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Protective effect of selenium-enriched lactobacilluson CCI_4-induced liver injury in mice and its possible mechanisms

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World Journal of Gastroenterology 2005年第37期11卷 5795-5800页

作者： Long Chen Dao-Dong Pan Juan Zhou ying-zi jiang College of Life Sciences Nanjing Normal University jiangsu Engineering Research Center for Bio-Medical Function Materials Nanjing 210097 Jiangsu Province China Department of Food Sciences Nanjing Normal University Nanjing 110097 Jiangsu Province China

AIM： To study the protective effects and mechanisms of Se-enriched lactobacillus on liver injury caused by carbon tetrachloride （CCl4） in mice. METHODS： Seventy-two ICR mice were randomly divided into four groups： normal group, CCl4-induced model group, low Se-enriched lactobacillus treatment group （L-Se group）, and high Se-enriched lactobacillus treatment group （H-Se group）. During a 3-wk experimental period, the common complete diet was orally provided daily for normal group and model group, and the mice in L-Se and H-Se groups were given a diet with 2 and 4 mg of organoselenium from Se-enriched lactobacillus per kg feed, respectively. From the 2nd wk of experiment, the model group, L-Se group, and H-Se group received abdominal cavity injection of olive oil solution containing 500 mL/L CCl4 （0.07 mL/100 g body mass） to induce liver injury, and the normal group was given olive oil on every other day for over 2 wk. In the first 2 wk post injection with CCl4, mice in each group were killed. The specimens of blood, liver tissue, and macrophages in abdominal cavity fluid were taken. Then the activities of the following liver tissue injury-associated enzymes including glutathione peroxidase （GSH-Px）, superoxide dismutase （SOD）, alanine aminotransferase （ALT） and aspartate aminotransferase （AST） as well as malondialdehyde （MDA） content were assayed. Changes of phagocytic rate and phagocytic index in macrophages were observed with Wright-Giemsa stain. Plasma TNF-α level was measured by radioimmunoassay. The level of intracellular free Ca^2＋（[Ca^2＋]i） in hepatocytes was detected under a laser scanning confocal microscope. RESULTS： During the entire experimental period, the AST and ALT activities in liver were greatly enhanced by CCl4 and completely blunted by both low and high doses of Se-enriched lactobacillus. The Se-enriched lactobacillus- protected liver homogenate GSH-Px and SOD activities were higher or significantly higher than those in model group and were close t

关键词： Se-enriched lactobacillus Liver injury Carbon tetrachloride Macrophage Ca^2+

Discovering broader antiviral strategies:Role of interferon-induced transmembrane proteins in virus infection

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hLife 2024年第8期2卷 377-379页

作者： zi-ying jiang Chu Xie Pei-Huang Wu Zhi-Xuan Li Mu-Sheng Zeng Cong Sun State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-Sen University Cancer CenterGuangdongChina Division of Infectious Diseases Department of MedicineBrigham and Women’s HospitalMassachusettsUSA Broad Institute of Harvard and MIT MassachusettsUSA

Host antiviral strategies have been studied for a long time,and the antibody response and T-cell response represent the classic host antiviral *** entry of enveloped viruses into host cells is a complex process that could involve interactions ofmultiple viral glycoproteins and host-cell *** this process is the key to preventing *** general,antigenspecific neutralizing antibodies are thought to effectively bind to viral glycoproteins to block virus ***,there are other unknown host factors that inhibit or enhance the virus entry into the host ***,Yang et *** that interferon-induced transmembrane protein-1(IFITM1)inhibited Epstein–Barr virus(EBV)infection in epithelial cells(ECs)by competing with viral glycoproteins to bind to Ephrin receptor A2(EphA2),thereby blocking this key entry receptor[1](Figure 1).Together with previous research,this finding hints at the importance of discovering broader host protective *** are known to be critical sites for EBV infection and ***2 has been reported as one of the most crucial EBV entry receptors on the EC surface,which binds to viral glycoprotein H/L(gH/gL)and glycoprotein B(gB)[2]to drive the internalization and fusion of EBV[3].However,ECs with low susceptibility to EBV can still express a high level of EphA2[4],raising questions about additional factors that influence host susceptibility.

