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Effect of the yaw angle on turbulent flow structures around the submarine model

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Journal of Hydrodynamics 2024年第3期36卷 421-434页

作者： yi-jing Hu yi Qu qin Wu Biao Huang School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China Beijing Institute of Electronic System Engineering Beijing100854China

The objective of this paper is to investigate the turbulent flow structures around the submarine model and evaluate the effect of the yaw angle on the turbulent flow *** large eddy simulation based on the boundary data immersion method is used to *** computational domain consists of 1.2×10^(8)uniformly distributed Cartesian orthogonal grid nodes to capture the basic flow characteristics around the *** pressure coefficient,friction coefficient and wake velocity distribution are in good agreement with the experimental *** different types of vortex structures were mainly captured around the model,including horseshoe vortex,sail tip vortex and crossflow separation *** the increase of the yaw angle,the asymmetry of the horseshoe vortex and the tip vortex gradually increases,and the vortex strength of the vortex leg on the windward of the horseshoe vortex and the vortex strength of the tip vortex also increase *** the crossflow separation vortex,the flow separation zone gradually expands and migrates downstream with the increase of the yaw angle.

关键词： Vortex structure submarine model boundary data immersion method yaw angle

Gene therapy for monogenic disorders: challenges, strategies, and perspectives

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Journal of Genetics and Genomics 2024年第2期51卷 133-143页

作者： yi Zhang Zhi-ying Wu Department of Medical Genetics and Center for Rare Diseases Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Medical Neurobiology of Zhejiang Province HangzhouZhejiang 310009China

Monogenic disorders refer to a group of human diseases caused by mutations in single genes. While disease-modifying therapies have offered some relief from symptoms and delayed progression for some monogenic diseases, most of these diseases still lack effective treatments. In recent decades, gene therapy has emerged as a promising therapeutic strategy for genetic disorders. Researchers have developed various gene manipulation tools and gene delivery systems to treat monogenic diseases. Despite this progress, concerns about inefficient delivery, persistent expression, immunogenicity, toxicity, capacity limitation, genomic integration, and limited tissue specificity still need to be addressed. This review gives an overview of commonly used gene therapy and delivery tools, along with the challenges they face and potential strategies to counter them.

关键词： Gene therapy Monogenic diseases Geneediting Genedelivery Challenges

Targeting ferroptosis and ferritinophagy:new targets for cardiovascular diseases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 1-22页

作者： yi LUAN Yang YANG ying LUAN Hui LIU Han XING Jinyan PEI Hengdao LIU Bo qin Kaidi REN Clinical Systems Biology Research Laboratories Translational Medicine Centerthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China State Key Laboratory for Artificial Microstructures and Mesoscopic Physics School of PhysicsPeking UniversityBeijing100871China School of Laboratory Medicine Xinxiang Medical UniversityXinxiang453003China Quality Management Department Henan No.3 Provincial People’s HospitalZhengzhou450052China Department of Cardiology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Center for Translational Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Henan Key Laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou450052China Henan Engineering Research Center for Application&Translation of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou450052China

Cardiovascular diseases(CVDs)are a leading factor driving mortality ***,an essential trace mineral,is important in numerous biological processes,and its role in CVDs has raised broad discussion for ***-mediated cell death,namely ferroptosis,has attracted much attention due to its critical role in cardiomyocyte damage and ***,ferritinophagy is the upstream mechanism that induces ferroptosis,and is closely related to *** review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy,and the regulatory pathways and molecular targets involved in ferritinophagy,and to determine their roles in ***,we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating ***,this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.

关键词： Cardiovascular disease Iron Ferroptosis Ferritinophagy Therapeutic target

Flexible piezoelectret film sensor for noncontact mechanical signal capture by multiple transmission media

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Nano Research 2024年第8期17卷 7643-7657页

