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Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese medicine and Western medicine

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Military Medical Research 2024年第3期11卷 313-322页

作者： ying-Hui Jin Yan-Ping Wang ying-Lan Xie Gui-Hua Tian Xiao-Yu Zhang Nan-Nan Shi Ke-Hu Yang Xin Sun Yao-Long Chen Da-Rong Wu Xin-Feng Guo Long Ge Chen Zhao Cheng Lu Yin Jiang Jing Guo Si-Yu Yan Yong-Bo Wang Qiao Huang Xiang-ying Ren ying-yue rao Yun-Yun Wang Meng-Qian Yuan Xian-Tao Zeng Hong-Cai Shang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China China Center for Evidence Based Traditional Chinese Medicine Beijing 100029China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430074China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China China Center for Evidence-Based Medicine West China Hospital of Sichuan UniversityChengdu 610041China State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Evidence-based Medicine Team Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120China Nanjing University of Chinese Medicine Nanjing 210023China Jiangsu Province Hospital of Chinese Medicine Nanjing 210029China

Integrated traditional Chinese medicine(TCM)and Western medicine(WM)is a new medical science grounded in the knowledge bases of both TCM and WM,which then forms a unique modern medical system in *** TCM and WM has a long history in China,and has made important achievements in the process of clinical diagnosis and ***,the methodological defects in currently published clinical practice guidelines(CPGs)limit its *** organic integration of TCM and WM is a deeper integration of TCM and *** realize the progression of"integration"to"organic integration",a targeted and standardized guideline development methodology is ***,the purpose of this study is to establish a standardized development procedure for clinical practice guidelines for the organic integration of TCM and WM to promote the systematic integration of TCM and WM research results into clinical practice guidelines in order to achieve optimal results as the whole is greater than the sum of the parts.

关键词： Methodology Traditional Chinese medicine Western medicine Organic integration Clinical practice guidelines(CPGs)

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin rao yue Lin Gen Wei Jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng rao Guiyun Song Wei Song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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Spatial distribution characteristics and mechanism of nonhydrological time-variable gravity in China's Mainland

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Earth and Planetary Physics 2022年第1期6卷 96-107页

作者： yue Shen QiuYu Wang WeiLong rao WenKe Sun University of Chinese Academy of Sciences Beijing 100049China

The purpose of this study is to explore nonhydrological mass transfer in China's *** this purpose,gravity recovery and climate experiment(GRACE)data were obtained to study the spatial distribution of time variant gravity signals in China's ***,from auxiliary hydrological data processed according to the current hydrological model,a new more comprehensive hydrological model of China's Mainland was ***,the time variant signals of this new hydrological model were removed from the time variant gravity field computed from GRACE data,thus obtaining a description of the nonhydrological mass transfer of China's *** physical sources and mechanisms of the resulting mass transfer are then *** improved,more realistic,hydrological model used here was created by selecting the hydrological components with the best correlations in existing hydrological models,by use of correlation calculation,analysis,and *** improved model includes water in soils and deeper strata,in the vegetation canopy,in lakes,snow,and glaciers,and in other water components(mainly reservoir storage,swamps,and rivers).The spatial distribution of the transfer signals due to nonhydrological mass in China's Mainland was obtained by subtracting the combined hydrological model from the GRACE time-variable gravity *** results show that the nonhydrological signals in China's Mainland collected in GRACE data were mainly positive signals,and were distributed in the Bohai Rim and the northern and eastern parts of the Tibetan *** above nonhydrological mass transfer signals have been studied further and are *** results show that the nonhydrological mass migration signals in the Bohai Rim region originate primarily from sea level change and marine sediment *** mass accumulation from Indian plate collision in the Tibetan Plateau appears to be the main reason for the increase in the residual gravity field in that region.

