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Two NPF transporters mediate iron long-distance transport and homeostasis in Arabidopsis

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Plant Communications 2022年第4期3卷 161-162页

作者： Si-ying Chen Tian-Yu Gu Zi-Ai Qi Jing Yan Zi-Jun fang Yu-Ting Lu Hui Li Ji-Ming Gong 不详

(Plant Communications 2,100244,November 82021)Figure S3E has been amended since,in the originally published version of the figure,the roots of npf5.9-T and Col-3 under+Fe condition were inadvertent duplicates of the r... 详细信息

关键词： roots homeostasis Figure

口服益生菌对肝部分切除术患者术后感染和肝功能恢复的影响

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上海交通大学学报（医学版） 2022年第1期42卷 9-15页

作者：吴懿方芳黄浩陈瑛上海交通大学附属第一人民医院肝胆胰外科上海200080 上海交通大学附属第一人民医院护理部上海200080

目的·探讨口服益生菌对肝部分切除术患者术后感染和肝功能恢复的影响。方法·入组上海交通大学附属第一人民医院165例行肝部分切除术的患者,应用随机数字表将患者分为传统机械性肠道准备组(MBP组,n=55)、无肠道准备组(NBP组,n=55)和益... 详细信息

目的·探讨口服益生菌对肝部分切除术患者术后感染和肝功能恢复的影响。方法·入组上海交通大学附属第一人民医院165例行肝部分切除术的患者,应用随机数字表将患者分为传统机械性肠道准备组(MBP组,n=55)、无肠道准备组(NBP组,n=55)和益生菌肠道准备组(PBP组,n=55)。收集患者临床资料,包括基本信息,术后发热情况,排气排便时间,术后第1、3、5日感染指标和肝功能指标,并进行组间比较。结果·3组患者基本资料比较,差异均无统计学意义(均P>0.05)。术后第5日,PBP组患者白细胞计数显著低于MBP组(P=0.012)和NBP组(P=0.029)。术后第3日、第5日PBP组谷丙转氨酶水平较MBP组和NBP组显著降低(术后第3日:P=0.040,P=0.036。术后第5日:P=0.002,P=0.019)。结论·口服益生菌肠道准备有助于减轻肝部分切除术后感染,加快肝功能恢复。

关键词：肝部分切除术肠道准备益生菌术后感染肝功能

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论哈代小说的多样化叙事情境及其文体效果

南昌大学学报（人文社会科学版） 2007年第1期38卷 117-120页

作者：方英宁波大学科技学院外语系浙江宁波315211

奥地利学者F.K.斯坦泽提出了叙事情境的概念,我国学者罗钢对这一术语的内涵提出了修正。根据罗钢的观点,叙事情境是对传统意义上的叙事人称和叙事视角概念的综合。哈代在其小说中运用了“编辑者全知”型、“中立的全知”型、人物叙事情... 详细信息

奥地利学者F.K.斯坦泽提出了叙事情境的概念,我国学者罗钢对这一术语的内涵提出了修正。根据罗钢的观点,叙事情境是对传统意义上的叙事人称和叙事视角概念的综合。哈代在其小说中运用了“编辑者全知”型、“中立的全知”型、人物叙事情境等多种叙事情境,有些段落甚至采用了重合的叙事情境。这种叙事情境的多样化,创造出多样化的文体效果,增强了小说的悲剧力量。

关键词：哈代小说叙事情境文体效果

Saturable Nonlinearity in Photovoltaic-Photorefractive Crystals Under Open-circuit Condition

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Chinese Physics Letters 2000年第11期17卷 804-805页

作者： GUO Ru LING Zhen-fang CHEN Xiao-Hu ZHANG Guo-Quan ZHANG Xin-Zheng WEN Hai-Dong JIANG ying LIU Si-Min College of Physics Science Nankai UniversityTianjin 300071

We show that the refractive index change induced by a focused incident beam with an additional incoherent uniform illumination in photovoltaic-photorefractive crystals under open-circuit condition has a saturable nonlinearity *** incoherent uniform background illumination can be used to increase the effective dark *** formation time of the photovoltaic soliton can be decreased by keeping the intensity of the soliton at a higher value without over-saturation by use of the background illumination.