作者： Xingchen Ma Qianqian Hu Lian Zhou Xinhao Xiang yi qin Ke Zhang Pengfei He ying Dai Wenxin Niu Xiaoqing Zhang Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092China Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) School of MedicineTongji UniversityShanghai 201619China Department of Rehabilitation Sciences Tongji University School of MedicineShanghai 200092China School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Mechanical signal capture without physical contact has emerged as a highly promising research field and attracted tremendous attention due to its prosperous applications in household medical care,lifestyle monitoring and remote operation,offering users high level of safety,convenience and ***,noncontact sensing is ideal to maximize the immersive user experience in the human–machine interaction(HMI),eliminating interference to human activities and mechanical fatigue to the sensor,***,we report a self-powered flexible sensor integrated with irradiation cross-linked polypropylene(IXPP)piezoelectret film for noncontact sensing,featuring multi-functions to detect mechanical signals transmitted through solid,liquid and gaseous media and would facilitate their versatile practical *** folded-structure configuration of the sensor facilitates the improvement of the noncontact sensing *** solid media,such as the rectangular wooden stick used in this study,the sensor can detect mechanical stimulus exerted at a distance of 100 cm.A system detection sensitivity up to 57 pC/kPa with a low detection limit of 0.6 kPa is achieved at a noncontact distance of 10 *** when partly or completely immersed in water,the sensor effectively traces movement signals of human bodies underwater,demonstrating great advantages for non-inductive aquatic fitness training ***,due to the low acoustic impedance of piezoelectret film,speech recognition through gaseous medium is also *** further introduce application demonstrations of the developed film sensors to monitor exercise postures and physiological signals without direct contact between human body and the sensor,displaying great potential to be incorporated into future smart *** study commendably expands the application scope of piezoelectret materials,which will have profound implications for exploring novel intelligent human–machine interactions.

关键词： noncontact sensing piezoelectret multiple transmission media mechanical signal capture

Well-dispersed Sb particles embedded on N-doped carbon nanofibers toward high-performance Li-ion battery

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Rare Metals 2024年第7期43卷 2994-3006页

作者： ying Li yi-Han Zhao Lu-Lu Zhao Peng-Fei Wang ying Xie Ting-Feng yi School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China

The alloy-type material Sb is widely used in the anode materials of lithium-ion batteries(LIBs)due to its high theoretical specific ***,its serious volume expansion problem during alloying/dealloying of Li~+limits its practical *** this work,C-Sb composite was constructed as anode material of LIBs by electrospinning route for the first time,Sb was introduced into the polyacrylonitrile-based hard carbon and coal tar pitch-based soft carbon composite amorphous carbon fiber with a diameter of 300-600 nm,which realized high cycling *** C-Sb-2(the mass ratio of polyacrylonitrile to Sb source is 1:2)electrode displayed charge capacities of 1098.5,930.3,841.7,753.5,643.9 and 545.8 mAh·g^(-1)at 0.1,0.2,0.3,0.5,1 and 2 A·g^(-1),*** when the current density returned to 0.1 A·g^(-1),the charge capacity was 939.3 mAh·g^(-1),revealing good stability and *** introduction of Sb into the amorphous carbon improved its conductivity and addressed the volume expansion issue of high specific capacity Sb during charge/***-situ XRD analysis confirmed the high reversibility of the C-Sb-2 during charging and *** functional theory(DFT)calculations revealed the gradual enhancement of the interface interaction between Sb_(x)Li_(y) and amorphous carbon(AMC)with increasing lithium content,contributing to the anchoring of alloy nanoparticles on the AMC surface and buffering the volume change of the ***,the gradual lithiation of Sb facilitated the electron transfer from Sb_(x)Li_(y) to *** findings hold promise for designing lithium storage materials with exceptional performance,highlighting the potential of C-Sb composites as anode materials for efficient next-generation lithium storage.

关键词： Li-ion battery Metallic Sb Carbon Electrospinning Cycling stability

Stretchable and self-healing conductive fibers from hierarchical silver nanowires-assembled network

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Nano Research 2024年第2期17卷 763-770页

作者： ying-ying Wu Hong Chen Fan Zhang Pan Guo Haili qin Huai-Ping Cong Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China

Conductive fibers(CFs)with features of high conductivity,stretchability,self-healability,and electromechanical stability are key components of the increasingly popular wearable ***,since the lack of structural design of conductive network and interfacial interaction between soft polymer and conductive additives,it is still hard to enable CFs to meet above ***,we describe a facial drawing method from a hydrogel reservoir which is remolded into ultrathin and stretchable CFs with excellent multi-responsive *** hydrogel reservoir was fabricated in synergy of an ice-templating method and in situ polymerization using the assembled framework as a *** on the effective fabrication mechanism,the diameter of CFs could be well-tuned from 90 to 400μm by adjusting the dipping depth of the glass rod,accompanied with conductivity increased from 0.75 to 2.5 S/*** the hierarchical network structure was well maintained in the CFs,professional performances have been proved on the stretchability and electromechanical *** presence of massive hydrogen bonding and Ag–S bond enabled the CFs with excellent self-healability under the conditions of contact,electric field,and near infrared light,***,the CFs with high sensing property could be integrated into an advanced textile sensor through an effective healing-induced integration strategy,demonstrating its great potentials as superior two-dimensional(2D)electronic skins.