关键词： GRACE hydrological model time-variable gravity signal nonhydrological signal

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DPP-4 inhibitors and GLP-1RAs:cardiovascular safety and benefits

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Military Medical Research 2023年第2期10卷 227-241页

作者： Michael Razavi ying-ying Wei Xiao-Quan rao Ji-Xin Zhong Tulane University School of Medicine New OrleansLA 70112USA Department of Rheumatology and Immunology Tongji HospitalTongji Medical College of Huazhong University of Science and Technology1095 Jiefang AveWuhan 430032China Department of Cardiovascular Medicine Tongji HospitalTongji Medical College of Huazhong University of Science and Technology1095 Jiefang AveWuhan 430032China Institute of Allergy and Clinical Immunology Tongji HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhan 430032China

Glucagon-like peptide-1 receptor agonists(GLP-1RAs)and dipeptidyl peptidase-4 inhibitors are commonly used treatments for patients with type 2 diabetes mellitus(T2DM).Both anti-diabetic treatments function by playing key modulatory roles in the incretin *** these drugs have been deemed effective in treating T2DM,the Food and Drug Administration(FDA)and some members of the scientific community have questioned the safety of these therapeutics relative to important cardiovascular *** a result,since 2008,the FDA has required all new drugs for glycemic control in T2DM patients to demonstrate cardiovascular *** present review article strives to assess the safety and benefits of incretin-based therapy,a new class of antidiabetic drug,on the health of patient cardiovascular *** the process,this review will also provide a physiological overview of the incretin system and how key components function in T2DM.

关键词： Glucagon-like peptide-1 receptor agonists Dipeptidyl peptidase-4 inhibitors Type 2 diabetes mellitus Cardiovascular outcome

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Atrial fibrillatory signal estimation using blind source extraction algorithm based on high-order statistics

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Science in China(Series F) 2008年第10期51卷 1572-1584页

作者： WANG Gang rao NiNi ZHANG ying School of life Science and Technology University of Electronic Science and Technology of China Chengdu 610054 China School of Automation Engineering University of Electronic Science and Technology of China Chengdu 610054 China

The analysis and the characterization of atrial fibrillation （AF） requires, in a previous key step, the extraction of the atrial activity （AA） free from 12-lead electrocardiogram （ECG）. This contribution proposes a novel non-invasive approach for the AA estimation in AF episodes. The method is based on blind source extraction （BSE） using high order statistics （HOS）. The validity and performance of this algorithm are confirmed by extensive computer simulations and experiments on realworld data. In contrast to blind source separation （BSS） methods, BSE only extract one desired signal, and it is easy for the machine to judge whether the extracted signal is AA source by calculating its spectrum concentration, while it is hard for the machine using BSS method to judge which one of the separated twelve signals is AA source. Therefore, the proposed method is expected to have great potential in clinical monitoring.

关键词： electrocardiogram (ECG) atrial fibrillation blind source separation (BSS) blind source extraction (BSE)

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Fruit shape detection by level set

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第8期8卷 1232-1236页

作者： GUI Jiang-sheng rao Xiu-qin ying Yi-bin School of Biosystems Engineering and Food Science Zhejiang University Hangzhou 310029 China

A novel approach for fruit shape detection in RGB space was proposed,which was based on fast level set and Chan-Vese model named as Modified Chan-Vese model(MCV) . This new algorithm is fast and suitable for fruit sorting because it does not need re-initializing. MCV has three advantages compared to the traditional methods. First,it provides a unified frame-work for detecting fruit shape boundary,and does not need any preprocessing even though the raw image is noisy or blurred. Second,if the fruit has different colors at the edges,it can detect perfect boundary. Third,it processed directly in color space without any transformations that may lose much information. The proposed method has been applied to fruit shape detection with promising result.

关键词： Machine vision Shape detection Level set Fruit sorting

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临床实践指南实施性促进研究之六:临床实践指南知识图谱构建中关于基本信息、背景和方法的建模表征研究

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医学新知 2022年第6期32卷 401-416页

作者：王永博刘郝弦高旷陈沐坤任相颖饶映月王诗淳李绪辉黄桥阎思宇朱彦靳英辉武汉大学中南医院循证与转化医学中心武汉430071 武汉大学计算机学院武汉430071 湖北中医药大学针灸骨伤学院武汉430061 中国中医科学院中医药信息研究所北京100700