关键词： form. illumination soliton

Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1159-1174页

作者： Heng Xu Hongfang Zhao Chunyong Ding Defang Jiang Zijie Zhao Yang Li Xiaoyu Ding Jing Gao Hu zhou Cheng Luo Guoqiang Chen Ao Zhang ying Xu Hao Zhang School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Chemical Biology Research Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghai 200025China Pharm-X center College of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China School of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xianlin RoadQixiaNanjing 210023 JiangsuChina University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRen-Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

As a terpenoids natural product isolated from the plant Thunder God Vine,Celastrol is widely studied for its pharmacological activities,including anti-tumor *** clinical application of Celastrol is strictly limited due to its severe side effects,whereas previously revealed targets and mechanism of Celastrol seldom reduce its in vivo toxicity via structural *** identification has a far-reaching influence on the development of innovative drugs,and omics data has been widely used for unbiased target ***,it is difficult to enrich target of specific phenotype from thousands of genes or proteins,especially for natural products with broad promising ***,we developed a text-mining-based web-server tool to enrich targets from omics data of inquired *** peroxiredoxin 1(PRDX1)was identified as the ROS-manipulating target protein of Celastrol in colorectal *** solved high-resolution crystal structure revealed the unique covalent binding mode of Celastrol with *** derivative compound 19-048 with improved potency against PRDX1 and selectivity towards PRDX2~PRDX6 were synthesized based on crystal structure *** Celastrol and 19-048 effectively suppressed the proliferation of colorectal cancer *** anti-tumor efficacy of Celastrol and 19-048 was significantly diminished on xenograft nude mice bearing PRDX1 knock-down colorectal cancer *** downstream genes of p53 signaling pathway were dramatically up-regulated with Celastrol or 19-048 *** findings reveal that the side effects of Celastrol could be reduced via structural modification,and PRDX1 inhibition is promising for the treatment of colorectal cancer.

关键词： colorectal cancer nude

High cholesterol intake remodels cholesterol turnover and energy homeostasis in Nile tilapia(Oreochromis niloticus)

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Marine Life Science & Technology 2023年第1期5卷 56-74页

作者： Rui-Xin Li Ling-Yun Chen Samwel M.Limbu Yu-Cheng Qian Wen-Hao zhou Li-Qiao Chen Yuan Luo fang Qiao Mei-Ling Zhang Zhen-Yu Du LANEH School of Life SciencesEast China Normal UniversityShanghai200241China Department of Aquaculture Technology School of Aquatic Sciences and Fisheries TechnologyUniversity of Dar es SalaamP.O.Box 60091Dar es SalaamTanzania

The roles of dietary cholesterol in fish physiology are currently *** issue reflects the limited studies on the metabolic consequences of cholesterol intake in *** present study investigated the metabolic responses to high cholesterol intake in Nile tilapia(Oreochromis niloticus),which were fed with four cholesterol-contained diets(0.8,1.6,2.4 and 3.2%)and a control diet for eight *** fish-fed cholesterol diets showed increased body weight,but accumulated cholesterol(the peak level was in the 1.6%cholesterol group).Then,we selected 1.6%cholesterol and control diets for further *** high cholesterol diet impaired liver function and reduced mitochondria number in ***,high cholesterol intake triggered protective adaptation via(1)inhibiting endogenous cholesterol synthesis,(2)elevating the expression of genes related to cholesterol esterification and efflux,and(3)promoting chenodeoxycholic acid synthesis and ***,high cholesterol intake reshaped the fish gut microbiome by increasing the abundance of Lactobacillus *** Mycobacterium spp.,both of which are involved in cholesterol and/or bile acids ***,high cholesterol intake inhibited lipid catabolic activities through mitochondrialβ-oxidation,and lysosome-mediated lipophagy,and depressed insulin signaling *** catabolism was elevated as a compulsory response to maintain energy ***,although high cholesterol intake promoted growth,it led to metabolic disorders in *** the first time,this study provides evidence for the systemic metabolic response to high cholesterol intake in *** knowledge contributes to an understanding of the metabolic syndromes caused by high cholesterol intake or deposition in fish.