关键词： conductive fibers self-assembled silver nanowires Ag–S coordination self-healing flexible sensors

Assessing Dietary Consumption of Sodium and Potassium in China through Wastewater Analysis

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Biomedical and Environmental Sciences 2024年第1期37卷 127-131页

作者： TAN Dong qin LIANG yi GUO Ting LI Yan ying SONG Yong Xin WANG De Gao College of Environmental Science and Engineering Dalian Maritime UniversityDalian 116026LiaoningChina College of Marine Engineering Dalian Maritime UniversityDalian 116026LiaoningChina

A causal relationship has been reported between the average population salt(sodium chloride)intake and the increased risk of stroke and cardiovascular and cerebrovascular diseases in some epidemiological and clinical *** World Health Organization has recommended that a sodium intake of<2 g/day is preventive against cardiovascular disease,although the current intake is in excess in most countries.

关键词： Wastewater intake Potassium

Hematite-facilitated microbial ammoxidation for enhanced nitrogen removal in constructed wetlands

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 35-45页

作者： Hao qin Wenbo Nie Duo yi Dongxu Yang Mengli Chen Tao Liu yi Chen Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment(Ministry of Education) Chongqing UniversityChongqing 400045China College of Environment and Ecology Chongqing UniversityChongqing 400045China Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 610031China

Constructed wetlands(CWs)are widely applied for decentralized wastewater ***,achieving efficient removal of ammonia(NH+-N)has proven challenging due to insufficient *** this study,natural hematite(Fe,O3)was employed as a CW substrate(H-CWs)for the first time to drive anaerobic ammonia oxidation coupled with iron(I)reduction(Feammox).Compared to gravel constructed wetlands(G-CWs),ammonia removal was enhanced by 38.14%to 54.03%and nitrous oxide(N_(2)0)emissions were reduced by 34.60%in *** synergistic removal of ammonia and nitrate by H-CWs also resulted in the absence of ammoxidation *** and 15N isotope tracer incubations showed that Feammox accounting for approximately 40%of all ammonia removal in the *** enrichment of iron phosphate(Fe_(3)Fe_(4)(PO_(4))_(6))promoted the accumulation of the Feammox intermediate compound *** nanowires were observed on the surface of H-CW substrates as well,suggesting that the observed biological ammoxidation was most likely related to extracellular electron transfer(EET).Microbial and metagenomics analysis revealed that H-CWs elevated the integrity and enhanced the abundance of functional microorganisms and genes associated with nitrogen ***,the efficient ammonia removal in the absence of O2 together with a reduction in N_(2)O emissions as described in this study may provide useful guidance for hematite-mediated anaerobic ammonia removal in CWs.

关键词： Constructed wetlands Nitrogen removal Feammox Hematite Iron cycle

Chain Extender-induced Hydrogen Bonding Organization Determines the Morphology and Properties of Thermoplastic Polycarbonate Polyurethane

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Chinese Journal of Polymer Science 2024年第1期42卷 87-96,I0009页

作者： yi-Lang qin Ping Zhu Chen-Xi Ouyang Xia Dong Fuwai Hospital Chinese Academyof Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBejing 100037China CASKey Laboratoryof Engineering Plastics CAS Research/Education Centerfor Excellence in Molecular SciencesInstitute ofChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Thermoplastic polycarbonate polyurethanes(PCUs) are multiblock copolymers that have been applied for medical devices for long time. Aliphatic diols are common chain extenders(CE) involved in the composition of the hard segments of PCU. However, limited knowledge was discovered about how the chemical structure of CE affects the hydrogen bonding organization within PCUs and their mechanical *** investigate this problem, a group of PCUs were synthesized respectively by extending the polymer chain with 1,4-butanediol(BDO),aminoethanol(MEA), ethanediol(EO) as three kinds of chain extenders. Tiny differences in the CE chemical structure results in remarkable variations in phase separation, condensed morphologies, thermal and mechanical properties, which are characterized by Fourier transform infrared spectrometer, atomic force microscopy, small-angle X-ray scattering, differential scanning calorimetry, and tensile tests. The microstructural evolution during unilateral deformation and the different mechanism induced by the different CEs was probed and unveil by in situ wide-and small-angle X-ray diffraction. Symmetry of CE can improve the organization of the hydrogen bonding. The coherence strength of the urethane/urea group also plays a key role by comparing the two PCUs with ethanediol and aminoethanol.

关键词： Thermoplastic polycarbonate polyurethane Chain extender Hydrogen bonding Mechanical properties