

Gastric cancer(GC), with its high incidence and mortality rates, is a highly fatal cancer that is common in East Asia particularly in China. Its recurrence and metastasis are the main causes of its poor prognosis. Circulating tumor cells(CTCs) or other blood biomarkers that are released into the circulating blood stream by tumors are thought to play a crucial role in the recurrence and metastasis of gastric cancer. Therefore, the detection of CTCs and other blood biomarkers has an important clinical significance; in fact, they can help predict the prognosis, assess the staging, monitor the therapeutic effects and determine the drug susceptibility. Recent research has identified many blood biomarkers in GC, such as various serum proteins, autoantibodies against tumor associated antigens, and cell-free DNAs. The analysis of CTCs and circulating cell-free tumor DNA(ctDNA) in the peripheral blood of patients with gastric cancer is called as liquid biopsy. These blood biomarkers provide the disease status for individuals and have clinical meaning. In this review, we focus on the recent scientific advances regarding CTCs and other blood biomarkers, and discuss their origins and clinical meaning.

关键词： Gastric cancer Biomarker Circulating tumor cells Autoantibodies Cell-free DNA

Using oligonucleotide suspension arrays for laboratory identification of bacteria responsible for bacteremia

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第4期9卷 291-298页

作者： Xiao-li HOU Han-liang JIANG Qing-yi CAO li-ying zhao Barbara J. CHANG Zhi CHEN Institute of Infectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Microbiology and Immunology School of Biomedical Biomolecular and Chemical Sciences University of Western Australia Nedlands WA 6009 Australia

The aim of this study was to develop and validate an oligonucleotide suspension array for rapid identification of 15 bacterial species responsible for bacteremia, particularly prevalent in Chinese hospitals. The multiplexed array, based on the QIAGEN liquiChip Workstation, included 15 oligonucleotide probes which were covalently bound to different bead sets. PCR amplicons of a variable region of the bacterial 23S rRNA genes were hybridized to the bead-bound probes. Thirty-eight strains belonging to 15 species were correctly identified on the basis of their corresponding species-specific hybridization profiles. The results show that the suspension array, in a single assay, can differentiate isolates over a wide range of strains and species, and suggest the potential utility of suspension array system to clinical laboratory diagnosis.

关键词： Oligonucleotide array Bacteremia 23S rRNA Multiplexed detection

Techniques and feasibility of laparoscopic extended right hemicolectomy with D3 lymphadenectomy

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World Journal of Gastroenterology 2014年第30期20卷 10531-10536页

作者： li-ying zhao Hao liu Ya-Nan Wang Hai-Jun Deng Qi Xue Guo-Xin li Department of General Surgery Nanfang HospitalSouthern Medical University

AIM: To illustrate the critical techniques and feasibility of laparoscopic extended right hemicolectomy (LERH), according to our previous experience.

关键词： Colon cancer Hepatic flexure Laparoscopic colectomy D3 lymphadenectomy Anatomy