关键词： Cholesterol metabolism Metabolic response Energy metabolism Gut microbiome

有限元网格中波动的频散与稳定性的一种改进方法

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地震工程与工程振动 2000年第1期20卷 21-26页

作者：房营光莫海鸿广东工业大学广州510080 华南理工大学广州510641

本文采用含有频率的高阶位移函数，由二维波动方程导出了波在有限元网格中传播的频散关系，利用这一关系给出了波动的稳定条件。理论分析和数值计算结果表明，文中的有限元方法明显地改善了有限元网格中波动的频散性和稳定性。

关键词：有限元网格波动频散关系稳定条件地震工程

Cloning of GF14 Gene from the Bulbs of Fritillaria crrishoa

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High Technology Letters 2002年第3期8卷 32-35页

作者：李玉峰 MO Min Lin Juan Xu ying Yan fang Chen fang College of Life Science Sichuan University Chengdu 610064 P.R.China

GF14 widely occurs in plant species functioning as a regulatory protein in cell signal transdution, including monoamine synthesis, exocytosis and cell cycle regulation. A partial sequence, 413 bp in length, is cloned from the bulbs of F. crrihosa by means of RT PCR technique. Sequence alignment with the BLAST program shows that it is highly similar to GF14 gene. A new full length cDNA, 1133 bp, is obtained by RACE techniques. It contains a major open reading frame of 262 amino acids, 5’and 3’ untranslated regions and a long Poly (A) tail. Sequence analysis of deduced GF14 protein from F. crrihosa indicates several conserved motifs of GF14 proteins are also found in sequence of GF14 protein of F. crrihosa.

关键词： GF14 gene Fritillaria crrihosa clone RT PCR

ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI

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Science Bulletin 2019年第14期64卷 998-1010页

作者： Jiachen Li Dan Jin Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang Yuying zhou Xi Zhang Tianzi Jiang Yong Liu ying Han Department of Neurology Xuanwu Hospital of Capital Medical University Beijing 100053 China Department of Radiology Chinese PLA General Hospital Beijing 100853 China Université Normandie Inserm Université de Caen-Normandie Inserm UMR-S U1237 GIP Cyceron Caen 14000 France Department of Radiology Tianjin Huanhu Hospital Tianjin 300350 China Department of Radiology Tianjin Medical University General Hospital Tianjin 300052 China Center of Alzheimer's Disease Beijing Institute for Brain Disorders Beijing 100053 China Beijing Institute of Geriatrics Beijing 100053 China National Clinical Research Center for Geriatric Disorders Beijing 100053 China Brainnetome Center & National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing 100190 China School of Artificial Intelligence University of Chinese Academy of Sciences Beijing 100049 China Center for Excellence in Brain Science and Intelligence Technology Institute of Automation Chinese Academy of Sciences Beijing 100190 China Department of Neurology Qilu Hospital of Shandong University Ji'nan 250012 China Department of Neurology Tianjin Huanhu Hospital Tianjin 300350 China Institute of Geriatrics and Gerontology Chinese PLA General Hospital Beijing 100853 China Department of Radiology Qilu Hospital Ji'nan 250012 China Department of Radiology Xuanwu Hospital of Capital Medical University Beijing 100053 China

Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P?

关键词： Brain spontaneous activity Multisite Biomarkers Leave-one-site-out cross-validation Alzheimer's disease