关键词： EphA2 protective inhibited

斯韦泽案:美国联邦最高法院学术自由判决第一案

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教育学报 2017年第5期13卷 93-102页

作者：秦发盈李子江曲阜师范大学继续教育学院山东曲阜272234 北京师范大学教育历史与文化研究院北京100875

斯韦泽案是20世纪50年代冷战时期美国联邦最高法院真正介入学术自由的第一案。通过梳理和分析斯韦泽案的案件过程及其引发的公共舆论对判决的影响,发现斯韦泽案件的判决依据是模糊的、存在争议的,引发了不少对斯韦泽案的误读。为此,应... 详细信息

斯韦泽案是20世纪50年代冷战时期美国联邦最高法院真正介入学术自由的第一案。通过梳理和分析斯韦泽案的案件过程及其引发的公共舆论对判决的影响,发现斯韦泽案件的判决依据是模糊的、存在争议的,引发了不少对斯韦泽案的误读。为此,应从以沃伦为主导的多数意见和以法兰克福特为主导的附带意见两个方面来澄清斯韦泽案的判决依据,解释引发误读的原因。斯韦泽案推动了美国大学教授协会和联邦最高法院就学术自由制度、合法性等方面的首次对话,拓展了学术自由主体的法理阐释范围,为学术自由在美国宪法权利中的证成迈出了重要的一步,但对它在美国学术自由史上的地位及影响需要客观评价,不应过度夸大其对学术自由宪法权利诠释的作用。

关键词：斯韦泽案学术自由宪法第一修正案

Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping Lin Jun Xu Delong jiang Jiayang Hou ying Liang Zhongyue Zou Xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Contrastive Learning

Application of a Feedback Journal Club

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Chinese Medical Journal 2017年第22期130卷 2752-2754页

作者： Nan-Ze Yu Pan-Xi YU Xiao-Jun Wang Xiao Long Elan Yang Jiu-Zuo Huang Yang Wang Wei-Ming Kang ying-zi jiang Kang Li Jun Zhao Hui Pan Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China The 16th Department Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical CQIlege Beijing 100144 China Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Education Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

The first documented journal club was organized in 1875 by William Osler at McGill University, to keep staff informed of medical science in a cost-effective manner. Nowadays, journal club has already become a common form of interactive education in hope to keep medical practitioners up-to-date of current literature, understand research design and statistics, and expand critical appraisal skills. A considerable amount of literatures describing journal clubs in different forms have been published; most were to enhance students＇ critical thinking, research competency,

关键词： Feedback Journal Club Publication

吡咯烷二硫代氨基甲酸酯对TGF-β2诱导人晶状体上皮细胞EMT的抑制作用

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国际眼科杂志 2023年第7期23卷 1072-1079页

作者：姜子英王佳伟雷新兰胡军湖北科技学院口腔与眼视光医学院中国湖北省咸宁市437000 武汉大学爱尔眼科医院中国湖北省武汉市430000 华中科技大学同济医学院眼科中国湖北省武汉市430000

目的:探究吡咯脘二硫代氨基甲酸酯(PDTC)对转化生长因子-beta2(TGF-β2)诱导人晶状体上皮细胞(LECs)上皮-间充质转化(EMT)的逆转机制。方法:TGF-β2诱导人晶状体上皮细胞EMT,并给予不同浓度PDTC处理TGF-β2诱导的LECs。CCK-8、划痕试验... 详细信息