在计算机辅助临床决策和实践中,现行临床实践指南的可读性和可操作性存在诸多不足。通过对指南的结构、知识及知识间的关系进行规范化的表示,发掘指南通用性的结构框架;通过建模表证,促进指南知识的标准化、规范化表达,构建便于共享和... 详细信息

在计算机辅助临床决策和实践中,现行临床实践指南的可读性和可操作性存在诸多不足。通过对指南的结构、知识及知识间的关系进行规范化的表示,发掘指南通用性的结构框架;通过建模表证,促进指南知识的标准化、规范化表达,构建便于共享和可移植的标准化指南知识库,有利于满足临床决策支持系统发展的需要,推动临床实践指南的实施和临床诊疗服务质量的提升。知识图谱的引入为指南数字智能化提供了坚实的基础,然而目前介绍指南知识图谱构建的方法学研究较为罕有。本研究以《中国非肌层浸润性膀胱癌治疗与监测循证临床实践指南(2018年标准版)》的知识图谱构建为例,通过梳理指南模块,解析指南基本信息、背景和方法内容范围,结合专家意见设置各概念间的层级关系,根据多级概念层及概念实例设计概念结构表,调整概念间的关系结构,并改进实体与实体间的关系。本文旨在探讨指南中基本信息、背景和方法部分的建模和表征方法,以期为今后其他临床实践指南的知识图谱构建提供参考。

关键词：指南基本信息指南背景指南方法非肌层浸润性膀胱癌知识图谱 Neo4j

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Single photon emitter deterministically coupled to a topological corner state

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Light(Science & Applications) 2024年第1期13卷 135-141页

作者： Mujie rao Fulong Shi Zhixuan rao Jiawei Yang Changkun Song Xiaodong Chen Jianwen Dong ying Yu Siyuan Yu State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySchool of PhysicsSun Yat-Sen UniversityGuangzhou 510006China Hefei National Laboratory Hefei 230088China

Incorporating topological physics into the realm of quantum photonics holds the promise of developing quantum light emitters with inherent topological robustness and immunity to ***,the deterministic interaction of quantum emitters with topologically nontrivial resonances remains largely *** we present a single photon emitter that utilizes a single semiconductor quantum dot,deterministically coupled to a second-order topological corner state in a photonic crystal *** investigating the Purcell enhancement of both single photon count and emission rate within this topological cavity,we achieve an experimental Purcell factor of Fp=***,we demonstrate the on-demand emission of polarized single photons,with a second-order autocorrelation function g(2)(0)as low as 0.024±*** approach facilitates the customization of light-matter interactions in topologically nontrivial environments,thereby offering promising applications in the field of quantum photonics.

关键词： topological quantum deterministic

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Do companies influenced by smart cities pay more attention to green governance?Mechanism and optimal spatial correlation

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Chinese Journal of Population,Resources and Environment 2024年第1期22卷 48-57页

作者： Xiaoxu Guo rao Zhang yue Zhang College of Finance Nanjing Agricultural UniversityNanjing 210095China

Smart cities are a way for China to construct an innovative and environmentally conscious *** paper examines the impact of smart cities on corporate green governance and provides a theoretical foundation for formulating and executing smart city policy in *** on panel data from Chinese A-share listed companies in Shanghai and Shenzhen from 2008 to 2020,this study constructs a multiperiod double-difference model to examine the influence of smart cities on corporate green ***,it uses a spatial double-difference model to investigate the spatial spillover effect of smart cities on neighboring *** findings indicate that smart cities effectively enhance corporate green *** the influencing mechanisms reveals that resource allocation efficiency,technological innovation,management environmental awareness,and regional environmental enforcement efforts act as ***,the study reveals that the impact of smart cities on promoting corporate green governance is more pronounced in regions with lower levels of marketization and resource-based ***,the research explores the spatial spillover effects of smart cities,with an effective radius of approximately 350 *** optimal spatial correlation zone for green governance of businesses in neighboring areas in relation to smart cities is within a range of 250-350 *** is manifested by the significant promotion of green governance in neighboring area businesses facilitated by smart cities.

关键词： Smart cities Corporate green governance Mediating effects Spatial associations

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