目的:探究吡咯脘二硫代氨基甲酸酯(PDTC)对转化生长因子-beta2(TGF-β2)诱导人晶状体上皮细胞(LECs)上皮-间充质转化(EMT)的逆转机制。方法:TGF-β2诱导人晶状体上皮细胞EMT,并给予不同浓度PDTC处理TGF-β2诱导的LECs。CCK-8、划痕试验检测细胞增殖与迁移,Western Blot检测EMT标志物E-cadherin、α-SMA和NF-κB信号传导通路相关蛋白表达,以及凋亡相关蛋白BAX、BCL-2、Caspase-3、细胞周期蛋白D_1的表达。结果:TGF-β2处理组细胞增殖和迁移活力明显高于未添加TGF-β2的实验组;E-cadherin表达下调,α-SMA表达上调。在TGF-β2的作用下NF-κB p65和磷酸化的NF-κB p65表达增加(P<0.05)且在TGF-β210 ng/mL刺激浓度时LECs表现出较强的增殖活力和迁移能力。PDTC逆转EMT和诱导细胞凋亡的机制研究表明,PDTC干预处理后细胞活力和迁移能力都显著降低,PDTC抑制IκB的磷酸化进而抑制NF-κB核移位,NF-κB信号通路中NF-κBp65/p-NF-κB p65、Iκκ-α/p-Iκκ-α表达下调(P<0.05),诱导促凋亡蛋白BAX/Caspase-3表达上调、抑凋亡蛋白BCL-2、细胞周期蛋白Cyclin D_1表达下调,NF-κB/IκB mRNA表达下调,凋亡相关mRNA BAX表达上调BCL-2表达下调。结论:PDTC可显著逆转由TGF-β2诱导的LECs细胞EMT过程,可能与抑制NF-κB信号通路活化使NF-κB p65/IκB/Iκκ-α表达降低以及激活凋亡相关蛋白表达有关,PDTC可通过抑制NF-κB信号通路达到逆转EMT的进程并使异常增殖的细胞发生凋亡,这将为后发性白内障的治疗提供新的潜在的治疗药物。

关键词：吡咯烷二硫代氨基甲酸酯转化生长因子-β2 核因子-κB 上皮-间质转化人晶状体上皮细胞

Electrode/Electrolyte Optimization‑Induced Double‑Layered Architecture for High‑Performance Aqueous zinc‑(Dual)Halogen Batteries

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Nano-Micro Letters 2025年第3期17卷 121-137页

作者： Chengwang Zhou Zhezheng Ding Shengzhe ying Hao jiang Yan Wang Timing Fang You Zhang Bing Sun Xiao Tang Xiaomin Liu School of Textiles and Clothing School of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071ShandongPeople’s Republic of China Centre for Clean Energy Technology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyUltimoNSW 2007Australia School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanPeople’s Republic of China

Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical ***,the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical ***,a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid(ZEA)artificial film and ZnF2-rich solid electrolyte interphase(SEI)layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer,therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal *** double-layered architecture not only modulates Zn2+flux and suppresses the zinc dendrite growth,but also blocks the direct contact between the metal anode and electrolyte,thus mitigating the corrosion from the active *** employing optimized metal anodes and electrolytes,the as-developed zinc-(dual)halogen batteries present high areal capacity and satisfactory cycling *** work provides a new avenue for developing aqueous zinc-(dual)halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual)halogen batteries

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo zi-Fei Xu ying Zeng Yun-Dong Wu Xiao-jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Research landmarks on the 60th anniversary of Epstein-Barr virus

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Science China Life Sciences 2024年

作者： Lan-Yi Zhong Chu Xie Le-Le Zhang Yan-Lin Yang Yuan-Tao Liu Ge-Xin Zhao Guo-Long Bu Xian-Shu Tian zi-ying jiang Bo-Yu Yuan Peng-Lin Li Pei-Huang Wu Wei-Hua Jia Christian Münz Benjamin E.Gewurz Qian Zhong Cong Sun Mu-Sheng Zeng State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangdong Provincial Clinical Research Center for Cancer Sun Yat-sen University Cancer Center Viral Immunobiology Institute of Experimental Immunology University of Zürich Division of Infectious Diseases Department of Medicine Brigham and Women's Hospital Department of Microbiology Harvard Medical School Harvard Program in Virology Broad Institute of Harvard and MIT

Epstein-Barr virus(EBV), the first human oncovirus discovered in 1964, has become a focal point in virology, immunology, and oncology because of its unique biological characteristics and significant role in human diseases. As we commemorate the 60th anniversary of EBV's discovery, it is an opportune moment to reflect on the major advancements in our understanding of this complex virus. In this review, we highlight key milestones in EBV research, including its virion structure and life cycle, interactions with the host immune system, association with EBV-associated diseases, and targeted intervention strategies.

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